메뉴 건너뛰기




Volumn 5, Issue 2, 2010, Pages 267-276

Apolipoprotein B: Not just a biomarker but a causal factor in hepatic endoplasmic reticulum stress and insulin resistance

Author keywords

ApoB; Dyslipidemia; Endoplasmic reticulum stress; Insulin resistance; Lipid; Unfolded protein response

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; APOLIPOPROTEIN B; BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; BIOLOGICAL MARKER; BMS 201038; FATTY ACID; I KAPPA B KINASE INHIBITOR; INSULIN; METFORMIN; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN INHIBITOR; MIPOMERSEN; PROTEIN KINASE R; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN; X BOX BINDING PROTEIN 1;

EID: 77950289592     PISSN: 17460875     EISSN: None     Source Type: Journal    
DOI: 10.2217/clp.10.15     Document Type: Review
Times cited : (8)

References (79)
  • 1
    • 43249119219 scopus 로고    scopus 로고
    • Intestinal lipoprotein overproduction in insulin-resistant states
    • Adeli K, Lewis GF: Intestinal lipoprotein overproduction in insulin-resistant states. Curr. Opin. Lipidol. 19(3), 221-228 (2008).
    • (2008) Curr. Opin. Lipidol , vol.19 , Issue.3 , pp. 221-228
    • Adeli, K.1    Lewis, G.F.2
  • 2
    • 85026079592 scopus 로고    scopus 로고
    • Metabolic syndrome: Focus on dyslipidemia
    • (Silver Spring)
    • Ginsberg HN, Zhang YL, Hernandez-Ono A: Metabolic syndrome: focus on dyslipidemia. Obesity (Silver Spring) 14(Suppl. 14), S1-S49 (2006).
    • (2006) Obesity , vol.14 , Issue.SUPPL. 14
    • Ginsberg, H.N.1    Zhang, Y.L.2    Hernandez-Ono, A.3
  • 4
    • 16844362015 scopus 로고    scopus 로고
    • Diabetic dyslipidaemia: Insights for optimizing patient management
    • Verges B: Diabetic dyslipidaemia: insights for optimizing patient management. Curr. Med. Res. Opin. 21(Suppl. 1), S29-S40 (2005).
    • (2005) Curr. Med. Res. Opin , vol.21 , Issue.SUPPL. 1
    • Verges, B.1
  • 5
    • 33646826006 scopus 로고    scopus 로고
    • Lipid and lipoprotein dysregulation in insulin resistant states
    • Avramoglu RK, Basciano H, Adeli K: Lipid and lipoprotein dysregulation in insulin resistant states. Clin. Chim. Acta 368(1-2), 1-19 (2006).
    • (2006) Clin. Chim. Acta , vol.368 , Issue.1-2 , pp. 1-19
    • Avramoglu, R.K.1    Basciano, H.2    Adeli, K.3
  • 6
    • 19944366619 scopus 로고    scopus 로고
    • Regulation of plasma triglycerides in insulin resistance and diabetes
    • Ginsberg HN, Zhang YL, Hernandez-Ono A: Regulation of plasma triglycerides in insulin resistance and diabetes. Arch. Med. Res. 36(3), 232-240 (2005).
    • (2005) Arch. Med. Res , vol.36 , Issue.3 , pp. 232-240
    • Ginsberg, H.N.1    Zhang, Y.L.2    Hernandez-Ono, A.3
  • 7
    • 38149136598 scopus 로고    scopus 로고
    • Inhibition of Apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents
    • Ota T, Gayet C, Ginsberg HN: Inhibition of Apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents. J. Clin. Invest. 118(1), 316-332 (2008).
    • (2008) J. Clin. Invest , vol.118 , Issue.1 , pp. 316-332
    • Ota, T.1    Gayet, C.2    Ginsberg, H.N.3
  • 8
    • 14644397903 scopus 로고    scopus 로고
    • The endoplasmic reticulum chaperone improves insulin resistance in Type 2 diabetes
    • Ozawa K, Miyazaki M, Matsuhisa M et al.: The endoplasmic reticulum chaperone improves insulin resistance in Type 2 diabetes. Diabetes 54(3), 657-663 (2005).
    • (2005) Diabetes , vol.54 , Issue.3 , pp. 657-663
    • Ozawa, K.1    Miyazaki, M.2    Matsuhisa, M.3
  • 9
    • 5644231992 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress links obesity, insulin action, and Type 2 diabetes
    • Ozcan U, Cao Q, Yilmaz E et al.: Endoplasmic reticulum stress links obesity, insulin action, and Type 2 diabetes. Science 306(5695), 457-461 (2004).
    • (2004) Science , vol.306 , Issue.5695 , pp. 457-461
    • Ozcan, U.1    Cao, Q.2    Yilmaz, E.3
  • 10
    • 34250899722 scopus 로고    scopus 로고
    • Signal integration in the endoplasmic reticulum unfolded protein response
    • Ron D, Walter P: Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev. Mol. Cell Biol. 8(7), 519-529 (2007).
