Spindle multipolarity is prevented by centrosomal clustering

Science

Volumn 307, Issue 5706, 2005, Pages 127-129

  Quintyne, Nicholas J ^a   Reing, Janet E ^a   Hoffelder, Diane R ^a   Gollin, Susanne M ^a   Saunders, William S ^a  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; PROTEINS; TUMORS;

CHROMOSOME SEGREGATION; CYTOPLASMIC DYNEIN; MULTIPOLAR SPINDLES; TUMOR CELLS;

GENES;

DYNEIN ADENOSINE TRIPHOSPHATASE; NUCLEAR MITOTIC APPARATUS; NUCLEAR PROTEIN; UNCLASSIFIED DRUG;

MEDICINE;

ARTICLE; CELL POLARITY; CENTROSOME; CHROMOSOME ABERRATION; CHROMOSOME SEGREGATION; CYTOPLASM; GENE AMPLIFICATION; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; MICROTUBULE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; TUMOR CELL;

ANTIGENS, NUCLEAR; CELL LINE; CELL LINE, TUMOR; CENTROSOME; DEMECOLCINE; DYNEIN ATPASE; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; MITOTIC SPINDLE APPARATUS; NUCLEAR MATRIX-ASSOCIATED PROTEINS; NUCLEAR PROTEINS; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 11844289563     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1104905     Document Type: Article

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28. The authors thank D. Compton for antibodies to NuMA and HSET; A. Merdes for the pGW-NUMA1 plasmid; T. Schroer for the CC1 plasmid and DLIC and Arp1 antibodies; M. Winey for the hMps1 plasmid; Z. Yu for culturing the UP3 cells; and X. Huang, J. Brodsky, and V. Nanda for helpful discussions. The work was supported by NIH grant DE016086 and American Cancer Society grant RSG-96-016-06 to W.S.S. and the Oral Cavity Cancer Center suppported by NIH grant P60DE130S9.