-
1
-
-
27644562426
-
Pharmacokinetic interaction between tenofovir and atazanavir coadministration with ritonavir in healthy subjects
-
Quebec City, Canada
-
Agarwala S., Eley T., Villegas C., Wang Y., Hughes E., and Grasela D. Pharmacokinetic interaction between tenofovir and atazanavir coadministration with ritonavir in healthy subjects. 6th International Workshop on Clinical Pharmacology of HIV Therapy, Abstract 16. Quebec City, Canada (2005)
-
(2005)
6th International Workshop on Clinical Pharmacology of HIV Therapy, Abstract 16
-
-
Agarwala, S.1
Eley, T.2
Villegas, C.3
Wang, Y.4
Hughes, E.5
Grasela, D.6
-
2
-
-
0023656787
-
Initial studies on the cellular pharmacology of 2′,3′-dideoxyinosine, an inhibitor of HIV infectivity
-
Ahluwalia G., Cooney D.A., Mitsuya H., Fridland A., Flora K.P., Hao Z., Dalal M., Broder S., and Johns D.G. Initial studies on the cellular pharmacology of 2′,3′-dideoxyinosine, an inhibitor of HIV infectivity. Biochem. Pharmacol. 36 (1987) 3797-3800
-
(1987)
Biochem. Pharmacol.
, vol.36
, pp. 3797-3800
-
-
Ahluwalia, G.1
Cooney, D.A.2
Mitsuya, H.3
Fridland, A.4
Flora, K.P.5
Hao, Z.6
Dalal, M.7
Broder, S.8
Johns, D.G.9
-
3
-
-
0242333229
-
Antiviral dynamics and sex differences of zidovudine and lamivudine triphosphate concentrations in HIV-infected individuals
-
Anderson P.L., Kakuda T.N., Kawle S., and Fletcher C.V. Antiviral dynamics and sex differences of zidovudine and lamivudine triphosphate concentrations in HIV-infected individuals. AIDS 17 (2003) 2159-2168
-
(2003)
AIDS
, vol.17
, pp. 2159-2168
-
-
Anderson, P.L.1
Kakuda, T.N.2
Kawle, S.3
Fletcher, C.V.4
-
4
-
-
0032506055
-
Phenotypic mechanism of HIV-1 resistance to 3′-azido-3′-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase
-
Arion D., Kaushik N., McCormick S., Borkow G., and Parniak M.A. Phenotypic mechanism of HIV-1 resistance to 3′-azido-3′-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase. Biochemistry 37 (1998) 15908-15917
-
(1998)
Biochemistry
, vol.37
, pp. 15908-15917
-
-
Arion, D.1
Kaushik, N.2
McCormick, S.3
Borkow, G.4
Parniak, M.A.5
-
5
-
-
0029162556
-
Mammalian deoxyribonucleoside kinases
-
Arner E.S., and Eriksson S. Mammalian deoxyribonucleoside kinases. Pharmacol. Ther. 67 (1995) 155-186
-
(1995)
Pharmacol. Ther.
, vol.67
, pp. 155-186
-
-
Arner, E.S.1
Eriksson, S.2
-
6
-
-
39049101609
-
Tenofovir disoproxil fumarate, emtricitabine, and efavirenz compared with zidovudine/lamivudine and efavirenz in treatment-naive patients: 144-week analysis
-
Arribas J.R., Pozniak A.L., Gallant J.E., Dejesus E., Gazzard B., Campo R.E., Chen S.S., McColl D., Holmes C.B., Enejosa J., Toole J.J., and Cheng A.K. Tenofovir disoproxil fumarate, emtricitabine, and efavirenz compared with zidovudine/lamivudine and efavirenz in treatment-naive patients: 144-week analysis. J. Acquir. Immune Defic. Syndr. 47 (2008) 74-78
-
(2008)
