메뉴 건너뛰기




Volumn 2, Issue 3, 2009, Pages 150-167

Mitochondrial medicine and the neurodegenerative mitochondriopathies

Author keywords

Mitochondria; Mitochondrial biogenesis; Mitochondriopathies; Neurodegenerative diseases; Oxidative stress

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ALPHA TOCOPHEROL; CHOLINESTERASE INHIBITOR; DIMEBON; KETASYN; MEDIUM CHAIN TRIACYLGLYCEROL; MINOCYCLINE; NICOTINIC ACID; PLACEBO; RESVERATROL; RIBOFLAVIN; ROSIGLITAZONE; THIAMINE; UNCLASSIFIED DRUG;

EID: 74549210060     PISSN: None     EISSN: 14248247     Source Type: Journal    
DOI: 10.3390/ph2030150     Document Type: Article
Times cited : (40)

References (107)
  • 1
    • 34547777983 scopus 로고    scopus 로고
    • Is aging part of Alzheimer's disease, or is Alzheimer's disease part of aging?
    • Swerdlow, R.H. Is aging part of Alzheimer's disease, or is Alzheimer's disease part of aging? Neurobiol. Aging 2007, 28, 1465-1480.
    • (2007) Neurobiol. Aging , vol.28 , pp. 1465-1480
    • Swerdlow, R.H.1
  • 2
    • 0006164301 scopus 로고    scopus 로고
    • McKeith, I.G.; Galasko, D.; Kosaka, K.; Perry, E.K.; Dickson, D.W.; Hansen, L.A.; Salmon, D.P.; Lowe, J.; Mirra, S.S.; Byrne, E.J.; Lennox, G.; Quinn, N.P.; Edwardson, J.A.; Ince, P.G.; Bergeron, C.; Burns, A.; Miller, B.L.; Lovestone, S.; Collerton, D.; Jansen, E.N.; Ballard, C.; de Vos, R.A.; Wilcock, G.K.; Jellinger, K.A.; Perry, R.H. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop. Neurology 1996, 47, 1113-1124.
    • McKeith, I.G.; Galasko, D.; Kosaka, K.; Perry, E.K.; Dickson, D.W.; Hansen, L.A.; Salmon, D.P.; Lowe, J.; Mirra, S.S.; Byrne, E.J.; Lennox, G.; Quinn, N.P.; Edwardson, J.A.; Ince, P.G.; Bergeron, C.; Burns, A.; Miller, B.L.; Lovestone, S.; Collerton, D.; Jansen, E.N.; Ballard, C.; de Vos, R.A.; Wilcock, G.K.; Jellinger, K.A.; Perry, R.H. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop. Neurology 1996, 47, 1113-1124.
  • 3
    • 34648819814 scopus 로고    scopus 로고
    • Treating neurodegeneration by modifying mitochondria: Potential solutions to a "complex" problem
    • Swerdlow, R.H. Treating neurodegeneration by modifying mitochondria: Potential solutions to a "complex" problem. Antioxid. Redox Signal 2007, 9, 1591-1603.
    • (2007) Antioxid. Redox Signal , vol.9 , pp. 1591-1603
    • Swerdlow, R.H.1
  • 4
    • 68949158352 scopus 로고    scopus 로고
    • The Neurodegenerative Mitochondriopathies
    • Swerdlow, R.H. The Neurodegenerative Mitochondriopathies. J. Alzheimers Dis. 2009.
    • (2009) J. Alzheimers Dis
    • Swerdlow, R.H.1
  • 5
    • 0036982389 scopus 로고    scopus 로고
    • Mitochondria in Alzheimer's disease
    • Swerdlow, R.H.; Kish, S.J. Mitochondria in Alzheimer's disease. Int. Rev. Neurobiol. 2002, 53, 341-385.
    • (2002) Int. Rev. Neurobiol , vol.53 , pp. 341-385
    • Swerdlow, R.H.1    Kish, S.J.2
  • 6
    • 0025024024 scopus 로고
    • Cytochrome oxidase deficiency in Alzheimer's disease
    • Parker, W.D., Jr.; Filley, C.M.; Parks, J.K. Cytochrome oxidase deficiency in Alzheimer's disease. Neurology 1990, 40, 1302-1303.
