Mice with a deletion in the gene for CCAAT/enhancer-binding protein β are protected against diet-induced obesity

Diabetes

Volumn 56, Issue 1, 2007, Pages 161-167

  Millward, Carrie A ^a   Heaney, Jason D ^b   Sinasac, David S ^b   Chu, Eric C ^a   Bederman, Ilya R ^a   Gilge, Danielle A ^a   Previs, Stephen F ^a   Croniger, Colleen M ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; CARBON DIOXIDE; CCAAT ENHANCER BINDING PROTEIN BETA; CHOLESTEROL; FAT; FATTY ACID; FATTY ACID SYNTHASE; TRANSCRIPTION FACTOR; TRIACYLGLYCEROL; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY FAT; BROWN ADIPOSE TISSUE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FATTY ACID BLOOD LEVEL; FATTY ACID OXIDATION; FATTY LIVER; FEMALE; FOOD INTAKE; GENE DELETION; GENE EXPRESSION; LIPID DIET; LIPID METABOLISM; LIPID STORAGE; LIPOGENESIS; LIVER LEVEL; MALE; MOUSE; MUSCLE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRIACYLGLYCEROL BLOOD LEVEL; WILD TYPE;

ANIMALS; BASE SEQUENCE; BODY WEIGHT; CARBON DIOXIDE; CCAAT-ENHANCER-BINDING PROTEIN-BETA; DIET, FAT-RESTRICTED; DIETARY FATS; DNA PRIMERS; GENE DELETION; MICE; MICE, KNOCKOUT; OBESITY; REFERENCE VALUES;

EID: 33847020843     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db06-0310     Document Type: Article

References (37)

