-
2
-
-
0035751937
-
Assessing TP53 status in human tumours to evaluate clinical outcome
-
Soussi T, Beroud C. Assessing TP53 status in human tumours to evaluate clinical outcome. Nat Rev Cancer 2001; 1:233-40.
-
(2001)
Nat Rev Cancer
, vol.1
, pp. 233-240
-
-
Soussi, T.1
Beroud, C.2
-
4
-
-
0027501841
-
Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene
-
Juven T, Barak Y, Zauberman A, George DL, Oren M. Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene. Oncogene 1993; 8:3411-6.
-
(1993)
Oncogene
, vol.8
, pp. 3411-3416
-
-
Juven, T.1
Barak, Y.2
Zauberman, A.3
George, D.L.4
Oren, M.5
-
6
-
-
0026649648
-
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
-
Momand J, Zambetti GP, Olson DC, George D, Levine AJ. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 1992; 69:1237-45.
-
(1992)
Cell
, vol.69
, pp. 1237-1245
-
-
Momand, J.1
Zambetti, G.P.2
Olson, D.C.3
George, D.4
Levine, A.J.5
-
7
-
-
0029171789
-
Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene
-
Chen J, Lin J, Levine AJ. Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene. Mol Med 1995; 1:142-52.
-
(1995)
Mol Med
, vol.1
, pp. 142-152
-
-
Chen, J.1
Lin, J.2
Levine, A.J.3
-
8
-
-
3142570737
-
Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity
-
Xirodimas DP, Saville MK, Bourdon JC, Hay RT, Lane DP. Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. Cell 2004; 118:83-97.
-
(2004)
Cell
, vol.118
, pp. 83-97
-
-
Xirodimas, D.P.1
Saville, M.K.2
Bourdon, J.C.3
Hay, R.T.4
Lane, D.P.5
-
9
-
-
0031724593
-
Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6
-
Freedman DA, Levine AJ. Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6. Mol Cell Biol 1998; 18:7288-93.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 7288-7293
-
-
Freedman, D.A.1
Levine, A.J.2
-
10
-
-
0034282220
-
The MDM2 RING-finger domain is required to promote p53 nuclear export
-
Geyer RK, Yu ZK, Maki CG. The MDM2 RING-finger domain is required to promote p53 nuclear export. Nat Cell Biol 2000; 2:569-73.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 569-573
-
-
Geyer, R.K.1
Yu, Z.K.2
Maki, C.G.3
-
11
-
-
0031583962
-
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
-
Honda R, Tanaka H, Yasuda H. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett 1997; 420:25-7.
-
(1997)
FEBS Lett
, vol.420
, pp. 25-27
-
-
Honda, R.1
Tanaka, H.2
Yasuda, H.3
-
12
-
-
0031014946
-
Proteolytic cleavage of human p53 by calpain: A potential regulator of protein stability
-
Kubbutat MH, Vousden KH. Proteolytic cleavage of human p53 by calpain: a potential regulator of protein stability. Molecular & Cellular Biology 1997; 17:460-8.
-
(1997)
Molecular & Cellular Biology
, vol.17
, pp. 460-468
-
-
Kubbutat, M.H.1
Vousden, K.H.2
-
13
-
-
0030905284
-
Mdm2 promotes the rapid degradation of p53
-
Haupt Y, Maya R, Kazaz A, Oren M. Mdm2 promotes the rapid degradation of p53. Nature 1997; 387:296-9.
-
(1997)
Nature
, vol.387
, pp. 296-299
-
-
Haupt, Y.1
Maya, R.2
Kazaz, A.3
Oren, M.4
-
14
-
-
0348134742
-
Mono-versus polyubiquitination: Differential control of p53 fate by Mdm2
-
Li M, Brooks CL, Wu-Baer F, Chen D, Baer R, Gu W. Mono-versus polyubiquitination: differential control of p53 fate by Mdm2. Science 2003; 302:1972-5.
-
(2003)
Science
, vol.302
, pp. 1972-1975
-
-
Li, M.1
Brooks, C.L.2
Wu-Baer, F.3
Chen, D.4
Baer, R.5
Gu, W.6
-
15
-
-
0028834902
-
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
-
Jones SN, Roe AE, Donehower LA, Bradley A. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 1995; 378:206-8.
-
(1995)
Nature
, vol.378
, pp. 206-208
-
-
Jones, S.N.1
Roe, A.E.2
Donehower, L.A.3
Bradley, A.4
-
16
-
-
0028823020
-
-
Montes de Oca Luna R, Wagner DS, Lozano G. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 1995; 378:203-6.
