Insulin-like growth facfor 1 (IGF-1) and aging: Controversies and new insights

Biogerontology

Volumn 4, Issue 1, 2003, Pages 1-8

  Bartke, A ^a   Chandrashekar, V ^a   Dominici, F ^b   Turyn, D ^b   Kinney, B ^a   Steger, R ^a   Kopchick, J J ^c  

^a SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Instituto de Quimica y Fisicoquimica Biologicas Buenos Aires   (Argentina)

^c OHIO UNIVERSITY   (United States)

Author keywords

Body size; Growth; Growth hormone; Insulin signaling; Insulin like growth factor 1; Long lived mice

Indexed keywords

GROWTH HORMONE; GROWTH HORMONE RECEPTOR; INSULIN; NEUROPROTECTIVE AGENT; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

AGING; BODY SIZE; CALORIC RESTRICTION; DELETION MUTANT; ENERGY RESOURCE; GENE FUNCTION; GROWTH REGULATION; HORMONE RESISTANCE; HUMAN; INSULIN SENSITIVITY; KNOCKOUT MOUSE; LIFESPAN; LONGEVITY; MACROMOLECULE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; REPRODUCTION; REVIEW; SIGNAL TRANSDUCTION; THERMOGENESIS; ANIMAL; GENETICS; LIFE EXPECTANCY; METABOLISM; PHYSIOLOGY; TRANSGENIC ANIMAL;

AGING; ANIMALS; ANIMALS, GENETICALLY MODIFIED; GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; LIFE EXPECTANCY; RECEPTOR, IGF TYPE 1; RECEPTORS, SOMATOTROPIN; SIGNAL TRANSDUCTION;

EID: 0037231580     PISSN: 13895729     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022448532248     Document Type: Review

References (73)