    • (1990) Neurology , vol.40 , pp. 1302-1303
    • Parker Jr., W.D.1    Filley, C.M.2    Parks, J.K.3
  • 7
    • 34347353834 scopus 로고    scopus 로고
    • Mitochondria in cybrids containing mtDNA from persons with mitochondriopathies
    • Swerdlow, R.H. Mitochondria in cybrids containing mtDNA from persons with mitochondriopathies. J. Neurosci. Res. 2007, 85, 3416-3428.
    • (2007) J. Neurosci. Res , vol.85 , pp. 3416-3428
    • Swerdlow, R.H.1
  • 9
    • 3042513691 scopus 로고    scopus 로고
    • Mitochondria dysfunction of Alzheimer's disease cybrids enhances Abeta toxicity
    • Cardoso, S.M.; Santana, I.; Swerdlow, R.H.; Oliveira, C.R. Mitochondria dysfunction of Alzheimer's disease cybrids enhances Abeta toxicity. J. Neurochem. 2004, 89, 1417-1426.
    • (2004) J. Neurochem , vol.89 , pp. 1417-1426
    • Cardoso, S.M.1    Santana, I.2    Swerdlow, R.H.3    Oliveira, C.R.4
  • 11
    • 67650732998 scopus 로고    scopus 로고
    • Impaired balance of mitochondrial fission and fusion in Alzheimer's disease
    • Wang, X.; Su, B.; Lee, H.G.; Li, X.; Perry, G.; Smith, M.A.; Zhu, X. Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. J. Neurosci. 2009, 29, 9090-9103.
    • (2009) J. Neurosci , vol.29 , pp. 9090-9103
    • Wang, X.1    Su, B.2    Lee, H.G.3    Li, X.4    Perry, G.5    Smith, M.A.6    Zhu, X.7
  • 12
    • 3042736860 scopus 로고    scopus 로고
    • Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: Up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease
    • Reddy, P.H.; McWeeney, S.; Park, B.S.; Manczak, M.; Gutala, R.V.; Partovi, D.; Jung, Y.; Yau, V.; Searles, R.; Mori, M.; Quinn, J. Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: Up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease. Hum. Mol. Genet. 2004, 13, 1225-1240.
    • (2004) Hum. Mol. Genet , vol.13 , pp. 1225-1240
    • Reddy, P.H.1    McWeeney, S.2    Park, B.S.3    Manczak, M.4    Gutala, R.V.5    Partovi, D.6    Jung, Y.7    Yau, V.8    Searles, R.9    Mori, M.10    Quinn, J.11
  • 13
    • 70149093436 scopus 로고    scopus 로고
    • Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease
    • Yao, J.; Irwin, R.W.; Zhao, L.; Nilsen, J.; Hamilton, R.T.; Brinton, R.D. Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA 2009, 106, 14670-14675.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 14670-14675
    • Yao, J.1    Irwin, R.W.2    Zhao, L.3    Nilsen, J.4    Hamilton, R.T.5    Brinton, R.D.6
  • 16
    • 35948969760 scopus 로고    scopus 로고
    • Amyloid precursor protein and mitochondrial dysfunction in Alzheimer's disease
    • Anandatheerthavarada, H.K.; Devi, L. Amyloid precursor protein and mitochondrial dysfunction in Alzheimer's disease. Neuroscientist 2007, 13, 626-638.
    • (2007) Neuroscientist , vol.13 , pp. 626-638
    • Anandatheerthavarada, H.K.1    Devi, L.2
  • 18
    • 33748283747 scopus 로고    scopus 로고
    • Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction
    • Devi, L.; Prabhu, B.M.; Galati, D.F.; Avadhani, N.G.; Anandatheerthavarada, H.K. Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction. J. Neurosci. 2006, 26, 9057-9068.
    • (2006) J. Neurosci , vol.26 , pp. 9057-9068
    • Devi, L.1    Prabhu, B.M.2    Galati, D.F.3    Avadhani, N.G.4    Anandatheerthavarada, H.K.5
  • 19
    • 0028200649 scopus 로고
    • Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative
    • Gabuzda, D.; Busciglio, J.; Chen, L. B.; Matsudaira, P.; Yankner, B.A. Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative. J. Biol. Chem. 1994, 269, 13623-13628.
