The "O" class: Crafting clinical care with FoxO transcription factors

Advances in Experimental Medicine and Biology

Volumn 665, Issue , 2009, Pages 242-260

  Maiese, Kenneth ^a   Chong, Zhao Zhong ^b   Hall, Jinling ^b   ChenShang, Yan ^b  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR FKHRL1; TRANSCRIPTION FACTOR FOXO; TRANSCRIPTION FACTOR FOXO4; TRANSCRIPTION FACTOR FOXO6; UNCLASSIFIED DRUG; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, HUMAN; FOXO3 PROTEIN, HUMAN; FOXO4 PROTEIN, HUMAN; FOXO6 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ANGIOGENESIS; ARTICLE; BLOOD VESSEL TONE; BREAST CANCER; CANCER GROWTH; CELL CYCLE REGULATION; CELL DAMAGE; CELL METABOLISM; CELL PROLIFERATION; CELL SURVIVAL; COLON CANCER; DIABETES MELLITUS; DISEASE COURSE; FERTILITY; HEART DEVELOPMENT; HUMAN; IMMUNOSURVEILLANCE; LONGEVITY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; STEM CELL; STOMACH CANCER; PHYSIOLOGY; REVIEW;

FORKHEAD TRANSCRIPTION FACTORS; HUMANS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 76749150709     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4419-1599-3_18     Document Type: Article

References (175)

1. Weigel D. Jurgens G. Kuttner F, et al. The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the drosophila embryo. Cell 1989: 57(4) :645-658.
2. Kaestner KH, Knochel W; Martinez DE. Unified nomenclature for the winged helix/forkhead transcription factors. Genes Dev 2000: 14(2):142-146. (Pubitemid 30070978)
3. Maiese K, Chong ZZ. Shang YC. -Sly as a FOXO": New parhs with forkhead signaling in the brain. Curr Neurovasc Res 2007; 4(4) :295-302. (Pubitemid 350171831)
4. Parry P, Wei Y, EvansG. Cloning and characterization of the t(X ;II) breakpoint from a leukemic cell line ident ify a new member of the forkhead gene family. Genes Chromosomes Cancer 1994: 11(2) :79-84. (Pubitemid 24300181)
5. HillionJ, Le Coniat M,Jonveaux P, et al. AF6q21. A novel parmer of the MLL gene in t(6 ;11)(q21:q23). defines a forkhead transcriptional factor subfamily. Blood 1997; 90(9) :3714-3719. (Pubitemid 27473443)
6. Castrillon DH. Miao L, Kollipara R, et al. Suppression of ovarian follicle activation in mice by the tran scription factor Foxo3a. Science 2003; 301(5630):215-218. (Pubitemid 36858475)
7. Furuyama T. Nakazawa T. Nakano I, et al. Identification of the differential distribution patterns of mRNAs and consensus bind ing sequences for mouse DAF-16 homologues, Biochem 2000: 349(Pt 2):629-634. (Pubitemid 30465799)
8. Furuyama T, Yamashita H, Kitayama K, et al. Effects of aging and caloric restriction on the gene expression of Foxol , 3. And 4 (FKHR. FKHRLl, and AFX) in the rat skeletal muscles. Microsc Res Tech 2002; 59(4) :331-334. (Pubitemid 35332954)
9. Hoekman MF. Jacobs FM. Smidt MP, et al. Spatial and temporal expression of FoxO transcription factors in the developing and adult murine brain. Gene Expr Patterns 2006; 6(2) :134-140. (Pubitemid 43071907)
10. Maiese K, Chong ZZ , Shang yc. OutFOXOing disease and disability : The therapeuti c potential of targeting FoxO proteins. Trends Mol Med 2008; 14(5):219-227.
11. Modur V. Nagarajan R, EversBM, et al. FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer. J Bioi Chern 2002; 277(49) :47928-47937. (Pubitemid 36159321)
12. Biggs WH. Cavenee WK. Arden KC. Identification and characterization of members of the FKHR (FOX 0) subclass of winged-helix transcription factors in the mouse. Mamm Genome 2001 ; 12(6) :416-425 (Pubitemid 32463734)
13. Maiese K. Chong ZZ. Shang YC, et al. A "FOXO' in sight: Targeting Foxo proteins from conception to cancer. Med Res Rev 2009; 29(3) :395-418.
14. Clark KL, Halay ED, Lai E, et al. Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5. Nature 1993; 364(6436):412-420. (Pubitemid 23263212)
15. Larson ET. Eilers B. Menon S, et al. A winged-helix protein from Sulfolobus turreted icosahedral virus points toward stabilizing disulfide bonds in the int racellular proteins of a hyperthermophilic virus. Virology 2007; 368(2) :249-261. (Pubitemid 350016222)
16. Jin C. Marsden I. Chen X, et al. Sequence specific collective motions in a winged helix DNA binding domain detected by 15N relaxation NMR. Biochemistry 1998; 37(17) :6179-6187. (Pubitemid 28196775)
17. Tsai KL, Sun YJ, Huang CY, et al. Crystal structure of the human FOX03a-DBD/DNA complex suggests the effects of post-translational modification Nucleic Acids Res 2007; 35(20) :6984-6994.
