Insulin signaling and life span

Pflugers Archiv European Journal of Physiology

Volumn 459, Issue 2, 2010, Pages 301-314

  Avogaro, Angelo ^a   De Kreutzenberg, Saula Vigili ^a   Fadini, Gian Paolo ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Apoptosis; Cell death; Diabetes; Insulin; Signal transduction

Indexed keywords

INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; REACTIVE OXYGEN METABOLITE; SIRTUIN 1;

APOPTOSIS; CELL PROLIFERATION; DIABETES MELLITUS; HUMAN; HYPERINSULINEMIA; INFLAMMATION; INSULIN RESISTANCE; LIFESPAN; LONGEVITY; METABOLIC DISORDER; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TELOMERE;

ANIMALS; CALORIC RESTRICTION; HUMANS; INFLAMMATION; INSULIN; INSULIN RESISTANCE; INSULIN-LIKE GROWTH FACTOR I; LIFE EXPECTANCY; LONGEVITY; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SHC SIGNALING ADAPTOR PROTEINS; SIGNAL TRANSDUCTION; SIRTUIN 1; STEM CELLS; TELOMERE;

EID: 73749085210     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-009-0721-8     Document Type: Review

References (139)

1. KA Al-Regaiey MM Masternak M Bonkowski L Sun A Bartke 2005 Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction Endocrinology 146 851 860 1:CAS:528:DC%2BD2MXotlWnsg%3D%3D 15498882
2. K Ando T Fujita 2009 Metabolic syndrome and oxidative stress Free Radic Biol Med 47 213 218 1:CAS:528:DC%2BD1MXnsFKlsr0%3D 19409982
3. G Aubert PM Lansdorp 2008 Telomeres and aging Physiol Rev 88 557 579 1:CAS:528:DC%2BD1cXls1KhsL4%3D 18391173
4. SN Austad 2006 Why women live longer than men: sex differences in longevity Gend Med 3 79 92 16860268
5. A Avogaro SV de Kreutzenberg GP Fadini 2008 Oxidative stress and vascular disease in diabetes: is the dichotomization of insulin signaling still valid? Free Radic Biol Med 44 1209 1215 1:CAS:528:DC%2BD1cXjtVCitrw%3D 18191647
6. JL Barger T Kayo TD Pugh TA Prolla R Weindruch 2008 Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart Exp Gerontol 43 859 866 1:CAS:528:DC%2BD1cXhtVart7vN 18657603
7. A Bartke V Chandrashekar F Dominici D Turyn B Kinney R Steger JJ Kopchick 2003 Insulin-like growth factor 1 (IGF-1) and aging: controversies and new insights Biogerontology 4 1 8 1:CAS:528:DC%2BD3sXhtlahtr0%3D 12652183
8. CA Baumann V Ribon M Kanzaki DC Thurmond S Mora S Shigematsu PE Bickel JE Pessin AR Saltiel 2000 CAP defines a second signalling pathway required for insulin-stimulated glucose transport Nature 407 202 207 1:CAS:528: DC%2BD3cXmvVSmtb0%3D 11001060
9. JW Baynes SR Thorpe 1999 Role of oxidative stress in diabetic complications: a new perspective on an old paradigm Diabetes 48 1 9 1:CAS:528:DyaK1MXhvV2rtA%3D%3D 9892215
10. P Bernardi M Forte 2007 The mitochondrial permeability transition pore Novartis Found Symp 287 157 164 1:CAS:528:DC%2BD1cXltFCqsbk%3D 18074637 discussion 164-159
11. I Berniakovich M Trinei M Stendardo E Migliaccio S Minucci P Bernardi PG Pelicci M Giorgio 2008 p66Shc-generated oxidative signal promotes fat accumulation J Biol Chem 283 34283 34293 1:CAS:528:DC%2BD1cXhsVelu7rF 18838380
12. M Bluher BB Kahn CR Kahn 2003 Extended longevity in mice lacking the insulin receptor in adipose tissue Science 299 572 574 12543978
13. L Bordone D Cohen A Robinson MC Motta E van Veen A Czopik AD Steele H Crowe S Marmor J Luo W Gu L Guarente 2007 SIRT1 transgenic mice show phenotypes resembling calorie restriction Aging Cell 6 759 767 1:CAS:528:DC%2BD2sXhsVeksbbJ 17877786
14. L Bordone L Guarente 2005 Calorie restriction, SIRT1 and metabolism: understanding longevity Nat Rev Mol Cell Biol 6 298 305 1:CAS:528: DC%2BD2MXivVaktLg%3D 15768047 (Pubitemid 40516896)
15. SW Brouilette A Whittaker SE Stevens P van der Harst AH Goodall NJ Samani 2008 Telomere length is shorter in healthy offspring of subjects with coronary artery disease: support for the telomere hypothesis Heart 94 422 425 1:STN:280:DC%2BD1c7ovVWhtA%3D%3D 18347373