    • (1994) J. Biol. Chem , vol.269 , pp. 13623-13628
    • Gabuzda, D.1    Busciglio, J.2    Chen, L.B.3    Matsudaira, P.4    Yankner, B.A.5
  • 20
    • 0033866833 scopus 로고    scopus 로고
    • Khan, S.M.; Cassarino, D.S.; Abramova, N.N.; Keeney, P.M.; Borland, M.K.; Trimmer, P.A.; Krebs, C.T.; Bennett, J.C.; Parks, J.K.; Swerdlow, R.H.; Parker, W.D., Jr.; Bennett, J.P., Jr. Alzheimer's disease cybrids replicate beta-amyloid abnormalities through cell death pathways. Ann. Neurol. 2000, 48, 148-155.
    • Khan, S.M.; Cassarino, D.S.; Abramova, N.N.; Keeney, P.M.; Borland, M.K.; Trimmer, P.A.; Krebs, C.T.; Bennett, J.C.; Parks, J.K.; Swerdlow, R.H.; Parker, W.D., Jr.; Bennett, J.P., Jr. Alzheimer's disease cybrids replicate beta-amyloid abnormalities through cell death pathways. Ann. Neurol. 2000, 48, 148-155.
  • 21
    • 3042806534 scopus 로고    scopus 로고
    • A "mitochondrial cascade hypothesis" for sporadic Alzheimer's disease
    • Swerdlow, R.H.; Khan, S.M. A "mitochondrial cascade hypothesis" for sporadic Alzheimer's disease. Med. Hypotheses 2004, 63, 8-20.
    • (2004) Med. Hypotheses , vol.63 , pp. 8-20
    • Swerdlow, R.H.1    Khan, S.M.2
  • 22
    • 67649687124 scopus 로고    scopus 로고
    • The Alzheimer's disease mitochondrial cascade hypothesis: An update
    • Swerdlow, R.H.; Khan, S.M. The Alzheimer's disease mitochondrial cascade hypothesis: An update. Exp. Neurol. 2009, 218, 308-315.
    • (2009) Exp. Neurol , vol.218 , pp. 308-315
    • Swerdlow, R.H.1    Khan, S.M.2
  • 23
    • 0024848034 scopus 로고
    • Abnormalities of the electron transport chain in idiopathic Parkinson's disease
    • Parker, W.D., Jr.; Boyson, S.J.; Parks, J.K. Abnormalities of the electron transport chain in idiopathic Parkinson's disease. Ann. Neurol. 1989, 26, 719-723.
    • (1989) Ann. Neurol , vol.26 , pp. 719-723
    • Parker Jr., W.D.1    Boyson, S.J.2    Parks, J.K.3
  • 26
    • 0020680904 scopus 로고
    • Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis
    • Langston, J.W.; Ballard, P.; Tetrud, J.W.; Irwin, I. Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. Science 1983, 219, 979-980.
    • (1983) Science , vol.219 , pp. 979-980
    • Langston, J.W.1    Ballard, P.2    Tetrud, J.W.3    Irwin, I.4
  • 27
    • 0029908226 scopus 로고    scopus 로고
    • Swerdlow, R.H.; Parks, J.K.; Miller, S.W.; Tuttle, J.B.; Trimmer, P.A.; Sheehan, J.P.; Bennett, J.P., Jr.; Davis, R.E.; Parker, W.D., Jr. Origin and functional consequences of the complex I defect in Parkinson's disease. Ann. Neurol. 1996, 40, 663-671.
    • Swerdlow, R.H.; Parks, J.K.; Miller, S.W.; Tuttle, J.B.; Trimmer, P.A.; Sheehan, J.P.; Bennett, J.P., Jr.; Davis, R.E.; Parker, W.D., Jr. Origin and functional consequences of the complex I defect in Parkinson's disease. Ann. Neurol. 1996, 40, 663-671.
  • 31
    • 33646351299 scopus 로고    scopus 로고
    • Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons
    • Kraytsberg, Y.; Kudryavtseva, E.; McKee, A.C.; Geula, C.; Kowall, N.W.; Khrapko, K. Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons. Nat. Genet. 2006, 38, 518-520.
    • (2006) Nat. Genet , vol.38 , pp. 518-520
    • Kraytsberg, Y.1    Kudryavtseva, E.2    McKee, A.C.3    Geula, C.4    Kowall, N.W.5    Khrapko, K.6
  • 32
    • 10444243239 scopus 로고    scopus 로고
    • Mitochondrial ND5 mutations in idiopathic Parkinson's disease
    • Parker, W.D., Jr.; Parks, J.K. Mitochondrial ND5 mutations in idiopathic Parkinson's disease. Biochem. Biophys. Res. Commun. 2005, 326, 667-669.
