Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway

Nature Immunology

Volumn 9, Issue 10, 2008, Pages 1157-1164

  Cao, Weiping ^a   Manicassamy, Santhakumar ^a   Tang, Hua ^a   Kasturi, Sudhir Pai ^a   Pirani, Ali ^b   Murthy, Niren ^c   Pulendran, Bali ^a,b  

^a EMORY UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; DNA; INTERFERON; INTERFERON REGULATORY FACTOR 7; MAMMALIAN TARGET OF RAPAMYCIN; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHATIDYLINOSITOL 3 KINASE; RAPAMYCIN; S6 KINASE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 9;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTING CELL; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; CPG ISLAND; CYTOKINE PRODUCTION; DENDRITIC CELL; ENCAPSULATION; GENE EXPRESSION; GENETIC TRANSFECTION; IMMUNOASSAY; IMMUNOBLOTTING; IN VIVO STUDY; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; REGULATORY MECHANISM; VIRUS STRAIN; YELLOW FEVER FLAVIVIRUS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; DENDRITIC CELLS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMANS; IMMUNOBLOTTING; IMMUNOSUPPRESSIVE AGENTS; INTERFERON TYPE I; MICE; MICE, KNOCKOUT; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN KINASES; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; SIROLIMUS; TOLL-LIKE RECEPTOR 9; TRANSFECTION;

EID: 52549127241     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.1645     Document Type: Article

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