A Drosophila MAPKKK, D-MEKK1, mediates stress responses through activation of p38 MAPK

EMBO Journal

Volumn 20, Issue 19, 2001, Pages 5421-5430

  Inoue, H ^a   Tateno, M ^a   Fujimura Kamada, K ^a   Takaesu, G ^a   Adachi Yamada, T ^a   Ninomiya Tsuji, J ^a   Irie, K ^a   Nishida, Y ^a   Matsumoto, K ^a  

^a NAGOYA UNIVERSITY   (Japan)

Author keywords

Drosophila; MAPKKK; P38 MAPK; Stress responses

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; PROTEIN SERINE THREONINE KINASE; SYNAPTOPHYSIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DROSOPHILA; ENZYME ACTIVATION; HYPEROSMOLARITY; MAMMAL CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; SEQUENCE HOMOLOGY; STRESS; THERMOSTABILITY;

ADAPTATION, BIOLOGICAL; AMINO ACID SEQUENCE; ANIMALS; DROSOPHILA; ENVIRONMENT; ENZYME ACTIVATION; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR SEQUENCE DATA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0035477853     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.19.5421     Document Type: Article

References (46)

1. Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing
2. p38 mitogen-activated protein kinase can be involved in transforming growth factor β superfamily signal transduction in Drosophila wing morphogenesis
3. Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3: Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase
4. Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling
5. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
6. Functional cDNA libraries from Drosophila embryos
7. A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases
8. 2-terminal kinase through the small G proteins Ras and Rac
9. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
10. Stress-activated protein kinase-2/38 and a rapamycin-sensitive pathway are required for C2C12 myogenesis
11. Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase
12. MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42
13. Isolation of Drosophila cyclin D, a protein expressed in the morphogenetic furrow before entry into S phase
14. Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway
15. PH domain: The first anniversary
16. hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movement
17. Molecular cloning and characterization of a Drosophila p38 mitogen-activated protein kinase
18. A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression
19. MAP kinase pathways in yeast: For mating and more
20. + exchange through distinct Cdc42-dependent and RhoA-dependent pathways
21. Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade
22. Signal transduction by the c-Jun N-terminal kinase (JNK) from inflammation to development
23. A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons
24. Sounding the alarm: Protein kinase cascades activated by stress and inflammation
25. A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf
26. PH domains: Diverse sequences with a common fold recruit signaling molecules to the cell surface
27. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs
28. Requirement of p38 mitogen-activated protein kinase for neuronal differentiation in PC12 cells
29. The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway
30. JNK signaling and morphogenesis in Drosophila
31. Intercellular signaling and the polarization of body axes during Drosophila oogenesis
32. The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye
33. Mitogen-activated protein kinase pathways
34. A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila
35. The role of RhoA in tissue polarity and Frizzled signalling
36. NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain
37. The Drosophila p38 MAPK pathway is required during oogenesis for egg asymmetric development
38. TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development
39. A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways
40. New pCaSpeR P-element vectors
41. M-spondin, a novel ECM protein highly homologous to vertebrate F-spondin, is localized at the muscle attachment sites in the Drosophila embryo
42. Pk92B: A Drosophila melanogaster protein kinase that belongs to the MEKK family
43. Identification of 2 serine residues of MEK-1 that are differentially phosphorylated during activation by faf and MEK kinase
44. 2-terminal kinase activation in response to changes in the microtubule cytoskeleton
45. p38 mitogen-activated protein kinase pathway promotes skeletal muscle differentiation. Participation of the Mef2c transcription factor