    • (2007) Nat. Rev. Mol. Cell Biol , vol.8 , Issue.7 , pp. 519-529
    • Ron, D.1    Walter, P.2
  • 11
    • 71949098172 scopus 로고    scopus 로고
    • Signalling pathways in the unfolded protein response: Development from yeast to mammals
    • Mori K: Signalling pathways in the unfolded protein response: development from yeast to mammals. J. Biochem. 146(6), 743-750 (2009).
    • (2009) J. Biochem , vol.146 , Issue.6 , pp. 743-750
    • Mori, K.1
  • 12
    • 45849137877 scopus 로고    scopus 로고
    • Regulation of hepatic lipogenesis by the transcription factor XBP1
    • Lee AH, Scapa EF, Cohen DE, Glimcher LH: Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 320(5882), 1492-1496 (2008).
    • (2008) Science , vol.320 , Issue.5882 , pp. 1492-1496
    • Lee, A.H.1    Scapa, E.F.2    Cohen, D.E.3    Glimcher, L.H.4
  • 13
    • 44349163999 scopus 로고    scopus 로고
    • Dephosphorylation of translation initiation factor 2a enhances glucose tolerance and attenuates hepatosteatosis in mice
    • Oyadomari S, Harding HP, Zhang Y, Oyadomari M, Ron D: Dephosphorylation of translation initiation factor 2a enhances glucose tolerance and attenuates hepatosteatosis in mice. Cell Metab. 7(6), 520-532 (2008).
    • (2008) Cell Metab , vol.7 , Issue.6 , pp. 520-532
    • Oyadomari, S.1    Harding, H.P.2    Zhang, Y.3    Oyadomari, M.4    Ron, D.5
  • 14
    • 57049111040 scopus 로고    scopus 로고
    • UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators
    • Rutkowski DT, Wu J, Back SH et al.: UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Dev. Cell. 15(6), 829-840 (2008).
    • (2008) Dev. Cell , vol.15 , Issue.6 , pp. 829-840
    • Rutkowski, D.T.1    Wu, J.2    Back, S.H.3
  • 15
    • 34548189283 scopus 로고    scopus 로고
    • ATF6a optimizes long-term endoplasmic reticulum function to protect cells from chronic stress
    • Wu J, Rutkowski DT, Dubois M et al.: ATF6a optimizes long-term endoplasmic reticulum function to protect cells from chronic stress. Dev. Cell. 13(3), 351-364 (2007).
    • (2007) Dev. Cell , vol.13 , Issue.3 , pp. 351-364
    • Wu, J.1    Rutkowski, D.T.2    Dubois, M.3
  • 16
    • 10444226462 scopus 로고    scopus 로고
    • ER stress and the unfolded protein response
    • Schroder M, Kaufman RJ: ER stress and the unfolded protein response. Mutat. Res. 569(1-2), 29-63 (2005).
    • (2005) Mutat. Res , vol.569 , Issue.1-2 , pp. 29-63
    • Schroder, M.1    Kaufman, R.J.2
  • 17
    • 0037353039 scopus 로고    scopus 로고
    • An integrated stress response regulates amino acid metabolism and resistance to oxidative stress
    • Harding HP, Zhang Y, Zeng H et al.: An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol. Cell. 11(3), 619-633 (2003).
    • (2003) Mol. Cell , vol.11 , Issue.3 , pp. 619-633
    • Harding, H.P.1    Zhang, Y.2    Zeng, H.3
  • 18
    • 0030297537 scopus 로고    scopus 로고
    • A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response
    • Cox JS, Walter P: A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell 87(3), 391-404 (1996).
    • (1996) Cell , vol.87 , Issue.3 , pp. 391-404
    • Cox, J.S.1    Walter, P.2
  • 19
    • 0030954870 scopus 로고    scopus 로고
    • The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response
    • Sidrauski C, Walter P: The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response. Cell 90(6), 1031-1039 (1997).
    • (1997) Cell , vol.90 , Issue.6 , pp. 1031-1039
    • Sidrauski, C.1    Walter, P.2
  • 20
    • 0037011917 scopus 로고    scopus 로고
    • IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
    • Calfon M, Zeng H, Urano F et al.: IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 415(6867), 92-96 (2002).
    • (2002) Nature , vol.415 , Issue.6867 , pp. 92-96
    • Calfon, M.1    Zeng, H.2    Urano, F.3
  • 21
    • 0032525990 scopus 로고    scopus 로고
    • A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/ endoribonuclease (Ire1p) in mammalian cells
    • Tirasophon W, Welihinda AA, Kaufman RJ: A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/ endoribonuclease (Ire1p) in mammalian cells. Genes Dev. 12(12), 1812-1824 (1998).
    • (1998) Genes Dev , vol.12 , Issue.12 , pp. 1812-1824
    • Tirasophon, W.1    Welihinda, A.A.2    Kaufman, R.J.3
  • 22
    • 34548172495 scopus 로고    scopus 로고
    • Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6a and XBP1
    • Yamamoto K, Sato T, Matsui T et al.: Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6a and XBP1. Dev. Cell. 13(3), 365-376 (2007) .