18. Wijchers PJ. Burbach JP. Smidt MP. In control of biology: Of mice, men and Foxes. Biochem J 2006; 397(2):233-246. (Pubitemid 44076893)
19. Jagani Z. Singh A. Khosravi-Far R. FoxO tumor suppressors and BCR-ABL-induced leukemia: A matter of evasion of apoptosis. Biochim Biophys Acta 2008; 1785(1) :63-84. (Pubitemid 350192084)
20. Maiese K, Chong ZZ , Shang YC, et al. Clever cancer strategies with FoxO transcription factors. Cell Cycle 2008; 7(24) :3829-3839
21. Van der Horst A. Burgering BM. Stressing the role of FoxO proteins in lifespan and disease. Nat Rev Mol Cell Bioi 2007; 8(6) :440-450. (Pubitemid 46809159)
22. Chong ZZ. Li F. Maiese K. Activating Akr and the brain's resources to drive cellular survival and prevent inflammatory injury. Histol Hisropathol 2005; 20(1):299-315. (Pubitemid 40029007)
23. Anitha M. Gondha C. SutliffR, et al. GDNF rescues hyperglycemia-induced diabetic enteric neuropathy through activation of the PI3K/ Akt pathway.J Clin Invest 2006; 116(2):344-356. (Pubitemid 43228351)
24. Chong ZZ. Kang JQ. Maiese K. Erythropoietin is a novel vascular protectanr through activation of Aktl and mitochondrial modulation of cysteine proteases. Circulation 2002; 106(23) :2973-2979. (Pubitemid 35424751)
25. Chong ZZ. Li F, Maiese K. Erythropoietin requires NF-kappaB and its nuclear translocation to prevent early and late apoptotic neuronal injury during beta-amyloid toxicity. Curr Neurovasc Res 2005; 2(5):387-399. (Pubitemid 41789605)
26. Kim KH. Oudit GY, Backx PH. Erythropoietin protects against doxorubicin-induced cardiomyopathy via a phosphatidylinosirol 3-kinase-dependent pathway. J Pharmacol Exp Ther 2008; 324(1):160-169. (Pubitemid 350294149)
27. Tajes M. Yeste-Velasco M, Zhu X, et al. Activation of Akr by lithium : Pro-survival pathways in aging. Mech Ageing Dev 2009; 130(4):253-261.
28. Chong ZZ. Kang JQ. Maiese K. Aktl drives endothelial cell membrane asymmetry and microglial activation through Bcl-x(L) and caspase 1.3. And 9. Exp Cell Res 2004; 296(2) :196-207. (Pubitemid 38624641)
29. KangJQ. Chong ZZ. MaieseK. Critical role for Aktl in the modulation of apoptotic phosphatidylserine exposure and microglial activation Mol Pharmacol2003; 64(3) :557-569. (Pubitemid 37048558)
30. Kang JQ. Chong ZZ. Maiese K. Aktl protects against inflammator y microglial activation through maintenance of membrane asymmetry and modulation of cysteine protease activity. J Neurosci Res 2003; 74(1 ):37-51. (Pubitemid 37176665)
31. Maiese K, Chong ZZ. Hou J, et al. Erythropoietin and oxidative stress. Curr Neurovasc Res 2008; 5(2):125-142. (Pubitemid 351838578)
32. Chong ZZ Maiese K. Erythropoietin involves the phospharidylinoslrol 3-kinase pathway. 14-3-3 protein and FOX03a nuclear trafficking to preserve endothelial cell integrity. Br J Pharmacol 2007; 150(7):839-850. (Pubitemid 46536625)
33. MaieseK, Li F, Chong ZZ. New avenuesof exploration for erythropoietin. JAMA 2005; 293(1):90-95.
34. Van der Heide LP. Jacobs FM. Burbach JP., et al. Fox06 transcriptional activity is regulated by Thr26 and Serl84. independent of nucleo-cytoplasmic shut tling. Biochem J 2005; 391(Pt 3):623-629. (Pubitemid 41634788)
35. Maiese K, Chong ZZ. Shang YC, et al. FoxO proteins : Cunning concepts and considerations for the cardiovascular system. Clin Sci (Lond) 2009; 116(3) :191-203.
36. Li F, Chong ZZ. Maiese K. Cell Life Versus Cell Longevity: The Mysteries Surrounding the NAD( +) Precursor Nicotinamide Curt Med Chern 2006; 13(8):883-895.
37. Maiese K. Chong ZZ. Li F. Driving cellular plasticity and survival through the signal transduction pathways of metaborropic glutamate receptors. Curr Neurovasc Res 2005; 2(5) :425-446 (Pubitemid 41789608)
