메뉴 건너뛰기




Volumn 4, Issue 4, 2007, Pages 295-302

"Sly as a FOXO": New paths with forkhead signaling in the brain

Author keywords

Akt; Amyotrophic lateral sclerosis; Apoptosis; Diabetes; Erythropoietin; FKHRL1; FOXO3a; Neuromuscular disease; Oxidative stress; Psychiatric; Stem cells; Stroke; Systemic lupus erythematosus

Indexed keywords

TRANSCRIPTION FACTOR FKHRL1;

EID: 36448967502     PISSN: 15672026     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720207782446306     Document Type: Review
Times cited : (72)

References (129)
  • 2
    • 0032518255 scopus 로고    scopus 로고
    • Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily
    • Anderson, MJ, Viars, CS, Czekay, S, Cavenee, WK, Arden, KC. (1998) Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. Genomics 47: 187-99.
    • (1998) Genomics , vol.47 , pp. 187-199
    • Anderson, M.J.1    Viars, C.S.2    Czekay, S.3    Cavenee, W.K.4    Arden, K.C.5
  • 4
    • 9644291424 scopus 로고    scopus 로고
    • The relationship between impaired glucose tolerance, type 2 diabetes, and cognitive function
    • Awad, N, Gagnon, M, Messier, C. (2004) The relationship between impaired glucose tolerance, type 2 diabetes, and cognitive function. J Clin Exp Neuropsychol 26: 1044-80.
    • (2004) J Clin Exp Neuropsychol , vol.26 , pp. 1044-1080
    • Awad, N.1    Gagnon, M.2    Messier, C.3
  • 5
    • 12944294341 scopus 로고    scopus 로고
    • Foxo3a induces motoneuron death through the Fas pathway in cooperation with JNK
    • Barthelemy, C, Henderson, CE, Pettmann, B. (2004) Foxo3a induces motoneuron death through the Fas pathway in cooperation with JNK. BMC Neurosci 5: 48.
    • (2004) BMC Neurosci , vol.5 , pp. 48
    • Barthelemy, C.1    Henderson, C.E.2    Pettmann, B.3
  • 6
    • 34250837002 scopus 로고    scopus 로고
    • Activation of FOXO3a by the green tea polyphenol epigallocatechin-3-gallate induces estrogen receptor {alpha} expression reversing invasive phenotype of breast cancer cells
    • Belguise, K, Guo, S, Sonenshein, GE. (2007) Activation of FOXO3a by the green tea polyphenol epigallocatechin-3-gallate induces estrogen receptor {alpha} expression reversing invasive phenotype of breast cancer cells. Cancer Res 67: 5763-70.
    • (2007) Cancer Res , vol.67 , pp. 5763-5770
    • Belguise, K.1    Guo, S.2    Sonenshein, G.E.3
  • 7
    • 0037160097 scopus 로고    scopus 로고
    • Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1
    • Bitterman, KJ, Anderson, RM, Cohen, HY, Latorre-Esteves, M, Sinclair, DA. (2002) Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. J Biol Chem 277: 45099-107.
    • (2002) J Biol Chem , vol.277 , pp. 45099-45107
    • Bitterman, K.J.1    Anderson, R.M.2    Cohen, H.Y.3    Latorre-Esteves, M.4    Sinclair, D.A.5
  • 10
    • 0035135841 scopus 로고    scopus 로고
    • Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)
    • Brunet, A, Park, J, Tran, H, Hu, LS, Hemmings, BA, Greenberg, ME. (2001) Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol Cell Biol 21: 952-65.
    • (2001) Mol Cell Biol , vol.21 , pp. 952-965
    • Brunet, A.1    Park, J.2    Tran, H.3    Hu, L.S.4    Hemmings, B.A.5    Greenberg, M.E.6
  • 12
    • 0035918148 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways
    • Cahill, CM, Tzivion, G, Nasrin, N, Ogg, S, Dore, J, Ruvkun, G, Alexander-Bridges, M. (2001) Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways. J Biol Chem 276: 13402-10.
    • (2001) J Biol Chem , vol.276 , pp. 13402-13410
    • Cahill, C.M.1    Tzivion, G.2    Nasrin, N.3    Ogg, S.4    Dore, J.5    Ruvkun, G.6    Alexander-Bridges, M.7
  • 13
    • 0038152845 scopus 로고    scopus 로고
    • Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a
    • Castrillon, DH, Miao, L, Kollipara, R, Horner, JW, DePinho, RA. (2003) Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science 301: 215-8.
    • (2003) Science , vol.301 , pp. 215-218
    • Castrillon, D.H.1    Miao, L.2    Kollipara, R.3    Horner, J.W.4    DePinho, R.A.5
  • 14
    • 0043170836 scopus 로고    scopus 로고
    • Proteolytic regulation of Forkhead transcription factor FOXO3a by caspase-3-like proteases
    • Charvet, C, Alberti, I, Luciano, F, Jacquel, A, Bernard, A, Auberger, P, Deckert, M. (2003) Proteolytic regulation of Forkhead transcription factor FOXO3a by caspase-3-like proteases. Oncogene 22: 4557-68.
    • (2003) Oncogene , vol.22 , pp. 4557-4568
    • Charvet, C.1    Alberti, I.2    Luciano, F.3    Jacquel, A.4    Bernard, A.5    Auberger, P.6    Deckert, M.7
  • 15
    • 22144441636 scopus 로고    scopus 로고
    • mGluRI targets microglial activation and selectively prevents neuronal cell engulfment through Akt and caspase dependent pathways
    • Chong, ZZ, Kang, J, Li, F, Maiese, K. (2005a) mGluRI targets microglial activation and selectively prevents neuronal cell engulfment through Akt and caspase dependent pathways. Curr Neurovasc Res 2: 197-211.
    • (2005) Curr Neurovasc Res , vol.2 , pp. 197-211
    • Chong, Z.Z.1    Kang, J.2    Li, F.3    Maiese, K.4
  • 16
    • 2442461973 scopus 로고    scopus 로고
    • Akt1 drives endothelial cell membrane asymmetry and microglial activation through Bcl-x(L) and caspase 1, 3, and 9
    • Chong, ZZ, Kang, JQ, Maiese, K. (2004a) Akt1 drives endothelial cell membrane asymmetry and microglial activation through Bcl-x(L) and caspase 1, 3, and 9. Exp Cell Res 296: 196-207.
    • (2004) Exp Cell Res , vol.296 , pp. 196-207
    • Chong, Z.Z.1    Kang, J.Q.2    Maiese, K.3
  • 17
    • 0037338625 scopus 로고    scopus 로고
    • Apaf-1, Bcl-xL, cytochrome c, and caspase-9 form the critical elements for cerebral vascular protection by erythropoietin
    • Chong, ZZ, Kang, JQ, Maiese, K. (2003a) Apaf-1, Bcl-xL, cytochrome c, and caspase-9 form the critical elements for cerebral vascular protection by erythropoietin. J Cereb Blood Flow Metab 23: 320-30.