    • (2007) Dev. Cell , vol.13 , Issue.3 , pp. 365-376
    • Yamamoto, K.1    Sato, T.2    Matsui, T.3
  • 23
    • 68949202889 scopus 로고    scopus 로고
    • Intersection of the unfolded protein response and hepatic lipid metabolism
    • Lee AH, Glimcher LH: Intersection of the unfolded protein response and hepatic lipid metabolism. Cell Mol. Life Sci. 66(17), 2835-2850 (2009).
    • (2009) Cell Mol. Life Sci , vol.66 , Issue.17 , pp. 2835-2850
    • Lee, A.H.1    Glimcher, L.H.2
  • 24
    • 3142658576 scopus 로고    scopus 로고
    • XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation
    • Shaffer AL, Shapiro-Shelef M, Iwakoshi NN et al.: XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. Immunity 21(1), 81-93 (2004).
    • (2004) Immunity , vol.21 , Issue.1 , pp. 81-93
    • Shaffer, A.L.1    Shapiro-Shelef, M.2    Iwakoshi, N.N.3
  • 25
    • 5444222234 scopus 로고    scopus 로고
    • XBP1: A link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum
    • Sriburi R, Jackowski S, Mori K, Brewer JW: XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum. J. Cell Biol. 167(1), 35-41 (2004).
    • (2004) J. Cell Biol , vol.167 , Issue.1 , pp. 35-41
    • Sriburi, R.1    Jackowski, S.2    Mori, K.3    Brewer, J.W.4
  • 26
    • 34147172715 scopus 로고    scopus 로고
    • Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis
    • Sriburi R, Bommiasamy H, Buldak GL et al.: Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis. J. Biol. Chem. 282(10), 7024-7034 (2007).
    • (2007) J. Biol. Chem , vol.282 , Issue.10 , pp. 7024-7034
    • Sriburi, R.1    Bommiasamy, H.2    Buldak, G.L.3
  • 27
    • 5444264022 scopus 로고    scopus 로고
    • Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response
    • Lu PD, Harding HP, Ron D: Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response. J. Cell Biol. 167(1), 27-33 (2004).
    • (2004) J. Cell Biol , vol.167 , Issue.1 , pp. 27-33
    • Lu, P.D.1    Harding, H.P.2    Ron, D.3
  • 28
    • 33847020843 scopus 로고    scopus 로고
    • Mice with a deletion in the gene for CCAAT/ enhancer-binding protein b are protected against diet-induced obesity
    • Millward CA, Heaney JD, Sinasac DS et al.: Mice with a deletion in the gene for CCAAT/ enhancer-binding protein b are protected against diet-induced obesity. Diabetes 56(1), 161-167 (2007).
    • (2007) Diabetes , vol.56 , Issue.1 , pp. 161-167
    • Millward, C.A.1    Heaney, J.D.2    Sinasac, D.S.3
  • 29
    • 34447529373 scopus 로고    scopus 로고
    • CCAAT/enhancer-binding protein b deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice
    • Schroeder-Gloeckler JM, Rahman SM, Janssen RC et al.: CCAAT/enhancer-binding protein b deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice. J. Biol. Chem. 282(21), 15717-15729 (2007).
    • (2007) J. Biol. Chem , vol.282 , Issue.21 , pp. 15717-15729
    • Schroeder-Gloeckler, J.M.1    Rahman, S.M.2    Janssen, R.C.3
  • 30
    • 3142545837 scopus 로고    scopus 로고
    • Human CCAAT/enhancer-binding protein b gene expression is activated by endoplasmic reticulum stress through an unfolded protein response element downstream of the protein coding sequence
    • Chen C, Dudenhausen EE, Pan YX, Zhong C, Kilberg MS: Human CCAAT/enhancer-binding protein b gene expression is activated by endoplasmic reticulum stress through an unfolded protein response element downstream of the protein coding sequence. J. Biol. Chem. 279(27), 27948-27956 (2004).
    • (2004) J. Biol. Chem , vol.279 , Issue.27 , pp. 27948-27956
    • Chen, C.1    Dudenhausen, E.E.2    Pan, Y.X.3    Zhong, C.4    Kilberg, M.S.5
  • 31
    • 50349102475 scopus 로고    scopus 로고
    • Regulation and glucose signal transduction in the liver: Implication of the transcription factor CHREBP
    • Apollinare Bochardat Prize 2007
    • Postic C: Apollinare Bochardat Prize 2007. Regulation and glucose signal transduction in the liver: implication of the transcription factor CHREBP. J. Annu. Diabetol. Hotel Dieu 149-159 (2007).
    • (2007) J. Annu. Diabetol. Hotel Dieu , pp. 149-159
    • Postic, C.1
  • 32
    • 55849112292 scopus 로고    scopus 로고
    • PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation
    • Bobrovnikova-Marjon E, Hatzivassiliou G, Grigoriadou C et al.: PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation. Proc. Natl Acad. Sci. USA 105(42), 16314-16319 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , Issue.42 , pp. 16314-16319
    • Bobrovnikova-Marjon, E.1    Hatzivassiliou, G.2    Grigoriadou, C.3
  • 33
    • 34548220998 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2
    • Colgan SM, Tang D, Werstuck GH, Austin RC: Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2. Int. J. Biochem. Cell Biol. 39(10), 1843-1851 (2007).