-
Montes de Oca Luna R, Wagner DS, Lozano G. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 1995; 378:203-6.
-
-
-
-
17
-
-
10144259344
-
MDMX: A novel p53-binding protein with some functional properties of MDM2
-
Shvarts A, Steegenga WT, Riteco N, van Laar T, Dekker P, Bazuine M, van Ham RC, van der Houven van Oordt W, Hateboer G, van der Eb AJ, Jochemsen AG. MDMX: a novel p53-binding protein with some functional properties of MDM2. EMBO J 1996; 15:5349-57.
-
(1996)
EMBO J
, vol.15
, pp. 5349-5357
-
-
Shvarts, A.1
Steegenga, W.T.2
Riteco, N.3
van Laar, T.4
Dekker, P.5
Bazuine, M.6
van Ham, R.C.7
van der Houven van Oordt, W.8
Hateboer, G.9
van der Eb, A.J.10
Jochemsen, A.G.11
-
18
-
-
33645769536
-
A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network
-
Toledo F, Krummel KA, Lee CJ, Liu CW, Rodewald LW, Tang M, Wahl GM. A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network. Cancer Cell 2006; 9:273-85.
-
(2006)
Cancer Cell
, vol.9
, pp. 273-285
-
-
Toledo, F.1
Krummel, K.A.2
Lee, C.J.3
Liu, C.W.4
Rodewald, L.W.5
Tang, M.6
Wahl, G.M.7
-
19
-
-
0034863683
-
Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53
-
Parant J, Chavez-Reyes A, Little NA, Yan W, Reinke V, Jochemsen AG, Lozano G. Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Nat Genet 2001; 29:92-5.
-
(2001)
Nat Genet
, vol.29
, pp. 92-95
-
-
Parant, J.1
Chavez-Reyes, A.2
Little, N.A.3
Yan, W.4
Reinke, V.5
Jochemsen, A.G.6
Lozano, G.7
-
20
-
-
0036311067
-
Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development
-
Migliorini D, Denchi EL, Danovi D, Jochemsen A, Capillo M, Gobbi A, Helin K, Pelicci PG, Marine JC. Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development. Mol Cell Biol 2002; 22:5527-38.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 5527-5538
-
-
Migliorini, D.1
Denchi, E.L.2
Danovi, D.3
Jochemsen, A.4
Capillo, M.5
Gobbi, A.6
Helin, K.7
Pelicci, P.G.8
Marine, J.C.9
-
21
-
-
0036606416
-
mdmx is a negative regulator of p53 activity in vivo
-
Finch RA, Donoviel DB, Potter D, Shi M, Fan A, Freed DD, Wang CY, Zambrowicz BP, Ramirez-Solis R, Sands AT, Zhang N. mdmx is a negative regulator of p53 activity in vivo. Cancer Res 2002; 62:3221-5.
-
(2002)
Cancer Res
, vol.62
, pp. 3221-3225
-
-
Finch, R.A.1
Donoviel, D.B.2
Potter, D.3
Shi, M.4
Fan, A.5
Freed, D.D.6
Wang, C.Y.7
Zambrowicz, B.P.8
Ramirez-Solis, R.9
Sands, A.T.10
Zhang, N.11
-
22
-
-
28344454072
-
Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development
-
Steinman HA, Hoover KM, Keeler ML, Sands AT, Jones SN. Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development. Oncogene 2005; 24:7935-40.
-
(2005)
Oncogene
, vol.24
, pp. 7935-7940
-
-
Steinman, H.A.1
Hoover, K.M.2
Keeler, M.L.3
Sands, A.T.4
Jones, S.N.5
-
23
-
-
33644879150
-
Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling
-
Lengner CJ, Steinman HA, Gagnon J, Smith TW, Henderson JE, Kream BE, Stein GS, Lian JB, Jones SN. Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling. J Cell Biol 2006; 172:909-21.