1. Adashi EY, Resnick CE, D'Ercole AJ, Svoboda ME and Van Wyk JJ (1985) Insulin-like growth factors as intraovarian regulators of granulosa cell growth and function. Endocr Rev 6: 400-418
2. Bartke A, Brown-Borg H, Kinney B, Mattison J, Wright C, Hauck S, Coschigano K and Kopchick J (2000) Growth hormone and aging. J Am Aging Assoc 23: 219-225
3. Bartke A, Wright JC, Mattison J, Ingram DK, Miller RA and Roth GS (2001) Extending the lifespan of long-lived mice. Nature 414: 412
4. Bartke A, Chandrashekar V, Bailey B, Zaczek D and Turyn D (2002) Consequences of growth hormone (GH) overexpression and GH resistance. Neuropeptides 36: 201-208
5. Baum HBA, Katznelson L, Sherman JC, Biller BMK, Hayden DL, Schoenfeld JC, Cannistraro KE and Klibanski A (1998) Effects of a physiological growth hormone (GH) therapy on cognition and quality of life in patients with adult-onset GH deficiency. J Clin Endocrinol Metab 83: 3184-3189
6. Baynes JW and Monnier VM (1989) The Maillard Reaction in Aging, Diabetes and Nutrition. Alan R. Liss, New York.
7. Brown-Borg HM, Borg KE, Meliska CJ and Bartke A (1996) Dwarf mice and the ageing process. Nature 384: 33
8. Butler AA, Yakar S and LeRoith D (2002) Insulin-like growth factor-I: compartmentalization within the somatotropic axis? News Physiol Sci 17: 82-85
9. Chan J, Stampfer M, Giovannucci E, Gann P, Ma J, Wilkinson P, Hennekens C and Pollak M (1998) Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science 279: 563-571
10. Chandrashekar V, Bartke A, Coschigano KT and Kopchick JJ (1999) Pituitary and testicular function in growth hormone receptor gene knockout mice. Endocrinology 140: 1082-1088
11. Chandrashekar V, Bartke A, Awoniyi CA, Tsai-Morris CH, Dufau ML, Russell LD and Kopchick JJ (2001) Testicular endocrine function in growth hormone receptor gene disrupted mice. Endocrinology 142: 3443-3450
12. Clancy DJ, Gems D, Harshman LG, Oldham S, Stocker H, Hafen E, Leevers SJ and Partridge L (2001) Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 292: 104-106
13. Clemmons DR (2001) Insulin-like growth factor-1 and its binding proteins. In: DeGroot LJ and Jameson JL (eds) Endocrinology 4th ed, Vol 1, Chapter 33, pp 439-460, WB Saunders, Philadelphia
14. Coschigano KT, Riders ME, Bellush LL and Kopchick JJ (1999) Glucose Metabolism in Growth Hormone Receptor/Binding Protein Gene Disrupted Mice. Annual Meeting, The Endocrine Society, San Diego, California, Abstract P3-537, p 553
15. Coschigano KT, Clemmons D, Bellush LL and Kopchick JJ (2000) Assessment of growth parameters and life span of GHR/BP gene-disrupted mice. Endocrinology 141: 2608-2613
16. Danilovich N, Wernsing D, Coschigano KT, Kopchick JJ and Bartke A (1999) Deficits in female reproductive function in GH-R-KO mice: role of IGF-I. Endocrinology 140: 2637-2640
17. D'Costa AP, Lenham JE, Ingram RL and Sonntag WE (1993) Moderate caloric restriction increases type 1 IGF receptors and protein synthesis in aging rats. Mech Ageing Dev 71(1-2): 59-71
18. Dominici FP, Arostegui Diaz G, Bartke A, Kopchick JJ and Turyn D (2000) Compensatory alterations of insulin signal transduction in liver of growth hormone receptor knockout mice. J Endocrinol 166: 579-590
19. Dupont J, Khan J, Qu B-H, Metzler P, Helman L and LaRoith D (2001) Insulin and IGF-I induce different patterns of gene expression in mouse fibroblast NIH-3T3 cells: identification by cDNA microarray analysis. Endocrinology 142: 4969-4975
20. Eigenmann JE, Amador A and Patterson DF (1988) Insulin-like growth factor I levels in proportionate dogs, chondrodystrophic dogs and in giant dogs. Acta Endocrinol 118: 105-108
21. Eklund J and Bradford CE (1977) Longevity and lifetime body weight in mice selected for rapid growth. Nature 265: 48-49
22. Esquifino AI, Villanúa MA, Szary A, Yau J and Bartke A (1991) Ectopic pituitary transplants restore immunocompetence in Ames dwarf mice. Acta Endocrinol 125: 67-72
23. Facchini FS, Hua N, Abbasi F and Reaven GM (2001) Insulin resistance as a predictor of age-related diseases. J Clin Endocrinol Metab 86: 3574-3578
24. Flurkey K, Papaconstantinou J, Miller RA and Harrison DE (2001) Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc Natl Acad Sci USA 98: 6736-6741
25. Forster MJ, Sumien N, Morris P and Sohal RS (2002) Genotype and age influence the effect of caloric restriction on mortality. In: Aging from Molecules to Humans; 31st Annual Meeting of the American Aging Association; 16th Annual Meeting of the American College of Clinical Gerontology, San Diego, California
26. French RA, Broussard SR, Meier WA, Minshall C, Arkins S, Zachary JF, Dantzer R and Kelley KW (2002) Age-associated loss of bone marrow hematopoietic cells is reversed by GH and accompanies thymic reconstitution. Endocrinology 143: 690-699