    • (2007) Int. J. Biochem. Cell Biol , vol.39 , Issue.10 , pp. 1843-1851
    • Colgan, S.M.1    Tang, D.2    Werstuck, G.H.3    Austin, R.C.4
  • 34
    • 7244221504 scopus 로고    scopus 로고
    • Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1
    • Lee JN, Ye J: Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1. J. Biol. Chem. 279(43), 45257-45265 (2004).
    • (2004) J. Biol. Chem , vol.279 , Issue.43 , pp. 45257-45265
    • Lee, J.N.1    Ye, J.2
  • 35
    • 0035947778 scopus 로고    scopus 로고
    • Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2a
    • Novoa I, Zeng H, Harding HP, Ron D: Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2a. J. Cell Biol. 153(5), 1011-1022 (2001).
    • (2001) J. Cell Biol , vol.153 , Issue.5 , pp. 1011-1022
    • Novoa, I.1    Zeng, H.2    Harding, H.P.3    Ron, D.4
  • 36
    • 0034515724 scopus 로고    scopus 로고
    • ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs
    • Ye J, Rawson RB, Komuro R et al.: ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol. Cell. 6(6), 1355-1364 (2000).
    • (2000) Mol. Cell , vol.6 , Issue.6 , pp. 1355-1364
    • Ye, J.1    Rawson, R.B.2    Komuro, R.3
  • 37
    • 32044453080 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response
    • Zhang K, Shen X, Wu J et al.: Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell 124(3), 587-599 (2006).
    • (2006) Cell , vol.124 , Issue.3 , pp. 587-599
    • Zhang, K.1    Shen, X.2    Wu, J.3
  • 38
    • 0037083755 scopus 로고    scopus 로고
    • IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response
    • Lee K, Tirasophon W, Shen X et al.: IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev. 16(4), 452-466 (2002).
    • (2002) Genes Dev , vol.16 , Issue.4 , pp. 452-466
    • Lee, K.1    Tirasophon, W.2    Shen, X.3
  • 39
    • 1842509855 scopus 로고    scopus 로고
    • ATF6 modulates SREBP2-mediated lipogenesis
    • Zeng L, Lu M, Mori K et al.: ATF6 modulates SREBP2-mediated lipogenesis. EMBO J. 23(4), 950-958 (2004).
    • (2004) EMBO J , vol.23 , Issue.4 , pp. 950-958
    • Zeng, L.1    Lu, M.2    Mori, K.3
  • 40
    • 69849116067 scopus 로고    scopus 로고
    • The ATF6-Met67Val substitution is associated with increased plasma cholesterol levels
    • Meex SJ, Weissglas-Volkov D, van der Kallen CJ et al.: The ATF6-Met67Val substitution is associated with increased plasma cholesterol levels. Arterioscler. Thromb. Vasc. Biol. 29(9), 1322-1327 (2009).
    • (2009) Arterioscler. Thromb. Vasc. Biol , vol.29 , Issue.9 , pp. 1322-1327
    • Meex, S.J.1    Weissglas-Volkov, D.2    Van Der Kallen, C.J.3
  • 41
    • 10044271037 scopus 로고    scopus 로고
    • SREBP transcription factors: Master regulators of lipid homeostasis
    • Eberle D, Hegarty B, Bossard P, Ferre P, Foufelle F: SREBP transcription factors: master regulators of lipid homeostasis. Biochimie 86(11), 839-848 (2004).
    • (2004) Biochimie , vol.86 , Issue.11 , pp. 839-848
    • Eberle, D.1    Hegarty, B.2    Bossard, P.3    Ferre, P.4    Foufelle, F.5
  • 42
    • 20644448229 scopus 로고    scopus 로고
    • Lipid synthetic transcription factor SREBP
    • Hitoshi S: Lipid synthetic transcription factor, SREBP. Nippon Rinsho 63(5), 897-907 (2005).
    • (2005) Nippon Rinsho , vol.63 , Issue.5 , pp. 897-907
    • Hitoshi, S.1
  • 43
    • 66449137379 scopus 로고    scopus 로고
    • GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice
    • Kammoun HL, Chabanon H, Hainault I et al.: GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. J. Clin. Invest. 119(5), 1201-1215 (2009).
    • (2009) J. Clin. Invest , vol.119 , Issue.5 , pp. 1201-1215
    • Kammoun, H.L.1    Chabanon, H.2    Hainault, I.3
  • 44
    • 77950259787 scopus 로고    scopus 로고
    • Spontaneous development of ER stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 (iPLA2b) expression: A role for regulation by SREBP-1
    • Lei X, Zhang S, Barbour SE et al.: Spontaneous development of ER stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 (iPLA2b) expression: a role for regulation by SREBP-1. J. Biol. Chem. (2009).
    • (2009) J. Biol. Chem.
    • Lei, X.1    Zhang, S.2    Barbour, S.E.3
  • 45
    • 27544438601 scopus 로고    scopus 로고
    • Apolipoprotein B: A clinically important apolipoprotein which assembles atherogenic lipoproteins and promotes the development of atherosclerosis
    • Olofsson SO, Boren J: Apolipoprotein B: a clinically important apolipoprotein which assembles atherogenic lipoproteins and promotes the development of atherosclerosis. J. Intern. Med. 258(5), 395-410 (2005).