-
(2006)
J Cell Biol
, vol.172
, pp. 909-921
-
-
Lengner, C.J.1
Steinman, H.A.2
Gagnon, J.3
Smith, T.W.4
Henderson, J.E.5
Kream, B.E.6
Stein, G.S.7
Lian, J.B.8
Jones, S.N.9
-
24
-
-
33644757727
-
Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development
-
Xiong S, Van Pelt CS, Elizondo-Fraire AC, Liu G, Lozano G. Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development. Proc Natl Acad Sci USA 2006; 103:3226-31.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 3226-3231
-
-
Xiong, S.1
Van Pelt, C.S.2
Elizondo-Fraire, A.C.3
Liu, G.4
Lozano, G.5
-
25
-
-
33644772395
-
Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4
-
Grier JD, Xiong S, Elizondo-Fraire AC, Parant JM, Lozano G. Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4. Mol Cell Biol 2006; 26:192-8.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 192-198
-
-
Grier, J.D.1
Xiong, S.2
Elizondo-Fraire, A.C.3
Parant, J.M.4
Lozano, G.5
-
26
-
-
33751011894
-
Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated caspase-3-independent cell death
-
Boesten LS, Zadelaar SM, De Clercq S, Francoz S, van Nieuwkoop A, Biessen EA, Hofmann F, Feil S, Feil R, Jochemsen AG, Zurcher C, Havekes LM, van Vlijmen BJ, Marine JC. Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated caspase-3-independent cell death. Cell Death Differ 2006; 13:2089-98.
-
(2006)
Cell Death Differ
, vol.13
, pp. 2089-2098
-
-
Boesten, L.S.1
Zadelaar, S.M.2
De Clercq, S.3
Francoz, S.4
van Nieuwkoop, A.5
Biessen, E.A.6
Hofmann, F.7
Feil, S.8
Feil, R.9
Jochemsen, A.G.10
Zurcher, C.11
Havekes, L.M.12
van Vlijmen, B.J.13
Marine, J.C.14
-
27
-
-
33644778697
-
Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo
-
Francoz S, Froment P, Bogaerts S, De Clercq S, Maetens M, Doumont G, Bellefroid E, Marine JC. Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo. Proc Natl Acad Sci USA 2006; 103:3232-7.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 3232-3237
-
-
Francoz, S.1
Froment, P.2
Bogaerts, S.3
De Clercq, S.4
Maetens, M.5
Doumont, G.6
Bellefroid, E.7
Marine, J.C.8
-
28
-
-
33947250363
-
Distinct roles of Mdm2 and Mdm4 in red cell production
-
Maetens M, Doumont G, Clercq SD, Francoz S, Froment P, Bellefroid E, Klingmuller U, Lozano G, Marine JC. Distinct roles of Mdm2 and Mdm4 in red cell production. Blood 2007; 109:2630-3.
-
(2007)
Blood
, vol.109
, pp. 2630-2633
-
-
Maetens, M.1
Doumont, G.2
Clercq, S.D.3
Francoz, S.4
Froment, P.5
Bellefroid, E.6
Klingmuller, U.7
Lozano, G.8
Marine, J.C.9
-
29
-
-
34250344087
-
Loss of Mdm4 results in p53-dependent dilated cardiomyopathy
-
Xiong S, Van Pelt CS, Elizondo-Fraire AC, Fernandez-Garcia B, Lozano G. Loss of Mdm4 results in p53-dependent dilated cardiomyopathy. Circulation 2007; 115:2925-30.
-
(2007)
Circulation
, vol.115
, pp. 2925-2930
-
-
Xiong, S.1
Van Pelt, C.S.2
Elizondo-Fraire, A.C.3
Fernandez-Garcia, B.4
Lozano, G.5
-
30
-
-
0027232042
-
p53 Mutation and MDM2 amplification in human soft tissue sarcomas
-
Leach FS, Tokino T, Meltzer P, Burrell M, Oliner JD, Smith S, Hill DE, Sidransky D, Kinzler KW, Vogelstein B. p53 Mutation and MDM2 amplification in human soft tissue sarcomas. Cancer Res 1993; 53:2231-4.
-
(1993)
Cancer Res
, vol.53
, pp. 2231-2234
-
-
Leach, F.S.1
Tokino, T.2
Meltzer, P.3
Burrell, M.4
Oliner, J.D.5
Smith, S.6
Hill, D.E.7
Sidransky, D.8
Kinzler, K.W.9
Vogelstein, B.10
-
31
-
-
33845270990
-
Regulating the p53 pathway: In vitro hypotheses, in vivo veritas
-
Toledo F, Wahl GM. Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat Rev Cancer 2006; 6:909-23.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 909-923
-
-
Toledo, F.1
Wahl, G.M.2
-
32
-
-
33750590095
-
Inactivation of the p53 pathway in retinoblastoma
-
Laurie NA, Donovan SL, Shih CS, Zhang J, Mills N, Fuller C, Teunisse A, Lam S, Ramos Y, Mohan A, Johnson D, Wilson M, Rodriguez-Galindo C, Quarto M, Francoz S, Mendrysa SM, Guy RK, Marine JC, Jochemsen AG, Dyer MA. Inactivation of the p53 pathway in retinoblastoma. Nature 2006; 444:61-6.