    • (2003) J Cereb Blood Flow Metab , vol.23 , pp. 320-330
    • Chong, Z.Z.1    Kang, J.Q.2    Maiese, K.3
  • 18
    • 0037365196 scopus 로고    scopus 로고
    • Erythropoietin fosters both intrinsic and extrinsic neuronal protection through modulation of microglia, Akt1, Bad, and caspase-mediated pathways
    • Chong, ZZ, Kang, JQ, Maiese, K. (2003b) Erythropoietin fosters both intrinsic and extrinsic neuronal protection through modulation of microglia, Akt1, Bad, and caspase-mediated pathways. Br J Pharmacol 138: 1107-1118.
    • (2003) Br J Pharmacol , vol.138 , pp. 1107-1118
    • Chong, Z.Z.1    Kang, J.Q.2    Maiese, K.3
  • 19
    • 0037016065 scopus 로고    scopus 로고
    • Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases
    • Chong, ZZ, Kang, JQ, Maiese, K. (2002a) Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases. Circulation 106: 2973-9.
    • (2002) Circulation , vol.106 , pp. 2973-2979
    • Chong, Z.Z.1    Kang, J.Q.2    Maiese, K.3
  • 20
    • 1542409923 scopus 로고    scopus 로고
    • Essential cellular regulatory elements of oxidative stress in early and late phases of apoptosis in the central nervous system
    • Chong, ZZ, Kang, JQ, Maiese, K. (2004b) Essential cellular regulatory elements of oxidative stress in early and late phases of apoptosis in the central nervous system. Antioxid Redox Signal 6: 277-87.
    • (2004) Antioxid Redox Signal , vol.6 , pp. 277-287
    • Chong, Z.Z.1    Kang, J.Q.2    Maiese, K.3
  • 21
    • 11144308859 scopus 로고    scopus 로고
    • Activating Akt and the brain's resources to drive cellular survival and prevent inflammatory injury
    • Chong, ZZ, Li, F, Maiese, K. (2005b) Activating Akt and the brain's resources to drive cellular survival and prevent inflammatory injury. Histol Histopathol 20: 299-315.
    • (2005) Histol Histopathol , vol.20 , pp. 299-315
    • Chong, Z.Z.1    Li, F.2    Maiese, K.3
  • 22
    • 34147100616 scopus 로고    scopus 로고
    • Cellular demise and inflammatory microglial activation during beta-amyloid toxicity are governed by Wnt1 and canonical signaling pathways
    • Chong, ZZ, Li, F, Maiese, K. (2007a) Cellular demise and inflammatory microglial activation during beta-amyloid toxicity are governed by Wnt1 and canonical signaling pathways. Cell Signal 19: 1150-62.
    • (2007) Cell Signal , vol.19 , pp. 1150-1162
    • Chong, Z.Z.1    Li, F.2    Maiese, K.3
  • 23
    • 18844440792 scopus 로고    scopus 로고
    • Employing new cellular therapeutic targets for Alzheimer's disease: A change for the better?
    • Chong, ZZ, Li, F, Maiese, K. (2005c) Employing new cellular therapeutic targets for Alzheimer's disease: a change for the better? Curr Neurovasc Res 2: 55-72.
    • (2005) Curr Neurovasc Res , vol.2 , pp. 55-72
    • Chong, Z.Z.1    Li, F.2    Maiese, K.3
  • 24
    • 29044433048 scopus 로고    scopus 로고
    • Erythropoietin requires NF-kappaB and its nuclear translocation to prevent early and late apoptotic neuronal injury during beta-amyloid toxicity
    • Chong, ZZ, Li, F, Maiese, K. (2005d) Erythropoietin requires NF-kappaB and its nuclear translocation to prevent early and late apoptotic neuronal injury during beta-amyloid toxicity. Curr Neurovasc Res 2: 387-99.
    • (2005) Curr Neurovasc Res , vol.2 , pp. 387-399
    • Chong, Z.Z.1    Li, F.2    Maiese, K.3
  • 25
    • 33646775275 scopus 로고    scopus 로고
    • Group I metabotropic receptor neuroprotection requires Akt and its substrates that govern FOXO3a, Bim, and beta-catenin during oxidative stress
    • Chong, ZZ, Li, F, Maiese, K. (2006) Group I metabotropic receptor neuroprotection requires Akt and its substrates that govern FOXO3a, Bim, and beta-catenin during oxidative stress. Curr Neurovasc Res 3: 107-17.
    • (2006) Curr Neurovasc Res , vol.3 , pp. 107-117
    • Chong, Z.Z.1    Li, F.2    Maiese, K.3
  • 26
    • 18844434370 scopus 로고    scopus 로고
    • Oxidative stress in the brain: Novel cellular targets that govern survival during neurodegenerative disease
    • Chong, ZZ, Li, F, Maiese, K. (2005e) Oxidative stress in the brain: Novel cellular targets that govern survival during neurodegenerative disease. Prog Neurobiol 75: 207-46.
    • (2005) Prog Neurobiol , vol.75 , pp. 207-246
    • Chong, Z.Z.1    Li, F.2    Maiese, K.3
  • 27
    • 20444399515 scopus 로고    scopus 로고
    • Stress in the brain: Novel cellular mechanisms of injury linked to Alzheimer's disease
    • Chong, ZZ, Li, F, Maiese, K. (2005f) Stress in the brain: novel cellular mechanisms of injury linked to Alzheimer's disease. Brain Res Brain Res Rev 49: 1-21.
    • (2005) Brain Res Brain Res Rev , vol.49 , pp. 1-21
    • Chong, Z.Z.1    Li, F.2    Maiese, K.3
  • 28
    • 33847797307 scopus 로고    scopus 로고
    • The pro-survival pathways of mTOR and protein kinase B target glycogen synthase kinase-3beta and nuclear factor-kappaB to foster endogenous microglial cell protection
    • Chong, ZZ, Li, F, Maiese, K. (2007b) The pro-survival pathways of mTOR and protein kinase B target glycogen synthase kinase-3beta and nuclear factor-kappaB to foster endogenous microglial cell protection. Int J Mol Med 19: 263-72.
    • (2007) Int J Mol Med , vol.19 , pp. 263-272
    • Chong, Z.Z.1    Li, F.2    Maiese, K.3
  • 29
    • 0037369477 scopus 로고    scopus 로고
    • Erythropoietin prevents early and late neuronal demise through modulation of Akt1 and induction of caspase 1, 3, and 8
    • Chong, ZZ, Lin, SH, Kang, JQ, Maiese, K. (2003c) Erythropoietin prevents early and late neuronal demise through modulation of Akt1 and induction of caspase 1, 3, and 8. J Neurosci Res 71: 659-69.
    • (2003) J Neurosci Res , vol.71 , pp. 659-669
    • Chong, Z.Z.1    Lin, S.H.2    Kang, J.Q.3    Maiese, K.4
  • 30
    • 24744458598 scopus 로고    scopus 로고
    • The sirtuin inhibitor nicotinamide enhances neuronal cell survival during acute anoxic injury through Akt, Bad, PARP, and mitochondrial associated "anti-apoptotic" pathways
    • Chong, ZZ, Lin, SH, Li, F, Maiese, K. (2005g) The sirtuin inhibitor nicotinamide enhances neuronal cell survival during acute anoxic injury through Akt, Bad, PARP, and mitochondrial associated "anti-apoptotic" pathways. Curr Neurovasc Res 2: 271-85.