38. Salvesen GS, Riedl SJ. Caspase mechanisms. Adv Exp Med Bioi 2008; 615:13-23.
39. Chong ZZ, KangJQ, Maiese K. Apaf-l, Bcl-xl., Cytochrome c, and caspase-9 form the critical elements for cerebral vascular protection by erythropoietin. J Cereb Blood Flow Metab 2003 ; 23(3) :320-330. (Pubitemid 36307576)
40. Chong ZZ, KangJQ, Maiese K. Erythropoietin fosters both intrinsic and extrinsic neuronal protection through modulation of microglia, Aktl, Bad, and caspase-mediated pathways. BrJ Pharmacol 2003; 138(6) :1107-1118 (Pubitemid 36459833)
41. Chong ZZ, KangJQ, Maiese K. Essential cellular regulatory elements of oxidative stress in early and late phases of apoptosis in the central nervous system. Antioxid Redox Signal 2004; 6(2) :277-287 (Pubitemid 38332585)
42. Chong ZZ, Li F, Maiese K. Group I rnetabotropic receptor neuroprotection requires Akt and its substrates that govern FOX03a, Bim, and heta-catenin during oxidative stress. Curr Neurovasc Res 2006 ; 3(2):107-117. (Pubitemid 43764787)
43. Chong ZZ, Lin SH, Maiese K. The NAD+ precursor nicotinamide governs neuronal survival during oxidative stress through protein kinase B coupled to FOX03a and mitochondrial membrane potential. J Cereb Blood Flow Metab 2004 ; 24(7) :728-743 (Pubitemid 38880218)
44. Obexer P, Geiger K, Ambros PF, et al. FKHRLl-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells. Cell Death Differ 2007; 14(3) :534-547.
45. Gomez-Gutierrez JG, Souza V, Hao HY, et al. Adenovirus-mediated gene transfer of FKHRLI triple mutant efficiently induces apoptosis in melanoma cells. Cancer Bioi Ther 2006; 5(7):875-883. (Pubitemid 44775149)
46. Shang YC, Chong ZZ, Hou J, et al. The forkhead transcription factor Fox03a controls microglial inflammatory activation and eventual apoptotic injury through caspase 3. Curr Neurovasc Res 2009; 6(1):20-31.
47. Matsuzaki H, Daitoku H, Ham M,, et al. Insulin -induced phosphorylation of FKHR (Foxol) targets to proteasomal degradation Proc Natl Acad Sci USA 2003; 100(20):11285-11290. (Pubitemid 37205927)
48. Plas DR, Thompson CB. Akt activation promotes degradation of tuberin and FOX03a via the proreasome, J Bioi Chern 2003 ; 278(14):12361-12366. (Pubitemid 36800220)
49. Leong ML, Maiyar AC, Kim B, et al. Expression of the serum- and glucocorticoid-inducible protein kinase, Sgk, is a cell survival response to multiple types of environmental stress stimuli in mammary epithelial cells.J Bioi Chern 2003; 278(8) :5871-5882. (Pubitemid 36800834)
50. Lehtinen MK, Yuan Z, Boag PR, et al. A conserved MST-FOXO signaling pathway mediates oxidative- stress responses and extends life span. Cell 2006; 125(5):987-1001. (Pubitemid 43795191)
51. Song JJ, Lee YJ. Differential cleavage of Mstl by caspase-71-3 is responsible for TRAIL-induced activation of the MAPK superfamily. Cell Signal 2008 ; 20(5) :892-906.
52. Matsuzaki H, Daitoku H, Hatta M, et al. Acetylation of Foxol alters its DNA-binding ability and sensitivity to phosphorylation. Proc Natl Acad Sci USA 2005 ; 102(32) :11278-11283. (Pubitemid 41153811)
53. Li F. Chong ZZ. Maiese K. Winding through the WNT pathway during cellular development and demise. Histol Histoparhol 2006; 21(1) :103-124. (Pubitemid 43033719)
54. Maiese K, Li F, Chong ZZ, et al. The Wnt signaling pathway: Aging gracefully as a protectionist? Pharmacol Ther 2008; 118(1) :58-81.
55. Maiese K. Triple play: Promoting neurovascular longevity with nicotinamide, WNT, and erythropoietin in diabetes mellitus Biomed Pharmacorher 2008; 62(4):218-232. (Pubitemid 351635845)
56. Li F, Chong ZZ, Maiese K. Vital elements of the wnt-frizzled signaling pathway in the nervous system. Curr Neurovasc Res 2005 ; 2(4) :331-340. (Pubitemid 41297370)
57. Maiese K, Chong ZZ, Shang YC, et al. Rogue proliferation versus restorative protection: Where do we draw the line for Wnt and forkhead signaling? Expert Opin Ther Targets 2008; 12(7):905-916. (Pubitemid 352003328)
58. Chong ZZ, Li F, Maiese K. Cellular demise and inflammatory microglial activation during beta-amyloid toxicity are governed by Wntl and canonical signaling pathways. Cell Signal. 2007 ; 19(6):1150-1162. (Pubitemid 46561553)
59. Smith WW; Norton DD, Gorospe M, et al. Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity.J Cell Bioi 2005 ; 169(2) :331-339 (Pubitemid 40656570)
60. Hoogeboom D, Essers MA, Polderman PE, et al. Interaction of FOXO with [beraj-catenin inh ibits [beraj-catentn/T cell factor activity.J Bioi Chern 2008; 283(14):9224-9230.
61. Kerdiles YM, Beisner DR, Tinoco Ret al. Foxol links homing and survival of naive T cells by regulating Lseleccin, CCR7 and interleukin 7 receptor. Nat Immunol 2009; 10(2):176-184.