    • (2005) J. Intern. Med , vol.258 , Issue.5 , pp. 395-410
    • Olofsson, S.O.1    Boren, J.2
  • 46
    • 33947510911 scopus 로고    scopus 로고
    • Selective inhibition of eukaryotic translation initiation factor 2 a dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic b-cell dysfunction and apoptosis
    • Cnop M, Ladriere L, Hekerman P et al.: Selective inhibition of eukaryotic translation initiation factor 2 a dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic b-cell dysfunction and apoptosis. J. Biol. Chem. 282(6), 3989-3997 (2007).
    • (2007) J. Biol. Chem , vol.282 , Issue.6 , pp. 3989-3997
    • Cnop, M.1    Ladriere, L.2    Hekerman, P.3
  • 47
    • 33745116619 scopus 로고    scopus 로고
    • Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic b-cell apoptosis
    • Karaskov E, Scott C, Zhang L, Teodoro T, Ravazzola M, Volchuk A: Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic b-cell apoptosis. Endocrinology 147(7), 3398-3407 (2006).
    • (2006) Endocrinology , vol.147 , Issue.7 , pp. 3398-3407
    • Karaskov, E.1    Scott, C.2    Zhang, L.3    Teodoro, T.4    Ravazzola, M.5    Volchuk, A.6
  • 48
    • 33845575826 scopus 로고    scopus 로고
    • Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death
    • Borradaile NM, Han X, Harp JD, Gale SE, Ory DS, Schaffer JE: Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death. J. Lipid Res. 47(12), 2726-2737 (2006).
    • (2006) J. Lipid Res , vol.47 , Issue.12 , pp. 2726-2737
    • Borradaile, N.M.1    Han, X.2    Harp, J.D.3    Gale, S.E.4    Ory, D.S.5    Schaffer, J.E.6
  • 49
    • 33645210475 scopus 로고    scopus 로고
    • Midline NK/T-cell lymphoma nasal-type: Treatment outcome, the effect of l-asparaginase based regimen, and prognostic factors
    • Yong W, Zheng W, Zhu J et al.: Midline NK/T-cell lymphoma nasal-type: treatment outcome, the effect of l-asparaginase based regimen, and prognostic factors. Hematol. Oncol. 24(1), 28-32 (2006).
    • (2006) Hematol. Oncol , vol.24 , Issue.1 , pp. 28-32
    • Yong, W.1    Zheng, W.2    Zhu, J.3
  • 50
    • 30944451788 scopus 로고    scopus 로고
    • Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis
    • Wang D, Wei Y, Pagliassotti MJ: Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis. Endocrinology. 147(2), 943-951 (2006).
    • (2006) Endocrinology , vol.147 , Issue.2 , pp. 943-951
    • Wang, D.1    Wei, Y.2    Pagliassotti, M.J.3
  • 51
    • 0142042348 scopus 로고    scopus 로고
    • Blocking microsomal triglyceride transfer protein interferes with ApoB secretion without causing retention or stress in the ER
    • Liao W, Hui TY, Young SG, Davis RA: Blocking microsomal triglyceride transfer protein interferes with ApoB secretion without causing retention or stress in the ER. J. Lipid Res. 44(5), 978-985 (2003).
    • (2003) J. Lipid Res , vol.44 , Issue.5 , pp. 978-985
    • Liao, W.1    Hui, T.Y.2    Young, S.G.3    Davis, R.A.4
  • 52
    • 0037085471 scopus 로고    scopus 로고
    • Blocking the secretion of hepatic very low density lipoproteins renders the liver more susceptible to toxin-induced injury
    • Bjorkegren J, Beigneux A, Bergo MO, Maher JJ, Young SG: Blocking the secretion of hepatic very low density lipoproteins renders the liver more susceptible to toxin-induced injury. J. Biol. Chem. 277(7), 5476-5483 (2002).
    • (2002) J. Biol. Chem , vol.277 , Issue.7 , pp. 5476-5483
    • Bjorkegren, J.1    Beigneux, A.2    Bergo, M.O.3    Maher, J.J.4    Young, S.G.5
  • 53
    • 0037244002 scopus 로고    scopus 로고
    • Microsomal triglyceride transfer protein and its role in ApoB-lipoprotein assembly
    • Hussain MM, Shi J, Dreizen P: Microsomal triglyceride transfer protein and its role in ApoB-lipoprotein assembly. J. Lipid Res. 44(1), 22-32 (2003).
    • (2003) J. Lipid Res , vol.44 , Issue.1 , pp. 22-32
    • Hussain, M.M.1    Shi, J.2    Dreizen, P.3
  • 54
    • 0037040195 scopus 로고    scopus 로고
    • The late addition of core lipids to nascent apolipoprotein B100, resulting in the assembly and secretion of triglyceride-rich lipoproteins, is independent of both microsomal triglyceride transfer protein activity and new triglyceride synthesis
    • Pan M, Liang JS, Fisher EA, Ginsberg HN: The late addition of core lipids to nascent apolipoprotein B100, resulting in the assembly and secretion of triglyceride-rich lipoproteins, is independent of both microsomal triglyceride transfer protein activity and new triglyceride synthesis. J. Biol. Chem. 277(6), 4413-4421 (2002).