16. HM Brown-Borg 2009 Hormonal control of aging in rodents: the somatotropic axis Mol Cell Endocrinol 299 64 71 1:CAS:528:DC%2BD1MXhtVCnsrk%3D 18674587
17. A Brunet LB Sweeney JF Sturgill KF Chua PL Greer Y Lin H Tran SE Ross R Mostoslavsky HY Cohen LS Hu HL Cheng MP Jedrychowski SP Gygi DA Sinclair FW Alt ME Greenberg 2004 Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase Science 303 2011 2015 1:CAS:528:DC%2BD2cXisVGlt70%3D 14976264
18. M Capri S Salvioli F Sevini S Valensin L Celani D Monti G Pawelec G De Benedictis ES Gonos C Franceschi 2006 The genetics of human longevity Ann N Y Acad Sci 1067 252 263 1:CAS:528:DC%2BD28Xms1Oksbs%3D 16803995
19. JJ Carrero P Stenvinkel B Fellstrom AR Qureshi K Lamb O Heimburger P Barany K Radhakrishnan B Lindholm I Soveri L Nordfors PG Shiels 2008 Telomere attrition is associated with inflammation, low fetuin-A levels and high mortality in prevalent haemodialysis patients J Intern Med 263 302 312 1:CAS:528:DC%2BD1cXktVWru78%3D 18070000
20. CS Carter MM Ramsey RL Ingram AB Cashion WT Cefalu ZQ Wang WE Sonntag 2002 Models of growth hormone and IGF-1 deficiency: applications to studies of aging processes and life-span determination J Gerontol A Biol Sci Med Sci 57 B177 B188 11983714
21. G Ceolotto M Bevilacqua I Papparella E Baritono L Franco C Corvaja M Mazzoni A Semplicini A Avogaro 2004 Insulin generates free radicals by an NAD(P)H, phosphatidylinositol 3-kinase-dependent mechanism in human skin fibroblasts ex vivo Diabetes 53 1344 1351 1:CAS:528:DC%2BD2cXjslKhsrc%3D 15111505
22. G Ceolotto I Papparella L Lenzini M Sartori M Mazzoni E Iori L Franco A Gallo SV de Kreutzenberg A Tiengo AC Pessina A Avogaro A Semplicini 2006 Insulin generates free radicals in human fibroblasts ex vivo by a protein kinase C-dependent mechanism, which is inhibited by pravastatin Free Radic Biol Med 41 473 483 1:CAS:528:DC%2BD28XntFWru7c%3D 16843828
23. D Cesselli AP Beltrami S Rigo N Bergamin F D'Aurizio R Verardo S Piazza E Klaric R Fanin B Toffoletto S Marzinotto L Mariuzzi N Finato M Pandolfi A Leri C Schneider CA Beltrami P Anversa 2009 Multipotent progenitor cells are present in human peripheral blood Circ Res 104 1225 1234 1:CAS:528:DC%2BD1MXlslCqu7o%3D 19390058
24. SM Chambers CA Shaw C Gatza CJ Fisk LA Donehower MA Goodell 2007 Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation PLoS Biol 5 e201 17676974
25. E Cohen A Dillin 2008 The insulin paradox: aging, proteotoxicity and neurodegeneration Nat Rev Neurosci 9 759 767 1:CAS:528:DC%2BD1cXhtFeit7fM 18769445
26. F Cosentino P Francia GG Camici PG Pelicci M Volpe TF Luscher 2008 Final Common molecular pathways of aging and cardiovascular disease: role of the p66Shc protein Arterioscler Thromb Vasc Biol 28 622 628 1:CAS:528: DC%2BD1cXjt1Sls7g%3D 18162611
27. D Dabelea 2009 The accelerating epidemic of childhood diabetes Lancet 373 1999 2000 19481250
28. JE Davis NK Gabler J Walker-Daniels ME Spurlock 2008 Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat Obesity 16 1248 1255 1:CAS:528:DC%2BD1cXmsFCgu7s%3D 18421279
29. JE Davis NK Gabler J Walker-Daniels ME Spurlock 2009 The c-Jun N-Terminal kinase mediates the induction of oxidative stress and insulin resistance by palmitate and toll-like receptor 2 and 4 ligands in 3T3-L1 adipocytes Horm Metab Res 41 523 530 1:CAS:528:DC%2BD1MXhtVCgs7vP 19277946
30. S Demissie D Levy EJ Benjamin LA Cupples JP Gardner A Herbert M Kimura MG Larson JB Meigs JF Keaney A Aviv 2006 Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham heart study Aging Cell 5 325 330 1:CAS:528:DC%2BD28Xoslait78%3D 16913878
31. MS Dionne LN Pham M Shirasu-Hiza DS Schneider 2006 Akt and FOXO dysregulation contribute to infection-induced wasting in Drosophila Curr Biol 16 1977 1985 1:CAS:528:DC%2BD28XhtFSrtbjM 17055976