62. Naito AT, Akazawa H, Takano H, et al. Phosphatidylinositol 3-kinase-Akt pathway plays a critical role in early cardiomyogenesis by regulating canonical Wnt signaling. Circ Res 2005; 97(2) :144-151. (Pubitemid 41033470)
63. Emami KH, Corey E. When prostate cancer meets bone: Control by wnts Cancer Lett 2007; 253(2) :170-179 (Pubitemid 47023104)
64. Pohl BS, Knochel W. Overexpression of the transcriptional repressor FoxD3 prevents neural crest formation in xenopus embryos. Mech Dev 2001; 103(1-2):93-106. (Pubitemid 32457910)
65. Perreault N, Sackett SD, Katz JP, et al. Foxll is a mesenchymal modifier of min in carcinogenesis of stomach and colon. Genes Dev 2005 ; 19(3):311-315. (Pubitemid 40189293)
66. Balciunaite G, Keller MP, Balciunaire E, et al. Wnt glycoprorelns regulate the expression of FoxNI, the gene defective in nude mice. Nat Immunol 2002; 3(11) :1102-1108. (Pubitemid 35363665)
67. Ormestad M, AstorgaJ, Landgren H, et al. FoxfI and FoxfL control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production. Development 2006; 133(5):833-843.
68. Kimura-Yoshida C, Tian E, Nakano H., et al., Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anter ior visceral endoderm-specific genes. Proc Natl Acad Sci USA 2007; 104(14) :5919-5924. (Pubitemid 47175634)
69. Sauvageot CM, Kesari S, Stiles CD. Molecular pathogenesis of adult brain tumors and the role of stem cells. Neurol Clin 2007; 25(4):891-924, vii. (Pubitemid 47600578)
70. Xu HT, Wei Q,Liu Yet al. Overexpression ofaxin downregulares TCF-4 and inhibits the development of lung cancer. Ann Surg Oncol 2007; 14(11):3251-3259. (Pubitemid 47594295)
71. Kurayoshi M, Oue N, Yamamoto H, et al. Expression of Wnt-5a is correlated with aggressiveness of gastric cancer by stimulating cell migration and invasion. Cancer Res 2006; 66(21):10439-10448. (Pubitemid 44799765)
72. Tomita H, Yamada Y, Oyama T, et al. Development of gastric tumors in Apc(Min/+) mice by the activation of the bera-catenin/Tcf signaling pathway. Cancer Res 2007; 67(9):4079-4087. (Pubitemid 46815052)
73. Maiese K, Chong ZZ, Li F, et al. Erythropoietin: Elucidating new cellular targets that broaden therapeutic strategies. Prog Neurobiol 2008; 85:194-213.
74. Kikuchi S, Nagai T, Kunitarna M, et al. Active FKHRLI overcomes imatinib resistance in chronic myelogenous leukemia-derived cell lines via the production of tumor necrosis factor-related apoprosis-inducing ligand. Cancer Sci 2007 ; 98(12):1949-1958. (Pubitemid 350002202)
75. Nowak K, Killmer K, Gessner C, et al. E2F-l regulates expression of FOXO1 and FOX03a. Biochim Biophys Acta 2007; 1769(4):244-252. (Pubitemid 46702333)
76. Bouchard C, Lee S, Paulus-Hock V, et al. FoxO transcription factors suppress Myc-driven lymphornagenesis via direct activation of Arf. Genes Dev 2007; 21(21):2775-2787. (Pubitemid 350070723)
77. Chong ZZ, Li F, Maiese K. Oxidative stress in the brain: Novel cellular targets that govern survival during neurodegenerative disease. Prog Neurobiol 2005 ; 75(3) :207-246. (Pubitemid 40693131)
78. Maiese K, Chong ZZ. Nicotinamide: Necessary nutrient emerges as a novel cytoprotectant for the brain. Trends Pharmacol Sci 2003; 24(5):228-232. (Pubitemid 36588870)
79. Chong ZZ , KangJ, Li F, et al. mGluRl targets microglial activation and selectively prevents neuronal cell engulfment through Akt and caspase dependent pathways. CUrt Neurovasc Res 2005 ; 2(3):197-211. (Pubitemid 40980179)
80. Li F, Chong ZZ, Maiese K. Microglial integrity is maintained by erythropoietin through integration of Akt and its substrates of glycogen synthase kinase-Jbeta, beta-caten in, and nuclear factor-kappaB. Curr Neurovasc Res 2006; 3(3):187-201. (Pubitemid 44198472)
81. Lin SH, Maiese K. The rneraborropic glutamate receptor system protects against ischemic free radical programmed cell death in rat brain endothelial cells.J Cereb Blood Flow Metab 2001 ; 21(3 ):262-275. (Pubitemid 32207426)
82. Chong ZZ. Lin SH, KangJQ, et al. The tyrosine phosphatase SHP2 modulates MAP kinase p38 and caspase 1 and 3 to foster neuronal survival. Cell Mol Neurobiol 2003; 23(4-5):561-578. (Pubitemid 37071485)
83. Salinas M, Diaz R, Abraham NG, et al. Nerve growth factor protects against 6-hydroxydopamine-induced oxidative stress by increasing expression ofheme oxygenase-I in a phosphatidylinositol 3-kinase-dependent manner.J BioI Chern 2003; 278(16):13898-13904. (Pubitemid 36799930)
84. Chong ZZ, Maiese K. The Src homology 2 domain tyrosine phospharases SHP -I and SHP-2 : Diversified control of cell growth, inRammation, and injury. Histol Histopathol 2007 ; 22(11) :1251-1267. (Pubitemid 47470319)
85. Maiese K. Diabetic stress: New triumphs and challenges to maintain vascular longevity. Expert Rev Cardiovasc Ther 2008; 6(3):281-284.