    • (2005) Curr Neurovasc Res , vol.2 , pp. 271-285
    • Chong, Z.Z.1    Lin, S.H.2    Li, F.3    Maiese, K.4
  • 31
    • 0036254579 scopus 로고    scopus 로고
    • Nicotinamide Modulates Mitochondrial Membrane Potential and Cysteine Protease Activity during Cerebral Vascular Endothelial Cell Injury
    • Chong, ZZ, Lin, SH, Maiese, K. (2002b) Nicotinamide Modulates Mitochondrial Membrane Potential and Cysteine Protease Activity during Cerebral Vascular Endothelial Cell Injury. J Vasc Res 39: 131-47.
    • (2002) J Vasc Res , vol.39 , pp. 131-147
    • Chong, Z.Z.1    Lin, S.H.2    Maiese, K.3
  • 32
    • 3042730681 scopus 로고    scopus 로고
    • The NAD+ precursor nicotinamide governs neuronal survival during oxidative stress through protein kinase B coupled to FOXO3a and mitochondrial membrane potential
    • Chong, ZZ, Lin, SH, Maiese, K. (2004c) The NAD+ precursor nicotinamide governs neuronal survival during oxidative stress through protein kinase B coupled to FOXO3a and mitochondrial membrane potential. J Cereb Blood Flow Metab 24: 728-43.
    • (2004) J Cereb Blood Flow Metab , vol.24 , pp. 728-743
    • Chong, Z.Z.1    Lin, S.H.2    Maiese, K.3
  • 33
    • 34047234725 scopus 로고    scopus 로고
    • Erythropoietin involves the phosphatidylinositol 3-kinase pathway, 14-3-3 protein and FOXO3a nuclear trafficking to preserve endothelial cell integrity
    • Chong, ZZ, Maiese, K. (2007a) Erythropoietin involves the phosphatidylinositol 3-kinase pathway, 14-3-3 protein and FOXO3a nuclear trafficking to preserve endothelial cell integrity. Br J Pharmacol 150: 839-50.
    • (2007) Br J Pharmacol , vol.150 , pp. 839-850
    • Chong, Z.Z.1    Maiese, K.2
  • 34
    • 34748831102 scopus 로고    scopus 로고
    • The Src homology 2 domain tyrosine phosphatases SHP-1 and SHP-2: Diversified control of cell growth, inflammation, and injury
    • Chong, ZZ, Maiese, K. (2007b) The Src homology 2 domain tyrosine phosphatases SHP-1 and SHP-2: diversified control of cell growth, inflammation, and injury. Histol Histopathol 22: 1251-67.
    • (2007) Histol Histopathol , vol.22 , pp. 1251-1267
    • Chong, Z.Z.1    Maiese, K.2
  • 35
    • 34547797469 scopus 로고    scopus 로고
    • Vascular injury during elevated glucose can be mitigated by erythropoietin and Wnt signaling
    • Chong, ZZ, Shang, YC, Maiese, K. (2007c) Vascular injury during elevated glucose can be mitigated by erythropoietin and Wnt signaling. Curr Neurovasc Res 4: 194-204.
    • (2007) Curr Neurovasc Res , vol.4 , pp. 194-204
    • Chong, Z.Z.1    Shang, Y.C.2    Maiese, K.3
  • 36
    • 0027270989 scopus 로고
    • Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5
    • Clark, KL, Halay, ED, Lai, E, Burley, SK. (1993) Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5. Nature 364: 412-20.
    • (1993) Nature , vol.364 , pp. 412-420
    • Clark, K.L.1    Halay, E.D.2    Lai, E.3    Burley, S.K.4
  • 39
    • 34347395347 scopus 로고    scopus 로고
    • 14-3-3 integrates prosurvival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1-transformed hematopoietic cells
    • Dong, S, Kang, S, Gu, TL, Kardar, S, Fu, H, Lonial, S, Khoury, HJ, Khuri, F, Chen, J. (2007) 14-3-3 integrates prosurvival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1-transformed hematopoietic cells. Blood 110: 360-9.
    • (2007) Blood , vol.110 , pp. 360-369
    • Dong, S.1    Kang, S.2    Gu, T.L.3    Kardar, S.4    Fu, H.5    Lonial, S.6    Khoury, H.J.7    Khuri, F.8    Chen, J.9
  • 40
    • 26044474486 scopus 로고    scopus 로고
    • Nicotinamide prevents the development of hyperphosphataemia by suppressing intestinal sodium-dependent phosphate transporter in rats with adenine-induced renal failure
    • Eto, N, Miyata, Y, Ohno, H, Yamashita, T. (2005) Nicotinamide prevents the development of hyperphosphataemia by suppressing intestinal sodium-dependent phosphate transporter in rats with adenine-induced renal failure. Nephrol Dial Transplant 20: 1378-84.
    • (2005) Nephrol Dial Transplant , vol.20 , pp. 1378-1384
    • Eto, N.1    Miyata, Y.2    Ohno, H.3    Yamashita, T.4
  • 42
    • 16644395300 scopus 로고    scopus 로고
    • Activating FOXO3a, NF-kappaB and p53 by targeting IKKs: An effective multi-faceted targeting of the tumor-cell phenotype?
    • Finnberg, N, El-Deiry, WS. (2004) Activating FOXO3a, NF-kappaB and p53 by targeting IKKs: an effective multi-faceted targeting of the tumor-cell phenotype? Cancer Biol Ther 3: 614-6.
    • (2004) Cancer Biol Ther , vol.3 , pp. 614-616
    • Finnberg, N.1    El-Deiry, W.S.2
  • 43
    • 0033887456 scopus 로고    scopus 로고
    • Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
    • Frye, RA. (2000) Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun 273: 793-8.
    • (2000) Biochem Biophys Res Commun , vol.273 , pp. 793-798
    • Frye, R.A.1
  • 44
    • 0037178789 scopus 로고    scopus 로고
    • FOXO forkhead transcription factors induce G(2)-M checkpoint in response to oxidative stress
    • Furukawa-Hibi, Y, Yoshida-Araki, K, Ohta, T, Ikeda, K, Motoyama, N. (2002) FOXO forkhead transcription factors induce G(2)-M checkpoint in response to oxidative stress. J Biol Chem 277: 26729-32.
    • (2002) J Biol Chem , vol.277 , pp. 26729-26732
    • Furukawa-Hibi, Y.1    Yoshida-Araki, K.2    Ohta, T.3    Ikeda, K.4    Motoyama, N.5
  • 45
    • 0034661826 scopus 로고    scopus 로고
    • Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues
    • Furuyama, T, Nakazawa, T, Nakano, I, Mori, N. (2000) Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. Biochem J 349: 629-34.
    • (2000) Biochem J , vol.349 , pp. 629-634
    • Furuyama, T.1    Nakazawa, T.2    Nakano, I.3    Mori, N.4
  • 46
    • 0037303635 scopus 로고    scopus 로고
    • Brain insulin: Regulation, mechanisms of action and functions
    • Gerozissis, K. (2003) Brain insulin: regulation, mechanisms of action and functions. Cell Mol Neurobiol 23: 1-25.