-
(2006)
Nature
, vol.444
, pp. 61-66
-
-
Laurie, N.A.1
Donovan, S.L.2
Shih, C.S.3
Zhang, J.4
Mills, N.5
Fuller, C.6
Teunisse, A.7
Lam, S.8
Ramos, Y.9
Mohan, A.10
Johnson, D.11
Wilson, M.12
Rodriguez-Galindo, C.13
Quarto, M.14
Francoz, S.15
Mendrysa, S.M.16
Guy, R.K.17
Marine, J.C.18
Jochemsen, A.G.19
Dyer, M.A.20
more..
-
33
-
-
0028098165
-
Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas
-
Cordon-Cardo C, Latres E, Drobnjak M, Oliva MR, Pollack D, Woodruff JM, Marechal V, Chen J, Brennan MF, Levine AJ. Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas. Cancer Res 1994; 54:794-9.
-
(1994)
Cancer Res
, vol.54
, pp. 794-799
-
-
Cordon-Cardo, C.1
Latres, E.2
Drobnjak, M.3
Oliva, M.R.4
Pollack, D.5
Woodruff, J.M.6
Marechal, V.7
Chen, J.8
Brennan, M.F.9
Levine, A.J.10
-
34
-
-
0029914660
-
Overexpression of the MDM2 oncogene in leukemia and lymphoma
-
color plates XVI following 5
-
Watanabe T, Ichikawa A, Saito H, Hotta T. Overexpression of the MDM2 oncogene in leukemia and lymphoma. Leuk Lymphoma 1996; 21:391-7, color plates XVI following 5.
-
(1996)
Leuk Lymphoma
, vol.21
, pp. 391-397
-
-
Watanabe, T.1
Ichikawa, A.2
Saito, H.3
Hotta, T.4
-
35
-
-
0036157247
-
Impact of alterations affecting the p53 pathway in bladder cancer on clinical outcome, assessed by conventional and array-based methods
-
Lu ML, Wikman F, Orntoft TF, Charytonowicz E, Rabbani F, Zhang Z, Dalbagni G, Pohar KS, Yu G, Cordon-Cardo C. Impact of alterations affecting the p53 pathway in bladder cancer on clinical outcome, assessed by conventional and array-based methods. Clin Cancer Res 2002; 8:171-9.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 171-179
-
-
Lu, M.L.1
Wikman, F.2
Orntoft, T.F.3
Charytonowicz, E.4
Rabbani, F.5
Zhang, Z.6
Dalbagni, G.7
Pohar, K.S.8
Yu, G.9
Cordon-Cardo, C.10
-
36
-
-
0032417695
-
Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis
-
Jones SN, Hancock AR, Vogel H, Donehower LA, Bradley A. Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis. Proc Natl Acad Sci USA 1998; 95:15608-12.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 15608-15612
-
-
Jones, S.N.1
Hancock, A.R.2
Vogel, H.3
Donehower, L.A.4
Bradley, A.5
-
37
-
-
14444281159
-
-
Lundgren K, Montes de Oca Luna R, McNeill YB, Emerick EP, Spencer B, Barfield CR, Lozano G, Rosenberg MP, Finlay CA. Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53. Genes Dev 1997; 11:714-25.
-
Lundgren K, Montes de Oca Luna R, McNeill YB, Emerick EP, Spencer B, Barfield CR, Lozano G, Rosenberg MP, Finlay CA. Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53. Genes Dev 1997; 11:714-25.
-
-
-
-
38
-
-
0029824669
-
Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: Transforming ability and frequent detection in human cancer
-
Sigalas I, Calvert AH, Anderson JJ, Neal DE, Lunec J. Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer. Nat Med 1996; 2:912-7.
-
(1996)
Nat Med
, vol.2
, pp. 912-917
-
-
Sigalas, I.1
Calvert, A.H.2
Anderson, J.J.3
Neal, D.E.4
Lunec, J.5
-
39
-
-
0141706686
-
Tumor promotion by Mdm2 splice variants unable to bind p53
-
Fridman JS, Hernando E, Hemann MT, de Stanchina E, Cordon-Cardo C, Lowe SW. Tumor promotion by Mdm2 splice variants unable to bind p53. Cancer Res 2003; 63:5703-6.