J. Acquir. Immune Defic. Syndr.
, vol.47
, pp. 74-78
-
-
Arribas, J.R.1
Pozniak, A.L.2
Gallant, J.E.3
Dejesus, E.4
Gazzard, B.5
Campo, R.E.6
Chen, S.S.7
McColl, D.8
Holmes, C.B.9
Enejosa, J.10
Toole, J.J.11
Cheng, A.K.12
-
7
-
-
34447278547
-
Pharmacokinetics of the anti-human immunodeficiency virus agent 1-(beta-D-dioxolane)thymine in rhesus monkeys
-
Asif G., Hurwitz S.J., Obikhod A., Delinsky D., Narayanasamy J., Chu C.K., McClure H.M., and Schinazi R.F. Pharmacokinetics of the anti-human immunodeficiency virus agent 1-(beta-D-dioxolane)thymine in rhesus monkeys. Antimicrob. Agents Chemother. 51 (2007) 2424-2429
-
(2007)
Antimicrob. Agents Chemother.
, vol.51
, pp. 2424-2429
-
-
Asif, G.1
Hurwitz, S.J.2
Obikhod, A.3
Delinsky, D.4
Narayanasamy, J.5
Chu, C.K.6
McClure, H.M.7
Schinazi, R.F.8
-
8
-
-
0028205185
-
Metabolism and mechanism of antiretroviral action of purine and pyrimidine derivatives
-
Balzarini J. Metabolism and mechanism of antiretroviral action of purine and pyrimidine derivatives. Pharm. World Sci. 16 (1994) 113-126
-
(1994)
Pharm. World Sci.
, vol.16
, pp. 113-126
-
-
Balzarini, J.1
-
9
-
-
0023502171
-
2′,3′-Dideoxycytidine: regulation of its metabolism and anti-retroviral potency by natural pyrimidine nucleosides and by inhibitors of pyrimidine nucleotide synthesis
-
Balzarini J., Cooney D.A., Dalal M., Kang G.J., Cupp J.E., DeClercq E., Broder S., and Johns D.G. 2′,3′-Dideoxycytidine: regulation of its metabolism and anti-retroviral potency by natural pyrimidine nucleosides and by inhibitors of pyrimidine nucleotide synthesis. Mol. Pharmacol. 32 (1987) 798-806
-
(1987)
Mol. Pharmacol.
, vol.32
, pp. 798-806
-
-
Balzarini, J.1
Cooney, D.A.2
Dalal, M.3
Kang, G.J.4
Cupp, J.E.5
DeClercq, E.6
Broder, S.7
Johns, D.G.8
-
10
-
-
0035984791
-
Antiretrovirus activity of a novel class of acyclic pyrimidine nucleoside phosphonates
-
Balzarini J., Pannecouque C., De Clercq E., Aquaro S., Perno C.F., Egberink H., and Holy A. Antiretrovirus activity of a novel class of acyclic pyrimidine nucleoside phosphonates. Antimicrob. Agents Chemother. 46 (2002) 2185-2193
-
(2002)
Antimicrob. Agents Chemother.
, vol.46
, pp. 2185-2193
-
-
Balzarini, J.1
Pannecouque, C.2
De Clercq, E.3
Aquaro, S.4
Perno, C.F.5
Egberink, H.6
Holy, A.7
-
11
-
-
0020596551
-
Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS)
-
Barre-Sinoussi F., Chermann J.C., Rey F., Nugeyre M.T., Chamaret S., Gruest J., Dauguet C., Axler-Blin C., Vezinet-Brun F., Rouzioux C., Rozenbaum W., and Montagnier L. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science 220 (1983) 868-871
-
(1983)
Science
, vol.220
, pp. 868-871
-
-
Barre-Sinoussi, F.1
Chermann, J.C.2
Rey, F.3
Nugeyre, M.T.4
Chamaret, S.5
Gruest, J.6
Dauguet, C.7
Axler-Blin, C.8
Vezinet-Brun, F.9
Rouzioux, C.10
Rozenbaum, W.11
Montagnier, L.12
-
12
-
-
0033921632
-
In vitro selection of mutations in the human immunodeficiency virus type 1 reverse transcriptase that decrease susceptibility to (-)-beta-D-dioxolane-guanosine and suppress resistance to 3′-azido-3′-deoxythymidine
-
Bazmi H.Z., Hammond J.L., Cavalcanti S.C., Chu C.K., Schinazi R.F., and Mellors J.W. In vitro selection of mutations in the human immunodeficiency virus type 1 reverse transcriptase that decrease susceptibility to (-)-beta-D-dioxolane-guanosine and suppress resistance to 3′-azido-3′-deoxythymidine. Antimicrob. Agents Chemother. 44 (2000) 1783-1788
-
(2000)
Antimicrob. Agents Chemother.