    • (2003) Cell Mol Neurobiol , vol.23 , pp. 1-25
    • Gerozissis, K.1
  • 47
    • 0035906329 scopus 로고    scopus 로고
    • Niacin, poly(ADP-ribose) polymerase-1 and genomic stability
    • Hageman, GJ, Stierum, RH. (2001) Niacin, poly(ADP-ribose) polymerase-1 and genomic stability. Mutat Res 475: 45-56.
    • (2001) Mutat Res , vol.475 , pp. 45-56
    • Hageman, G.J.1    Stierum, R.H.2
  • 48
    • 29044445105 scopus 로고    scopus 로고
    • The function and integrity of the neurovascular unit rests upon the integration of the vascular and inflammatory cell systems
    • Han, HS, Suk, K. (2005) The function and integrity of the neurovascular unit rests upon the integration of the vascular and inflammatory cell systems. Curr Neurovasc Res 2: 409-23.
    • (2005) Curr Neurovasc Res , vol.2 , pp. 409-423
    • Han, H.S.1    Suk, K.2
  • 49
    • 0035437146 scopus 로고    scopus 로고
    • DNA damage-induced cell-cycle arrest of hematopoietic cells is overridden by activation of the PI-3 kinase/Akt signaling pathway
    • Henry, MK, Lynch, JT, Eapen, AK, Quelle, FW. (2001) DNA damage-induced cell-cycle arrest of hematopoietic cells is overridden by activation of the PI-3 kinase/Akt signaling pathway. Blood 98: 834-41.
    • (2001) Blood , vol.98 , pp. 834-841
    • Henry, M.K.1    Lynch, J.T.2    Eapen, A.K.3    Quelle, F.W.4
  • 50
    • 30444442827 scopus 로고    scopus 로고
    • Spatial and temporal expression of FoxO transcription factors in the developing and adult murine brain
    • Hoekman, MF, Jacobs, FM, Smidt, MP, Burbach, JP. (2006) Spatial and temporal expression of FoxO transcription factors in the developing and adult murine brain. Gene Expr Patterns 6: 134-40.
    • (2006) Gene Expr Patterns , vol.6 , pp. 134-140
    • Hoekman, M.F.1    Jacobs, F.M.2    Smidt, M.P.3    Burbach, J.P.4
  • 51
    • 9444237436 scopus 로고    scopus 로고
    • Phosphatidylserine receptor is required for the engulfment of dead apoptotic cells and for normal embryonic development in zebrafish
    • Hong, JR, Lin, GH, Lin, CJ, Wang, WP, Lee, CC, Lin, TL, Wu, JL. (2004) Phosphatidylserine receptor is required for the engulfment of dead apoptotic cells and for normal embryonic development in zebrafish. Development 131: 5417-27.
    • (2004) Development , vol.131 , pp. 5417-5427
    • Hong, J.R.1    Lin, G.H.2    Lin, C.J.3    Wang, W.P.4    Lee, C.C.5    Lin, T.L.6    Wu, J.L.7
  • 52
  • 54
    • 0029768312 scopus 로고    scopus 로고
    • Effects of nicotinamide on prevention and treatment of streptozotocininduced diabetes mellitus in rats
    • Hu, Y, Wang, Y, Wang, L, Zhang, H, Zhao, B, Zhang, A, Li, Y. (1996) Effects of nicotinamide on prevention and treatment of streptozotocininduced diabetes mellitus in rats. Chin Med J (Engl) 109: 819-22.
    • (1996) Chin Med J (Engl) , vol.109 , pp. 819-822
    • Hu, Y.1    Wang, Y.2    Wang, L.3    Zhang, H.4    Zhao, B.5    Zhang, A.6    Li, Y.7
  • 55
    • 33846998653 scopus 로고    scopus 로고
    • Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells
    • Hur, EM, Youssef, S, Haws, ME, Zhang, SY, Sobel, RA, Steinman, L. (2007) Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells. Nat Immunol 8: 74-83.
    • (2007) Nat Immunol , vol.8 , pp. 74-83
    • Hur, E.M.1    Youssef, S.2    Haws, M.E.3    Zhang, S.Y.4    Sobel, R.A.5    Steinman, L.6
  • 56
    • 0029050644 scopus 로고
    • Large supplements of nicotinic acid and nicotinamide increase tissue NAD+ and poly(ADP-ribose) levels but do not affect diethylnitrosamine-induced altered hepatic foci in Fischer-344 rats
    • Jackson, TM, Rawling, JM, Roebuck, BD, Kirkland, JB. (1995) Large supplements of nicotinic acid and nicotinamide increase tissue NAD+ and poly(ADP-ribose) levels but do not affect diethylnitrosamine-induced altered hepatic foci in Fischer-344 rats. J Nutr 125: 1455-61.
    • (1995) J Nutr , vol.125 , pp. 1455-1461
    • Jackson, T.M.1    Rawling, J.M.2    Roebuck, B.D.3    Kirkland, J.B.4
  • 57
    • 0032574757 scopus 로고    scopus 로고
    • Sequence specific collective motions in a winged helix DNA binding domain detected by 15N relaxation NMR
    • Jin, C, Marsden, I, Chen, X, Liao, X. (1998) Sequence specific collective motions in a winged helix DNA binding domain detected by 15N relaxation NMR. Biochemistry 37: 6179-87.
    • (1998) Biochemistry , vol.37 , pp. 6179-6187
    • Jin, C.1    Marsden, I.2    Chen, X.3    Liao, X.4
  • 58
    • 20944443597 scopus 로고    scopus 로고
    • Inflammatory arthritis requires Foxo3a to prevent Fas ligand-induced neutrophil apoptosis
    • Jonsson, H, Allen, P, Peng, SL. (2005) Inflammatory arthritis requires Foxo3a to prevent Fas ligand-induced neutrophil apoptosis. Nat Med 11: 666-71.
    • (2005) Nat Med , vol.11 , pp. 666-671
    • Jonsson, H.1    Allen, P.2    Peng, S.L.3
  • 59
    • 0342614209 scopus 로고    scopus 로고
    • Unified nomenclature for the winged helix/forkhead transcription factors
    • Kaestner, KH, Knochel, W, Martinez, DE. (2000) Unified nomenclature for the winged helix/forkhead transcription factors. Genes Dev 14: 142-6.
    • (2000) Genes Dev , vol.14 , pp. 142-146
    • Kaestner, K.H.1    Knochel, W.2    Martinez, D.E.3
  • 60
    • 4544358547 scopus 로고    scopus 로고
    • Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch/red muscle) fiber genes, and impaired glycemic control
    • Kamei, Y, Miura, S, Suzuki, M, Kai, Y, Mizukami, J, Taniguchi, T, Mochida, K, Hata, T, Matsuda, J, Aburatani, H, Nishino, I, Ezaki, O. (2004) Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch/red muscle) fiber genes, and impaired glycemic control. J Biol Chem 279: 41114-23.
    • (2004) J Biol Chem , vol.279 , pp. 41114-41123
    • Kamei, Y.1    Miura, S.2    Suzuki, M.3    Kai, Y.4    Mizukami, J.5    Taniguchi, T.6    Mochida, K.7    Hata, T.8    Matsuda, J.9    Aburatani, H.10    Nishino, I.11    Ezaki, O.12
  • 61
    • 0141646358 scopus 로고    scopus 로고
    • Akt1 protects against inflammatory microglial activation through maintenance of membrane asymmetry and modulation of cysteine protease activity
    • Kang, JQ, Chong, ZZ, Maiese, K. (2003a) Akt1 protects against inflammatory microglial activation through maintenance of membrane asymmetry and modulation of cysteine protease activity. J Neurosci Res 74: 37-51.