86. Slomka M. Zieminska E, LazarewiczJ. Nicotinamide and l- rnethylnicotinarnide reduce homocysteine neurotoxicity in primary cultures of rat cerebellar granule cells. Acta Neurobiol Exp 2008; 68(1):1-9. (Pubitemid 351490377)
87. Nakamura T, Sakamoto K. Forkhead transcription factor FOXO subfamily is essential for reactive oxygen species-induced apoptosis. Mol Cell Endocrinol 2007; 281(1-2):47-55 (Pubitemid 350296601)
88. Barthelemy C, Henderson CE, Pettmann B. Foxoda induces motoneuron death through the Fas pathway in cooperation with JNK. BMC Neurosci 2004; 5(1):48
89. YouH, Yamamoto K, Mak TW Regulation of transactivation-independent proapoptotic activity of p53 by FOX03a. Proc Natl Acad Sci USA 2006; 103(24):9051-9056. (Pubitemid 43902531)
90. Won CK, Ji HH, Koh PO. Estradiol prevents the focal cerebral ischemic injur y-induced decrease of forkhead transcription factors phosphorylation. Neurosci Lett 2006; 398( 1-2):39-43.
91. Caporali A, Sala-Newby GB, Meloni M, et al. Identification of the prosurvival activity of nerve growth factor on cardiac myocytes. Cell Death Differ 2008; 15(2):299-311.
92. Tothova Z, Kollipara R, Huntly BJ, et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 2007 ; 128(2) :325-339. (Pubitemid 46137992)
93. Ferrara N, Rinaldi B, Corbi G, et al. Exercise training promotes SIRTI activity in aged rats. Rejuvenation Res 2008; 11(1):139-150. (Pubitemid 351271626)
94. Maiese K, Chong ZZ, Shang yc. Mechanistic insights into diabetes mellitus and oxidative stress. Curr Med Chern 2007; 14(16) :1729-1738. (Pubitemid 47163410)
95. Maiese K, Morhan SD, Chong ZZ. Oxidative stress biology and cell injury during type 1 and type 2 diabetes mellitus. Curr Neurovasc Res 2007; 4(1) :63-71. (Pubitemid 46280293)
96. Maiese K, Chong Z, Li F. Reducing oxidative stress and enhancing neurovascular longevity during diabetes mellitus. In: Neurovascular Medicine: Pursuing Cellular Longevity for Healthy Aging. Maiese, K, ed., New York: Oxford University Press, 2009.
97. Donahoe SM, Stewart GC, McCabe CH, et al. Diabetes and mortality following acute coronary syndromes. JAMA 2007; 298(7):765-775. (Pubitemid 47263159)
98. Lin K, Dorman JB, Rodan A, et al. Daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 1997; 278(5341):1319-1322. (Pubitemid 27495748)
99. Ogg S, Paradis S, Gottlieb S, et al. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity Signalsin C. elegans. Nature 1997; 389(6654):994-999. (Pubitemid 27485694)
100. Guo S, Rena G, Cichy S, et al. Phosphorylation of serine 256 by prot ein kinase B disrupts transact ivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding prorein-I promoter activity through a conserved insulin response sequence. J Bioi Chern 1999; 274(24) :17184-17192.
101. NakaeJ, Park BC, AcciliD. Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway. J Bioi Chern 1999; 274(23) :15982-15985.
102. Kim JR, Jung HS, Bae SW, et al. Polymorph isms in FOXO gene family and association analysis with BMI. Obesity (Silver Spring) 2006; 14(2):188-193. (Pubitemid 46214748)
103. Marchetti V, Menghini R, Rizza S, et al. Benfotiamine counteracts glucose toxicity effects on endothelial progenitor cell differentiation via Akt/FoxO signaling. Diabetes 2006; 55(8):2231-2237. (Pubitemid 44743619)
104. Fallarino F,Bianchi R, Orabona C, et al. CTLA-4-Ig activates forkhead transcription factors and protects dendritic cells from oxidative stress in nonobese diabetic mice. J Exp Med 2004; 200(8):1051-1062. (Pubitemid 39431129)
105. Nakae J, Cao Y, Oki M, et al. Forkhead transcription factor FoxOl in adipose tissue regulates energy storage and expenditure. Diabetes 2008; 57(3) :563-576.
106. Puig O, Tjian R. Transcriptional feedback control of insulin receptor by dFOXO/FOXOI. Genes Dev 2005; 19(20):2435-2446. (Pubitemid 41483691)
107. Kamagate A, Dong HH. Foxo1 integrates insulin signaling to VLDL production. Cell Cycle 2008; 7(20) :3162-3170.
108. Ni YG, Wang N, Cao DJ, et al. FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases. Proc Natl Acad Sci USA 2007; 104(51) :20517-20522.
