Synthetic peptides as inactivators of multimeric enzymes: Inhibition of Plasmodium falciparum triosephosphate isomerase by interface peptides

FEBS Letters

Volumn 501, Issue 1, 2001, Pages 19-23

  Singh, S Kumar ^a   Maithal, Kapil ^a   Balaram, Hemalatha ^b   Balaram, P ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

Author keywords

Enzyme inhibition; Interface peptide; Malaria; PfTIM, Plasmodium falciparum triosephosphate isomerase (EC 5.3.1.1); Plasmodium falciparum triosephosphate isomerase

Indexed keywords

ALANYLASPARAGINYLTRYPTOPHANYLLYSYLCYSTEINYLASPARAGINYLGLYCYLTHREONYLLEUCYLGLUTAMIC ACID; LYSYLPHENYLALANYLGLYCYLASPARAGINYLGLYCYLSERYLTYROSYLTHREONYLGLYCYLGLUTAMYLVALYLSERINE; LYSYLTYROSYLGLYCYLASPARAGINYLGLYCYLSERYLCYSTEINYLTHREONYLGLYCYLGLUTAMYLVALYLSERINE; MUTANT PROTEIN; OLIGOMER; SYNTHETIC PEPTIDE; TRIOSEPHOSPHATE ISOMERASE; UNCLASSIFIED DRUG; PEPTIDE; PROTEIN SUBUNIT;

AMINO ACID SEQUENCE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INACTIVATION; ENZYME INHIBITION; IC50; PEPTIDE SYNTHESIS; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN QUATERNARY STRUCTURE; PROTEIN STABILITY; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; GENETICS; IC 50; KINETICS; METABOLISM; MUTATION; SYNTHESIS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; DRUG DESIGN; INHIBITORY CONCENTRATION 50; KINETICS; MODELS, MOLECULAR; MUTATION; PEPTIDES; PLASMODIUM FALCIPARUM; PROTEIN STRUCTURE, QUATERNARY; PROTEIN SUBUNITS; TRIOSE-PHOSPHATE ISOMERASE;

EID: 0035854727     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/S0014-5793(01)02606-0     Document Type: Article

References (44)