32. W Droge HM Schipper 2007 Oxidative stress and aberrant signaling in aging and cognitive decline Aging Cell 6 361 370 1:CAS:528:DC%2BD2sXntVOjsrw%3D 17517043
33. S Emanuele M Lauricella G Tesoriere 2008 Histone deacetylase inhibitors: apoptotic effects and clinical implications (Review) Int J Oncol 33 637 646 1:CAS:528:DC%2BD1cXht1KhtbnP 18813776
34. JL Evans BA Maddux ID Goldfine 2005 The molecular basis for oxidative stress-induced insulin resistance Antioxid Redox Signal 7 1040 1052 1:CAS:528:DC%2BD2MXlsl2is7k%3D 15998259
35. GP Fadini C Agostini E Boscaro A Avogaro 2009 Mechanisms and significance of progenitor cell reduction in the metabolic syndrome Metab Syndr Relat Disord 7 5 10 19183074
36. Fadini GP, de Kreutzenberg S, Agostini C, Boscaro E, Tiengo A, Dimmeler S, Avogaro A (2009) Low CD34+ cell count and metabolic syndrome synergistically increase the risk of adverse outcomes. Atherosclerosis (in press)
37. GP Fadini SV de Kreutzenberg A Coracina I Baesso C Agostini A Tiengo A Avogaro 2006 Circulating CD34+ cells, metabolic syndrome, and cardiovascular risk Eur Heart J 27 2247 2255 1:CAS:528:DC%2BD28XhtFSku7vO 16912055
38. GP Fadini M Miorin M Facco S Bonamico I Baesso F Grego M Menegolo SV de Kreutzenberg A Tiengo C Agostini A Avogaro 2005 Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus J Am Coll Cardiol 45 1449 1457 1:CAS:528:DC%2BD2MXjvVKku7k%3D 15862417
39. GP Fadini S Sartore C Agostini A Avogaro 2007 Significance of endothelial progenitor cells in subjects with diabetes Diabetes Care 30 1305 1313 1:CAS:528:DC%2BD2sXmtFKmsr0%3D 17277037 (Pubitemid 46684670)
40. GP Fadini S Sartore M Schiavon M Albiero I Baesso A Cabrelle C Agostini A Avogaro 2006 Diabetes impairs progenitor cell mobilisation after hindlimb ischaemia-reperfusion injury in rats Diabetologia 49 3075 3084 1:STN:280:DC%2BD28nmtFSisg%3D%3D 17072586
41. AL Fitzpatrick RA Kronmal JP Gardner BM Psaty NS Jenny RP Tracy J Walston M Kimura A Aviv 2007 Leukocyte telomere length and cardiovascular disease in the cardiovascular health study Am J Epidemiol 165 14 21 17043079
42. F Flachsbart PJ Croucher S Nikolaus J Hampe C Cordes S Schreiber A Nebel 2006 Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity Exp Gerontol 41 98 102 1:CAS:528:DC%2BD28XhvFygsQ%3D%3D 16257164
43. JC Florez 2008 Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes? Diabetologia 51 1100 1110 1:CAS:528:DC%2BD1cXmslWgs7w%3D 18504548
44. L Fontana 2009 The scientific basis of caloric restriction leading to longer life Curr Opin Gastroenterol 25 144 150 1:CAS:528:DC%2BD1MXisFOhtL4%3D 19262201
45. C Franceschi F Olivieri F Marchegiani M Cardelli L Cavallone M Capri S Salvioli S Valensin G De Benedictis A Di Iorio C Caruso G Paolisso D Monti 2005 Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians Mech Ageing Dev 126 351 361 1:CAS:528:DC%2BD2cXhtFGhsbzJ 15621218
46. OH Franco EW Steyerberg FB Hu J Mackenbach W Nusselder 2007 Associations of diabetes mellitus with total life expectancy and life expectancy with and without cardiovascular disease Arch Intern Med 167 1145 1151 17563022
47. S Furukawa T Fujita M Shimabukuro M Iwaki Y Yamada Y Nakajima O Nakayama M Makishima M Matsuda I Shimomura 2004 Increased oxidative stress in obesity and its impact on metabolic syndrome J Clin Invest 114 1752 1761 1:CAS:528:DC%2BD2cXhtFaiur7F 15599400
48. JJ Fuster V Andres 2006 Telomere biology and cardiovascular disease Circ Res 99 1167 1180 1:CAS:528:DC%2BD28Xht1antr3P 17122447
49. AS Gami BJ Witt DE Howard PJ Erwin LA Gami VK Somers VM Montori 2007 Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies J Am Coll Cardiol 49 403 414 1:CAS:528:DC%2BD2sXhtVCks7s%3D 17258085
