Mechanisms of hepatic very low density lipoprotein overproduction in insulin resistance. Evidence for enhanced lipoprotein assembly, reduced intracellular ApoB degradation, and increased microsomal triglyceride transfer protein in a fructose-fed hamster model

Journal of Biological Chemistry

Volumn 275, Issue 12, 2000, Pages 8416-8425

  Taghibiglou, Changiz ^a   Carpentier, André ^b   Van Iderstine, Stephen C ^a   Chen, Biao ^a   Rudy, Debbie ^a   Aiton, Andrea ^a   Lewis, Gary F ^b   Adeli, Khosrow ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FRUCTOSE; LOW DENSITY LIPOPROTEIN; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HAMSTER; IMMUNOBLOTTING; INSULIN RESISTANCE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN SECRETION;

ANIMALS; APOLIPOPROTEINS B; CARRIER PROTEINS; CELLS, CULTURED; CHOLESTEROL ESTER TRANSFER PROTEINS; CHRONIC DISEASE; CRICETINAE; DIETARY SUCROSE; DISEASE MODELS, ANIMAL; FRUCTOSE; GLUCOSE CLAMP TECHNIQUE; GLYCOPROTEINS; HYPERINSULINISM; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; LIPOPROTEINS, VLDL; LIVER; MALE; MESOCRICETUS; MICROSOMES, LIVER;

ANIMALIA; CRICETINAE; MESOCRICETUS AURATUS;

EID: 0034708682     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.12.8416     Document Type: Article

References (78)