    • (2003) J Neurosci Res , vol.74 , pp. 37-51
    • Kang, J.Q.1    Chong, Z.Z.2    Maiese, K.3
  • 62
    • 0042355359 scopus 로고    scopus 로고
    • Critical role for Akt1 in the modulation of apoptotic phosphatidylserine exposure and microglial activation
    • Kang, JQ, Chong, ZZ, Maiese, K. (2003b) Critical role for Akt1 in the modulation of apoptotic phosphatidylserine exposure and microglial activation. Mol Pharmacol 64: 557-69.
    • (2003) Mol Pharmacol , vol.64 , pp. 557-569
    • Kang, J.Q.1    Chong, Z.Z.2    Maiese, K.3
  • 63
    • 33845262863 scopus 로고    scopus 로고
    • Role of the Akt/FoxO3a pathway in TGFbeta1-mediated mesangial cell dysfunction: A novel mechanism related to diabetic kidney disease
    • Kato, M, Yuan, H, Xu, ZG, Lanting, L, Li, SL, Wang, M, Hu, MC, Reddy, MA, Natarajan, R. (2006) Role of the Akt/FoxO3a pathway in TGFbeta1-mediated mesangial cell dysfunction: a novel mechanism related to diabetic kidney disease. J Am Soc Nephrol 17: 3325-35.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 3325-3335
    • Kato, M.1    Yuan, H.2    Xu, Z.G.3    Lanting, L.4    Li, S.L.5    Wang, M.6    Hu, M.C.7    Reddy, M.A.8    Natarajan, R.9
  • 65
    • 12144258472 scopus 로고    scopus 로고
    • HIV-1 accessory protein Vpr inhibits the effect of insulin on the Foxo subfamily of forkhead transcription factors by interfering with their binding to 14-3-3 proteins: Potential clinical implications regarding the insulin resistance of HIV-1-infected patients
    • Kino, T, De Martino, MU, Charmandari, E, Ichijo, T, Outas, T, Chrousos, GP. (2005) HIV-1 accessory protein Vpr inhibits the effect of insulin on the Foxo subfamily of forkhead transcription factors by interfering with their binding to 14-3-3 proteins: potential clinical implications regarding the insulin resistance of HIV-1-infected patients. Diabetes 54: 23-31.
    • (2005) Diabetes , vol.54 , pp. 23-31
    • Kino, T.1    De Martino, M.U.2    Charmandari, E.3    Ichijo, T.4    Outas, T.5    Chrousos, G.P.6
  • 66
  • 69
    • 0035013610 scopus 로고    scopus 로고
    • Cardiovascular disease in type 2 diabetes: Challenge for treatment and prevention
    • Laakso, M. (2001) Cardiovascular disease in type 2 diabetes: challenge for treatment and prevention. J Intern Med 249: 225-35.
    • (2001) J Intern Med , vol.249 , pp. 225-235
    • Laakso, M.1
  • 70
    • 35548988777 scopus 로고    scopus 로고
    • A winged-helix protein from sulfolobus turreted icosahedral virus points toward stabilizing disulfide bonds in the intracellular proteins of a hyperthermophilic virus
    • Epub ahead of print
    • Larson, ET, Eilers, B, Menon, S, Reiter, D, Ortmann, A, Young, MJ, Lawrence, CM. (2007) A winged-helix protein from sulfolobus turreted icosahedral virus points toward stabilizing disulfide bonds in the intracellular proteins of a hyperthermophilic virus. Virology [Epub ahead of print].
    • (2007) Virology
    • Larson, E.T.1    Eilers, B.2    Menon, S.3    Reiter, D.4    Ortmann, A.5    Young, M.J.6    Lawrence, C.M.7
  • 71
  • 73
    • 0037458622 scopus 로고    scopus 로고
    • Expression of the serum- and glucocorticoid-inducible protein kinase, Sgk, is a cell survival response to multiple types of environmental stress stimuli in mammary epithelial cells
    • Leong, ML, Maiyar, AC, Kim, B, O'Keeffe, BA, Firestone, GL. (2003) Expression of the serum- and glucocorticoid-inducible protein kinase, Sgk, is a cell survival response to multiple types of environmental stress stimuli in mammary epithelial cells. J Biol Chem 278: 5871-82.
    • (2003) J Biol Chem , vol.278 , pp. 5871-5882
    • Leong, M.L.1    Maiyar, A.C.2    Kim, B.3    O'Keeffe, B.A.4    Firestone, G.L.5
  • 74
    • 33645999375 scopus 로고    scopus 로고
    • Cell life versus cell longevity: The mysteries surrounding the NAD(+) precursor nicotinamide
    • Li, F, Chong, ZZ, Maiese, K. (2006a) Cell life versus cell longevity: the mysteries surrounding the NAD(+) precursor nicotinamide. Curr Med Chem 13: 883-95.
    • (2006) Curr Med Chem , vol.13 , pp. 883-895
    • Li, F.1    Chong, Z.Z.2    Maiese, K.3
  • 75
    • 11344254385 scopus 로고    scopus 로고
    • Erythropoietin on a tightrope: Balancing neuronal and vascular protection between intrinsic and extrinsic pathways
    • Li, F, Chong, ZZ, Maiese, K. (2004a) Erythropoietin on a tightrope: balancing neuronal and vascular protection between intrinsic and extrinsic pathways. Neurosignals 13: 265-89.
    • (2004) Neurosignals , vol.13 , pp. 265-289
    • Li, F.1    Chong, Z.Z.2    Maiese, K.3
  • 76
    • 33746910279 scopus 로고    scopus 로고
    • Microglial integrity is maintained by erythropoietin through integration of Akt and its substrates of glycogen synthase kinase-3beta, beta-catenin, and nuclear factor-kappaB
    • Li, F, Chong, ZZ, Maiese, K. (2006b) Microglial integrity is maintained by erythropoietin through integration of Akt and its substrates of glycogen synthase kinase-3beta, beta-catenin, and nuclear factor-kappaB. Curr Neurovasc Res 3: 187-201.
    • (2006) Curr Neurovasc Res , vol.3 , pp. 187-201
    • Li, F.1    Chong, Z.Z.2    Maiese, K.3
  • 77
    • 11144287874 scopus 로고    scopus 로고
    • Navigating novel mechanisms of cellular plasticity with the NAD+ precursor and nutrient nicotinamide
    • Li, F, Chong, ZZ, Maiese, K. (2004b) Navigating novel mechanisms of cellular plasticity with the NAD+ precursor and nutrient nicotinamide. Front Biosci 9: 2500-2520.