, vol.44
, pp. 1783-1788
-
-
Bazmi, H.Z.1
Hammond, J.L.2
Cavalcanti, S.C.3
Chu, C.K.4
Schinazi, R.F.5
Mellors, J.W.6
-
13
-
-
10744229088
-
Monitoring of didanosine and stavudine intracellular trisphosphorylated anabolite concentrations in HIV-infected patients
-
Becher F., Landman R., Mboup S., Kane C.N., Canestri A., Liegeois F., Vray M., Prevot M.H., Leleu G., and Benech H. Monitoring of didanosine and stavudine intracellular trisphosphorylated anabolite concentrations in HIV-infected patients. AIDS 18 (2004) 181-187
-
(2004)
AIDS
, vol.18
, pp. 181-187
-
-
Becher, F.1
Landman, R.2
Mboup, S.3
Kane, C.N.4
Canestri, A.5
Liegeois, F.6
Vray, M.7
Prevot, M.H.8
Leleu, G.9
Benech, H.10
-
14
-
-
26044432728
-
In vitro activity of SPD754, a new deoxycytidine nucleoside reverse transcriptase inhibitor (NRTI), against 215 HIV-1 isolates resistant to other NRTIs
-
Bethell R.C., Lie Y.S., and Parkin N.T. In vitro activity of SPD754, a new deoxycytidine nucleoside reverse transcriptase inhibitor (NRTI), against 215 HIV-1 isolates resistant to other NRTIs. Antiviral Chem. Chemother. 16 (2005) 295-302
-
(2005)
Antiviral Chem. Chemother.
, vol.16
, pp. 295-302
-
-
Bethell, R.C.1
Lie, Y.S.2
Parkin, N.T.3
-
15
-
-
34547637722
-
In vitro interactions between apricitabine and other deoxycytidine analogues
-
Bethell R., De Muys J., Lippens J., Richard A., Hamelin B., Ren C., and Collins P. In vitro interactions between apricitabine and other deoxycytidine analogues. Antimicrob. Agents Chemother. 51 (2007) 2948-2953
-
(2007)
Antimicrob. Agents Chemother.
, vol.51
, pp. 2948-2953
-
-
Bethell, R.1
De Muys, J.2
Lippens, J.3
Richard, A.4
Hamelin, B.5
Ren, C.6
Collins, P.7
-
16
-
-
0036174438
-
Assessment of mitochondrial toxicity in human cells treated with tenofovir: comparison with other nucleoside reverse transcriptase inhibitors
-
Birkus G., Hitchcock M.J., and Cihlar T. Assessment of mitochondrial toxicity in human cells treated with tenofovir: comparison with other nucleoside reverse transcriptase inhibitors. Antimicrob. Agents Chemother. 46 (2002) 716-723
-
(2002)
Antimicrob. Agents Chemother.
, vol.46
, pp. 716-723
-
-
Birkus, G.1
Hitchcock, M.J.2
Cihlar, T.3
-
17
-
-
33846681607
-
Multidrug resistance-associated proteins 3, 4, and 5
-
Borst P., de Wolf C., and van de Wetering K. Multidrug resistance-associated proteins 3, 4, and 5. Pflugers Arch. 453 (2007) 661-673
-
(2007)
Pflugers Arch.