109. Kamei Y, Miura S, Suzuki M, et al. Skeletal muscle FOX01 (FKHR) transgenic mice have less skeletal muscle mass,down-regulated type I (slow twitch/red muscle) fiber genes, and impaired glycemiccontrol. J Bioi Chern 2004; 279(39) :41114-41123. (Pubitemid 39287713)
110. Liu CM, Yang Z, Liu CW, et al. Effect of RNA oligonucleotide targeting Foxo-I on muscle growth in normal and cancer cachexia mice. Cancer Gene Ther 2007; 14(12) :945-952. (Pubitemid 350115358)
111. Sandri M, Lin J, Handschin C, et al. PGC-lalpha protects skeletal muscle from atrophy by suppressing Fox03 action and atrophy-specific gene transcription. Proc Natl Acad Sci USA 2006; 103(44) :16260-16265 (Pubitemid 44715184)
112. Balan V, Miller GS, Kaplun L, et al. Life span extension and neuronal cell protection by Drosophila nicot inamidase. J Bioi Chern 2008; 283(41) :27810-27819.
113. Chong ZZ , Maiese K. Enhanced tolerance against early and late apoptotic oxidative stress in mammalian neurons through nicotinamidase and sirtuin mediated pathways. CUrt Neurovasc Res 2008; 5(3) :159-170
114. Myatt SS, Lam EW: The emerging roles of forkhead box (Fox) proteins in cancer. Nat Rev Cancer 2007; 7(11) :847-859. (Pubitemid 350006253)
115. Nemoto S, FergussonMM, Finkel T. Nutrient availabilityregulates SIRTl through a forkhead-dependent pathway. Science 2004; 306(5704):2105-2108. (Pubitemid 40007664)
116. Motta MC, Divecha N, Lemieux M, et al. Mammalian SIRT1 represses forkhead transcription factors. Cell 2004; 116(4):551-563. (Pubitemid 38264432)
117. Kyoung Kim H, Kyoung Kim Y, Song IH, et al. Down-regulation of a forkhead transcription factor, FOX03a, accelerates cellular senescence in human dermal fibroblasts. J Gerontol A Bioi Sci Med Sci 2005; 60(1) :4-9.
118. Alcendor RR, Gao S, Zhai P, et al. Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ Res 2007; 100(10) :1512-1521. (Pubitemid 46834764)
119. Li M, Chiu JF, Mossman BT, et al. Down-regulation of manganese-superoxide dismutase through phosphorylation of FOX03a by Akt in explanred vascular smooth muscle cells from old rats. J Bioi Chern 2006; 281(52) :40429-40439. (Pubitemid 46041846)
120. Miyauchi H, Minamino T, Tateno K, et al. Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway. EMBO J 2004; 23(1) :212-220. (Pubitemid 38165761)
121. Miyamoto K. Araki KY. Naka K, et al. Foxo.Ia Is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell 2007; 1:101-112. (Pubitemid 46865800)
122. Arcasoy MO. The non-haematopoieric biological effects of erythropoietin. Br J Haernatol 2008; 141(1):14-31.
123. Cariou A. Claessens YEo Pene F, et al. Early high-dose erythropoietin therapy and hypothermia after out-of-hospital cardiac arrest: A matched control study. Resuscitation 2008; 76(3):397-404. (Pubitemid 351192222)
124. Maiese K. Chong ZZ. Shang yc. Raves and risks for erythropoietin. Cytokine Growth Factor Rev 2008; 19(2):145-155.
125. Chong ZZ. Shang YC. Maiese K. Vascular injury during elevated glucose can be mitigated by erythropoietin and Wnt signaling. Curr Neurovasc Res 2007; 4(3):194-204. (Pubitemid 47235971)
126. Bakker WJ. van Dijk TB. Parren-van Amelsvoort M, et al. Differential regulation of Foxoda target genes in erythropoiesis Mol Cell Bioi 2007; 27(10) :3839-3854. (Pubitemid 46726190)
127. Furukawa-Hibi Y,Yoshida-Araki K, Ohca T, et al. FOXO forkhead transcription factors induce G(2)-M checkpoint in response to oxidative mess.J Bioi Chern 2002 ; 277(30):26729-26732. (Pubitemid 34951676)
128. Liu L. Rajareddy S. Reddy P, et al. Infertility caused by retardation of follicular development in mice with oocyte-specific expression of Fox03a. Development 2007; 134(1):199-209. (Pubitemid 46152720)
129. Watkins WJ. Umbers AJ, Woad KJ, et al. Mutational screening of FOX03A and FOXOIA in women with premature ovarian failure. Fertil Sreril 2006; 86(5) :1518-1521. (Pubitemid 44602042)
130. Hosaka T, Biggs WH. 3rd. Tieu D, et al. Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Proc Natl Acad Sci USA 2004 ; 101(9):2975-2980. (Pubitemid 38327721)
131. Furuyama T. Kitayama K. Shimoda Yet al. Abnormal angiogenesis in Foxol (Fkhrj-deficienr mice.J Bioi Chern 2004; 279(33) :34741-34749 (Pubitemid 39318105)
132. Evans-Anderson HJ. Alfieri CM. YutzeyKE, et al. Regulation of cardiomyocyte proliferation and myocardial growth during development by FOXO transcription factors. Circ Res 2008; 102(6):686-694. (Pubitemid 351457856)