    • (2002) J. Biol. Chem , vol.277 , Issue.6 , pp. 4413-4421
    • Pan, M.1    Liang, J.S.2    Fisher, E.A.3    Ginsberg, H.N.4
  • 55
    • 49649122219 scopus 로고    scopus 로고
    • The many intersecting pathways underlying apolipoprotein B secretion and degradation
    • Brodsky JL, Fisher EA: The many intersecting pathways underlying apolipoprotein B secretion and degradation. Trends Endocrinol. Metab. 19(7), 254-259 (2008).
    • (2008) Trends Endocrinol. Metab , vol.19 , Issue.7 , pp. 254-259
    • Brodsky, J.L.1    Fisher, E.A.2
  • 56
    • 66349135636 scopus 로고    scopus 로고
    • The ever-expanding role of degradation in the regulation of apolipoprotein B metabolism
    • Ginsberg HN, Fisher EA: The ever-expanding role of degradation in the regulation of apolipoprotein B metabolism. J. Lipid Res. 50(Suppl.) S162-S166 (2009).
    • (2009) J. Lipid Res , vol.50 , Issue.SUPPL.
    • Ginsberg, H.N.1    Fisher, E.A.2
  • 57
    • 0034717836 scopus 로고    scopus 로고
    • Progress towards understanding the role of microsomal triglyceride transfer protein in Apolipoprotein-B lipoprotein assembly
    • Gordon DA, Jamil H: Progress towards understanding the role of microsomal triglyceride transfer protein in Apolipoprotein-B lipoprotein assembly. Biochim. Biophys. Acta 1486(1), 72-83 (2000).
    • (2000) Biochim. Biophys. Acta , vol.1486 , Issue.1 , pp. 72-83
    • Gordon, D.A.1    Jamil, H.2
  • 58
    • 33846151732 scopus 로고    scopus 로고
    • Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia
    • Cuchel M, Bloedon LT, Szapary PO et al.: Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia. N. Engl. J. Med. 356(2), 148-156 (2007).
    • (2007) N. Engl. J. Med , vol.356 , Issue.2 , pp. 148-156
    • Cuchel, M.1    Bloedon, L.T.2    Szapary, P.O.3
  • 59
    • 0037124084 scopus 로고    scopus 로고
    • Complexity in the secretory pathway: The assembly and secretion of apolipoprotein B-containing lipoproteins
    • Fisher EA, Ginsberg HN: Complexity in the secretory pathway: the assembly and secretion of apolipoprotein B-containing lipoproteins. J. Biol. Chem. 277(20), 17377-17380 (2002).
    • (2002) J. Biol. Chem , vol.277 , Issue.20 , pp. 17377-17380
    • Fisher, E.A.1    Ginsberg, H.N.2
  • 60
    • 0034708682 scopus 로고    scopus 로고
    • Mechanisms of hepatic very low density lipoprotein overproduction in insulin resistance. Evidence for enhanced lipoprotein assembly, reduced intracellular ApoB degradation, and increased microsomal triglyceride transfer protein in a fructose-fed hamster model
    • Taghibiglou C, Carpentier A, Van Iderstine SC et al.: Mechanisms of hepatic very low density lipoprotein overproduction in insulin resistance. Evidence for enhanced lipoprotein assembly, reduced intracellular ApoB degradation, and increased microsomal triglyceride transfer protein in a fructose-fed hamster model. J. Biol. Chem. 275(12), 8416-8425 (2000).
    • (2000) J. Biol. Chem , vol.275 , Issue.12 , pp. 8416-8425
    • Taghibiglou, C.1    Carpentier, A.2    Van Iderstine, S.C.3
  • 61
    • 67651171781 scopus 로고    scopus 로고
    • Apolipoprotein B100 acts as a molecular link between lipid-induced endoplasmic reticulum stress and hepatic insulin resistance
    • Su Q, Tsai J, Xu E et al.: Apolipoprotein B100 acts as a molecular link between lipid-induced endoplasmic reticulum stress and hepatic insulin resistance. Hepatology 50(1), 77-84 (2009).
    • (2009) Hepatology , vol.50 , Issue.1 , pp. 77-84
    • Su, Q.1    Tsai, J.2    Xu, E.3
  • 62
    • 0036739255 scopus 로고    scopus 로고
    • The N-linked oligosaccharides at the amino terminus of human ApoB are important for the assembly and secretion of VLDL
    • Vukmirica J, Nishimaki-Mogami T, Tran K et al.: The N-linked oligosaccharides at the amino terminus of human ApoB are important for the assembly and secretion of VLDL. J. Lipid Res. 43(9), 1496-1507 (2002).