, vol.453
, pp. 661-673
-
-
Borst, P.1
de Wolf, C.2
van de Wetering, K.3
-
18
-
-
0034125257
-
Predictive value of treatment effects in SIV/SHIV infections in monkeys
-
Bottiger D., and Oberg B. Predictive value of treatment effects in SIV/SHIV infections in monkeys. Curr. Opin. Anti-Infect. Investig. Drugs 2 (2000) 255-264
-
(2000)
Curr. Opin. Anti-Infect. Investig. Drugs
, vol.2
, pp. 255-264
-
-
Bottiger, D.1
Oberg, B.2
-
19
-
-
0029927011
-
Cellular phosphorylation of anti-HIV nucleosides. Role of nucleoside diphosphate kinase
-
Bourdais J., Biondi R., Sarfati S., Guerreiro C., Lascu I., Janin J., and Veron M. Cellular phosphorylation of anti-HIV nucleosides. Role of nucleoside diphosphate kinase. J. Biol. Chem. 271 (1996) 7887-7890
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 7887-7890
-
-
Bourdais, J.1
Biondi, R.2
Sarfati, S.3
Guerreiro, C.4
Lascu, I.5
Janin, J.6
Veron, M.7
-
20
-
-
0032189850
-
Adverse effects of reverse transcriptase inhibitors: mitochondrial toxicity as common pathway
-
Brinkman K., ter Hofstede H.J., Burger D.M., Smeitink J.A., and Koopmans P.P. Adverse effects of reverse transcriptase inhibitors: mitochondrial toxicity as common pathway. AIDS 12 (1998) 1735-1744
-
(1998)
AIDS
, vol.12
, pp. 1735-1744
-
-
Brinkman, K.1
ter Hofstede, H.J.2
Burger, D.M.3
Smeitink, J.A.4
Koopmans, P.P.5
-
21
-
-
73549103358
-
The development of antiretroviral therapy and its impact on the global HIV/AIDS pandemic
-
Broder S. The development of antiretroviral therapy and its impact on the global HIV/AIDS pandemic. Antiviral Res. 85 (2010) 1-18
-
(2010)
Antiviral Res.
, vol.85
, pp. 1-18
-
-
Broder, S.1
-
22
-
-
67651167085
-
Risk of myocardial infarction and abacavir therapy: no increased risk across 52 GlaxoSmithKline-sponsored clinical trials in adult subjects
-
Brothers C.H., Hernandez J.E., Cutrell A.G., Curtis L., Ait-Khaled M., Bowlin S.J., Hughes S.H., Yeo J.M., and Lapierre D.H. Risk of myocardial infarction and abacavir therapy: no increased risk across 52 GlaxoSmithKline-sponsored clinical trials in adult subjects. J. Acquir. Immune Defic. Syndr. 51 (2009) 20-28
-
(2009)
J. Acquir. Immune Defic. Syndr.
, vol.51
, pp. 20-28
-
-
Brothers, C.H.1
Hernandez, J.E.2
Cutrell, A.G.3
Curtis, L.4
Ait-Khaled, M.5
Bowlin, S.J.6
Hughes, S.H.7
Yeo, J.M.8
Lapierre, D.H.9
-
24
-
-
33745869106
-
Efficacy and tolerability of 10-day monotherapy with apricitabine in antiretroviral-naive, HIV-infected patients
-
Cahn P., Cassetti I., Wood R., Phanuphak P., Shiveley L., Bethell R.C., and Sawyer J. Efficacy and tolerability of 10-day monotherapy with apricitabine in antiretroviral-naive, HIV-infected patients. AIDS 20 (2006) 1261-1268
-
(2006)
AIDS
, vol.20
, pp. 1261-1268
-
-
Cahn, P.1
Cassetti, I.2
Wood, R.3
Phanuphak, P.4
Shiveley, L.5
Bethell, R.C.6
Sawyer, J.7
-
25
-
-
73549083681
-
A phase I study to explore the safety, tolerability, and pharmacokinetics of Fosalvudine Tidoxil in patients infected with HIV-1
-
Toronto, Canada
-
Cahn P., Reuss F., Rolon M., Wit F., Boehm E., and Lange J. A phase I study to explore the safety, tolerability, and pharmacokinetics of Fosalvudine Tidoxil in patients infected with HIV-1. 16th International AIDS Conference, Abstract THLB0216. Toronto, Canada (2006)
-
(2006)
16th International AIDS Conference, Abstract THLB0216
-
-
Cahn, P.1
Reuss, F.2
Rolon, M.3
Wit, F.4