1. E. Roth Jr., V. Joulin, S. Miwa, A. Yoshida, J. Akatsuka, M. Cohen-Solal, R. Rosa, Blood, 71, (1988), 1408-1413.
2. S.S. Velanker, S.S. Ray, R.S. Gokhale, S. Suma, H. Balaram, P. Balaram, M.R.N. Murthy, Structure, 5, (1997), 751-761.
3. C.R. Dunn, M.J. Banfield, J.J. Barker, C.W. Higham, K.M. Moreton, D. Turgut-Balik, R.L. Brady, J.J. Holbrook, Nat. Struct. Biol., 3, (1996), 912-915.
4. H. Kim, U. Certa, H. Dobeli, P. Jakob, W.G. Hol, Biochemistry, 37, (1998), 4388-4396.
5. W.G.J. Hol, Angew. Chem. Int. Ed. Engl., 25, (1986), 767-778.
6. R. Zutshi, M. Brickner, J. Chmielewski, Curr. Opin. Chem. Biol., 2, (1998), 62-66.
7. V. Prasanna, S. Bhattacharjya, P. Balaram, Biochemistry, 37, (1998), 6883-6893.
8. H.J. Schramm, J. Boetzel, J. Buttner, E. Fritsche, W. Gohring, E. Jaeger, S. Konig, O. Thumfart, T. Wenger, N.E. Nagel, W. Schramm, Antiviral Res., 30, (1996), 155-170.
9. H.J. Schramm, A. Billich, E. Jaeger, K.P. Rücknagel, G. Arnold, W. Schramm, Biochem. Biophys. Res. Commun., 194, (1993), 595-600.
10. Z.Y. Zhang, R.A. Poorman, L.L. Maggiora, R.L. Heinrikson, F.J. Kezdy, J. Biol. Chem., 266, (1991), 15591-15594.
11. L.M. Babe, J. Rose, C.S. Craik, Protein Sci., 1, (1992), 1244-1253.
12. M. Brickner, J. Chmielewski, Chem. Biol., 5, (1998), 339-343.
13. B.M. Dutia, M.C. Frame, J.H. Subak-Sharpe, W.N. Clark, H.S. Marsden, Nature, 321, (1986), 439-441.
14. A. Haigh, R. Greaves, P. O'Hare, Nature, 344, (1990), 257-259.
15. A. Nordhoff, C. Tziatzios, J.A. van den Broek, M.K. Schott, H.R. Kalbitzer, K. Becker, D. Schubert, R.H. Schirmer, Eur. J. Biochem., 245, (1997), 273-282.
16. S.J. Putman, A.F. Coulson, I.R. Farley, B. Riddleston, J.R. Knowles, Biochem. J., 129, (1972), 301-310.
17. B. Gopal, S.S. Ray, R.S. Gokhale, H. Balaram, M.R.N. Murthy, P. Balaram, Biochemistry, 38, (1999), 478-486.
18. R.S. Gokhale, S.S. Ray, H. Balaram, P. Balaram, Biochemistry, 38, (1999), 423-431.
19. S.G. Waley, Biochem. J., 135, (1973), 165-192.
20. R.K. Wierenga, K.H. Kalk, W.G. Hol, J. Mol. Biol., 198, (1987), 109-121.
21. P. Ostoa-Saloma, G. Garza-Ramos, J. Ramirez, I. Becker, M. Berzunza, A. Landa, A. Gomez-Puyou, M. Tuena de Gomez-Puyou, R. Perez-Montfort, Eur. J. Biochem., 244, (1997), 700-705.
22. S.C. Mande, V. Mainfroid, K.H. Kalk, K. Goraj, J.A. Martial, W.G.J. Hol, Protein Sci., 3, (1994), 810-821.
23. K.U. Yuksel, A.Q. Sun, R.W. Gracy, K.D. Schnackerz, J. Biol. Chem., 269, (1994), 5005-5008.
24. J.R. Knowles, Nature, 350, (1991), 121-124.
25. D. Maes, J.P. Zeelen, N. Thanki, N. Beaucamp, M. Alvarez, M.H. Thi, J. Backmann, J.A. Martial, L. Wyns, R. Jaenicke, R.K. Wierenga, Proteins, 37, (1999), 441-453.
26. H. Walden, G.S. Bell, R.J. Russell, B. Siebers, R. Hensel, G.L. Taylor, J. Mol. Biol., 306, (2001), 745-757.
27. J. Ranie, V.P. Kumar, H. Balaram, Mol. Biochem. Parasitol., 61, (1993), 159-169.
28. A. Anderson, R.A. Cooper, J. Gen. Microbiol., 62, (1970), 324-329.
29. Creighton, T.E. (1984) in: Protein Structure and Molecular Principles, p. 14, W.H. Freeman and Company, New York.
30. B. Plaut, J.R. Knowles, Biochem. J., 129, (1972), 311-320.
31. C. Chothia, J. Mol. Biol., 105, (1976), 1-12.
32. R. Perez-Montfort, G. Garza-Ramos, G.H. Alcantara, H. Reyes-Vivas, X.G. Gao, E. Maldonado, M. Tuena de Gomez-Puyou, A. Gomez-Puyou, Biochemistry, 38, (1999), 4114-4120.
33. A. Gómez-Puyou, E. Saavedra-Lira, I. Becker, R.A. Zubillaga, A. Rojo-Domínguez, R. Pérez-Montfort, Chem. Biol., 2, (1995), 847-855.
34. G. Garza-Ramos, R. Perez-Montfort, A. Rojo-Dominguez, M.T. de Gomez-Puyou, A. Gomez-Puyou, Eur. J. Biochem., 241, (1996), 114-120.
35. G. Garza-Ramos, N. Cabrera, E. Saavedra-Lira, M. Tuena de Gomez-Puyou, P. Ostoa-Saloma, R. Perez-Montfort, A. Gomez-Puyou, Eur. J. Biochem., 253, (1998), 684-691.
36. E. Lolis, T. Alber, R.C. Davenport, D. Rose, F.C. Hartman, G.A. Petsko, Biochemistry, 29, (1990), 6609-6618.
37. R.K. Wierenga, M.E. Noble, J.P. Postma, H. Groendijk, K.H. Kalk, W.G. Hol, F.R. Opperdoes, Proteins, 10, (1991), 33-49.
38. Z. Zhang, S. Sugio, E.A. Komives, K.D. Liu, J.R. Knowles, G.A. Petsko, D. Ringe, Biochemistry, 33, (1994), 2830-2837.
39. S.K. Burley, G.A. Petsko, Science, 229, (1985), 23-28.
40. S.K. Burley, G.A. Petsko, Adv. Protein Chem., 39, (1988), 125-189.
41. R. Zutshi, J. Chmielewski, Bioorg. Med. Chem. Lett., 10, (2000), 1901-1903.
42. Hol, W.G.J., Vellieux, F.M.D., Verlinde, C.M.J., Wierenga, R.K., Noble, M.E.M. and Read, R.J. (1991) in: Molecular Conformation and Biological Interactions (Balaram, P. and Ramaseshan, S., Eds.), pp. 215-244, Indian Academy of Sciences, Bangalore.
43. D.A. Kuntz, R. Osowski, M. Schudok, R.K. Wierenga, K. Muller, H. Kessler, F.R. Opperdoes, Eur. J. Biochem., 207, (1992), 441-447.
44. M. Callens, J.V. Roy, J.Ph. Zeelan, T.V. Borchert, D. Nalis, R.K. Wierenga, F.R. Opperdoes, Biochem. Biophys. Res. Commun., 195, (1993), 667-672.