50. JP Gardner S Li SR Srinivasan W Chen M Kimura X Lu GS Berenson A Aviv 2005 Rise in insulin resistance is associated with escalated telomere attrition Circulation 111 2171 2177 1:CAS:528:DC%2BD2MXjsFKgtbg%3D 15851602
51. M Giorgio E Migliaccio F Orsini D Paolucci M Moroni C Contursi G Pelliccia L Luzi S Minucci M Marcaccio P Pinton R Rizzuto P Bernardi F Paolucci PG Pelicci 2005 Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis Cell 122 221 233 1:CAS:528:DC%2BD2MXntFGjs7c%3D 16051147
52. M Giorgio M Trinei E Migliaccio PG Pelicci 2007 Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals? Nat Rev Mol Cell Biol 8 722 728 1:CAS:528:DC%2BD2sXpsVartbw%3D 17700625
53. R Gredilla G Barja 2005 Minireview: the role of oxidative stress in relation to caloric restriction and longevity Endocrinology 146 3713 3717 1:CAS:528:DC%2BD2MXpsVehu70%3D 15919745
54. L Guarente 2007 Sirtuins in aging and disease Cold Spring Harb Symp Quant Biol 72 483 488 1:CAS:528:DC%2BD1cXnvVWltrg%3D 18419308
55. J Guo Z Gertsberg N Ozgen SF Steinberg 2009 p66Shc links alpha1-adrenergic receptors to a reactive oxygen species-dependent AKT-FOXO3A phosphorylation pathway in cardiomyocytes Circ Res 104 660 669 1:CAS:528:DC%2BD1MXisFelurg%3D 19168439
56. MC Haigis LP Guarente 2006 Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction Genes Dev 20 2913 2921 1:CAS:528:DC%2BD28XhtFynu7bJ 17079682
57. SJ Hauck WS Hunter N Danilovich JJ Kopchick A Bartke 2001 Reduced levels of thyroid hormones, insulin, and glucose, and lower body core temperature in the growth hormone receptor/binding protein knockout mouse Exp Biol Med (Maywood) 226 552 558 1:CAS:528:DC%2BD3MXktVajtLo%3D
58. Y Higaki T Mikami N Fujii MF Hirshman K Koyama T Seino K Tanaka LJ Goodyear 2008 Oxidative stress stimulates skeletal muscle glucose uptake through a phosphatidylinositol 3-kinase-dependent pathway Am J Physiol Endocrinol Metab 294 E889 E897 1:CAS:528:DC%2BD1cXlvFCju7o%3D 18303121
59. T Hofer L Fontana SD Anton EP Weiss D Villareal B Malayappan C Leeuwenburgh 2008 Long-term effects of caloric restriction or exercise on DNA and RNA oxidation levels in white blood cells and urine in humans Rejuvenation Res 11 793 799 1:CAS:528:DC%2BD1cXhtVGgtrnE 18729811
60. Y Honda S Honda 2002 Oxidative stress and life span determination in the nematode Caenorhabditis elegans Ann N Y Acad Sci 959 466 474 1:CAS:528:DC%2BD38XktFajsrg%3D 11976220
61. TJ Hsieh P Fustier CC Wei SL Zhang JG Filep SS Tang JR Ingelfinger IG Fantus P Hamet JS Chan 2004 Reactive oxygen species blockade and action of insulin on expression of angiotensinogen gene in proximal tubular cells J Endocrinol 183 535 550 1:CAS:528:DC%2BD2MXis1SktA%3D%3D 15590980
62. PM Humpert R Neuwirth MJ Battista O Voronko M von Eynatten I Konrade G Rudofsky Jr T Wendt A Hamann M Morcos PP Nawroth A Bierhaus 2005 SDF-1 genotype influences insulin-dependent mobilization of adult progenitor cells in type 2 diabetes Diabetes Care 28 934 936 15793201
63. D Jay H Hitomi KK Griendling 2006 Oxidative stress and diabetic cardiovascular complications Free Radic Biol Med 40 183 192 1:CAS:528: DC%2BD28XksVeitA%3D%3D 16413400
64. MA Kang TM Mott EC Tapley EE Lewis S Luckhart 2008 Insulin regulates aging and oxidative stress in Anopheles stephensi J Exp Biol 211 741 748 1:CAS:528:DC%2BD1cXls1Cqs7s%3D 18281336
65. M Kato H Yuan ZG Xu L Lanting SL Li M Wang MC Hu MA Reddy R Natarajan 2006 Role of the Akt/FoxO3a pathway in TGF-beta1-mediated mesangial cell dysfunction: a novel mechanism related to diabetic kidney disease J Am Soc Nephrol 17 3325 3335 1:CAS:528:DC%2BD28XhtlGiu7nI 17082237
66. F Kim M Pham I Luttrell DD Bannerman J Tupper J Thaler TR Hawn EW Raines MW Schwartz 2007 Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity Circ Res 100 1589 1596 1:CAS:528: DC%2BD2sXmtVGjtb0%3D 17478729