Boehm, E.5
Lange, J.6
-
26
-
-
73549122404
-
A phase-II study of 14 days monotherapy with the nucleoside-analogue fosalvudine tidoxil in treatment-naïve HIV-1 infected adults
-
Sydney, Australia
-
Cahn P., Schuermann D., Reuss F., Wit F., Boehm E., and Lange J. A phase-II study of 14 days monotherapy with the nucleoside-analogue fosalvudine tidoxil in treatment-naïve HIV-1 infected adults. 4th IAS Conference on Pathogenesis, Treatment, and Prevention, Abstract WEBEP114LB. Sydney, Australia (2007)
-
(2007)
4th IAS Conference on Pathogenesis, Treatment, and Prevention, Abstract WEBEP114LB
-
-
Cahn, P.1
Schuermann, D.2
Reuss, F.3
Wit, F.4
Boehm, E.5
Lange, J.6
-
27
-
-
35548934433
-
Racivir demonstrates safety and efficacy in patients harboring HIV with the M184V mutation and <3 TAM
-
Los Angeles, CA
-
Cahn P., Sosa N., Wiznia A., Patel M., Ward D., Palella F., Sierra-Madero J., Wheeler D., DeJesus E., Otto M., and Team R.S. Racivir demonstrates safety and efficacy in patients harboring HIV with the M184V mutation and <3 TAM. 14th Conference on Retroviruses and Opportunistic Infections, Abstract 488. Los Angeles, CA (2007)
-
(2007)
14th Conference on Retroviruses and Opportunistic Infections, Abstract 488
-
-
Cahn, P.1
Sosa, N.2
Wiznia, A.3
Patel, M.4
Ward, D.5
Palella, F.6
Sierra-Madero, J.7
Wheeler, D.8
DeJesus, E.9
Otto, M.10
Team, R.S.11
-
28
-
-
73549091300
-
48-week data from study AVX-201-a randomised phase IIb study of apricitabine in treatment-experienced patients with M184V and NRTI resistance
-
Cahn P., Altclas J., Martins M., Losso M., Cassetti I., Cox S., and Cooper D.A. 48-week data from study AVX-201-a randomised phase IIb study of apricitabine in treatment-experienced patients with M184V and NRTI resistance. J. Int. AIDS Soc. 11 Suppl. 1 (2008) O41
-
(2008)
J. Int. AIDS Soc.
, vol.11
, Issue.SUPPL. 1
-
-
Cahn, P.1
Altclas, J.2
Martins, M.3
Losso, M.4
Cassetti, I.5
Cox, S.6
Cooper, D.A.7
-
29
-
-
34250310413
-
Combination antiretroviral therapy without a nucleoside reverse transcriptase inhibitor: experience from 334 patients in three cohorts
-
Calmy A., Petoumenos K., Lewden C., Law M., Bocquentin F., Hesse K., Cooper D., Carr A., and Bonnet F. Combination antiretroviral therapy without a nucleoside reverse transcriptase inhibitor: experience from 334 patients in three cohorts. HIV Med. 8 (2007) 171-180
-
(2007)
HIV Med.
, vol.8
, pp. 171-180
-
-
Calmy, A.1
Petoumenos, K.2
Lewden, C.3
Law, M.4
Bocquentin, F.5
Hesse, K.6
Cooper, D.7
Carr, A.8
Bonnet, F.9
-
30
-
-
0034008520
-
A syndrome of lipoatrophy, lactic acidaemia and liver dysfunction associated with HIV nucleoside analogue therapy: contribution to protease inhibitor-related lipodystrophy syndrome
-
Carr A., Miller J., Law M., and Cooper D.A. A syndrome of lipoatrophy, lactic acidaemia and liver dysfunction associated with HIV nucleoside analogue therapy: contribution to protease inhibitor-related lipodystrophy syndrome. AIDS 14 (2000) F25-F32
-
(2000)
AIDS
, vol.14
-
-
Carr, A.1
Miller, J.2
Law, M.3
Cooper, D.A.4
-
31
-
-
18744438445
-
Nucleoside transporters of mammalian cells
-
Cass C.E., Young J.D., Baldwin S.A., Cabrita M.A., Graham K.A., Griffiths M., Jennings L.L., Mackey J.R., Ng A.M., Ritzel M.W., Vickers M.F., and Yao S.Y. Nucleoside transporters of mammalian cells. Pharm. Biotechnol. 12 (1999) 313-352
-
(1999)
Pharm. Biotechnol.
