Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in xenopus egg extracts

Science

Volumn 283, Issue 5403, 1999, Pages 851-854

  Hinchcliffe, Edward H ^a   Li, Chuan ^b   Thompson, Elizabeth A ^a   Maller, James L ^b   Sluder, Greenfield ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLIN E;

ANIMAL CELL; ARTICLE; CELL CYCLE PHASE; CENTROSOME; DNA SYNTHESIS; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; ENZYME INACTIVATION; MITOSIS; NONHUMAN; PRIORITY JOURNAL; XENOPUS;

ANIMALS; APHIDICOLIN; BLASTOMERES; CDC2-CDC28 KINASES; CELL CYCLE PROTEINS; CELL EXTRACTS; CENTROSOME; CYCLIN E; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; DNA; ENZYME INHIBITORS; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MICROSCOPY, VIDEO; MICROTUBULE-ASSOCIATED PROTEINS; OVUM; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; RECOMBINANT PROTEINS; S PHASE; TUMOR SUPPRESSOR PROTEINS; XENOPUS; XENOPUS PROTEINS;

ANIMALIA; ANURA;

EID: 0033525007     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.283.5403.851     Document Type: Article

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38. We thank F. J. Miller for help developing the observation chambers, C. Wilkerson and M. Cham for assistance in building the image acquisition computers, and R. Pope, T. Pederson, G. Witman, and B. Luna for comments on the manuscript Supported by the NIH (J.L.M. and G.S.), the Trustees of the Worcester Foundation (G.S.), and the Cabot Family Charitable Trust (G.S.). J.L.M. is an investigator of the Howard Hughes Medical Institute. E.H.H. is supported by an NIH postdoctoral training fellowship. The authors would like to dedicate this work to the memory of Dan Mazia.