67. KY Kim JK Kim JH Jeon SR Yoon I Choi Y Yang 2005 c-Jun N-terminal kinase is involved in the suppression of adiponectin expression by TNF-alpha in 3 T3-L1 adipocytes Biochem Biophys Res Commun 327 460 467 1:CAS:528:DC%2BD2MXksFyq 15629137
68. KD Kimura HA Tissenbaum Y Liu G Ruvkun 1997 daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans Science 277 942 946 1:CAS:528:DyaK2sXltlCqsb0%3D 9252323
69. Y Kodama DA Brenner 2009 c-Jun N-terminal kinase signaling in the pathogenesis of nonalcoholic fatty liver disease: Multiple roles in multiple steps Hepatology 49 6 8 1:CAS:528:DC%2BD1MXhsFGlt74%3D 19111006
70. SB Kondapaka M Zarnowski DR Yver EA Sausville SW Cushman 2004 7-hydroxystaurosporine (UCN-01) inhibition of Akt Thr308 but not Ser473 phosphorylation: a basis for decreased insulin-stimulated glucose transport Clin Cancer Res 10 7192 7198 1:CAS:528:DC%2BD2cXpsVKltbw%3D 15534092
71. J Krishnamurthy NE Sharpless 2007 Stem cells and the rate of living Cell Stem Cell 1 9 11 1:CAS:528:DC%2BD2sXptV2ku7Y%3D 18371325
72. HM Lakka DE Laaksonen TA Lakka LK Niskanen E Kumpusalo J Tuomilehto JT Salonen 2002 The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men Jama 288 2709 2716 12460094
73. Z Laron 2008 The GH-IGF1 axis and longevity. The paradigm of IGF1 deficiency Hormones (Athens) 7 24 27
74. JY Lee A Plakidas WH Lee A Heikkinen P Chanmugam G Bray DH Hwang 2003 Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids J Lipid Res 44 479 486 1:CAS:528:DC%2BD3sXitlCkurc%3D 12562875
75. SS Lee S Kennedy AC Tolonen G Ruvkun 2003 DAF-16 target genes that control C. elegans life-span and metabolism Science 300 644 647 1:CAS:528:DC%2BD3sXjtVymu7k%3D 12690206
76. C Li ES Ford G Zhao AH Mokdad 2009 Prevalence of pre-diabetes and its association with clustering of cardiometabolic risk factors and hyperinsulinemia among U.S. adolescents: national health and nutrition examination survey 2005-2006 Diabetes Care 32 342 347 18957533
77. Y Li W Xu MW McBurney VD Longo 2008 SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons Cell Metab 8 38 48 18590691
78. VD Longo BK Kennedy 2006 Sirtuins in aging and age-related disease Cell 126 257 268 1:CAS:528:DC%2BD28Xot1Ont7g%3D 16873059
79. M Mangel 2001 Complex adaptive systems, aging and longevity J Theor Biol 213 559 571 1:STN:280:DC%2BD3MnpsFWntg%3D%3D 11742525
80. MS Martin-Gronert JL Tarry-Adkins RL Cripps JH Chen SE Ozanne 2008 Maternal protein restriction leads to early life alterations in the expression of key molecules involved in the aging process in rat offspring Am J Physiol Regul Integr Comp Physiol 294 R494 R500 1:CAS:528:DC%2BD1cXit1ylurg%3D 18094069
81. JP McClung CA Roneker W Mu DJ Lisk P Langlais F Liu XG Lei 2004 Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase Proc Natl Acad Sci U S A 101 8852 8857 1:CAS:528:DC%2BD2cXltlWru70%3D 15184668
82. JE McEwen P Zimniak JL Mehta RJ Shmookler Reis 2005 Molecular pathology of aging and its implications for senescent coronary atherosclerosis Curr Opin Cardiol 20 399 406 16093759
83. TE Meyer SJ Kovács AA Ehsani S Klein JO Holloszy L Fontana 2006 Long-term caloric restriction ameliorates the decline in diastolic function in humans J Am Coll Cardiol 47 398 402 1:CAS:528:DC%2BD28XksFCntQ%3D%3D 16412867
84. E Migliaccio M Giorgio S Mele G Pelicci P Reboldi PP Pandolfi L Lanfrancone PG Pelicci 1999 The p66shc adaptor protein controls oxidative stress response and life span in mammals Nature 402 309 313 1:CAS:528: DyaK1MXnvFSksLc%3D 10580504
85. JC Milne PD Lambert S Schenk DP Carney JJ Smith DJ Gagne L Jin O Boss RB Perni CB Vu JE Bemis R Xie JS Disch PY Ng JJ Nunes AV Lynch H Yang H Galonek K Israelian W Choy A Iffland S Lavu O Medvedik DA Sinclair JM Olefsky MR Jirousek PJ Elliott CH Westphal 2007 Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes Nature 450 712 716 1:CAS:528: DC%2BD2sXhtlKmtbrM 18046409