1. Moller, D. E., and Flier, J. S. (1991) N. Engl. J. Med. 325, 938-948
2. Reaven, G. M. (1988) Diabetes 37, 1595-1607
3. Garg, A., Helderman, J. H., Koffler, M., Ayuso, R., Rosenstock, J., and Raskin, P. (1988) Metabolism 37, 982-987
4. Mykkanen, L., Haffner, S. M., Ronnemaa, T., Bergman, R., Leino, A., and Laakso, M. (1994) Metabolism 43, 523-528
5. Garg, A. (1996) Diabetes Care 19, 387-389
6. Reaven, G. M., Lerner, R. L., Stern, M. P., and Farquhar, J. W. (1967) J. Clin. Invest. 46, 1756-1767
7. Olefsky, J. M., Farquhar, J. W., and Reaven, G. M. (1974) Am. J. Med. 57, 551-560
8. Taskinen, M. R. (1995) Curr. Opin. Lipidol. 6, 153-160
9. Reaven, G. M., Chen, Y. D., Jeppesen, J., Maheux, P., and Krauss, R. M. (1993) J. Clin. Invest. 92, 141-146
10. Reaven, G. M. (1992) Metabolism 41, Suppl. 1, 16-19
11. Grundy, S. M., Mok, H. Y., Zech, L., Steinberg, D., and Berman, M. (1979) J. Clin. Invest. 63, 1274-1283
12. Kissebah, A. H., Alfarsi, S., and Adams, P. W. (1981) Metabolism 30, 856-868
13. Howard, B. V. (1987) J. Lipid Res. 28, 613-628
14. Reaven, G. M., and Chen, Y. D. (1988) Diabetes Metab. Rev. 4, 639-652
15. Sparks, J. D., and Sparks, C. E. (1994) Biochim. Biophys. Acta 1215, 9-32
16. Lewis, G. F., and Steiner, G. (1996) Diabetes Care 19, 390-393
17. Sparks, J. D., Sparks, C. E., and Miller, L. L. (1989) Biochem. J. 261, 83-88
18. Patsch, W., Franz, S., and Schonfeld, G. (1983) J. Clin. Invest. 71, 1161-1174
19. Sparks, C. E., Sparks, J. D., Bolognino, M., Salhanick, A., Strumph, P. S., and Amatruda, J. M. (1986) Metabolism 35, 1128-1136
20. Sparks, J. D., and Sparks, C. E. (1990) J. Biol. Chem. 265, 8854-8862
21. Salhanick, A. I., Schwartz, S. I., and Amatruda, J. M. (1991) Metabolism 40, 275-279
22. Lewis, G. F., Uffelman, K. D., Szeto, L. W., and Steiner, G. (1993) Diabetes 42, 833-842
23. Lewis, G. F., Uffelman, K. D., Szeto, L. W., Weller, B., and Steiner, G. (1995) J. Clin. Invest. 95, 158-166
24. Malmstrom, R., Packard, C. J., Caslake, M., Bedford, D., Stewart, P., Yki-Jarvinen, H., Shepherd, J., and Taskinen, M. R. (1997) Diabetologia 40, 454-462
25. Malmstrom, R., Packard, C. J., Watson, T. D., Rannikko, S., Caslake, M., Bedford, D., Stewart, P., Yki-Jarvinen, H., Shepherd, J., and Taskinen, M. R. (1997) Arterioscler. Thromb. Vasc. Biol. 17, 1454-1464
26. Malmstrom, R., Packard, C. J., Caslake, M., Bedford, D., Stewart, P., Yki-Jarvinen, H., Shepherd, J., and Taskinen, M. R. (1998) Diabetes 47, 779-787
27. Bjornsson, O. G., Duerden, J. M., Bartlett, S. M., Sparks, J. D., Sparks, C. E., and Gibbons, G. F. (1992) Biochem. J. 281, 381-386
28. Dashti, N., Williams, D. L., and Alaupovic, P. (1989) J. Lipid Res. 30, 1365-1373
29. Sparks, J. D., and Sparks, C. E. (1994) Biochem. Biophys. Res. Commun. 205, 417-422
30. Theriault, A., Cheung, R., and Adeli, K. (1992) Clin. Biochem. 25, 321-323
31. Adeli, K., and Theriault, A. (1992) Biochem. Cell Biol. 70, 1301-1312
32. Wiggins, D., and Gibbons, G. F. (1992) Biochem. J. 284, 457-462
33. Sparks, J. D., Phung, T. L., Bolognino, M., and Sparks, C. E. (1996) Biochem. J. 313, 567-574
34. Phung, T. L., Roncone, A., de Mesy Jensen, K. L., Sparks, C. E., and Sparks, J. D. (1997) J. Biol. Chem. 272, 30693-30702
35. Whitman, M., Downes, C. P., Keeler, M., Keller, T., and Cantley, L. (1988) Nature 332, 644-646
36. Jackson, B., Gee, A. N., Martinez-Cayuela, M., and Suckling, K. E. (1990) Biochim. Biophys. Acta 1045, 21-28
37. Ontko, J. A., Cheng, Q., and Yamamoto, M. (1990) J. Lipid Res. 31, 1983-1992
38. Hoang, V. Q., Botham, K. M., Benson, G. M., Eldredge, E. E., Jackson, B., Pearce, N., and Suckling, K. E. (1993) Biochim. Biophys. Acta 1210, 73-80
39. Nistor, A., Bulla, A., Filip, D. A., and Radu, A. (1987) Atherosclerosis 68, 159-173
40. Sullivan, M. P., Cerda, J. J., Robbins, F. L., Burgin, C. W., and Beatty, R. J. (1993) Lab. Anim. Sci. 43, 575-578
41. Simionescu, N., Sima, A., Dobrian, A., Tirziu, D., and Simionescu, M. (1993) Curr. Top. Pathol. 87, 1-45
42. Arbeeny, C. M., Meyers, D. S., Bergquist, K. E., and Gregg, R. E. (1992) J. Lipid Res. 33, 843-851
43. Liu, G. L., Fan, L. M., and Redinger, R. N. (1991) Comp. Biochem. Physiol. A 99, 223-228