    • (2002) J. Lipid Res , vol.43 , Issue.9 , pp. 1496-1507
    • Vukmirica, J.1    Nishimaki-Mogami, T.2    Tran, K.3
  • 63
    • 33746358256 scopus 로고    scopus 로고
    • Human ApoB overexpression and a high-cholesterol diet differently modify the brain APP metabolism in the transgenic mouse model of atherosclerosis
    • Bjelik A, Bereczki E, Gonda S et al.: Human ApoB overexpression and a high-cholesterol diet differently modify the brain APP metabolism in the transgenic mouse model of atherosclerosis. Neurochem. Int. 49(4), 393-400 (2006).
    • (2006) Neurochem. Int , vol.49 , Issue.4 , pp. 393-400
    • Bjelik, A.1    Bereczki, E.2    Gonda, S.3
  • 64
    • 77949898407 scopus 로고    scopus 로고
    • Nonsynonymous mutations within APOB in human familial hypo-b-lipoproteinemia - Evidence for feedback inhibition of lipogenesis and post-endoplasmic reticulum degradation of Apolipoprotein B
    • DOI: 10.1074/jbc.M109.060467. Epub ahead of print
    • Zhong S, Magnolo AL, Sundaram M et al.: Nonsynonymous mutations within APOB in human familial hypo-b-lipoproteinemia - evidence for feedback inhibition of lipogenesis and post-endoplasmic reticulum degradation of Apolipoprotein B. J. Biol. Chem. DOI: 10.1074/jbc.M109.060467. (2009) (Epub ahead of print).
    • (2009) J. Biol. Chem.
    • Zhong, S.1    Magnolo, A.L.2    Sundaram, M.3
  • 65
    • 0034723235 scopus 로고    scopus 로고
    • Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
    • Urano F, Wang X, Bertolotti A et al.: Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287(5453), 664-666 (2000).
    • (2000) Science , vol.287 , Issue.5453 , pp. 664-666
    • Urano, F.1    Wang, X.2    Bertolotti, A.3
  • 66
    • 33645815074 scopus 로고    scopus 로고
    • Autocrine tumor necrosis factor a links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1a-mediated NF-kB activation and down-regulation of TRAF2 expression
    • Hu P, Han Z, Couvillon AD, Kaufman RJ, Exton JH: Autocrine tumor necrosis factor a links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1a-mediated NF-kB activation and down-regulation of TRAF2 expression. Mol. Cell Biol. 26(8), 3071-3084 (2006).
    • (2006) Mol. Cell Biol , vol.26 , Issue.8 , pp. 3071-3084
    • Hu, P.1    Han, Z.2    Couvillon, A.D.3    Kaufman, R.J.4    Exton, J.H.5
  • 67
    • 0034708832 scopus 로고    scopus 로고
    • The c-Jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)
    • Aguirre V, Uchida T, Yenush L, Davis R, White MF: The c-Jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J. Biol. Chem. 275(12), 9047-9054 (2000).
    • (2000) J. Biol. Chem. , vol.275 , Issue.12 , pp. 9047-9054
    • Aguirre, V.1    Uchida, T.2    Yenush, L.3    Davis, R.4    White, M.F.5
  • 68
    • 58149279479 scopus 로고    scopus 로고
    • An endoluminal sleeve induces substantial weight loss and normalizes glucose homeostasis in rats with diet-induced obesity
    • (Silver Spring)
    • Aguirre V, Stylopoulos N, Grinbaum R, Kaplan LM: An endoluminal sleeve induces substantial weight loss and normalizes glucose homeostasis in rats with diet-induced obesity. Obesity (Silver Spring) 16(12), 2585-2592 (2008).
    • (2008) Obesity , vol.16 , Issue.12 , pp. 2585-2592
    • Aguirre, V.1    Stylopoulos, N.2    Grinbaum, R.3    Kaplan, L.M.4
  • 69
    • 0036217052 scopus 로고    scopus 로고
    • Disordered fat storage and mobilization in the pathogenesis of insulin resistance and Type 2 diabetes
    • Lewis GF, Carpentier A, Adeli K, Giacca A: Disordered fat storage and mobilization in the pathogenesis of insulin resistance and Type 2 diabetes. Endocr. Rev. 23(2), 201-229 (2002).
    • (2002) Endocr. Rev , vol.23 , Issue.2 , pp. 201-229
    • Lewis, G.F.1    Carpentier, A.2    Adeli, K.3    Giacca, A.4
  • 70
    • 0031953636 scopus 로고    scopus 로고
    • Effects of insulin and acipimox on VLDL1 and VLDL2 Apolipoprotein B production in normal subjects
    • Malmstrom R, Packard CJ, Caslake M et al.: Effects of insulin and acipimox on VLDL1 and VLDL2 Apolipoprotein B production in normal subjects. Diabetes 47(5), 779-787 (1998).
    • (1998) Diabetes , vol.47 , Issue.5 , pp. 779-787
    • Malmstrom, R.1    Packard, C.J.2    Caslake, M.3
  • 71
    • 29244465509 scopus 로고    scopus 로고
    • Human fat cell lipolysis: Biochemistry, regulation and clinical role
    • Arner P: Human fat cell lipolysis: biochemistry, regulation and clinical role. Best Pract. Res. Clin. Endocrinol. Metab. 19(4), 471-482 (2005).