-
(2003)
Cancer Res
, vol.63
, pp. 5703-5706
-
-
Fridman, J.S.1
Hernando, E.2
Hemann, M.T.3
de Stanchina, E.4
Cordon-Cardo, C.5
Lowe, S.W.6
-
40
-
-
1042266626
-
An alternative splice form of Mdm2 induces p53-independent cell growth and tumorigenesis
-
Steinman HA, Burstein E, Lengner C, Gosselin J, Pihan G, Duckett CS, Jones SN. An alternative splice form of Mdm2 induces p53-independent cell growth and tumorigenesis. J Biol Chem 2004; 279:4877-86.
-
(2004)
J Biol Chem
, vol.279
, pp. 4877-4886
-
-
Steinman, H.A.1
Burstein, E.2
Lengner, C.3
Gosselin, J.4
Pihan, G.5
Duckett, C.S.6
Jones, S.N.7
-
41
-
-
0029028354
-
Interaction between the retinoblastoma protein and the oncoprotein MDM2
-
Xiao ZX, Chen J, Levine AJ, Modjtahedi N, Xing J, Sellers WR, Livingston DM. Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature 1995; 375:694-8.
-
(1995)
Nature
, vol.375
, pp. 694-698
-
-
Xiao, Z.X.1
Chen, J.2
Levine, A.J.3
Modjtahedi, N.4
Xing, J.5
Sellers, W.R.6
Livingston, D.M.7
-
42
-
-
11144241617
-
The central acidic domain of MDM2 is critical in inhibition of retinoblastoma-mediated suppression of E2F and cell growth
-
Sdek P, Ying H, Zheng H, Margulis A, Tang X, Tian K, Xiao ZX. The central acidic domain of MDM2 is critical in inhibition of retinoblastoma-mediated suppression of E2F and cell growth. J Biol Chem 2004; 279:53317-122.
-
(2004)
J Biol Chem
, vol.279
, pp. 53317-54122
-
-
Sdek, P.1
Ying, H.2
Zheng, H.3
Margulis, A.4
Tang, X.5
Tian, K.6
Xiao, Z.X.7
-
43
-
-
28444437051
-
MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein
-
Sdek P, Ying H, Chang DL, Qiu W, Zheng H, Touitou R, Allday MJ, Xiao ZX. MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein. Mol Cell 2005; 20:699-708.
-
(2005)
Mol Cell
, vol.20
, pp. 699-708
-
-
Sdek, P.1
Ying, H.2
Chang, D.L.3
Qiu, W.4
Zheng, H.5
Touitou, R.6
Allday, M.J.7
Xiao, Z.X.8
-
44
-
-
19944431662
-
Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation
-
Uchida C, Miwa S, Kitagawa K, Hattori T, Isobe T, Otani S, Oda T, Sugimura H, Kamijo T, Ookawa K, Yasuda H, Kitagawa M. Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation. EMBO J 2005; 24:160-9.
-
(2005)
EMBO J
, vol.24
, pp. 160-169
-
-
Uchida, C.1
Miwa, S.2
Kitagawa, K.3
Hattori, T.4
Isobe, T.5
Otani, S.6
Oda, T.7
Sugimura, H.8
Kamijo, T.9
Ookawa, K.10
Yasuda, H.11
Kitagawa, M.12
-
45
-
-
0029028353
-
Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein
-
Martin K, Trouche D, Hagemeier C, Sorensen TS, La Thangue NB, Kouzarides T. Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein. Nature 1995; 375:691-4.
-
(1995)
Nature
, vol.375
, pp. 691-694
-
-
Martin, K.1
Trouche, D.2
Hagemeier, C.3
Sorensen, T.S.4
La Thangue, N.B.5
Kouzarides, T.6
-
46
-
-
38849139580
-
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
-
Yang JY, Zong CS, Xia W, Yamaguchi H, Ding Q, Xie X, Lang JY, Lai CC, Chang CJ, Huang WC, Huang H, Kuo HP, Lee DF, Li LY, Lien HC, Cheng X, Chang KJ, Hsiao CD, Tsai FJ, Tsai CH, Sahin AA, Muller WJ, Mills GB, Yu D, Hortobagyi GN, Hung MC. ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. Nat Cell Biol 2008; 10:138-48.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 138-148
-
-
Yang, J.Y.1
Zong, C.S.2
Xia, W.3
Yamaguchi, H.4
Ding, Q.5
Xie, X.6
Lang, J.Y.7
Lai, C.C.8
Chang, C.J.9
Huang, W.C.10
Huang, H.11
Kuo, H.P.12
Lee, D.F.13
Li, L.Y.14
Lien, H.C.15
Cheng, X.16
Chang, K.J.17
Hsiao, C.D.18
Tsai, F.J.19
Tsai, C.H.20
Sahin, A.A.21
Muller, W.J.22
Mills, G.B.23
Yu, D.24
Hortobagyi, G.N.25
Hung, M.C.26
more..