44. Wright, D. W., Hansen, R. I., Mondon, C. E., and Reaven, G. M. (1983) Am. J. Clin. Nutr. 38, 879-883
45. Sleder, J., Chen, Y. D., Cully, M. D., and Reaven, G. M. (1980) Metabolism 29, 303-305
46. Tobey, T. A., Mondon, C. E., Zavaroni, I., and Reaven, G. M. (1982) Metabolism 31, 608-612
47. Zavaroni, I., Sander, S., Scott, S., and Reaven, G. M. (1980) Metabolism 29, 970-973
48. Kasim-Karakas, S. E., Vriend, H., Almario, R., Chow, L. C., and Goodman, M. N. (1996) J. Lab. Clin. Med. 128, 208-213
49. Steiner, G., Haynes, F. J., Yoshino, G., and Vranic, M. (1984) Am. J. Physiol. 246, E187-192
50. Kazumi, T., Vranic, M., and Steiner, G. (1985) Endocrinology 117, 1145-1150
51. Kazumi, T., Vranic, M., and Steiner, G. (1986) Am. J. Physiol. 250, E325-330
52. Yoshino, G., Hirano, T., Maeda, E., Murata, Y., Naka, Y., Nagata, K., Kazumi, T., and Urayama, T. (1997) Atherosclerosis 129, 33-39
53. Boisfer, E., Lambert, G., Atger, V., Tran, N. Q., Pastier, D., Benetollo, C., Trottier, J. F., Beaucamps, I., Antonucci, M., Laplaud, M., Griglio, S., Chambaz, J., and Kalopissis, A. D. (1999) J. Biol. Chem. 274, 11564-11572
54. Sugiyama, Y., Odaka, H., Itokawa, S., Ishikawa, E., Tomari, Y., and Ikeda, H. (1995) Atherosclerosis 118, 145-153
55. Eisele, B., Budzinski, R., Muller, P., Maier, R., and Mark, M. (1997) J. Lipid Res. 38, 564-575
56. Buyer's Guide (1993) Lab. Anim. 27, 1-22
57. Reardon, M. F., Poapst, M. E., Uffelman, K. D., and Steiner, G. (1981) Clin. Chem. 27, 892-895
58. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951) J. Biol. Chem. 193, 265-275
59. Miller, L. L. (1973) in Isolated Liver Perfusion and Its Applications (Miller, L. L., ed) pp. 11-52, Raven Press, New York
60. Adeli, K. (1994) J. Biol. Chem. 269, 9166-9175
61. Macri, J., and Adeli, K. (1997) J. Biol. Chem. 272, 7328-7337
62. Boren, J., Wettesten, M., Sjoberg, A., Thorlin, T., Bondjers, G., Wiklund, O., and Olofsson, S. O. (1990) J. Biol. Chem. 265, 10556-10564
63. Adeli, K., Wettesten, M., Asp, L., Mohammadi, A., Macri, J., and Olofsson, S. O. (1997) J. Biol. Chem. 272, 5031-5039
64. Laemmli, U. K. (1970) Nature 227, 680-685
65. Bergman, R. N., Finegood, D. T., and Ader, M. (1985) Endocr. Rev. 6, 45-86
66. Boren, J., Graham, L., Wettesten, M., Scott, J., White, A., and Olofsson, S. O. (1992) J. Biol. Chem. 267, 9858-9867
67. Steiner, G., and Lewis, G. F. (1996) Diabetes 45, Suppl. 3, S24-26
68. Cummings, M. H., Watts, G. F., Umpleby, A. M., Hennessy, T. R., Naoumova, R., Slavin, B. M., Thompson, G. R., and Sonksen, P. H. (1995) Diabetologia 38, 959-967
69. Riches, F. M., Watts, G. F., Naoumova, R. P., Kelly, J. M., Croft, K. D., and Thompson, G. R. (1998) Int. J. Obes. Relat. Metab. Disord. 22, 414-423
70. Li, X., Grundy, S. M., and Patel, S. B. (1997) J. Lipid Res. 38, 1277-1288
71. Gordon, D. A., Jamil, H., Sharp, D., Mullaney, D., Yao, Z., Gregg, R. E., and Wetterau, J. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 7628-7632
72. Wetterau, J. R., Aggerbeck, L. P., Bouma, M. E., Eisenberg, C., Munck, A., Hermier, M., Schmitz, J., Gay, G., Rader, D. J., and Gregg, R. E. (1992) Science 258, 999-1001
73. Wetterau, J. R., Gregg, R. E., Harrity, T. W., Arbeeny, C., Cap, M., Connolly, F., Chu, C. H., George, R. J., Gordon, D. A., Jamil, H., Jolibois, K. G., Kunselman, L. K., Lan, S. J., Maccagnan, T. J., Ricci, B., Yan, M., Young, D., Chen, Y., Fryszman, O. M., Logan, J. V., Musial, C. L., Poss, M. A., Robl, J. A., Simpkins, L. M., Biller, S. A., Slusarchyk, W. A., Sulsky, R., Tauk, P., Magnin, D. R., Tino, J. A., Lawrence, M., Pickson, J. K., and Biller, S. A. (1998) Science 282, 751-754
74. Wetterau, J. R., Lin, M. C., and Jamil, H. (1997) Biochim. Biophys. Acta 1345, 136-150
75. Hagan, D. L., Kienzle, B., Jamil, H., and Hariharan, N. (1994) J. Biol. Chem. 269, 28737-28744
76. Lin, M. C., Gordon, D., and Wetterau, J. R. (1995) J. Lipid Res. 36, 1073-1081
77. Kuriyama, H., Yamashita, S., Shimomura, I., Funahashi, T., Ishigami, M., Aragane, K., Miyaoka, K., Nakamura, T., Takemura, K., Man, Z., Toide, K., Nakayama, N., Fukuda, Y., Lin, M. C., Wetterau, J. R., and Matsuzawa, Y. (1998) Hepatology 27, 557-562
78. Brett, D. J., Pease, R. J., Scott, J., and Gibbons, G. F. (1995) Biochem. J. 310, 11-14