Synthetic interface peptides as inactivators of multimeric enzymes: Inhibitory and conformational properties of three fragments from Lactobacillus casei thymidylate synthase

Biochemistry

Volumn 37, Issue 19, 1998, Pages 6883-6893

  Prasanna, Variath ^a,b   Bhattacharjya, Surajit ^a   Balaram, Padmanabhan ^a,b  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

THYMIDYLATE SYNTHASE;

ARTICLE; CONFORMATIONAL TRANSITION; ENZYME CONFORMATION; ENZYME INACTIVATION; ENZYME ISOLATION; ENZYME SUBUNIT; LACTOBACILLUS CASEI; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; STRUCTURE ANALYSIS;

ACETONE; AMINO ACID SEQUENCE; CATALYSIS; CIRCULAR DICHROISM; DIMERIZATION; ENZYME INHIBITORS; FLUOROCARBONS; LACTOBACILLUS CASEI; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; SOLUTIONS; THYMIDYLATE SYNTHASE; WATER;

BACTERIA (MICROORGANISMS); LACTOBACILLUS CASEI;

EID: 0032510706     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9720989     Document Type: Article

References (81)

1. Carreras, C. W., and Santi, D. V. (1995) Annu. Rev. Biochem. 64, 721-762.
2. Eckstein, J. W., Foster, P. G., Finer-Moore, J., Wataya, Y., and Santi, D. V. (1994) Biochemistry 33, 15086-15094.
3. Weichsel, A., and Montfort, W. R. (1995) Nat. Struct. Biol. 2, 1095-1101.
4. Santi, V., McHenry, C. S., and Sommer, H. (1974) Biochemistry 13, 471-481.
5. Danenberg, P. V., Langenbach, R. L., and Heidelberger, C. (1974) Biochemistry 13, 926-933.
6. Santi, D. V., and McHenry, C. S. (1972) Proc. Natl. Acad. Sci. U.S.A. 69, 1855-1857.
7. Langenbach, R. J., Danenberg, P. V., and Heidelberger, C. (1972) Biochem. Biophys. Res. Commun. 48, 1565-1571.
8. Appell, K., Bacquet, R., Bartlett, C., Booth, C., Freer, S., Fuhry, M., Gehring, M. R., Herrmann, S. M., Howland, E. F., Janson, C. A., Jones, T. R., Kan, C. C., Kathardekar, V., Lewis, K. K., Marzoni, G. P., Matthews, D. A., Mohr, C., Moomaw, E. W., Morse, C. A., Oatley, S. J., Ogden, R. C., Reddy, M. R., Reich, S. H., Schoettlin, W. S., Smith, W. W., Varney, M. D., Villafranca, J. E., Ward, R. W., Webber, S., Webber, S. E., Welsh, K. M., and White, J. (1991) J. Med. Chem. 34, 1925-1934.
9. Schoichet, B. K., Stroud, R. M., Santi, D. V., Kuntz, I. D., and Perry, K. M. (1993) Science 259, 1445-1450.
10. Hardy, L. W., Finer-Moore, J. S., Montfrot, W. R., Jones, M. O., Santi, D. V., and Stroud, R. M. (1987) Science 235, 448-455.
11. Perry, K. M., Fauman, E. B., Finer-Morre, J. S., Montfort, W. R., Maley, G. F., Maley, F., and Stroud, R. M. (1990) Proteins: Struct., Func., Genet. 8, 315-333.
12. Knighton, D. R., Kan, C., Howland, E., Janson, C. A., Hostomska, Z., Welsh, K. M., and Matthews, D. A. (1994) Nat. Struct. Biol. 1, 186-194.
13. Schiffer, C. A., Clifton, I. J., Davisson, V. J., Santi, D. V., and Stroud, R. M. (1995) Biochemistry 34, 16279-16287.
14. Perry, K. M., Pookanjanatavip, M., Zhao, J., Santi, D. V., and Stroud, R. A. (1992) Protein Sci. 1, 796-800.
15. Maley, F., Pedersen-Lane, J., and Changchien, L. (1995) Biochemistry 34, 1469-1474.