27. Friedlander AL, Butterfield GE, Moynihan S, Grillo J, Pollack M, Holloway L, Friedman L, Yesavage J, Matthias D, Lee S, Marcus R and Hoffman AR (2001) One year of insulin-like growth factor I treatment does not affect bone density, body composition, or psychological measures in postmenopausal women. J Clin Endocrinol Metab 86: 1496-1503
28. Gala RR and Shevach EM (1993) Influence of prolactin and growth hormone on the activation of dwarf mouse lymphocytes in vivo. Proc Soc Exp Biol Med 204: 224-230
29. Garcia-Segura LM, Cardona-Gomez GP, Chowen JA and Azcoitia I (2000) Insulin-like growth factor-I receptors and estrogen receptors interact in the promotion of neuronal survival and nuroprotection. J Neurocytol 29(5-6): 425-437
30. Gnessi L, Fabbri A and Spera G (1997) Gonadal peptides as mediators of development and functional control of the testis: an integrated system with hormones and local environment. Endocr Rev 18: 541-590
31. Groesbeck MD, Parlow AF and Daughaday WH (1987) Stimulation of supranormal growth in pubertal, adult plateaued, and hypophysectomized female rats by large doses of rat growth hormone: physiological effects and adverse consequences. Endocrinology 120: 1963-1975
32. Hall MA, Bartke A and Martinko JM (2002) Humoral immune response in mice overexpressing or deficient in growth hormone. Exp Biol Med 227: 535-544
33. Hauck SJ, Hunter WS, Danilovich N, Kopchick JJ and Bartke A (2001) Reduced levels of thyroid hormones, insulin, and glucose, and lower body core temperature in the growth hormone receptor/binding protein knockout mouse. Exp Biol Med 226: 552-558
34. Hebert PR, Ajani U, Cook NR, Lee IM, Chan KS and Hennekens CH (1997) Adult height and incidence of cancer in male physicians. (United States). Cancer Causes Control 8: 591-597
35. Heck S, Lezoualch F, Engert S and Bahl C (1999) Insulin-like growth factor-I mediated neuroprotection against oxidative stress is associated with activation of nuclear factor kappaB. J Biol Chem 274: 9823-9835
36. Hiney JK, Srivastava V, Nyberg CL, Ojeda SR and Dees WL (1996) Insulin-like growth factor I of peripheral origin acts centrally to accelerate the initiation of female puberty. Endocrinology 137: 3717-3728
37. Hsieh C-C, DeFord JH, Flurkey K, Harrison DE and Papaconstantinou J (2002a) Implications of the insulin signaling pathway in Snell dwarf mouse longevity: a similarity with the C. elegans longevity paradigm. Mech Ageing Dev 123: 1229-1243
38. Hsieh C-C, DeFord JH, Flurkey K, Harrison DE and Papaconstantinou J (2002b) Effects of the Pit 1 mutation on the insulin signaling pathway: implications on the longevity of the long-lived Snell dwarf mouse. Mech Ageing Dev 123: 1244-1255
39. Kalu DN, Orhii PB, Chen C, Lee DY, Hubbard GB, Lee S and Olatunjibello Y (1998) Aged-rodent models of long-term growth hormone therapy - lack of deleterious effect on longevity. J Gerontol: Biol Sci Med Sci 53: B452-B463
40. Khansari DN and Gustad T (1991) Effects of long-term, low-dose growth hormone therapy on immune function and life expectancy of mice. Mech Ageing Dev 57: 87-100
41. Kinney BA, Coschigano KT, Kopchick JJ and Bartke A (2001a) Evidence that age-induced decline in memory retention is delayed in growth hormone resistant GH-R-KO (Laron) mice. Physiol Behav 72: 653-660
42. Kinney BA, Meliska CJ, Steger RW and Bartke A (2001b) Evidence that Ames dwarf mice age differently from their normal siblings in behavioral and learning and memory parameters. Horm Behav 39: 277-284
43. Krzisnik C, Kolacio Z, Battelino T, Brown M, Parks JS and Laron Z (1999) The 'Little People' of the island of Krk - revisited. Etiology of hypopituitarism revealed. The Journal of Endocrine Genetics 1: 9-19
44. LeRoith D, Bondy CA, Yakar S, Liu J-L and Butler A (2001) The somatomedin hypothesis. Endocr Rev 22: 53-74
45. Lichtenwalner RJ, Forbes ME, Bennett SA, Lynch CD, Sonntag WE and Riddle DR (2001) Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis. Neuroscience 107: 603-613
46. Liu J-P, Baker J, Perkins AS, Robertson EJ and Efstratiadis A (1993) Mice carrying null mutations of the genes encoding insulin-like growth factor 1 (Igf1) and type 1 IGF receptor (Igf2r). Cell 75: 59-72
47. Lupu F, Terwillinger JD, Lee K, Segre GV and Efstratiadis A (2001) Roles of growth hormone and insulin-like growth factor I in mouse postnatal growth. Dev Biol 229: 141-162
48. Maison P, Balkau B, Simon D, Chanson P, Rosselin G and Eschwège E (1998) Growth hormone as a risk for premature mortality in healthy subjects: data from the Paris prospective study. BMJ 316: 1132-1133