, vol.12
, pp. 313-352
-
-
Cass, C.E.1
Young, J.D.2
Baldwin, S.A.3
Cabrita, M.A.4
Graham, K.A.5
Griffiths, M.6
Jennings, L.L.7
Mackey, J.R.8
Ng, A.M.9
Ritzel, M.W.10
Vickers, M.F.11
Yao, S.Y.12
-
32
-
-
34547229756
-
The safety and efficacy of tenofovir DF in combination with lamivudine and efavirenz through 6 years in antiretroviral-naive HIV-1-infected patients
-
Cassetti I., Madruga J.V., Suleiman J.M., Etzel A., Zhong L., Cheng A.K., and Enejosa J. The safety and efficacy of tenofovir DF in combination with lamivudine and efavirenz through 6 years in antiretroviral-naive HIV-1-infected patients. HIV Clin. Trials 8 (2007) 164-172
-
(2007)
HIV Clin. Trials
, vol.8
, pp. 164-172
-
-
Cassetti, I.1
Madruga, J.V.2
Suleiman, J.M.3
Etzel, A.4
Zhong, L.5
Cheng, A.K.6
Enejosa, J.7
-
33
-
-
0026640705
-
The role of cytoplasmic deoxycytidine kinase in the mitochondrial effects of the anti-human immunodeficiency virus compound, 2′,3′-dideoxycytidine
-
Chen C.H., and Cheng Y.C. The role of cytoplasmic deoxycytidine kinase in the mitochondrial effects of the anti-human immunodeficiency virus compound, 2′,3′-dideoxycytidine. J. Biol. Chem. 267 (1992) 2856-2859
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 2856-2859
-
-
Chen, C.H.1
Cheng, Y.C.2
-
34
-
-
20444367260
-
Anti-HIV activity of (-)-(2R,4R)-1- (2-hydroxymethyl-1,3-dioxolan-4-yl)-thymine against drug-resistant HIV-1 mutants and studies of its molecular mechanism
-
Chu C.K., Yadav V., Chong Y.H., and Schinazi R.F. Anti-HIV activity of (-)-(2R,4R)-1- (2-hydroxymethyl-1,3-dioxolan-4-yl)-thymine against drug-resistant HIV-1 mutants and studies of its molecular mechanism. J. Med. Chem. 48 (2005) 3949-3952
-
(2005)
J. Med. Chem.
, vol.48
, pp. 3949-3952
-
-
Chu, C.K.1
Yadav, V.2
Chong, Y.H.3
Schinazi, R.F.4
-
35
-
-
0030969223
-
Incorporation of selected nucleoside phosphonates and anti-human immunodeficiency virus nucleotide analogues into DNA by human DNA polymerases α, β and γ
-
Cihlar T., and Chen M.S. Incorporation of selected nucleoside phosphonates and anti-human immunodeficiency virus nucleotide analogues into DNA by human DNA polymerases α, β and γ. Antiviral Chem. Chemother. 8 (1997) 187-195
-
(1997)
Antiviral Chem. Chemother.
, vol.8
, pp. 187-195
-
-
Cihlar, T.1
Chen, M.S.2
-
36
-
-
0034852408
-
Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogs
-
Cihlar T., Ho E.S., Lin D.C., and Mulato A.S. Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogs. Nucleosides Nucleotides Nucleic Acids 20 (2001) 641-648
-
(2001)
Nucleosides Nucleotides Nucleic Acids
, vol.20
, pp. 641-648
-
-
Cihlar, T.1
Ho, E.S.2
Lin, D.C.3
Mulato, A.S.4
-
37
-
-
34147173854
-
Molecular assessment of the potential for renal drug interactions between tenofovir and HIV protease inhibitors
-
Cihlar T., Ray A.S., Laflamme G., Vela J.E., Tong L., Fuller M.D., Roy A., and Rhodes G.R. Molecular assessment of the potential for renal drug interactions between tenofovir and HIV protease inhibitors. Antiviral Ther. 12 (2007) 267-272
-
(2007)
Antiviral Ther.
