mGluRI targets microglial activation and selectively prevents neuronal cell engulfment through Akt and caspase dependent pathways

Current Neurovascular Research

Volumn 2, Issue 3, 2005, Pages 197-211

  Chong, Zhao Zhong ^a   Kang, Jingqiong ^a   Li, Faqi ^a   Maiese, Kenneth ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bromodeoxyuridine; Caspase 9; Cytochrome c; Metabotropic glutamate receptor; Microglia; Mitochondria; Nitric oxide; Protein kinase B

Indexed keywords

CASPASE; CYSTEINE PROTEINASE; CYTOCHROME C; GUANINE NUCLEOTIDE BINDING PROTEIN; METABOTROPIC RECEPTOR 1; PHOSPHATIDYLSERINE; PROTEIN KINASE B;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ACTIVATION; CELL PROLIFERATION; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; MICROGLIA; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; STATISTICAL ANALYSIS; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; ANNEXIN A5; APOPTOSIS; BENZIMIDAZOLES; BLOTTING, WESTERN; CARBOCYANINES; CASPASES; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; CYSTEINE ENDOPEPTIDASES; CYTOCHROMES C; DICARBOXYLIC ACIDS; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EMBRYO; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; METHOXYHYDROXYPHENYLGLYCOL; MICROGLIA; MODELS, BIOLOGICAL; NEURONS; NITRIC OXIDE DONORS; NITROPRUSSIDE; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; SIGNAL TRANSDUCTION; TIME FACTORS; TRIAZENES;

EID: 22144441636     PISSN: 15672026     EISSN: None     Source Type: Journal    
DOI: 10.2174/1567202054368317     Document Type: Article

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