-
47
-
-
33749188859
-
MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation
-
Yang JY, Zong CS, Xia W, Wei Y, Ali-Seyed M, Li Z, Broglio K, Berry DA, Hung MC. MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation. Mol Cell Biol 2006; 26:7269-82.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 7269-7282
-
-
Yang, J.Y.1
Zong, C.S.2
Xia, W.3
Wei, Y.4
Ali-Seyed, M.5
Li, Z.6
Broglio, K.7
Berry, D.A.8
Hung, M.C.9
-
48
-
-
0031835660
-
The Mdm2 oncoprotein interacts with the cell fate regulator Numb
-
Juven-Gershon T, Shifman O, Unger T, Elkeles A, Haupt Y, Oren M. The Mdm2 oncoprotein interacts with the cell fate regulator Numb. Mol Cell Biol 1998; 18:3974-82.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 3974-3982
-
-
Juven-Gershon, T.1
Shifman, O.2
Unger, T.3
Elkeles, A.4
Haupt, Y.5
Oren, M.6
-
50
-
-
0344995254
-
MDM2 and MDMX inhibit the transcriptional activity of ectopically expressed SMAD proteins
-
Yam CH, Siu WY, Arooz T, Chiu CH, Lau A, Wang XQ, Poon RY. MDM2 and MDMX inhibit the transcriptional activity of ectopically expressed SMAD proteins. Cancer Res 1999; 59:5075-8.
-
(1999)
Cancer Res
, vol.59
, pp. 5075-5078
-
-
Yam, C.H.1
Siu, W.Y.2
Arooz, T.3
Chiu, C.H.4
Lau, A.5
Wang, X.Q.6
Poon, R.Y.7
-
51
-
-
0037007236
-
Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation
-
Legube G, Linares LK, Lemercier C, Scheffner M, Khochbin S, Trouche D. Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation. EMBO J 2002; 21:1704-12.
-
(2002)
EMBO J
, vol.21
, pp. 1704-1712
-
-
Legube, G.1
Linares, L.K.2
Lemercier, C.3
Scheffner, M.4
Khochbin, S.5
Trouche, D.6
-
52
-
-
0035834428
-
Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin
-
Shenoy SK, McDonald PH, Kohout TA, Lefkowitz RJ. Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Science 2001; 294:1307-13.
-
(2001)
Science
, vol.294
, pp. 1307-1313
-
-
Shenoy, S.K.1
McDonald, P.H.2
Kohout, T.A.3
Lefkowitz, R.J.4
-
53
-
-
40449085773
-
Elevated Mdm2 expression induces chromosomal instability and confers a survival and growth advantage to B cells
-
Wang P, Lushnikova T, Odvody J, Greiner TC, Jones SN, Eischen CM. Elevated Mdm2 expression induces chromosomal instability and confers a survival and growth advantage to B cells. Oncogene 2008; 27:1590-8.
-
(2008)
Oncogene
, vol.27
, pp. 1590-1598
-
-
Wang, P.1
Lushnikova, T.2
Odvody, J.3
Greiner, T.C.4
Jones, S.N.5
Eischen, C.M.6
-
55
-
-
0037441475
-
The E2F-1 transcription factor is negatively regulated by its interaction with the MDMX protein
-
Strachan GD, Jordan-Sciutto KL, Rallapalli R, Tuan RS, Hall DJ. The E2F-1 transcription factor is negatively regulated by its interaction with the MDMX protein. J Cell Biochem 2003; 88:557-68.
-
(2003)
J Cell Biochem
, vol.88
, pp. 557-568
-
-
Strachan, G.D.1
Jordan-Sciutto, K.L.2
Rallapalli, R.3
Tuan, R.S.4
Hall, D.J.5
-
57
-
-
0942290415
-
Absence of p21 partially rescues Mdm4 loss and uncovers an antiproliferative effect of Mdm4 on cell growth
-
Steinman HA, Sluss HK, Sands AT, Pihan G, Jones SN. Absence of p21 partially rescues Mdm4 loss and uncovers an antiproliferative effect of Mdm4 on cell growth. Oncogene 2004; 23:303-6.