    • (2005) Biochem. Biophys. Res. Commun , vol.326 , pp. 667-669
    • Parker Jr., W.D.1    Parks, J.K.2
  • 33
    • 4644351698 scopus 로고    scopus 로고
    • High frequency of mitochondrial complex I mutations in Parkinson's disease and aging
    • Smigrodzki, R.; Parks, J.; Parker, W.D. High frequency of mitochondrial complex I mutations in Parkinson's disease and aging. Neurobiol. Aging 2004, 25, 1273-1281.
    • (2004) Neurobiol. Aging , vol.25 , pp. 1273-1281
    • Smigrodzki, R.1    Parks, J.2    Parker, W.D.3
  • 34
    • 0029125857 scopus 로고
    • Aging, energy, and oxidative stress in neurodegenerative diseases
    • Beal, M.F. Aging, energy, and oxidative stress in neurodegenerative diseases. Ann. Neurol. 1995, 38, 357-366.
    • (1995) Ann. Neurol , vol.38 , pp. 357-366
    • Beal, M.F.1
  • 35
    • 67649756320 scopus 로고    scopus 로고
    • Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease
    • Bueler, H. Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease. Exp. Neurol. 2009, 218, 235-246.
    • (2009) Exp. Neurol , vol.218 , pp. 235-246
    • Bueler, H.1
  • 36
    • 0031716355 scopus 로고    scopus 로고
    • Swerdlow, R.H.; Parks, J.K.; Cassarino, D.S.; Trimmer, P.A.; Miller, S.W.; Maguire, D.J.; Sheehan, J.P.; Maguire, R.S.; Pattee, G.; Juel, V.C.; Phillips, L.H.; Tuttle, J.B.; Bennett, J.P., Jr.; Davis, R.E.; Parker, W.D., Jr. Mitochondria in sporadic amyotrophic lateral sclerosis. Exp. Neurol. 1998, 153, 135-142.
    • Swerdlow, R.H.; Parks, J.K.; Cassarino, D.S.; Trimmer, P.A.; Miller, S.W.; Maguire, D.J.; Sheehan, J.P.; Maguire, R.S.; Pattee, G.; Juel, V.C.; Phillips, L.H.; Tuttle, J.B.; Bennett, J.P., Jr.; Davis, R.E.; Parker, W.D., Jr. Mitochondria in sporadic amyotrophic lateral sclerosis. Exp. Neurol. 1998, 153, 135-142.
  • 40
    • 1542348209 scopus 로고    scopus 로고
    • The energetics of Huntington's disease
    • Browne, S.E.; Beal, M.F. The energetics of Huntington's disease. Neurochem. Res. 2004, 29, 531-546.
    • (2004) Neurochem. Res , vol.29 , pp. 531-546
    • Browne, S.E.1    Beal, M.F.2
  • 41
    • 33749042331 scopus 로고    scopus 로고
    • Transcriptional repression of PGC-alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration
    • Cui, L.; Jeong, H.; Borovecki, F.; Parkhurst, C.N.; Tanese, N.; Krainc, D. Transcriptional repression of PGC-alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration. Cell 2006, 127, 59-69.
    • (2006) Cell , vol.127 , pp. 59-69
    • Cui, L.1    Jeong, H.2    Borovecki, F.3    Parkhurst, C.N.4    Tanese, N.5    Krainc, D.6
  • 43
    • 0030813487 scopus 로고    scopus 로고
    • Studies of human, mouse and yeast homologues indicate a mitochondrial function for frataxin
    • Koutnikova, H.; Campuzano, V.; Foury, F.; Dolle, P.; Cazzalini, O.; Koenig, M. Studies of human, mouse and yeast homologues indicate a mitochondrial function for frataxin. Nat. Genet. 1997, 16, 345-351.
    • (1997) Nat. Genet , vol.16 , pp. 345-351
    • Koutnikova, H.1    Campuzano, V.2    Foury, F.3    Dolle, P.4    Cazzalini, O.5    Koenig, M.6
  • 44
    • 54049142098 scopus 로고    scopus 로고
    • Friedreich ataxia
    • Pandolfo, M. Friedreich ataxia. Arch. Neurol. 2008, 65, 1296-1303.
    • (2008) Arch. Neurol , vol.65 , pp. 1296-1303
    • Pandolfo, M.1
  • 45
    • 0028558576 scopus 로고
    • The development of mitochondrial medicine
    • Luft, R. The development of mitochondrial medicine. Proc. Natl. Acad. Sci. U. S. A. 1994, 91, 8731-8738.
