-
1
-
-
0002398853
-
The biology of aging and longevity
-
Hazzard, W. et al., eds, McGraw-Hill
-
Miller, R. (1999) The biology of aging and longevity. In Principles of Geriatric Medicine and Gerontology (Hazzard, W. et al., eds), pp. 3-19, McGraw-Hill
-
(1999)
Principles of Geriatric Medicine and Gerontology
, pp. 3-19
-
-
Miller, R.1
-
2
-
-
0031916984
-
The free radical theory of aging matures
-
Beckman, K.B. and Ames, B.N. (1998) The free radical theory of aging matures. Physiol. Rev. 78, 547-581
-
(1998)
Physiol. Rev.
, vol.78
, pp. 547-581
-
-
Beckman, K.B.1
Ames, B.N.2
-
3
-
-
0033610079
-
Gene expression profile of aging and its retardation by caloric restriction
-
Lee, C.K. et al. (1999) Gene expression profile of aging and its retardation by caloric restriction. Science 285, 1390-1393
-
(1999)
Science
, vol.285
, pp. 1390-1393
-
-
Lee, C.K.1
-
4
-
-
0028220114
-
Extension of life-span by over-expression of superoxide dismutase and catalase in Drosophila melanogaster
-
Orr, W.C. and Sohal, R.S. (1994) Extension of life-span by over-expression of superoxide dismutase and catalase in Drosophila melanogaster. Science 263, 1128-1130
-
(1994)
Science
, vol.263
, pp. 1128-1130
-
-
Orr, W.C.1
Sohal, R.S.2
-
5
-
-
0024547664
-
Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity
-
Phillips, J.P. et al. (1989) Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity. Proc. Natl. Acad. Sci. U. S. A. 86, 2761-2765
-
(1989)
Proc. Natl. Acad. Sci. U. S. A.
, vol.86
, pp. 2761-2765
-
-
Phillips, J.P.1
-
6
-
-
0034284973
-
Extension of life-span with superoxide dismutase/catalase mimetics
-
Melov, S. et al. (2000) Extension of life-span with superoxide dismutase/catalase mimetics. Science 289, 1567-1569
-
(2000)
Science
, vol.289
, pp. 1567-1569
-
-
Melov, S.1
-
7
-
-
17344371881
-
Mutations in PROP1 cause familial combined pituitary hormone deficiency
-
Wu, W. et al. (1998) Mutations in PROP1 cause familial combined pituitary hormone deficiency. Nat. Genet. 18, 147-149
-
(1998)
Nat. Genet.
, vol.18
, pp. 147-149
-
-
Wu, W.1
-
8
-
-
0033784405
-
Gerontogenes mediate health and longevity in nematodes through increasing resistance to environmental toxins and stressors
-
Johnson, T.E. et al. (2000) Gerontogenes mediate health and longevity in nematodes through increasing resistance to environmental toxins and stressors. Exp. Gerontol. 35, 687-694
-
(2000)
Exp. Gerontol.
, vol.35
, pp. 687-694
-
-
Johnson, T.E.1
-
9
-
-
0034033586
-
Caloric restriction and aging: An update
-
Masoro, E.J. (2000) Caloric restriction and aging: an update. Exp. Gerontol. 35, 299-305
-
(2000)
Exp. Gerontol.
, vol.35
, pp. 299-305
-
-
Masoro, E.J.1
-
10
-
-
0031549576
-
Seminars in medicine of the Beth Israel Deaconess Medical Center. Caloric intake and aging
-
Weindruch, R. and Sohal, R.S. (1997) Seminars in medicine of the Beth Israel Deaconess Medical Center. Caloric intake and aging. New Engl. J. Med. 337, 986-994
-
(1997)
New Engl. J. Med.
, vol.337
, pp. 986-994
-
-
Weindruch, R.1
Sohal, R.S.2
-
11
-
-
0033581704
-
shc adaptor protein controls oxidative stress response and life span in mammals
-
shc adaptor protein controls oxidative stress response and life span in mammals. Nature 402, 309-313
-
(1999)
Nature
, vol.402
, pp. 309-313
-
-
Migliaccio, E.1
-
12
-
-
0030038103
-
Oxidative stress, caloric restriction, and aging
-
Sohal, R.S. and Weindruch, R. (1996) Oxidative stress, caloric restriction, and aging. Science 273, 59-63
-
(1996)
Science
, vol.273
, pp. 59-63
-
-
Sohal, R.S.1
Weindruch, R.2
-
13
-
-
0037192473
-
shc-dependent signaling pathway
-
shc-dependent signaling pathway. Science 295, 2450-2452
-
(2002)
Science
, vol.295
, pp. 2450-2452
-
-
Nemoto, S.1
Finkel, T.2
-
14
-
-
0033669885
-
Evolution of Shc functions from nematode to human
-
Luzi, L. et al. (2000) Evolution of Shc functions from nematode to human. Curr. Opin. Genet. Dev. 10, 668-674
-
(2000)
Curr. Opin. Genet. Dev.