    • (2004) Front Biosci , vol.9 , pp. 2500-2520
    • Li, F.1    Chong, Z.Z.2    Maiese, K.3
  • 78
    • 33845967865 scopus 로고    scopus 로고
    • Down-regulation of manganese-superoxide dismutase through phosphorylation of FOXO3a by Akt in explanted vascular smooth muscle cells from old rats
    • Li, M, Chiu, JF, Mossman, BT, Fukagawa, NK. (2006c) Down-regulation of manganese-superoxide dismutase through phosphorylation of FOXO3a by Akt in explanted vascular smooth muscle cells from old rats. J Biol Chem 281: 40429-39.
    • (2006) J Biol Chem , vol.281 , pp. 40429-40439
    • Li, M.1    Chiu, J.F.2    Mossman, B.T.3    Fukagawa, N.K.4
  • 79
    • 4143129696 scopus 로고    scopus 로고
    • Regulation of NF-kappaB, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a
    • Lin, L, Hron, JD, Peng, SL. (2004) Regulation of NF-kappaB, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a. Immunity 21: 203-13.
    • (2004) Immunity , vol.21 , pp. 203-213
    • Lin, L.1    Hron, J.D.2    Peng, S.L.3
  • 80
    • 0035031546 scopus 로고    scopus 로고
    • Nicotinamide: A nutritional supplement that provides protection against neuronal and vascular injury
    • Lin, SH, Chong, ZZ, Maiese, K. (2001) Nicotinamide: A nutritional supplement that provides protection against neuronal and vascular injury. J Med Food 4: 27-38.
    • (2001) J Med Food , vol.4 , pp. 27-38
    • Lin, S.H.1    Chong, Z.Z.2    Maiese, K.3
  • 81
    • 0035092461 scopus 로고    scopus 로고
    • The metabotropic glutamate receptor system protects against ischemic free radical programmed cell death in rat brain endothelial cells
    • Lin, SH, Maiese, K. (2001) The metabotropic glutamate receptor system protects against ischemic free radical programmed cell death in rat brain endothelial cells. J Cereb Blood Flow Metab 21: 262-75.
    • (2001) J Cereb Blood Flow Metab , vol.21 , pp. 262-275
    • Lin, S.H.1    Maiese, K.2
  • 82
    • 0033847695 scopus 로고    scopus 로고
    • Prevention of nitric oxide-induced neuronal injury through the modulation of independent pathways of programmed cell death
    • Lin, SH, Vincent, A, Shaw, T, Maynard, KI, Maiese, K. (2000) Prevention of nitric oxide-induced neuronal injury through the modulation of independent pathways of programmed cell death. J Cereb Blood Flow Metab 20: 1380-91.
    • (2000) J Cereb Blood Flow Metab , vol.20 , pp. 1380-1391
    • Lin, S.H.1    Vincent, A.2    Shaw, T.3    Maynard, K.I.4    Maiese, K.5
  • 84
    • 85047695408 scopus 로고    scopus 로고
    • Phosphorylation of forkhead transcription factors by erythropoietin and stem cell factor prevents acetylation and their interaction with coactivator p300 in erythroid progenitor cells
    • Mahmud, DL, G-Amlak, M, Deb, DK, Platanias, LC, Uddin, S, Wickrema, A. (2002) Phosphorylation of forkhead transcription factors by erythropoietin and stem cell factor prevents acetylation and their interaction with coactivator p300 in erythroid progenitor cells. Oncogene 21: 1556-62.
    • (2002) Oncogene , vol.21 , pp. 1556-1562
    • Mahmud, D.L.1    G-Amlak, M.2    Deb, D.K.3    Platanias, L.C.4    Uddin, S.5    Wickrema, A.6
  • 85
    • 3042819409 scopus 로고    scopus 로고
    • Insights into oxidative stress and potential novel therapeutic targets for Alzheimer disease
    • Maiese, K, Chong, ZZ. (2004) Insights into oxidative stress and potential novel therapeutic targets for Alzheimer disease. Restor Neurol Neurosci 22: 87-104.
    • (2004) Restor Neurol Neurosci , vol.22 , pp. 87-104
    • Maiese, K.1    Chong, Z.Z.2
  • 86
    • 0038061606 scopus 로고    scopus 로고
    • Nicotinamide: Necessary nutrient emerges as a novel cytoprotectant for the brain
    • Maiese, K, Chong, ZZ. (2003) Nicotinamide: necessary nutrient emerges as a novel cytoprotectant for the brain. Trends Pharmacol Sci 24: 228-32.
    • (2003) Trends Pharmacol Sci , vol.24 , pp. 228-232
    • Maiese, K.1    Chong, Z.Z.2
  • 87
    • 29044432690 scopus 로고    scopus 로고
    • Driving cellular plasticity and survival through the signal transduction pathways of metabotropic glutamate receptors
    • Maiese, K, Chong, ZZ, Li, F. (2005a) Driving cellular plasticity and survival through the signal transduction pathways of metabotropic glutamate receptors. Curr Neurovasc Res 2: 425-46.
    • (2005) Curr Neurovasc Res , vol.2 , pp. 425-446
    • Maiese, K.1    Chong, Z.Z.2    Li, F.3
  • 88
    • 34547444891 scopus 로고    scopus 로고
    • Mechanisitic insights into diabetes mellitus and oxidative stress
    • Maiese, K, Chong, ZZ, Shang, YC. (2007) Mechanisitic insights into diabetes mellitus and oxidative stress. Curr Med Chem 14: 1689-1699.
    • (2007) Curr Med Chem , vol.14 , pp. 1689-1699
    • Maiese, K.1    Chong, Z.Z.2    Shang, Y.C.3
  • 89
    • 5644245234 scopus 로고    scopus 로고
    • Erythropoietin in the brain: Can the promise to protect be fulfilled?
    • Maiese, K, Li, F, Chong, ZZ. (2004) Erythropoietin in the brain: can the promise to protect be fulfilled? Trends Pharmacol Sci 25: 577-583.
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 577-583
    • Maiese, K.1    Li, F.2    Chong, Z.Z.3
  • 90
    • 11244333356 scopus 로고    scopus 로고
    • New avenues of exploration for erythropoietin
    • Maiese, K, Li, F, Chong, ZZ. (2005b) New avenues of exploration for erythropoietin. JAMA 293: 90-5.
    • (2005) JAMA , vol.293 , pp. 90-95
    • Maiese, K.1    Li, F.2    Chong, Z.Z.3
  • 91
    • 0034839145 scopus 로고    scopus 로고
    • Effect of the Alzheimer amyloid fragment Abeta(25-35) on Akt/PKB kinase and survival of PC12 cells
    • Martin, D, Salinas, M, Lopez-Valdaliso, R, Serrano, E, Recuero, M, Cuadrado, A. (2001) Effect of the Alzheimer amyloid fragment Abeta(25-35) on Akt/PKB kinase and survival of PC12 cells. J Neurochem 78: 1000-8.
    • (2001) J Neurochem , vol.78 , pp. 1000-1008
    • Martin, D.1    Salinas, M.2    Lopez-Valdaliso, R.3    Serrano, E.4    Recuero, M.5    Cuadrado, A.6
  • 92
    • 0032742675 scopus 로고    scopus 로고
    • Activation of Akt kinase inhibits apoptosis and changes in Bcl-2 and Bax expression induced by nitric oxide in primary hippocampal neurons
    • Matsuzaki, H, Tamatani, M, Mitsuda, N, Namikawa, K, Kiyama, H, Miyake, S, Tohyama, M. (1999) Activation of Akt kinase inhibits apoptosis and changes in Bcl-2 and Bax expression induced by nitric oxide in primary hippocampal neurons. J Neurochem 73: 2037-46.