16. Hol, W. G. J. (1986) Angew. Chem., Int. Ed. Engl. 25, 767-778.
17. Dutia, B. M., Frame, M. C., Subak-Sharp, J. H., Clark, W. N., and Marsden, H. S. (1986) Nature 321, 439-441.
18. Schramm, H. J., Billich, A., Jaeger, E., Rucknagel, K., Arnold, G., and Schramm (1993) Biochem. Biophys. Res. Commun. 194, 595-600.
19. Zhang, Z., Poorman, R. A., Maggiora, L. L., Heinrikson, R. L., and Kezdy, F. J. (1991) J. Biol. Chem. 266, 15591-15594.
20. Haigh, A., Greaves, R., and O'Hara, P. (1990) Nature 344, 257-259.
21. Matthews, D. A., Appelt, K., and Oatley, S. J. (1989) J. Mol. Biol. 205, 449-454.
22. Matthews, D. A., Appelt, K., Oatley, S. J., and Xuong, N. (1990) J. Mol. Biol. 214, 923-936.
23. Dyson, H. J., Merutka, G., Waltho, J. P., Lerner, R. A., and Wright, P. E. (1992) J. Mol. Biol. 226, 795-817.
24. Blanco, J. F., Jimenez, M. A., Herranz, J., Rico, M., Santoro, J., and Nieto, J. L. (1993) J. Am. Chem. Soc. 115, 5887-5888.
25. Blanco, J. F., Rivas, G., and Serrano, L. (1994a) Nat. Struct. Biol. 1, 584-596.
26. Blanco, J. F., Jimenez, M. A., Pineda, A., Rico, M., Santoro, J., and Nieto, J. L. (1994b) Biochemistry 33, 6004-6014.
27. Searle, M. S., Williams, D. H., and Packman, L. C. (1995) Nat. Struct. Biol. 2, 999-1006.
28. Searle, M. S., Zerella, R., Williams, D. H., and Packman, L. C. (1996) Protein Eng. 9, 559-565.
29. Rajan, R., Awasthi, S. K., Bhattacharjya, S., and Balaram, P. (1997) Biopolymers 42, 125-128.
30. Bhattacharjya, S., and Balaram, P. (1997) Protein Sci. 6, 1065-1073.
31. Wahba, A. J., and Friedkin, M. (1961) J. Biol. Chem. 236, PC11-12.
32. Creighton, T. E. (1984) Protein Structure and Molecular Principles, p 14, W. H. Freeman & Company, New York.
33. Santi, D. V., McHenry, C. S., & Sommer, H. (1974) Biochemistry 13, 471-481.
34. Hudson, E. N., and Weber, G. (1973) Biochemistry 12, 4154-4161.
35. Agarwalla, S., Gokhale, R. S., Santi, D. V., and Balaram, P. (1996) Protein Sci. 5, 270-277.
36. Pardi, A., Billeter, M., and Wüthrich, K. (1984) J. Mol. Biol. 180, 741-751.
37. Wishart, D. S., Sykes, B. D., and Richards, F. M. (1991) J. Mol. Biol. 222, 311-333.
38. Jones, S., and Thornton, J. M. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 13-20.
39. Babe, L. M., Rose, J., and Craik, C. S. (1992) Protein Sci. 1, 1244-1253.
40. Jones, S., and Thornton, J. M. (1995) Prog. Biophys. Mol. Biol. 63, 31-65.
41. Janin, J., Miller, S., and Chothia, C. (1988) J. Mol. Biol. 204, 155-164.
42. Woody, R. W. (1985) in The Peptides: Analysis, Synthesis, Biology (Undenfriend, S., and Meienhofer, J., Eds.) Vol. 7, pp 16-114, Academic Press, New York.
43. Rajan, R., and Balaram, P. (1996) Int. J. Pept. Protein Res. 48, 328-336.
44. Luidens, M. K., Figge, J., Breese, K., and Vajda, S. (1996) Biopolymers 39, 367-376.
45. Vuilleumier, S., Sancho, J., Loewenthal, R., and Fersht, A. R. (1993) Biochemistry 32, 10303-10313.
46. Chakrabartty, A., Kortemme, T., Padmanabhan, S., and Baldwin, R. L. (1993) Biochemistry 32, 5560-5565.
47. Osterman, D., and Kaiser, E. T. (1985) J. Cell. Biochem. 29, 57-72.