86. T Minamino I Komuro 2007 Vascular cell senescence: contribution to atherosclerosis Circ Res 100 15 26 1:CAS:528:DC%2BD28XhtlGiurjK 17204661
87. T Minamino H Miyauchi K Tateno T Kunieda I Komuro 2004 Akt-induced cellular senescence: implication for human disease Cell Cycle 3 449 451 1:CAS:528:DC%2BD2cXhtVSis77P 15004530
88. T Minamino H Miyauchi T Yoshida K Tateno T Kunieda I Komuro 2004 Vascular cell senescence and vascular aging J Mol Cell Cardiol 36 175 183 1:CAS:528:DC%2BD2cXhtVOlsLk%3D 14871544
89. W Ming Cao K Murao H Imachi M Sato T Nakano T Kodama Y Sasaguri NC Wong J Takahara T Ishida 2001 Phosphatidylinositol 3-OH kinase-Akt/protein kinase B pathway mediates Gas6 induction of scavenger receptor a in immortalized human vascular smooth muscle cell line Arterioscler Thromb Vasc Biol 21 1592 1597 1:STN:280:DC%2BD3MrltV2lsw%3D%3D 11597931
90. H Miyauchi T Minamino K Tateno T Kunieda H Toko I Komuro 2004 Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway Embo J 23 212 220 1:CAS:528:DC%2BD2cXhtVequr0%3D 14713953
91. C Morisco G Condorelli V Trimarco A Bellis C Marrone G Condorelli J Sadoshima B Trimarco 2005 Akt mediates the cross-talk between beta-adrenergic and insulin receptors in neonatal cardiomyocytes Circ Res 96 180 188 1:CAS:528:DC%2BD2MXnt1ehuw%3D%3D 15591229
92. C Napoli I Martin-Padura F de Nigris M Giorgio G Mansueto P Somma M Condorelli G Sica G De Rosa P Pelicci 2003 Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet Proc Natl Acad Sci USA 100 2112 2116 1:CAS:528:DC%2BD3sXhsFGrtrk%3D 12571362
93. A Natalicchio F De Stefano S Perrini L Laviola A Cignarelli C Caccioppoli A Quagliara M Melchiorre A Leonardini A Conserva F Giorgino 2009 Involvement of the p66Shc protein in glucose transport regulation in skeletal muscle myoblasts Am J Physiol Endocrinol Metab 296 E228 E237 1:CAS:528:DC%2BD1MXitVaqs7s%3D 18957618
94. A Natalicchio L Laviola C De Tullio LA Renna C Montrone S Perrini G Valenti G Procino M Svelto F Giorgino 2004 Role of the p66Shc isoform in insulin-like growth factor I receptor signaling through MEK/Erk and regulation of actin cytoskeleton in rat myoblasts J Biol Chem 279 43900 43909 1:CAS:528:DC%2BD2cXot1ygt7o%3D 15262993
95. O Naveiras V Nardi PL Wenzel PV Hauschka F Fahey GQ Daley 2009 Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment Nature 460 259 263 1:CAS:528:DC%2BD1MXntV2js78%3D 19516257
96. T Nishikawa D Kukidome K Sonoda K Fujisawa T Matsuhisa H Motoshima T Matsumura E Araki 2007 Impact of mitochondrial ROS production in the pathogenesis of insulin resistance Diabetes Res Clin Pract 77 Suppl 1 S161 S164 1:CAS:528:DC%2BD2sXovFeisL8%3D 17481767
97. L Niskanen 1996 Insulin treatment in elderly patients with non-insulin-dependent diabetes mellitus. A double-edged sword? Drugs Aging 8 183 192 1:CAS:528:DyaK28XntVCntbs%3D 8720744
98. CJ O'Donnell S Demissie M Kimura D Levy JP Gardner C White RB D'Agostino PA Wolf J Polak LA Cupples A Aviv 2008 Leukocyte telomere length and carotid artery intimal medial thickness: the Framingham heart study Arterioscler Thromb Vasc Biol 28 1165 1171 18388332
99. SW Oh A Mukhopadhyay N Svrzikapa F Jiang RJ Davis HA Tissenbaum 2005 JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16 Proc Natl Acad Sci U S A 102 4494 4499 1:CAS:528:DC%2BD2MXivFCru7s%3D 15767565
100. E Pagnin G Fadini R de Toni A Tiengo L Calo A Avogaro 2005 Diabetes induces p66shc gene expression in human peripheral blood mononuclear cells: relationship to oxidative stress J Clin Endocrinol Metab 90 1130 1136 1:CAS:528:DC%2BD2MXhsVCgtbw%3D 15562031
101. S Pal MK Poddar 2008 Dietary protein-carbohydrate ratio: exogenous modulator of immune response with age Immunobiology 213 557 566 1:CAS:528:DC%2BD1cXhtFant73J 18656703