, vol.10
, pp. 668-674
-
-
Luzi, L.1
-
15
-
-
0034990328
-
Shc signaling in differentiating neural progenitor cells
-
Conti, L. et al. (2001) Shc signaling in differentiating neural progenitor cells. Nat. Neurosci. 4, 579-586
-
(2001)
Nat. Neurosci.
, vol.4
, pp. 579-586
-
-
Conti, L.1
-
16
-
-
0032213730
-
Emerging roles for SH2/PTB-containing Shc adaptor proteins in the developing mammalian brain
-
Cattaneo, E. and Pelicci, P.G. (1998) Emerging roles for SH2/PTB-containing Shc adaptor proteins in the developing mammalian brain. Trends Neurosci. 21, 476-481
-
(1998)
Trends Neurosci.
, vol.21
, pp. 476-481
-
-
Cattaneo, E.1
Pelicci, P.G.2
-
17
-
-
0037151066
-
Shc longevity gene is silenced through epigenetic modifications of an alternative promoter
-
Shc longevity gene is silenced through epigenetic modifications of an alternative promoter. J. Biol. Chem. 277, 22370-22376
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 22370-22376
-
-
Ventura, A.1
-
18
-
-
0030199613
-
Not all Shc's roads lead to Ras
-
Bonfini, L. et al. (1996) Not all Shc's roads lead to Ras. Trends Biochem. Sci. 21, 257-261
-
(1996)
Trends Biochem. Sci.
, vol.21
, pp. 257-261
-
-
Bonfini, L.1
-
19
-
-
0030783255
-
The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway
-
Okada, S. et al. (1997) The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway. J. Biol. Chem. 272, 28042-28049
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 28042-28049
-
-
Okada, S.1
-
20
-
-
0037166236
-
Phosphatidylinositol 3-kinase is required for insulin-stimulated tyrosine phosphorylation of Shc in 3T3-L1 adipocytes
-
Ugi, S. et al. (2002) Phosphatidylinositol 3-kinase is required for insulin-stimulated tyrosine phosphorylation of Shc in 3T3-L1 adipocytes. J. Biol. Chem. 277, 18592-18597
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 18592-18597
-
-
Ugi, S.1
-
21
-
-
0031056755
-
shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway
-
shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway. EMBO J. 16, 706-716
-
(1997)
EMBO J.
, vol.16
, pp. 706-716
-
-
Migliaccio, E.1
-
22
-
-
0035854682
-
Shc and its association with 14-3-3 protein in glomerular mesangial cells
-
Shc and its association with 14-3-3 protein in glomerular mesangial cells. J. Biol. Chem. 276, 26640-26647
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 26640-26647
-
-
Foschi, M.1
-
23
-
-
0028032399
-
Activators of protein kinase C stimulate association of Shc and the PEST tyrosine phosphatase
-
Habib, T. et al. (1994) Activators of protein kinase C stimulate association of Shc and the PEST tyrosine phosphatase. J. Biol. Chem. 269, 25243-25246
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 25243-25246
-
-
Habib, T.1
-
24
-
-
0037119469
-
Serine/threonine phosphorylation of ShcA. Regulation of protein-tyrosine phosphatase-pest binding and involvement in insulin signaling
-
Faisal, A. et al. (2002) Serine/threonine phosphorylation of ShcA. Regulation of protein-tyrosine phosphatase-pest binding and involvement in insulin signaling. J. Biol. Chem. 277, 30144-30152
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 30144-30152
-
-
Faisal, A.1
-
25
-
-
0034031776
-
Endothelin-1 inhibits apoptosis of vascular smooth muscle cells induced by nitric oxide and serum deprivation via MAP kinase pathway
-
Shichiri, M. et al. (2000) Endothelin-1 inhibits apoptosis of vascular smooth muscle cells induced by nitric oxide and serum deprivation via MAP kinase pathway. Arterioscler. Thromb. Vasc. Biol. 20, 989-997
-
(2000)
Arterioscler. Thromb. Vasc. Biol.
, vol.20
, pp. 989-997
-
-
Shichiri, M.1
-
26
-
-
0030998473
-
Insulin stimulates the phosphorylation of the 66- and 52-kilodalton Shc isoforms by distinct pathways
-
Kao, A.W. et al. (1997) Insulin stimulates the phosphorylation of the 66- and 52-kilodalton Shc isoforms by distinct pathways. Endocrinology 138, 2474-2480
-
(1997)
Endocrinology
, vol.138
, pp. 2474-2480
-
-
Kao, A.W.1
-
27
-
-
0039425278
-
Negative regulation of the forkhead transcription factor FKHR by Akt
-
Tang, E.D. et al. (1999) Negative regulation of the forkhead transcription factor FKHR by Akt. J. Biol. Chem. 274, 16741-16746
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 16741-16746
-
-
Tang, E.D.1
-
28
-
-
0033546192
-
Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence
-
Guo, S. et al. (1999) Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence. J. Biol. Chem. 274, 17184-17192
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 17184-17192
-
-
Guo, S.1
-
29
-
-
0037017396
-
FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: Protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity
-
Dijkers, P.F. et al. (2002) FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. J. Cell Biol. 156, 531-542
-
(2002)
J. Cell Biol.
, vol.156
, pp. 531-542
-
-
Dijkers, P.F.1
-
30
-
-
0034609737
-
Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
-
Dijkers, P.F. et al. (2000) Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. Curr Biol. 10, 1201-1204
-
(2000)
Curr Biol.