    • (1999) J Neurochem , vol.73 , pp. 2037-2046
    • Matsuzaki, H.1    Tamatani, M.2    Mitsuda, N.3    Namikawa, K.4    Kiyama, H.5    Miyake, S.6    Tohyama, M.7
  • 94
    • 0842263745 scopus 로고    scopus 로고
    • Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway
    • Miyauchi, H, Minamino, T, Tateno, K, Kunieda, T, Toko, H, Komuro, I. (2004) Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway. EMBO J 23: 212-20.
    • (2004) EMBO J , vol.23 , pp. 212-220
    • Miyauchi, H.1    Minamino, T.2    Tateno, K.3    Kunieda, T.4    Toko, H.5    Komuro, I.6
  • 96
    • 33846510345 scopus 로고    scopus 로고
    • Latent protein LANA2 from Kaposi's sarcoma-associated herpesvirus interacts with 14-3-3 proteins and inhibits FOXO3a transcription factor
    • Munoz-Fontela, C, Marcos-Villar, L, Gallego, P, Arroyo, J, Da Costa, M, Pomeranz, KM, Lam, EW, Rivas, C. (2007) Latent protein LANA2 from Kaposi's sarcoma-associated herpesvirus interacts with 14-3-3 proteins and inhibits FOXO3a transcription factor. J Virol 81: 1511-6.
    • (2007) J Virol , vol.81 , pp. 1511-1516
    • Munoz-Fontela, C.1    Marcos-Villar, L.2    Gallego, P.3    Arroyo, J.4    Da Costa, M.5    Pomeranz, K.M.6    Lam, E.W.7    Rivas, C.8
  • 97
  • 98
    • 10844236451 scopus 로고    scopus 로고
    • Nutrient availability regulates SIRT1 through a forkhead-dependent pathway
    • Nemoto, S, Fergusson, MM, Finkel, T. (2004) Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science 306: 2105-8.
    • (2004) Science , vol.306 , pp. 2105-2108
    • Nemoto, S.1    Fergusson, M.M.2    Finkel, T.3
  • 99
    • 33847077943 scopus 로고    scopus 로고
    • FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells
    • Obexer, P, Geiger, K, Ambros, PF, Meister, B, Ausserlechner, MJ. (2007) FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells. Cell Death Differ 14: 534-47.
    • (2007) Cell Death Differ , vol.14 , pp. 534-547
    • Obexer, P.1    Geiger, K.2    Ambros, P.F.3    Meister, B.4    Ausserlechner, M.J.5
  • 101
    • 0036974466 scopus 로고    scopus 로고
    • Diagnosis and management of diabetic neuropathy
    • Perkins, BA, Bril, V. (2002) Diagnosis and management of diabetic neuropathy. Curr Diab Rep 2: 495-500.
    • (2002) Curr Diab Rep , vol.2 , pp. 495-500
    • Perkins, B.A.1    Bril, V.2
  • 103
    • 12844271254 scopus 로고    scopus 로고
    • The emerging therapeutic potential of sirtuin-interacting drugs: From cell death to lifespan extension
    • Porcu, M, Chiarugi, A. (2005) The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension. Trends Pharmacol Sci 26: 94-103.
    • (2005) Trends Pharmacol Sci , vol.26 , pp. 94-103
    • Porcu, M.1    Chiarugi, A.2
  • 104
    • 0035379762 scopus 로고    scopus 로고
    • Type 2 diabetes: Epidemiology, pathophysiology, and diagnosis
    • Quinn, L. (2001) Type 2 diabetes: epidemiology, pathophysiology, and diagnosis. Nurs Clin North Am 36: 175-92, v.
    • (2001) Nurs Clin North Am , vol.36 , pp. 175-192
    • Quinn, L.1
  • 105
    • 35448972966 scopus 로고    scopus 로고
    • Akt and its downstream targets play key roles in mediating dormancy in land snails
    • Epub ahead of print
    • Ramnanan, CJ, Groom, AG, Storey, KB. (2007) Akt and its downstream targets play key roles in mediating dormancy in land snails. Comp Biochem Physiol B Biochem Mol Biol [Epub ahead of print].
    • (2007) Comp Biochem Physiol B Biochem Mol Biol
    • Ramnanan, C.J.1    Groom, A.G.2    Storey, K.B.3
  • 107
    • 0028790811 scopus 로고
    • A combined casein-free-nicotinamide diet prevents diabetes in the NOD mouse with minimum insulitis
    • Reddy, S, Bibby, NJ, Wu, D, Swinney, C, Barrow, G, Elliott, RB. (1995) A combined casein-free-nicotinamide diet prevents diabetes in the NOD mouse with minimum insulitis. Diabetes Res Clin Pract 29: 83-92.
    • (1995) Diabetes Res Clin Pract , vol.29 , pp. 83-92
    • Reddy, S.1    Bibby, N.J.2    Wu, D.3    Swinney, C.4    Barrow, G.5    Elliott, R.B.6
  • 108
    • 32944466267 scopus 로고    scopus 로고
    • High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of Foxo3a transcription factor independent of lipotoxicity and apoptosis
    • Relling, DP, Esberg, LB, Fang, CX, Johnson, WT, Murphy, EJ, Carlson, EC, Saari, JT, Ren, J. (2006) High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of Foxo3a transcription factor independent of lipotoxicity and apoptosis. J Hypertens 24: 549-61.
    • (2006) J Hypertens , vol.24 , pp. 549-561
    • Relling, D.P.1    Esberg, L.B.2    Fang, C.X.3    Johnson, W.T.4    Murphy, E.J.5    Carlson, E.C.6    Saari, J.T.7    Ren, J.8
  • 110
    • 0034648698 scopus 로고    scopus 로고
    • Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: Inhibition by PKB/Akt but not Raf signalling
    • Rytomaa, M, Lehmann, K, Downward, J. (2000) Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: inhibition by PKB/Akt but not Raf signalling. Oncogene 19: 4461-8.
    • (2000) Oncogene , vol.19 , pp. 4461-4468
    • Rytomaa, M.1    Lehmann, K.2    Downward, J.3
  • 111
    • 0038385888 scopus 로고    scopus 로고
    • Nicotinamide attenuates focal ischemic brain injury in rats: With special reference to changes in nicotinamide and NAD+ levels in ischemic core and penumbra
    • Sadanaga-Akiyoshi, F, Yao, H, Tanuma, S, Nakahara, T, Hong, JS, Ibayashi, S, Uchimura, H, Fujishima, M. (2003) Nicotinamide attenuates focal ischemic brain injury in rats: with special reference to changes in nicotinamide and NAD+ levels in ischemic core and penumbra. Neurochem Res 28: 1227-34.