133. Li HH. Willis MS, Lockyer P, et al. Arrogin-I inhibits Akr-dependenr cardiac hypertrophy in mice via ubiquitin-dependent coactivation offorkhead proteins J Clin Invest 2007; 117(11) :3211-3223. (Pubitemid 350096979)
134. Abid MR. Yano K, Guo S, et al. Forkhead transcription factors inhibit vascular smooth muscle cell proliferation and neointimal hyperplasia.J Bioi Chern 2005; 280(33) :29864-29873 (Pubitemid 41177064)
135. Liu ZP. Wang Z. Yanagisawa H, et al. Phenotypic modulation of smooth muscle cells through interaction of Fox04 and myocardin. Dev Cell 2005; 9(2) :261-270. (Pubitemid 41051744)
136. Li H. LiangJ, Castrillon DH. DePinho RA, et al. Fox04 regulates tumor necrosis factor alpha-directed smooth muscle cell migration by activating matrix meralloproreinase 9 gene transcription Mol Cell Bioi 2007; 27(7) :2676-2686. (Pubitemid 46581357)
137. Goettsch W; Gryczka C. Korff T, et al. Flow-dependent regulation of angiopoietin-2. J Cell Physiol 2008; 214(2) :491-503. (Pubitemid 350309006)
138. MorrisJB. Kenney B. Huynh H, et al. Regulation of the proapoptotic factor FOXOI (FKHR) in cardiomyocytes by growth factors and alpha I-adrenergic agonisrs. Endocrinology 2005; 146(10):4370-4376. (Pubitemid 41324033)
139. Sedding DG, Seay U. Fink L, et al. Mechanosensitive p27Kipl regulation and cell cycle entry in vascular smooth muscle cells. Circulation 2003; 108(5):616-622. (Pubitemid 36961179)
140. Hannenhalli S. Putt ME. Gilmore JM, et al. Transcriptional genomics associates FOX transcription factors with human heart failure. Circulation 2006; 114(12) :1269-1276. (Pubitemid 44402052)
141. Cools N. Ponsaerts P, Van Tendeloo VF, et al. Regulatory T cells and human disease. Clin Dev Immunol 2007; 2007:89195
142. Ebert LM. Tan BS. BrowningJ, et al. The regulatory T cell-associated transcription factor FoxP3 is expressed by tumor cells. Cancer Res 2008; 68(8) :3001-3009. (Pubitemid 351556301)
143. Kono K. Kawaida H. Takahashi A, et al. CD4(+)CD25high regulatory T cells increase with tumor stage in patients with gastric and esophageal cancers. Cancer Immunol Immunother. 2006; 55(9):1064-1071. (Pubitemid 43800721)
144. Chong ZZ. Li F. Maiese K. The pro-survival pathways of mTOR and protein kinase B target glycogen synthase kinase-3beta and nuclear factor-kappaB to foster endogenous microglial cell protection. Inr J Mol Med 2007; 19(2):263-272.
145. Lin L. Hron JD. Peng SL. Regulation of NF-kappaB, Th activation and autoinflammation by the forkhead transcription factor Foxoda. Immunity 2004; 21(2) :203-213. (Pubitemid 39094050)
146. Jonsson H, Allen P. Peng SL. Inflammatory arthritis requires Foxo3a to
147. Ludikhuize J, de Launay D. Groor D, et al. Inhibition of forkhead box class 0 family member transcription factors in rheumatoid synovial tissue. Arthritis Rheum 2007; 56(7) :2180-2191. (Pubitemid 47173565)
148. Kuo CC. Lin Sc. Altered FOXOI transcript levels in peripheral blood mononuclear cells of systemic lupus erythematosus and rheumatoid arthritis patients. Mol Med 2007; 13(11-12):561-566.
149. Fabre S. Carrette F, ChenJ, et al. FOXOI regulates L-Selectin and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase.J Immunol 2008; 181(5):2980-2989.
150. Sela U, Dayan M, Hershkoviz Ret al. The negative regulators Foxjl and Fox03a are up-regulated by a peptide that inhibits systemic lupus erythematosus-associated T cell responses. Eur J Immunol 2006; 36( 11):2971-2980. (Pubitemid 44782571)
151. Bosque A, Aguilo JI, Alava MA, et al. The induction of Bim expression in human T-cell blasts is dependent on nonapoptotic Fas/CD95 signaling. Blood 2007; 109(4):1627-1635. (Pubitemid 46239597)
152. Lynch RL, Konicek BW; McNulty AM, et al. The progression of LNCaP human prostate cancer cells to androgen independence involves decreased FOX03a expression and reduced p27KIP1 promoter transactivation. Mol Cancer Res 2005; 3(3) :163-169. (Pubitemid 40524899)
153. Li Y,Wang Z, Kong D, et al. Regulation of FOX03a/beta-catenin/GSK-3beta signaling by 3,3'-diindoIylmethane contributes to inhibition of cell proliferation and induction of apoptosis in prostate cancer cells. J Bioi Chern 2007; 282(29):21542-21550. (Pubitemid 47099972)
154. Cornforth AN, DavisJS, Khanifar E, et al. FOX03a mediates the androgen-dependent regulation of FLIP and contributes to TRAIL-induced apoptosis ofLNCaP cells. Oncogene 2008; 27(32):4422-4433.