102. J Papaconstantinou 2009 Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination Mol Cell Endocrinol 299 89 100 1:CAS:528:DC%2BD1MXhtVCns74%3D 19103250
103. M Pellegrini S Pacini CT Baldari 2005 p66SHC: the apoptotic side of Shc proteins Apoptosis 10 13 18 1:CAS:528:DC%2BD2MXhsVWmsbc%3D 15711918
104. CJ Percy L Brown DA Power DW Johnson GC Gobe 2009 Obesity and hypertension have differing oxidant handling molecular pathways in age-related chronic kidney disease Mech Ageing Dev 130 129 138 1:CAS:528: DC%2BD1MXhs1CjsLk%3D 19041334
105. JE Pessin AL Frattali 1993 Molecular dynamics of insulin/IGF-I receptor transmembrane signaling Mol Reprod Dev 35 339 344 1:CAS:528:DyaK2cXpsF2luw%3D%3D 8398111 discussion 344-335
106. PT Pfluger D Herranz S Velasco-Miguel M Serrano MH Tschop 2008 Sirt1 protects against high-fat diet-induced metabolic damage Proc Natl Acad Sci U S A 105 9793 9798 1:CAS:528:DC%2BD1cXovVKrs78%3D 18599449
107. P Pinton A Rimessi S Marchi F Orsini E Migliaccio M Giorgio C Contursi S Minucci F Mantovani MR Wieckowski G Del Sal PG Pelicci R Rizzuto 2007 Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc Science 315 659 663 1:CAS:528:DC%2BD2sXhtVyisLo%3D 17272725
108. S Purdom QM Chen 2003 p66(Shc): at the crossroad of oxidative stress and the genetics of aging Trends Mol Med 9 206 210 1:CAS:528:DC%2BD3sXjvFWnsrs%3D 12763525
109. N Rasouli B Molavi SC Elbein PA Kern 2007 Ectopic fat accumulation and metabolic syndrome Diabetes Obes Metab 9 1 10 1:CAS:528:DC%2BD2sXitlCgs7c%3D 17199713
110. E Ravussin LM Redman 2009 Adiposity and comorbidities: favorable impact of caloric restriction Nestle Nutr Workshop Ser Pediatr Program 63 135 146 19346773 discussion 147-150, 259-168
111. PM Ridker CH Hennekens JE Buring N Rifai 2000 C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women N Engl J Med 342 836 843 1:CAS:528:DC%2BD3cXisVensrs%3D 10733371 (Pubitemid 30165206)
112. O Sagi M Wolfson N Utko K Muradian V Fraifeld 2005 p66ShcA and ageing: modulation by longevity-promoting agent aurintricarboxylic acid Mech Ageing Dev 126 249 254 1:CAS:528:DC%2BD2cXhtFGhsb%2FJ 15621204
113. KD Salpea V Nicaud L Tiret PJ Talmud SE Humphries 2008 The association of telomere length with paternal history of premature myocardial infarction in the European atherosclerosis research study II J Mol Med 86 815 824 18414821
114. AR Saltiel JE Pessin 2002 Insulin signaling pathways in time and space Trends Cell Biol 12 65 71 1:CAS:528:DC%2BD38XhtFyrtbY%3D 11849969
115. JN Sampayo A Olsen GJ Lithgow 2003 Oxidative stress in Caenorhabditis elegans: protective effects of superoxide dismutase/catalase mimetics Aging Cell 2 319 326 1:CAS:528:DC%2BD3sXpvV2gu7g%3D 14677634
116. MJ Sampson MS Winterbone JC Hughes N Dozio DA Hughes 2006 Monocyte telomere shortening and oxidative DNA damage in type 2 diabetes Diabetes Care 29 283 289 1:CAS:528:DC%2BD28Xhs1Kiur4%3D 16443874
117. YY Sautin T Nakagawa S Zharikov RJ Johnson 2007 Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress Am J Physiol Cell Physiol 293 C584 C596 1:CAS:528:DC%2BD2sXpt12rtLo%3D 17428837
118. K Selesniemi HJ Lee JL Tilly 2008 Moderate caloric restriction initiated in rodents during adulthood sustains function of the female reproductive axis into advanced chronological age Aging Cell 7 622 629 1:CAS:528: DC%2BD1cXht1ClsLfO 18549458
119. WHH Sheu T-M Chang W-J Lee H-C Ou C-M Wu L-N Tseng H-F Lang C-S Wu C-J Wan IT Lee 2008 Effect of weight loss on proinflammatory state of mononuclear cells in obese women Obesity 16 1033 1038 1:CAS:528:DC%2BD1cXltlGjt7s%3D 18356846
120. A Sjoholm T Nystrom 2005 Endothelial inflammation in insulin resistance Lancet 365 610 612 15708106
121. JL Stern TM Bryan 2008 Telomerase recruitment to telomeres Cytogenet Genome Res 122 243 254 1:CAS:528:DC%2BD1MXhtlGrtr4%3D 19188693