, vol.10
, pp. 1201-1204
-
-
Dijkers, P.F.1
-
31
-
-
0037136563
-
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
-
Kops, G.J. et al. (2002) Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 419, 316-321
-
(2002)
Nature
, vol.419
, pp. 316-321
-
-
Kops, G.J.1
-
32
-
-
0035019007
-
Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse
-
Biggs, W.H. 3rd et al. (2001) Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse. Mamm. Genome 12, 416-425
-
(2001)
Mamm. Genome
, vol.12
, pp. 416-425
-
-
Biggs W.H. III1
-
33
-
-
0030659557
-
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
-
Ogg, S. et al. (1997) The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389, 994-999
-
(1997)
Nature
, vol.389
, pp. 994-999
-
-
Ogg, S.1
-
34
-
-
0030657540
-
daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
-
Lin, K. et al. (1997) daf-16: an HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 278, 1319-1322
-
(1997)
Science
, vol.278
, pp. 1319-1322
-
-
Lin, K.1
-
35
-
-
0034626747
-
Genetic pathways that regulate ageing in model organisms
-
Guarente, L. and Kenyon, C. (2000) Genetic pathways that regulate ageing in model organisms. Nature 408, 255-262
-
(2000)
Nature
, vol.408
, pp. 255-262
-
-
Guarente, L.1
Kenyon, C.2
-
36
-
-
0034769530
-
Relationship between increased longevity and stress resistance as assessed through gerontogene mutations in Caenorhabditis elegans
-
Johnson, T.E. et al. (2001) Relationship between increased longevity and stress resistance as assessed through gerontogene mutations in Caenorhabditis elegans. Exp. Gerontol. 36, 1609-1617
-
(2001)
Exp. Gerontol.
, vol.36
, pp. 1609-1617
-
-
Johnson, T.E.1
-
37
-
-
0032845215
-
Aging, DNA methylation and cancer
-
Issa, J.P. (1999) Aging, DNA methylation and cancer. Crit. Rev. Oncol. Hematol. 32, 31-43
-
(1999)
Crit. Rev. Oncol. Hematol.
, vol.32
, pp. 31-43
-
-
Issa, J.P.1
-
38
-
-
0036326662
-
DNA methylation and atherosclerosis
-
Dong, C. et al. (2002) DNA methylation and atherosclerosis. J. Nutr. 132, 2406S-2409S
-
(2002)
J. Nutr.
, vol.132
-
-
Dong, C.1
-
39
-
-
0036328026
-
Role of DNA methylation in the regulation of cell function: Autoimmunity, aging and cancer
-
Richardson, B.C. (2002) Role of DNA methylation in the regulation of cell function: autoimmunity, aging and cancer. J. Nutr. 132, 2401S-2405S
-
(2002)
J. Nutr.
, vol.132
-
-
Richardson, B.C.1
-
40
-
-
0030570416
-
Alterations of c-fos gene methylation in the processes of aging and tumorigenesis in human liver
-
Choi, E.K. et al. (1996) Alterations of c-fos gene methylation in the processes of aging and tumorigenesis in human liver. Mutat. Res. 354, 123-128
-
(1996)
Mutat. Res.
, vol.354
, pp. 123-128
-
-
Choi, E.K.1
-
41
-
-
0032831285
-
Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system
-
Post, W.S. et al. (1999) Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system. Cardiovasc. Res. 43, 985-991
-
(1999)
Cardiovasc. Res.
, vol.43
, pp. 985-991
-
-
Post, W.S.1
-
42
-
-
0032824713
-
Age-dependent alterations in mRNA level and promoter methylation of collagen α1(I) gene in human periodontal ligament
-
Takatsu, M. et al. (1999) Age-dependent alterations in mRNA level and promoter methylation of collagen α1(I) gene in human periodontal ligament. Mech. Ageing Dev. 110, 37-48
-
(1999)
Mech. Ageing Dev.
, vol.110
, pp. 37-48
-
-
Takatsu, M.1
-
43
-
-
0034854116
-
Methylation of the E-cadherin gene in bladder neoplasia and in normal urothelial epithelium from elderly individuals
-
Bornman, D.M. et al. (2001) Methylation of the E-cadherin gene in bladder neoplasia and in normal urothelial epithelium from elderly individuals. Am. J. Pathol. 159, 831-835
-
(2001)
Am. J. Pathol.
, vol.159
, pp. 831-835
-
-
Bornman, D.M.1
-
44
-
-
0037942739
-
Extended longevity in mice lacking the insulin receptor in adipose tissue
-
Bluher, M. et al. (2003) Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299, 572-574
-
(2003)
Science
, vol.299
, pp. 572-574
-
-
Bluher, M.1
|