155. Yang L, Xie S, Jamaluddin MS, et al. Induction of androgen receptor expression by phosphatidylinositol 3-kinase/ Akr downstream substrate, FOX03a, and their roles in apopto sis of LNCaP prostate cancer cells. J Bioi Chern 2005 ; 280(39):33558-33565. (Pubitemid 41397156)
156. Liu P, Kao TP, Huang H. CDKI promotes cell proliferation and survival via phosphorylation and inhibition of FOXOI transcription factor. Oncogene 2008; 27(34):4733-4744.
157. Kikuno N, Shiina H, Urakami S, et al. Knockdown of astrocyte-elevated gene-l inhibits prostate cancer progression through upregulation of FOX03a activity. Oncogene 2007; 26(55):7647-7655. (Pubitemid 350224215)
158. Trotman LC, Alimonti A, Scaglioni PPet al. Ident ification of a tumour suppressor network opposing nuclear Akt function Nature 2006; 441(7092) :523-527. (Pubitemid 44050155)
159. Jin GS, Kondo E, Miyake T, et al. Expression and int racellular localization of FKHRLI in mammary gland neoplasms. Acta Med Okayama 2004; 58(4):197-205 (Pubitemid 39277936)
160. Hu MC, Lee DF, Xia W, et al. IkappaB kinase promotes tumorigenesis through inhib ition of forkhead FOX03a. Cell 2004; 117(2):225-237. (Pubitemid 38496242)
161. Sunters A, Madureira PA, Pomeranz KM, et al. Paclitaxel-induced nuclear translocation of FOX03a in breast cancer cells is mediated by c-jun NH2-terminal kinase and Akt, Cancer Res 2006; 66(1):212-220. (Pubitemid 43166027)
162. Eddy SF, Kane SE, Sonenshein GE. Trastuzumab-resistant HER2-driven breast cancer cells are sensitive to epigallocatechin-3 gallate. Cancer Res 2007; 67(19) :9018-9023. (Pubitemid 47535884)
163. Zou Y, Tsai WE, Cheng CJ, et al. Forkhead box transcription factor FOX03a suppresses estrogen-dependent breast cancer cell proliferation and tumorigenesis. Breast Cancer Res 2008; 10(1):R21.
164. Paik JH, Kollipara R, Chu G, et al. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 2007; 128(2):309-323. (Pubitemid 46123514)
165. Delpuech 0 , Griffiths B, East P, et al. Induction ofMxil-SR{alpha} by FOX03a Contributes to Repression of Myc-Dependent Gene Expression. Mol Cell Bioi 2007; 27(13) :4917-4930. (Pubitemid 47016141)
166. Ticchioni M, Essafi M, Jeandel PY, et al. Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOX03a. Oncogene 2007; 26(50) :7081-7091. (Pubitemid 350064189)
167. Munoz-Fontela C, Marcos-Villar L, Gallego P, et al. Latent protein LANA2 from kaposi's sarcoma-associated herpesvirus interacts with 14-3-3 proteins and inhibits FOX03a transcription factor. J Virol 2007; 81(3) :1511-1516 (Pubitemid 46167873)
168. Hoekstra AV, Ward EC, Hardt JL, et al. Chemosensitization of endometrial cancer cells through AKT inhibition involves FOX01. Gynecol Oncol 2008; 108(3) :609-618.
169. Zerhelius B, Berglund L, Sundstrom J, et al. Use of multiple biomarkers to improve the prediction of death from cardiovascular causes. N Engl J Med 2008; 358:2107-2116. (Pubitemid 351679597)
170. Ward EC, Hoekstr a AY, Blok LJ, et al. The regulation and function of the forkhead transcription factor, Forkhead box 01, is dependent on the progesterone receptor in endometrial carcinoma. Endocrinology 2008; 149(4) :1942-1950. (Pubitemid 351468304)
171. Hellwinkel OJ, Rogmann JP, Asong LE, et al. A comprehensive analysis of transcript signatures of the phospharidylinosirol-S kinase/protein kinase B signal-transduction pathway in prostate cancer. BJU Int 2008; 101(11):1454-1460. (Pubitemid 351623985)
172. Kim JH, Kim MK, Lee HE, et al. Constitutive phosphorylation of the FOXOIA transcript ion factor as a prognostic variable in gastric cancer. Mod Pathol 2007; 20(8) :835-842. (Pubitemid 47077265)
173. Brunet A, Sweeney LB, Sturgill JF, et al. Stress-dependent regulation ofFOXO transcription factors by the SIRTl deacetylase. Science 2004; 303(5666):2011-2015. (Pubitemid 38393275)
174. Bakker WJ, Harris IS, Mak TW. FOX03a is activated in response to hypoxic st ress and inhibits HIFl-induced apoptosis via regulation of CITED2. Mol Cell 2007; 28(6) :941-953. (Pubitemid 350297029)
175. Han CY, Cho KB, Choi HS, et al. Role of FoxOI activation in MDRI expression in adriamycin-resistant breast cancer cells. Carcinogenesis 2008; 29(9) :1837-1844.