122. C Sun F Zhang X Ge T Yan X Chen X Shi Q Zhai 2007 SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B Cell Metab 6 307 319 1:CAS:528:DC%2BD2sXht1Sjsr3L 17908559
123. M Tatar A Kopelman D Epstein MP Tu CM Yin RS Garofalo 2001 A mutant drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function Science 292 107 110 1:CAS:528:DC%2BD3MXis1Grt74%3D 11292875
124. T Thum F Fleissner I Klink D Tsikas M Jakob J Bauersachs DO Stichtenoth 2007 Growth hormone treatment improves markers of systemic nitric oxide bioavailability via insulin-like growth factor-I J Clin Endocrinol Metab 92 4172 4179 1:CAS:528:DC%2BD2sXhtlartbzN 17726074
125. T Thum S Hoeber S Froese I Klink DO Stichtenoth P Galuppo M Jakob D Tsikas SD Anker PA Poole-Wilson J Borlak G Ertl J Bauersachs 2007 Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone- mediated increase of insulin-like growth-factor-1 Circ Res 100 434 443 1:CAS:528:DC%2BD2sXhsF2ku74%3D 17234973
126. L Tian Q Cai R Bowen H Wei 1995 Effects of caloric restriction on age-related oxidative modifications of macromolecules and lymphocyte proliferation in rats Free Radic Biol Med 19 859 865 1:CAS:528: DyaK2MXptVGjtb0%3D 8582660
127. E Vera A Canela MF Fraga M Esteller MA Blasco 2008 Epigenetic regulation of telomeres in human cancer Oncogene 27 6817 6833 1:CAS:528:DC%2BD1cXhtl2gsLfO 18762811
128. WJ Valentine AJPLNDCSR 2006 Improving life expectancy and decreasing the incidence of complications associated with type 2 diabetes: a modelling study of HbA1c targets Int J Clin Pract 60 1138 1145
129. CR Walkley GA McArthur LE Purton 2005 Cell division and hematopoietic stem cells: not always exhausting Cell Cycle 4 893 896 1:CAS:528: DC%2BD28XhslCrurw%3D 15970708
130. L Wang TC Schulz ES Sherrer DS Dauphin S Shin AM Nelson CB Ware M Zhan C-Z Song X Chen SN Brimble A McLean MJ Galeano EW Uhl KA D'Amour JD Chesnut MS Rao CA Blau AJ Robins 2007 Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling Blood 110 4111 4119 1:CAS:528:DC%2BD2sXhtl2qsbzL 17761519
131. MC Wang D Bohmann H Jasper 2005 JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling Cell 121 115 125 1:CAS:528:DC%2BD2MXjsVaksLw%3D 15820683
132. SP Weisberg D McCann M Desai M Rosenbaum RL Leibel AW Ferrante Jr 2003 Obesity is associated with macrophage accumulation in adipose tissue J Clin Invest 112 1796 1808 1:CAS:528:DC%2BD3sXhtVSmtLvO 14679176
133. KE Wellen GS Hotamisligil 2003 Obesity-induced inflammatory changes in adipose tissue J Clin Invest 112 1785 1788 1:CAS:528:DC%2BD3sXhtVSmtLrE 14679172
134. C Werner M Hanhoun T Widmann A Kazakov A Semenov J Poss J Bauersachs T Thum M Pfreundschuh P Muller J Haendeler M Bohm U Laufs 2008 Effects of physical exercise on myocardial telomere-regulating proteins, survival pathways, and apoptosis J Am Coll Cardiol 52 470 482 1:CAS:528:DC%2BD1cXpt1GrsLw%3D 18672169
135. P Weyrich F Machicao J Reinhardt J Machann F Schick O Tschritter N Stefan A Fritsche HU Haring 2008 SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention-the TULIP Study BMC Med Genet 9 100 19014491
136. MF White 2003 Insulin signaling in health and disease Science 302 1710 1711 1:CAS:528:DC%2BD3sXpsVWns7s%3D 14657487
137. LS Wong H Oeseburg RA de Boer WH van Gilst DJ van Veldhuisen P van der Harst 2009 Telomere biology in cardiovascular disease: the TERC-/- mouse as a model for heart failure and ageing Cardiovasc Res 81 244 252 1:CAS:528:DC%2BD1MXntVOjtQ%3D%3D 19047341
138. WS Xu RB Parmigiani PA Marks 2007 Histone deacetylase inhibitors: molecular mechanisms of action Oncogene 26 5541 5552 1:CAS:528: DC%2BD2sXovFersrY%3D 17694093
139. T Yoshizaki JC Milne T Imamura S Schenk N Sonoda JL Babendure JC Lu JJ Smith MR Jirousek JM Olefsky 2009 SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes Mol Cell Biol 29 1363 1374 1:CAS:528:DC%2BD1MXitlylsrY%3D 19103747