-
(2004)
Oncogene
, vol.23
, pp. 303-306
-
-
Steinman, H.A.1
Sluss, H.K.2
Sands, A.T.3
Pihan, G.4
Jones, S.N.5
-
58
-
-
38949124679
-
MdmX promotes bipolar mitosis to suppress transformation and tumorigenesis in p53-deficient cells and mice
-
Matijasevic Z, Steinman HA, Hoover K, Jones SN. MdmX promotes bipolar mitosis to suppress transformation and tumorigenesis in p53-deficient cells and mice. Mol Cell Biol 2008; 28:1265-73.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 1265-1273
-
-
Matijasevic, Z.1
Steinman, H.A.2
Hoover, K.3
Jones, S.N.4
-
59
-
-
0027179908
-
In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice
-
Harvey M, Sands AT, Weiss RS, Hegi ME, Wiseman RW, Pantazis P, Giovanella BC, Tainsky MA, Bradley A, Donehower LA. In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice. Oncogene 1993; 8:2457-67.
-
(1993)
Oncogene
, vol.8
, pp. 2457-2467
-
-
Harvey, M.1
Sands, A.T.2
Weiss, R.S.3
Hegi, M.E.4
Wiseman, R.W.5
Pantazis, P.6
Giovanella, B.C.7
Tainsky, M.A.8
Bradley, A.9
Donehower, L.A.10
-
60
-
-
0029881977
-
Abnormal centrosome amplification in the absence of p53
-
Fukasawa K, Choi T, Kuriyama R, Rulong S, Vande Woude GF. Abnormal centrosome amplification in the absence of p53. Science 1996; 271:1744-7.
-
(1996)
Science
, vol.271
, pp. 1744-1747
-
-
Fukasawa, K.1
Choi, T.2
Kuriyama, R.3
Rulong, S.4
Vande Woude, G.F.5
-
61
-
-
0028913739
-
A p53-dependent mouse spindle checkpoint
-
Cross SM, Sanchez CA, Morgan CA, Schimke MK, Ramel S, Idzerda RL, Raskind WH, Reid BJ. A p53-dependent mouse spindle checkpoint. Science 1995; 267:1353-6.
-
(1995)
Science
, vol.267
, pp. 1353-1356
-
-
Cross, S.M.1
Sanchez, C.A.2
Morgan, C.A.3
Schimke, M.K.4
Ramel, S.5
Idzerda, R.L.6
Raskind, W.H.7
Reid, B.J.8
-
62
-
-
0033525007
-
Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts
-
Hinchcliffe EH, Li C, Thompson EA, Maller JL, Sluder G. Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts. Science 1999; 283:851-4.
-
(1999)
Science
, vol.283
, pp. 851-854
-
-
Hinchcliffe, E.H.1
Li, C.2
Thompson, E.A.3
Maller, J.L.4
Sluder, G.5
-
63
-
-
0037048277
-
Two for two: Cdk2 and its role in centrosome doubling
-
Hinchcliffe EH, Sluder G. Two for two: Cdk2 and its role in centrosome doubling. Oncogene 2002; 21:6154-60.
-
(2002)
Oncogene
, vol.21
, pp. 6154-6160
-
-
Hinchcliffe, E.H.1
Sluder, G.2
-
64
-
-
0037195268
-
p53 and p21 form an inducible barrier that protects cells against cyclin E-cdk2 deregulation
-
Minella AC, Swanger J, Bryant E, Welcker M, Hwang H, Clurman BE. p53 and p21 form an inducible barrier that protects cells against cyclin E-cdk2 deregulation. Curr Biol 2002; 12:1817-27.
-
(2002)
Curr Biol
, vol.12
, pp. 1817-1827
-
-
Minella, A.C.1
Swanger, J.2
Bryant, E.3
Welcker, M.4
Hwang, H.5
Clurman, B.E.6
-
65
-
-
18144389836
-
Transcriptional control of BubR1 by p53 and suppression of centrosome amplification by BubR1
-
Oikawa T, Okuda M, Ma Z, Goorha R, Tsujimoto H, Inokuma H, Fukasawa K. Transcriptional control of BubR1 by p53 and suppression of centrosome amplification by BubR1. Mol Cell Biol 2005; 25:4046-61.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 4046-4061
-
-
Oikawa, T.1
Okuda, M.2
Ma, Z.3
Goorha, R.4
Tsujimoto, H.5
Inokuma, H.6
Fukasawa, K.7
-
66
-
-
34247887536
-
Direct evidence for the role of centrosomally localized p53 in the regulation of centrosome duplication
-
Shinmura K, Bennett RA, Tarapore P, Fukasawa K. Direct evidence for the role of centrosomally localized p53 in the regulation of centrosome duplication. Oncogene 2007; 26:2939-44.