49. Markowska AL, Mooney M and Sonntag WE (1998) Insulin-like growth factor-I (IGF-I) ameliorates age-related behavioral deficits. Neuroscience 87: 559-569
50. Masoro EJ (2001) Dietary restriction: an experimental approach to the study of the biology of aging. In: Masoro EJ and Austad SN (eds) Handbook of The Biology of Aging, 5th ed. Academic Press, San Diego, California
51. Mattison JA, Wright JC, Bronson RT, Roth GS, Ingram DK and Bartke A (2000) Studies of aging in Ames dwarf mice: effects of caloric restriction. J Am Aging Assoc 23: 9-16
52. McCarty MF (2003) A low-fat, whole-food vegan diet, as well as other strategies that down-regulate IGF-I activity, may slow the human aging process. Medical Hypotheses (in press)
53. Ong K, Kratzsch J, Kiess W, Dunger D and ALSPAC Study Team (2002) Circulating IGF-I levels in childhood are related to both current body composition and early postnatal growth rate. J Clin Endocrinol Metab 87: 1042-1044
54. Orme SM, McNally RJQ, Cartwright RA and Belchetz PE (1998) Mortality and cancer incidence in acromegaly: a retrospective cohort study. J Clin Endocrinol Metab 83: 2730-2734
55. Paolisso G, Gambardella A, Ammendola S, D'Amore A, Balbi V, Varricchio M and D'Onofrio F (1996) Glucose tolerance and insulin action in healthy centenarians. Am J Physiol 270: E890-E894
56. Paolisso G, Barbieri M, Rizzo MR, Carella C, Rotondi M, Bonafe M, Franceschi C, Rose G and De Benedictis G (2001) Low insulin resistance and preverved beta-cell function contribute to human longevity but are not associated with TH-INS genes. Exp Gerontol 37: 149-156
57. Papadakis MA, Grady D, Black D, Tierney MJ, Gooding GA, Schambelan M and Grunfeld C (1996) Growth hormone replacement in healthy older men improves body composition but not functional ability. Ann Intern Med 124: 708-716
58. Parr T (1997) Insulin exposure and aging theory. Gerontology 43: 182-200
59. Patronek GJ, Waters DJ and Glickman LT (1997) Comparative longevity of pet dogs and humans: implications for gerontology research. J Gerontol 52A: B171-B178
60. Roberts RC (1961) The lifetime growth and reproduction of selected strains of mice. Heredity 16: 369-381
61. Rudman D, Feller AG, Nagraj HS, Gergans GA, Lalitha PY, Goldberg AF, Schlenker RA, Cohn L, Rudman IW and Mattson DE (1990) Effects of human growth hormone in men over 60 years old. New Engl J Med 323: 1-6
62. Sacca L, Cittadini A and Fazio S (1994) Growth hormone and the heart. Endocr Rev 15: 555-573
63. Samaras TT and Elrick H (2002) Less is better. J Natl Med Assoc 94: 88-99
64. Sjogren K, Bohlooly YM, Olsson B, Coschigano K, Tornell J, Mohan S, Isaksson OGP, Baumann G, Kopchick J and Ohlsson C (2000) Disproportional skeletal growth and markedly decreased bond mineral content in growth hormone receptor -/- mice. Biochem Biophys Res Commun 267: 603-608
65. Sonntag WE, Cefalu WT, Ingram RL, Bennett SA, Lynch CD, Cooney PT, Thornton PL and Khan AS (1999) Pleiotropic effects of growth hormone and insulin-like growth factor (IGF) on biological aging: inferences from moderate caloric restricted animals. J Gerontol 54A: B521-B538
66. Sonntag WE, Lynch C, Thornton P, Khan A, Bennett S and Ingram R (2000) The effects of growth hormone and IGF-I deficiency on cerebrovascular and brain ageing. J Anat 4: 575-585
67. Sortino MA and Caboibucim OK (1996) Neuroprotective effect of insulin-like growth factor I in immortalized hypothalamic cells. Endocrinology 137: 1416-1422
68. Tatar M, Kopelman A, Epstein D, Tu M-P, Yin C-M and Garofalo RS (2001) A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 292: 107-110
69. Tretli S (1989) Height and weight in relation to breast cancer morbidity and mortality. A prospective study of 570,000 women in Norway. Int J Cancer 44: 23-30
70. Vance ME and Mauras N (1999) Growth hormone therapy in adults and children. New Engl J Med 341: 1206-1216
71. Wolf E, Kahnt E, Ehrlein J, Hermanns W, Brem G and Wanke R (1993) Effects of long-term elevated serum levels of growth hormone on life expectancy of mice: lessons from transgenic animal models. Mech Ageing Dev 68: 71-87
72. Zaczek DJ, Hammond JM, Suen L, Wandji S, Service D, Bartke A, Chandrashekar V, Coschigano K and Kopchick J (2002) Impact of growth hormone resistance on female reproductive function: new insight from growth hormone receptor knockout mice. Biol Reprod 67: 1115-1124
73. Zhou Y, Xu BC, Maheshwari HG, He L, Reed M, Lozykowski M, Okada S, Wagner TE, Cataldo LA, Coschigano K, Baumann G and Kopchick JJ (1997) A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (The Laron mouse). Proc Natl Acad Sci USA 94: 13215-13220