48. Muga, A., Surewicz, W. K., Wong, P. T. T., and Mantsch, H. H. (1990) Biochemistry 29, 2925-2930.
49. Wüthrich, K. (1986) NMR of proteins and nucleic acids, Wiley, New York.
50. Dyson, H. J., Rance, M., Houghten, R. A., Wright, P. E., and Lerner, R. A. (1988) J. Mol. Biol. 201, 201-217.
51. Wagner, G., Pardi, A., and Wüthrich, K. (1983) J. Am. Chem. Soc. 105, 5948-5949.
52. Ramachandran, G. N., Ramakrishnan, C., and Sasisekharan, V. (1963) J. Mol. Biol. 7, 95-99.
53. Sikkink, R., Haddy, A., MacKelvie, S., Mertz, P., Litwiller, R., and Rusnak, F. (1995) Biochemistry 34, 8348-8356.
54. Fisher, A., Laub, P. B., and Cooperman, B. S. (1995) Nat. Struct. Biol. 2, 951-955.
55. Jaenicke, R. (1987) Prog. Biophys. Mol. Biol. 49, 117-237.
56. Schumann, J., and Jaenicke, R. (1993) Eur. J. Biochem. 213, 1225-1233.
57. Gokhale, R. S., Agarwalla, S., Santi, D. V., and Balaram, P. (1996) Biochemistry 35, 7150-7158.
58. Gokhale, R. S., Agarwalla, S., Francis, V. S., Santi, D. V., and Balaram, P. (1994) J. Mol. Biol. 235, 89-94.
59. Montfort, W. R., Perry, K. M., Fauman, E. B., Finer-Moore, J. S., Maley, G. F., Hardy, L., Maley, F., and Stroud, R. M. (1990) Biochemistry 29, 6964-6977.
60. Awasthi, S. K., Raghotham, S., and Balaram, P. (1995) Biochem. Biophys. Res. Commun. 216, 375-381.
61. Struthers, M. D., Cheng R. P., and Imperiali, B. (1996) Science 271, 341-344.
62. Haque, T. S., and Gellman, S. H. (1997) J. Am. Chem. Soc 119, 2303-2304.
63. Dyson, H. J., Satterthwait, A. C., Lerner, R. A., and Wright, P. E. (1990) Biochemistry 29, 7828-7837.
64. Yang, J. J., Buck, M., Pitkeathly, M., Kotik, M., Haynie, D. T., Dobson, C. M., and Radford, S. E. (1995) J. Mol. Biol. 252, 483-492.
65. Kemmink, J., and Creighton, T. E. (1993) J. Mol. Biol. 234, 861-878.
66. Kemmink, J., and Creighton, T. E. (1995) Biochemistry 34, 12630-12635.
67. Munoz, V., Serrano, L., Jimenez, M. A., and Rico, M. (1995) J. Mol. Biol. 247, 648-669.
68. Hamada, D., Kuroda, Y., Tanaka, T., and Goto, Y. (1995) J. Mol. Biol. 254, 737-746.
69. Sonnichsen, F. D., Van Eyk, J. E., Hodges, R. S., and Sykes, B. D. (1992) Biochemistry 31, 8790-8798.
70. Minor, D. L., Jr., and Kim, P. S. (1994) Nature 367, 660-663.
71. Smith, C. K., and Regan, L. (1995) Science 270, 980-982.
72. O'Neil, K. T., and Degrado, W. F. (1990) Science 250, 646-650.
73. Chakrabartty, A., Schellman, J. A., and Baldwin, R. L. (1991) Nature 351, 586-588.
74. Creighton, T. E. (1994) Nat. Struct. Biol. 1, 135-138.
75. Dobson, C. M. (1995) Nat. Struct. Biol. 2, 513-517.
76. Hua, Q., Gozani, S. N., Chance, R. E., Hoffmann, J. A., Frank, B. H., and Weiss, M. A. (1995) Nat. Struct. Biol. 2, 129-138.
77. Carreras, C. W., Costi, P. M., and Santi, D. V. (1994) J. Biol. Chem. 269, 12444-12446.
78. Ma, J., Yee, A., Brewer, H. B., Jr., Das, S., and Potter, H. (1994) Nature 372, 92-94.
79. Primm, T. P., Walker, K. W., and Gilbert, H. F. (1996) J. Biol. Chem. 271, 33664-33669.
80. Marquardt, T., and Helenius, A. (1992) J. Cell Biol. 3, 505-513.
81. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950.