    • (1994) Proc. Natl. Acad. Sci. U. S. A , vol.91 , pp. 8731-8738
    • Luft, R.1
  • 46
    • 0034329742 scopus 로고    scopus 로고
    • Apoptosis in neurodegenerative disorders
    • Mattson, M. P. Apoptosis in neurodegenerative disorders. Nat. Rev. Mol. Cell Biol. 2000, 1, 120-129.
    • (2000) Nat. Rev. Mol. Cell Biol , vol.1 , pp. 120-129
    • Mattson, M.P.1
  • 48
    • 71549116704 scopus 로고    scopus 로고
    • Mitochondria in the elderly: Is acetylcarnitine a rejuvenator? Adv
    • Rev
    • Rosca, M.G.; Lemieux, H.; Hoppel, C.L. Mitochondria in the elderly: Is acetylcarnitine a rejuvenator? Adv. Drug Deliv. Rev. 2009.
    • (2009) Drug Deliv
    • Rosca, M.G.1    Lemieux, H.2    Hoppel, C.L.3
  • 50
    • 65249129156 scopus 로고    scopus 로고
    • Creatine and its potential therapeutic value for targeting cellular energy impairment in neurodegenerative diseases
    • Adhihetty, P.J.; Beal, M.F. Creatine and its potential therapeutic value for targeting cellular energy impairment in neurodegenerative diseases. Neuromolecular Med. 2008, 10, 275-290.
    • (2008) Neuromolecular Med , vol.10 , pp. 275-290
    • Adhihetty, P.J.1    Beal, M.F.2
  • 54
    • 68549130877 scopus 로고    scopus 로고
    • Drilling for energy in mitochondrial disease
    • Haller, R.G.; Vissing, J. Drilling for energy in mitochondrial disease. Arch. Neurol. 2009, 66, 931-932.
    • (2009) Arch. Neurol , vol.66 , pp. 931-932
    • Haller, R.G.1    Vissing, J.2
  • 56
    • 74549188639 scopus 로고
    • Brain glucose and ketone body metabolism in patients with Alzheimer's disease
    • Swerdlow, R.; Marcus, D.M.; Landman, J.; Harooni, M.; Freedman, M.L. Brain glucose and ketone body metabolism in patients with Alzheimer's disease. Clin. Res. 1989, 37, 461A.
    • (1989) Clin. Res , vol.37
    • Swerdlow, R.1    Marcus, D.M.2    Landman, J.3    Harooni, M.4    Freedman, M.L.5
  • 57
    • 69449085062 scopus 로고    scopus 로고
    • Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: A randomized, double-blind, placebo-controlled, multicenter trial
    • Henderson, S.T.; Vogel, J.L.; Barr, L.J.; Garvin, F.; Jones, J.J.; Costantini, L.C. Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: A randomized, double-blind, placebo-controlled, multicenter trial. Nutr. Metab. (Lond) 2009, 6, 31.
    • (2009) Nutr. Metab. (Lond) , vol.6 , pp. 31
    • Henderson, S.T.1    Vogel, J.L.2    Barr, L.J.3    Garvin, F.4    Jones, J.J.5    Costantini, L.C.6
  • 60
    • 0037849955 scopus 로고    scopus 로고
    • Idebenone treatment in Friedreich patients: One-year-long randomized placebo-controlled trial
    • Mariotti, C.; Solari, A.; Torta, D.; Marano, L.; Fiorentini, C.; Di Donato, S. Idebenone treatment in Friedreich patients: One-year-long randomized placebo-controlled trial. Neurology 2003, 60, 1676-1679.
    • (2003) Neurology , vol.60 , pp. 1676-1679
    • Mariotti, C.1    Solari, A.2    Torta, D.3    Marano, L.4    Fiorentini, C.5    Di Donato, S.6
  • 64
    • 28544444991 scopus 로고    scopus 로고
    • Vitamin C and vitamin E for Alzheimer's disease
    • Boothby, L.A.; Doering, P.L. Vitamin C and vitamin E for Alzheimer's disease. Ann. Pharmacother. 2005, 39, 2073-2080.
    • (2005) Ann. Pharmacother , vol.39 , pp. 2073-2080
    • Boothby, L.A.1    Doering, P.L.2
  • 69
    • 33847378451 scopus 로고    scopus 로고
    • Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: Systematic review and meta-analysis
    • Bjelakovic, G.; Nikolova, D.; Gluud, L.L.; Simonetti, R.G.; Gluud, C. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: Systematic review and meta-analysis. JAMA 2007, 297, 842-857.