-
(2007)
Oncogene
, vol.26
, pp. 2939-2944
-
-
Shinmura, K.1
Bennett, R.A.2
Tarapore, P.3
Fukasawa, K.4
-
67
-
-
3342973782
-
p53 localization at centrosomes during mitosis and postmitotic checkpoint are ATM-dependent and require serine 15 phosphorylation
-
Tritarelli A, Oricchio E, Ciciarello M, Mangiacasale R, Palena A, Lavia P, Soddu S, Cundari E. p53 localization at centrosomes during mitosis and postmitotic checkpoint are ATM-dependent and require serine 15 phosphorylation. Mol Biol Cell 2004; 15:3751-7.
-
(2004)
Mol Biol Cell
, vol.15
, pp. 3751-3757
-
-
Tritarelli, A.1
Oricchio, E.2
Ciciarello, M.3
Mangiacasale, R.4
Palena, A.5
Lavia, P.6
Soddu, S.7
Cundari, E.8
-
68
-
-
0035188129
-
Managing the centrosome numbers game: From chaos to stability in cancer cell division
-
Brinkley BR. Managing the centrosome numbers game: from chaos to stability in cancer cell division. Trends Cell Biol 2001; 11:18-21.
-
(2001)
Trends Cell Biol
, vol.11
, pp. 18-21
-
-
Brinkley, B.R.1
-
69
-
-
1642412809
-
The good, the bad and the ugly: The practical consequences of centrosome amplification
-
Sluder G, Nordberg JJ. The good, the bad and the ugly: the practical consequences of centrosome amplification. Curr Opin Cell Biol 2004; 16:49-54.
-
(2004)
Curr Opin Cell Biol
, vol.16
, pp. 49-54
-
-
Sluder, G.1
Nordberg, J.J.2
-
70
-
-
10944269112
-
Centrosomal amplification and spindle multipolarity in cancer cells
-
Saunders W. Centrosomal amplification and spindle multipolarity in cancer cells. Semin Cancer Biol 2005; 15:25-32.
-
(2005)
Semin Cancer Biol
, vol.15
, pp. 25-32
-
-
Saunders, W.1
-
71
-
-
0001769577
-
Ueber mehrpolige Mitosen als Mittel zur Analyse des Zellkerns
-
Boveri T. Ueber mehrpolige Mitosen als Mittel zur Analyse des Zellkerns. Vehr d phys med Ges zu Wurzburg NF 1902; 35:67-90.
-
(1902)
Vehr d phys med Ges zu Wurzburg NF
, vol.35
, pp. 67-90
-
-
Boveri, T.1
-
72
-
-
85011937940
-
-
Hansemann D. Ueber patologische Mitosen. Arch Pathol Anat Phys Klin Med 1891; 119:299-326.
-
Hansemann D. Ueber patologische Mitosen. Arch Pathol Anat Phys Klin Med 1891; 119:299-326.
-
-
-
-
73
-
-
9244263076
-
Aneuploidy and cancer
-
Rajagopalan H, Lengauer C. Aneuploidy and cancer. Nature 2004; 432:338-41.
-
(2004)
Nature
, vol.432
, pp. 338-341
-
-
Rajagopalan, H.1
Lengauer, C.2
-
74
-
-
0347762556
-
From polyploidy to aneuploidy, genome instability and cancer
-
Storchova Z, Pellman D. From polyploidy to aneuploidy, genome instability and cancer. Nat Rev Mol Cell Biol 2004; 5:45-54.
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 45-54
-
-
Storchova, Z.1
Pellman, D.2
-
75
-
-
33846065784
-
Aneuploidy acts both oncogenically and as a tumor suppressor
-
Weaver BA, Silk AD, Montagna C, Verdier-Pinard P, Cleveland DW. Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell 2007; 11:25-36.
-
(2007)
Cancer Cell
, vol.11
, pp. 25-36
-
-
Weaver, B.A.1
Silk, A.D.2
Montagna, C.3
Verdier-Pinard, P.4
Cleveland, D.W.5
-
77
-
-
0023792376
-
Genetic convergence and divergence in tumor progression
-
Heim S, Mandahl N, Mitelman F. Genetic convergence and divergence in tumor progression. Cancer Res 1988; 48:5911-6.
-
(1988)
Cancer Res
, vol.48
, pp. 5911-5916
-
-
Heim, S.1
Mandahl, N.2
Mitelman, F.3
|