1. Flegal KM, Carroll MD, Ogden CL, Johnson CL: Prevalence and trends in obesity among US adults, 1999-2000. JAMA 288:1723-1727, 2002
2. Willett WC, Dietz WH, Colditz GA: Guidelines for healthy weight. New Engl J Med 341:427-434, 1999
3. Kriska AM, Saremi A, Hanson RL, Bennett PH, Kobes S, Williams DE, Knowler WC: Physical activity, obesity, and the incidence of type 2 diabetes in a high-risk population. Am J Epidemiol 158:669-675, 2003
4. Bray GA: Medical consequences of obesity. J Clin Endocrinol Metab 89:2583-2589, 2004
5. Croniger C, Trus M, Lysek-Stupp K, Cohen H, Liu Y, Darlington GJ, Poli V, Hanson RW, Reshef L: Role of the isoforms of CCAAT/enhancer-binding protein in the initiation of phosphoenolpyruvate carboxykinase (GTP) gene transcription at birth. J Biol Chem 272:26306-26312, 1997
6. Liu S, Croniger C, Arizmendi C, Harada-Shiba M, Ren J, Poli V, Hanson RW, Friedman JE: Hypoglycemia and impaired hepatic glucose production in mice with a deletion of the C/EBPbeta gene. J Clin Invest 103:207-213, 1999
7. Wang ND, Finegold MJ, Bradley A, Ou CN, Abdelsayed SV, Wilde MD, Taylor LR, Wilson DR, Darlington GJ: Impaired energy homeostasis in C/EBP alpha knockout mice. Science 269:1108-1112, 1995
8. Tanaka T, Yoshida N, Kishimoto T, Akira S: Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene. EMBO J 16:7432-7443, 1997
9. Tang QQ, Zhang JW, Daniel Lane M: Sequential gene promoter interactions of C/EBPbeta, C/EBPalpha, and PPARgamma during adipogenesis. Biochem Biophys Res Commun 319:235-239, 2004
10. Rosen ED: The transcriptional basis of adipocyte development. Prostaglandins Leukot Essent Fatty Acids 73:31-34, 2005
11. Ramji DP, Foka P: CCAAT/enhancer-binding proteins: structure, function and regulation. Biochem J 365:561-575, 2002
12. Croniger CM, Millward C, Yang J, Kawai Y, Arinze IJ, Liu S, Harada-Shiba M, Chakravarty K, Friedman JE, Poli V, Hanson RW: Mice with a deletion in the gene for CCAAT/enhancer-binding protein beta have an attenuated response to cAMP and impaired carbohydrate metabolism. J Biol Chem 276:629-638, 2001
13. Screpanti I, Musiani P, Bellavia D, Cappelletti M, Aiello FB, Maroder M, Frati L, Modesti A, Gulino A, Poli V: Inactivation of the IL-6 gene prevents development of multicentric Castleman's disease in C/EBP beta-deficient mice. J Exp Med 184:1561-1566, 1996
14. McCabe BJ, Previs SF: Using isotope tracers to study metabolism: application in mouse models. Metab Eng 6:25-35, 2004
15. McCabe BJ, Bederman IR, Croniger C, Millward C, Norment C, Previs SF: Reproducibility of gas chromatography-mass spectrometry measurements of (2)H labeling of water: application for measuring body composition in mice. Anal Biochem 350:171-176, 2006
16. Brunengraber DZ, McCabe BJ, Kasumov T, Alexancer JC, Chandramouli V, Previs SF: Influence of diet on the modeling of adipose tissue triglycerides during growth. Am J Physiol Endocrinol Metab 285:E917-E925, 2003
17. Brunengraber DZ, McCabe BJ, Katanick J, Previs S: Gas chromatographymass spectrometry assay of 18O enrichment of water. Anal Biochem 306:278-282, 2002
18. Yu L, Sinha AK, Previs SF: Effect of sampling interval on the use of "doubly labeled" water for measuring CO2 production. Anal Biochem 337:343-346, 2005
19. Foretz M, Ancellin N, Andreelli F, Saintillan Y, Grondin P, Kahn A, Thorens B, Vaulont S, Viollet B: Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver. Diabetes 54:1331-1339, 2005
20. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432, 1994
21. Black BL, Croom J, Eisen EJ, Petro AE, Edwards CL, Surwit RS: Differential effects of fat and sucrose on body composition in A/J and C57BL/6 mice. Metabolism 47:1354-1359, 1998
22. Surwit RS, Feinglos MN, Rodin J, Sutherland A, Petro AE, Opara EC, Kuhn CM, Rebuffe-Scrive M: Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice. Metabolism 44:645-651, 1995
23. Rao MS, Reddy JK: Peroxisomal beta-oxidation and steatohepatitis. Semin Liver Dis 21:43-55, 2001
24. Reddy JK, Mannaerts GP: Peroxisomal lipid metabolism. Annu Rev Nutr 14:343-370, 1994
25. Yanagitani A, Yamada S, Yasui S, Shimomura T, Murai R, Murawaki Y, Hashiguchi K, Kanbe T, Saeki T, Ichiba M, Tanabe Y, Yoshida Y, Morino S, Kurimasa A, Usuda N, Yamazaki H, Kunisada T, Ito H, Shiota G: Retinoic acid receptor alpha dominant negative form causes steatohepatitis and liver tumors in transgenic mice. Hepatology 40:366-375, 2004
26. Argyropoulos G, Harper ME: Uncoupling proteins and thermoregulation. J Appl Physiol 92:2187-2198, 2002
27. Rolfe DF, Brown GC: Cellular energy utilization and molecular origin of standard metabolic rate in mammals. Physiol Rev 77:731-758, 1997
28. Nicholls DG: The thermogenic mechanism of brown adipose tissue (Review). Biosci Rep 3:431-441, 1983
29. Li B, Nolte LA, Ju JS, Han DH, Coleman T, Holloszy JO, Semenkovich CF: Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice. Nat Med 6:1115-1120, 2000
30. Broberger C: Brain regulation of food intake and appetite: molecules and networks. J Intern Med 258:301-327, 2005
31. Carmona MC, Hondares E, Rodriguez de la Concepcion ML, Rodriguez-Sureda V, Peinado-Onsurbe J, Poli V, Iglesias R, Villarroya F, Giralt M: Defective thermoregulation, impaired lipid metabolism, but preserved adrenergic induction of gene expression in brown fat of mice lacking C/EBPbeta. Biochem J 389:47-56, 2005
32. Tae HJ, Zhang S, Kim KH: cAMP activation of CAAT enhancer-binding protein-beta gene expression and promoter I of acetyl-CoA carboxylase. J Biol Chem 270:21487-21494, 1995
33. Shimano H, Horton JD, Hammer RE, Shimomura I, Brown MS, Goldstein JL: Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. J Clin Invest 98:1575-1584, 1996
34. Shimomura I, Hammer RE, Richardson JA, Ikemoto S, Bashmakov Y, Goldstein JL, Brown MS: Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev 12:3182-3194, 1998
35. Fan W, Yanase T, Nomura M, Okabe T, Goto K, Sato T, Kawano H, Kato S, Nawata H: Androgen receptor null male mice develop late-onset obesity caused by decreased energy expenditure and lipolytic activity but show normal insulin sensitivity with high adiponectin secretion. Diabetes 54:1000-1008, 2005
36. Clapham JC, Coulthard VH, Moore GB: Concordant mRNA expression of UCP-3, but not UCP-2, with mitochondrial thioesterase-1 in brown adipose tissue and skeletal muscle in db/db diabetic mice. Biochem Biophys Res Commun 287:1058-1062, 2001
37. Gentile L, Monti M, Sebastiano V, Merico V, Nicolai R, Calvani M, Garagna S, Redi CA, Zuccotti M: Single-cell quantitative RT-PCR analysis of Cpt1b and Cpt2 gene expression in mouse antral oocytes and in preimplantation embryos. Cytogenet Genome Res 105:215-221, 2004