    • (2007) JAMA , vol.297 , pp. 842-857
    • Bjelakovic, G.1    Nikolova, D.2    Gluud, L.L.3    Simonetti, R.G.4    Gluud, C.5
  • 72
    • 0036139524 scopus 로고    scopus 로고
    • Reactive oxygen species and signal transduction
    • Finkel, T. Reactive oxygen species and signal transduction. IUBMB Life 2001, 52, 3-6.
    • (2001) IUBMB Life , vol.52 , pp. 3-6
    • Finkel, T.1
  • 73
    • 0037376674 scopus 로고    scopus 로고
    • Oxidant signals and oxidative stress
    • Finkel, T. Oxidant signals and oxidative stress. Curr. Opin. Cell Biol. 2003, 15, 247-254.
    • (2003) Curr. Opin. Cell Biol , vol.15 , pp. 247-254
    • Finkel, T.1
  • 74
    • 34547877924 scopus 로고    scopus 로고
    • Mitochondrial medicine: Pharmacological targeting of mitochondria in disease
    • Armstrong, J.S. Mitochondrial medicine: Pharmacological targeting of mitochondria in disease. Br. J. Pharmacol. 2007, 151, 1154-1165.
    • (2007) Br. J. Pharmacol , vol.151 , pp. 1154-1165
    • Armstrong, J.S.1
  • 75
    • 33646349444 scopus 로고    scopus 로고
    • Mitochondrial oxidative damage in aging and Alzheimer's disease: Implications for mitochondrially targeted antioxidant therapeutics
    • Reddy, P.H. Mitochondrial oxidative damage in aging and Alzheimer's disease: Implications for mitochondrially targeted antioxidant therapeutics. J. Biomed. Biotechnol. 2006, 2006, 31372.
    • (2006) J. Biomed. Biotechnol , vol.2006 , pp. 31372
    • Reddy, P.H.1
  • 77
    • 47149108940 scopus 로고    scopus 로고
    • Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: A randomised, double-blind, placebo-controlled study
    • Doody, R.S.; Gavrilova, S.I.; Sano, M.; Thomas, R.G.; Aisen, P.S.; Bachurin, S.O.; Seely, L.; Hung, D. Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: A randomised, double-blind, placebo-controlled study. Lancet 2008, 372, 207-215.
    • (2008) Lancet , vol.372 , pp. 207-215
    • Doody, R.S.1    Gavrilova, S.I.2    Sano, M.3    Thomas, R.G.4    Aisen, P.S.5    Bachurin, S.O.6    Seely, L.7    Hung, D.8
  • 78
  • 79
    • 33847059997 scopus 로고    scopus 로고
    • The mitochondrial energy transduction system and the aging process
    • Navarro, A.; Boveris, A. The mitochondrial energy transduction system and the aging process. Am. J. Physiol. Cell Physiol. 2007, 292, C670-686.
    • (2007) Am. J. Physiol. Cell Physiol , vol.292
    • Navarro, A.1    Boveris, A.2
  • 80
    • 37849052672 scopus 로고    scopus 로고
    • Systemic and mitochondrial adaptive responses to moderate exercise in rodents
    • Boveris, A.; Navarro, A. Systemic and mitochondrial adaptive responses to moderate exercise in rodents. Free Radic. Biol. Med. 2008, 44, 224-229.
    • (2008) Free Radic. Biol. Med , vol.44 , pp. 224-229
    • Boveris, A.1    Navarro, A.2
  • 82
    • 1242296371 scopus 로고    scopus 로고
    • Effects of acute and chronic endurance exercise on mitochondrial uncoupling in human skeletal muscle
    • Fernstrom, M.; Tonkonogi, M.; Sahlin, K. Effects of acute and chronic endurance exercise on mitochondrial uncoupling in human skeletal muscle. J. Physiol. 2004, 554, 755-763.
    • (2004) J. Physiol , vol.554 , pp. 755-763
    • Fernstrom, M.1    Tonkonogi, M.2    Sahlin, K.3
  • 83
    • 62149112288 scopus 로고    scopus 로고
    • Why eating less keeps mitochondria working in aged skeletal muscle
    • Hepple, R.T. Why eating less keeps mitochondria working in aged skeletal muscle. Exerc. Sport Sci. Rev. 2009, 37, 23-28.