    • (2003) Neurochem Res , vol.28 , pp. 1227-1234
    • Sadanaga-Akiyoshi, F.1    Yao, H.2    Tanuma, S.3    Nakahara, T.4    Hong, J.S.5    Ibayashi, S.6    Uchimura, H.7    Fujishima, M.8
  • 113
    • 33751206845 scopus 로고    scopus 로고
    • The negative regulators Foxj1 and Foxo3a are up-regulated by a peptide that inhibits systemic lupus erythematosus-associated T cell responses
    • Sela, U, Dayan, M, Hershkoviz, R, Cahalon, L, Lider, O, Mozes, E. (2006) The negative regulators Foxj1 and Foxo3a are up-regulated by a peptide that inhibits systemic lupus erythematosus-associated T cell responses. Eur J Immunol 36: 2971-80.
    • (2006) Eur J Immunol , vol.36 , pp. 2971-2980
    • Sela, U.1    Dayan, M.2    Hershkoviz, R.3    Cahalon, L.4    Lider, O.5    Mozes, E.6
  • 114
    • 0035805516 scopus 로고    scopus 로고
    • Forkhead family transcription factor FKHRL1 is expressed in human megakaryocytes. Regulation of cell cycling as a downstream molecule of thrombopoietin signaling
    • Tanaka, M, Kirito, K, Kashii, Y, Uchida, M, Watanabe, T, Endo, H, Endoh, T, Sawada, K, Ozawa, K, Komatsu, N. (2001) Forkhead family transcription factor FKHRL1 is expressed in human megakaryocytes. Regulation of cell cycling as a downstream molecule of thrombopoietin signaling. J Biol Chem 276: 15082-9.
    • (2001) J Biol Chem , vol.276 , pp. 15082-15089
    • Tanaka, M.1    Kirito, K.2    Kashii, Y.3    Uchida, M.4    Watanabe, T.5    Endo, H.6    Endoh, T.7    Sawada, K.8    Ozawa, K.9    Komatsu, N.10
  • 116
    • 0037134040 scopus 로고    scopus 로고
    • Tran, H, Brunet, A, Grenier, JM, Datta, SR, Fornace, AJ, Jr., DiStefano, PS, Chiang, LW, Greenberg, ME. (2002) DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science 296: 530-4.
    • Tran, H, Brunet, A, Grenier, JM, Datta, SR, Fornace, AJ, Jr., DiStefano, PS, Chiang, LW, Greenberg, ME. (2002) DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science 296: 530-4.
  • 117
    • 2942726155 scopus 로고    scopus 로고
    • The ins and outs of FoxO shuttling: Mechanisms of FoxO translocation and transcriptional regulation
    • Van Der Heide, LP, Hoekman, MF, Smidt, MP. (2004) The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation. Biochem J 380: 297-309.
    • (2004) Biochem J , vol.380 , pp. 297-309
    • Van Der Heide, L.P.1    Hoekman, M.F.2    Smidt, M.P.3
  • 119
    • 34447626095 scopus 로고    scopus 로고
    • SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction
    • Wang, F, Nguyen, M, Qin, FX, Tong, Q. (2007) SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell 6: 505-14.
    • (2007) Aging Cell , vol.6 , pp. 505-514
    • Wang, F.1    Nguyen, M.2    Qin, F.X.3    Tong, Q.4
  • 120
    • 0036703627 scopus 로고    scopus 로고
    • Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt
    • Wick, A, Wick, W, Waltenberger, J, Weller, M, Dichgans, J, Schulz, JB. (2002) Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt. J Neurosci 22: 6401-7.
    • (2002) J Neurosci , vol.22 , pp. 6401-6407
    • Wick, A.1    Wick, W.2    Waltenberger, J.3    Weller, M.4    Dichgans, J.5    Schulz, J.B.6
  • 121
    • 33746069404 scopus 로고    scopus 로고
    • In control of biology: Of mice, men and Foxes
    • Wijchers, PJ, Burbach, JP, Smidt, MP. (2006) In control of biology: of mice, men and Foxes. Biochem J 397: 233-46.
    • (2006) Biochem J , vol.397 , pp. 233-246
    • Wijchers, P.J.1    Burbach, J.P.2    Smidt, M.P.3
  • 122
    • 2342466734 scopus 로고    scopus 로고
    • Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030
    • Wild, S, Roglic, G, Green, A, Sicree, R, King, H. (2004) Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27: 1047-53.
    • (2004) Diabetes Care , vol.27 , pp. 1047-1053
    • Wild, S.1    Roglic, G.2    Green, A.3    Sicree, R.4    King, H.5
  • 123
    • 33645993568 scopus 로고    scopus 로고
    • Estradiol prevents the focal cerebral ischemic injury-induced decrease of forkhead transcription factors phosphorylation
    • Won, CK, Ji, HH, Koh, PO. (2006) Estradiol prevents the focal cerebral ischemic injury-induced decrease of forkhead transcription factors phosphorylation. Neurosci Lett 398: 39-43.
    • (2006) Neurosci Lett , vol.398 , pp. 39-43
    • Won, C.K.1    Ji, H.H.2    Koh, P.O.3
  • 124
    • 0035936023 scopus 로고    scopus 로고
    • The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change
    • Yamaguchi, H, Wang, HG. (2001) The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change. Oncogene 20: 7779-86.
    • (2001) Oncogene , vol.20 , pp. 7779-7786
    • Yamaguchi, H.1    Wang, H.G.2
  • 126
    • 0036328592 scopus 로고    scopus 로고
    • FKHRL1 and its homologs are new targets of nerve growth factor Trk receptor signaling
    • Zheng, WH, Kar, S, Quirion, R. (2002) FKHRL1 and its homologs are new targets of nerve growth factor Trk receptor signaling. J Neurochem 80: 1049-61.
    • (2002) J Neurochem , vol.80 , pp. 1049-1061
    • Zheng, W.H.1    Kar, S.2    Quirion, R.3
  • 127
    • 0034671848 scopus 로고    scopus 로고
    • Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells
    • Zheng, WH, Kar, S, Quirion, R. (2000) Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells. J Biol Chem 275: 39152-8.
    • (2000) J Biol Chem , vol.275 , pp. 39152-39158
    • Zheng, W.H.1    Kar, S.2    Quirion, R.3
  • 128
    • 34248392876 scopus 로고    scopus 로고
    • FoxO4 is the main forkhead transcriptional factor localized in the gastrointestinal tracts of pigs
    • Zhou, ZQ, Wang, T, Pan, LM, Huang, RH, Shi, FX. (2007) FoxO4 is the main forkhead transcriptional factor localized in the gastrointestinal tracts of pigs. J Zhejiang Univ Sci 8: 39-44.
    • (2007) J Zhejiang Univ Sci , vol.8 , pp. 39-44
    • Zhou, Z.Q.1    Wang, T.2    Pan, L.M.3    Huang, R.H.4    Shi, F.X.5
  • 129
    • 2942682872 scopus 로고    scopus 로고
    • Regulation of FOXO3a by brain-derived neurotrophic factor in differentiated human SH-SY5Y neuroblastoma cells
    • Zhu, W, Bijur, GN, Styles, NA, Li, X. (2004) Regulation of FOXO3a by brain-derived neurotrophic factor in differentiated human SH-SY5Y neuroblastoma cells. Brain Res Mol Brain Res 126: 45-56.
    • (2004) Brain Res Mol Brain Res , vol.126 , pp. 45-56
    • Zhu, W.1    Bijur, G.N.2    Styles, N.A.3    Li, X.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.