    • (2005) Best Pract. Res. Clin. Endocrinol. Metab , vol.19 , Issue.4 , pp. 471-482
    • Arner, P.1
  • 72
    • 69949182326 scopus 로고    scopus 로고
    • Nuclear export-independent inhibition of Foxa2 by insulin
    • Howell JJ, Stoffel M: Nuclear export-independent inhibition of Foxa2 by insulin. J. Biol. Chem. 284(37), 24816-24824 (2009).
    • (2009) J. Biol. Chem , vol.284 , Issue.37 , pp. 24816-24824
    • Howell, J.J.1    Stoffel, M.2
  • 73
    • 54049094000 scopus 로고    scopus 로고
    • FoxO1 integrates insulin signaling to VLDL production
    • Kamagate A, Dong HH: FoxO1 integrates insulin signaling to VLDL production. Cell Cycle 7(20), 3162-3170 (2008).
    • (2008) Cell Cycle , vol.7 , Issue.20 , pp. 3162-3170
    • Kamagate, A.1    Dong, H.H.2
  • 74
    • 45849111008 scopus 로고    scopus 로고
    • Tumor necrosis factor-a directly stimulates the overproduction of hepatic apolipoprotein B100-containing VLDL via impairment of hepatic insulin signaling
    • Qin B, Anderson RA, Adeli K: Tumor necrosis factor-a directly stimulates the overproduction of hepatic apolipoprotein B100-containing VLDL via impairment of hepatic insulin signaling. Am. J. Physiol Gastrointest. Liver Physiol. 294(5), G1120-G1129 (2008).
    • (2008) Am. J. Physiol Gastrointest. Liver Physiol , vol.294 , Issue.5
    • Qin, B.1    Anderson, R.A.2    Adeli, K.3
  • 75
    • 67049134412 scopus 로고    scopus 로고
    • Inflammatory NF-kB activation promotes hepatic apolipoprotein B100 secretion: Evidence for a link between hepatic inflammation and lipoprotein production
    • Tsai J, Zhang R, Qiu W, Su Q, Naples M, Adeli K: Inflammatory NF-kB activation promotes hepatic apolipoprotein B100 secretion: evidence for a link between hepatic inflammation and lipoprotein production. Am. J. Physiol Gastrointest. Liver Physiol. 296(6), G1287-G1298 (2009).
    • (2009) Am. J. Physiol Gastrointest. Liver Physiol , vol.296 , Issue.6
    • Tsai, J.1    Zhang, R.2    Qiu, W.3    Su, Q.4    Naples, M.5    Adeli, K.6
  • 76
    • 0033636780 scopus 로고    scopus 로고
    • Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice
    • Shimomura I, Matsuda M, Hammer RE, Bashmakov Y, Brown MS, Goldstein JL: Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol. Cell 6(1), 77-86 (2000).
    • (2000) Mol. Cell , vol.6 , Issue.1 , pp. 77-86
    • Shimomura, I.1    Matsuda, M.2    Hammer, R.E.3    Bashmakov, Y.4    Brown, M.S.5    Goldstein, J.L.6
  • 77
    • 33751196629 scopus 로고    scopus 로고
    • Monitoring the activation state of insulin/ insulin-like growth factor-1 hybrid receptors using bioluminescence resonance energy transfer
    • Blanquart C, Gonzalez-Yanes C, Issad T: Monitoring the activation state of insulin/ insulin-like growth factor-1 hybrid receptors using bioluminescence resonance energy transfer. Mol. Pharmacol. 70(5), 1802-1811 (2006).
    • (2006) Mol. Pharmacol , vol.70 , Issue.5 , pp. 1802-1811
    • Blanquart, C.1    Gonzalez-Yanes, C.2    Issad, T.3
  • 78
    • 59749087965 scopus 로고    scopus 로고
    • Cross-species comparison of in vivo PK/PD relationships for second-generation antisense oligonucleotides targeting apolipoprotein B-100
    • Yu RZ, Lemonidis KM, Graham MJ et al.: Cross-species comparison of in vivo PK/PD relationships for second-generation antisense oligonucleotides targeting apolipoprotein B-100. Biochem. Pharmacol. 77(5), 910-919 (2009).
    • (2009) Biochem. Pharmacol , vol.77 , Issue.5 , pp. 910-919
    • Yu, R.Z.1    Lemonidis, K.M.2    Graham, M.J.3
  • 79
    • 77952144424 scopus 로고    scopus 로고
    • Metformin regulates palmitate-induced apoptosis and ER stress response in HepG2 liver cells
    • DOI: 10.3109/08923970903252220 . Epub ahead of print
    • Kim DS, Jeong SK, Kim HR, Kim DS, Chae SW, Chae HJ: Metformin regulates palmitate-induced apoptosis and ER stress response in HepG2 liver cells. Immunopharmacol. Immunotoxicol. DOI: 10.3109/08923970903252220 (2009) (Epub ahead of print).
    • (2009) Immunopharmacol. Immunotoxicol.
    • Kim, D.S.1    Jeong, S.K.2    Kim, H.R.3    Kim, D.S.4    Chae, S.W.5    Chae, H.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.