    • (2009) Exerc. Sport Sci. Rev , vol.37 , pp. 23-28
    • Hepple, R.T.1
  • 84
    • 0016773679 scopus 로고
    • Adaptation of skeletal muscle to endurance exercise
    • Holloszy, J.O. Adaptation of skeletal muscle to endurance exercise. Med. Sci. Sports 1975, 7, 155-164.
    • (1975) Med. Sci. Sports , vol.7 , pp. 155-164
    • Holloszy, J.O.1
  • 85
    • 67651237067 scopus 로고    scopus 로고
    • Mechanisms of exercise-induced mitochondrial biogenesis in skeletal muscle
    • Hood, D.A. Mechanisms of exercise-induced mitochondrial biogenesis in skeletal muscle. Appl. Physiol. Nutr. Metab. 2009, 34, 465-472.
    • (2009) Appl. Physiol. Nutr. Metab , vol.34 , pp. 465-472
    • Hood, D.A.1
  • 86
    • 0037230261 scopus 로고    scopus 로고
    • Plasticity of skeletal muscle mitochondria: Structure and function
    • Hoppeler, H.; Fluck, M. Plasticity of skeletal muscle mitochondria: Structure and function. Med. Sci. Sports Exerc. 2003, 35, 95-104.
    • (2003) Med. Sci. Sports Exerc , vol.35 , pp. 95-104
    • Hoppeler, H.1    Fluck, M.2
  • 87
    • 1342307974 scopus 로고    scopus 로고
    • The effect of aging and caloric restriction on mitochondrial protein density and oxygen consumption
    • Lambert, A.J.; Wang, B.; Yardley, J.; Edwards, J.; Merry, B.J. The effect of aging and caloric restriction on mitochondrial protein density and oxygen consumption. Exp. Gerontol. 2004, 39, 289-295.
    • (2004) Exp. Gerontol , vol.39 , pp. 289-295
    • Lambert, A.J.1    Wang, B.2    Yardley, J.3    Edwards, J.4    Merry, B.J.5
  • 88
    • 0031549576 scopus 로고    scopus 로고
    • Seminars in medicine of the Beth Israel Deaconess Medical Center. Caloric intake and aging
    • Weindruch, R.; Sohal, R.S. Seminars in medicine of the Beth Israel Deaconess Medical Center. Caloric intake and aging. N. Engl. J. Med. 1997, 337, 986-994.
    • (1997) N. Engl. J. Med , vol.337 , pp. 986-994
    • Weindruch, R.1    Sohal, R.S.2
  • 89
    • 63549108476 scopus 로고    scopus 로고
    • Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans
    • Greer, E.L.; Brunet, A. Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell 2009, 8, 113-127.
    • (2009) Aging Cell , vol.8 , pp. 113-127
    • Greer, E.L.1    Brunet, A.2
  • 90
    • 33751113602 scopus 로고    scopus 로고
    • Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction
    • Haigis, M.C.; Guarente, L.P. Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction. Genes Dev. 2006, 20, 2913-2921.
    • (2006) Genes Dev , vol.20 , pp. 2913-2921
    • Haigis, M.C.1    Guarente, L.P.2
  • 91
    • 77958056184 scopus 로고    scopus 로고
    • Biological effects of calorie restriction: From soup to nuts
    • Rev
    • Spindler, S.R. Biological effects of calorie restriction: From soup to nuts. Ageing Res. Rev. 2009.
    • (2009) Ageing Res
    • Spindler, S.R.1
  • 92
    • 34748850786 scopus 로고    scopus 로고
    • Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
    • Schulz, T.J.; Zarse, K.; Voigt, A.; Urban, N.; Birringer, M.; Ristow, M. Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab. 2007, 6, 280-293.
    • (2007) Cell Metab , vol.6 , pp. 280-293
    • Schulz, T.J.1    Zarse, K.2    Voigt, A.3    Urban, N.4    Birringer, M.5    Ristow, M.6
  • 93
    • 74549195187 scopus 로고    scopus 로고
    • Norrbom, J.; S, E.W.; Gustafsson, T.; Rundqvist, H.; Jansson, E.; Sundberg, C. Training response of mitochondrial transcription factors in human skeletal muscle. Acta Physiol. (Oxf) 2009.
    • Norrbom, J.; S, E.W.; Gustafsson, T.; Rundqvist, H.; Jansson, E.; Sundberg, C. Training response of mitochondrial transcription factors in human skeletal muscle. Acta Physiol. (Oxf) 2009.
  • 94
    • 70449380429 scopus 로고    scopus 로고
    • Does Antioxidant Vitamin Supplementation Protect against Muscle Damage?
    • McGinley, C.; Shafat, A.; Donnelly, A.E. Does Antioxidant Vitamin Supplementation Protect against Muscle Damage? Sports Med. 2009, 39, 1011-1032.
    • (2009) Sports Med , vol.39 , pp. 1011-1032
    • McGinley, C.1    Shafat, A.2    Donnelly, A.E.3
  • 95
    • 38149131289 scopus 로고    scopus 로고
    • Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance
    • Gomez-Cabrera, M.C.; Domenech, E.; Romagnoli, M.; Arduini, A.; Borras, C.; Pallardo, F.V.; Sastre, J.; Vina, J. Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am. J. Clin. Nutr. 2008, 87, 142-149.
    • (2008) Am. J. Clin. Nutr , vol.87 , pp. 142-149
    • Gomez-Cabrera, M.C.1    Domenech, E.2    Romagnoli, M.3    Arduini, A.4    Borras, C.5    Pallardo, F.V.6    Sastre, J.7    Vina, J.8
  • 97
    • 33744468523 scopus 로고    scopus 로고
    • Exercise and hormesis: Activation of cellular antioxidant signaling pathway
    • Ji, L.L.; Gomez-Cabrera, M.C.; Vina, J. Exercise and hormesis: Activation of cellular antioxidant signaling pathway. Ann. N. Y. Acad. Sci. 2006, 1067, 425-435.
    • (2006) Ann. N. Y. Acad. Sci , vol.1067 , pp. 425-435
    • Ji, L.L.1    Gomez-Cabrera, M.C.2    Vina, J.3
  • 98
    • 33644875954 scopus 로고    scopus 로고
    • Neuronal protection by sirtuins in Alzheimer's disease
    • Anekonda, T.S.; Reddy, P.H. Neuronal protection by sirtuins in Alzheimer's disease. J. Neurochem. 2006, 96, 305-313.
    • (2006) J. Neurochem , vol.96 , pp. 305-313
    • Anekonda, T.S.1    Reddy, P.H.2
  • 100
    • 43549088782 scopus 로고    scopus 로고
    • Resveratrol: A multitargeted agent for age-associated chronic diseases
    • Harikumar, K.B.; Aggarwal, B.B. Resveratrol: A multitargeted agent for age-associated chronic diseases. Cell Cycle 2008, 7, 1020-1035.
    • (2008) Cell Cycle , vol.7 , pp. 1020-1035
    • Harikumar, K.B.1    Aggarwal, B.B.2
  • 101
    • 17844385363 scopus 로고    scopus 로고
    • Pioglitazone induces mitochondrial biogenesis in human subcutaneous adipose tissue in vivo
    • Bogacka, I.; Xie, H.; Bray, G.A.; Smith, S.R. Pioglitazone induces mitochondrial biogenesis in human subcutaneous adipose tissue in vivo. Diabetes 2005, 54, 1392-1399.
    • (2005) Diabetes , vol.54 , pp. 1392-1399
    • Bogacka, I.1    Xie, H.2    Bray, G.A.3    Smith, S.R.4
  • 105
    • 48149114282 scopus 로고    scopus 로고
    • New roles for pyruvate kinase M2: Working out the Warburg effect
    • Ferguson, E.C.; Rathmell, J.C. New roles for pyruvate kinase M2: Working out the Warburg effect. Trends Biochem. Sci. 2008, 33, 359-362.
    • (2008) Trends Biochem. Sci , vol.33 , pp. 359-362
    • Ferguson, E.C.1    Rathmell, J.C.2
  • 106
    • 69949124867 scopus 로고    scopus 로고
    • Pyruvate into lactate and back: From the Warburg effect to symbiotic energy fuel exchange in cancer cells
    • Feron, O. Pyruvate into lactate and back: From the Warburg effect to symbiotic energy fuel exchange in cancer cells. Radiother. Oncol. 2009, 92, 329-333.
    • (2009) Radiother. Oncol , vol.92 , pp. 329-333
    • Feron, O.1
  • 107
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • Vander Heiden, M.G.; Cantley, L.C.; Thompson, C.B. Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science 2009, 324, 1029-1033.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.