, vol.12
, pp. 267-272
-
-
Cihlar, T.1
Ray, A.S.2
Laflamme, G.3
Vela, J.E.4
Tong, L.5
Fuller, M.D.6
Roy, A.7
Rhodes, G.R.8
-
38
-
-
38649089790
-
Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131
-
Cihlar T., Ray A.S., Boojamra C.G., Zhang L., Hui H., Laflamme G., Vela J.E., Grant D., Chen J., Myrick F., White K.L., Gao Y., Lin K.Y., Douglas J.L., Parkin N.T., Carey A., Pakdaman R., and Mackman R.L. Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131. Antimicrob. Agents Chemother. 52 (2008) 655-665
-
(2008)
Antimicrob. Agents Chemother.
, vol.52
, pp. 655-665
-
-
Cihlar, T.1
Ray, A.S.2
Boojamra, C.G.3
Zhang, L.4
Hui, H.5
Laflamme, G.6
Vela, J.E.7
Grant, D.8
Chen, J.9
Myrick, F.10
White, K.L.11
Gao, Y.12
Lin, K.Y.13
Douglas, J.L.14
Parkin, N.T.15
Carey, A.16
Pakdaman, R.17
Mackman, R.L.18
-
39
-
-
59749106127
-
Novel nucleotide human immunodeficiency virus reverse transcriptase inhibitor GS-9148 with a low nephrotoxic potential: characterization of renal transport and accumulation
-
Cihlar T., Laflamme G., Fisher R., Carey A.C., Vela J.E., Mackman R., and Ray A.S. Novel nucleotide human immunodeficiency virus reverse transcriptase inhibitor GS-9148 with a low nephrotoxic potential: characterization of renal transport and accumulation. Antimicrob. Agents Chemother. 53 (2009) 150-156
-
(2009)
Antimicrob. Agents Chemother.
, vol.53
, pp. 150-156
-
-
Cihlar, T.1
Laflamme, G.2
Fisher, R.3
Carey, A.C.4
Vela, J.E.5
Mackman, R.6
Ray, A.S.7
-
40
-
-
0028952146
-
HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy
-
Coffin J.M. HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. Science 267 (1995) 483-489
-
(1995)
Science
, vol.267
, pp. 483-489
-
-
Coffin, J.M.1
-
41
-
-
35548984611
-
Efficacy and novel pharmacology of elvucitabine in a 7 day placebo controlled monotherapy study
-
San Francisco, CA, USA
-
Colucci P., Pottage J., Robison H., Schrmann D., Donohue M., Gugliotti R., and Ducharme M.P. Efficacy and novel pharmacology of elvucitabine in a 7 day placebo controlled monotherapy study. 46th Interscience Conference on Antimicrobial Agents and Chemotherapy, Abstract H-1670d. San Francisco, CA, USA (2006)
-
(2006)
46th Interscience Conference on Antimicrobial Agents and Chemotherapy, Abstract H-1670d
-
-
Colucci, P.1
Pottage, J.2
Robison, H.3
Schrmann, D.4
Donohue, M.5
Gugliotti, R.6
Ducharme, M.P.7
-
42
-
-
59749101190
-
Multiple-dose pharmacokinetic behavior of elvucitabine, a nucleoside reverse transcriptase inhibitor, administered over 21 days with lopinavir-ritonavir in human immunodeficiency virus type 1-infected subjects
-
Colucci P., Pottage J.C., Robison H., Turgeon J., Schurmann D., Hoepelman I.M., and Ducharme M.P. Multiple-dose pharmacokinetic behavior of elvucitabine, a nucleoside reverse transcriptase inhibitor, administered over 21 days with lopinavir-ritonavir in human immunodeficiency virus type 1-infected subjects. Antimicrob. Agents Chemother. 53 (2009) 662-669
-
(2009)
Antimicrob. Agents Chemother.
, vol.53
, pp. 662-669
-
-
Colucci, P.1
Pottage, J.C.2
Robison, H.3
Turgeon, J.4
Schurmann, D.5
Hoepelman, I.M.6
Ducharme, M.P.7
-
43
-
-
65549113837
-
Apricitabine-a novel nucleoside reverse transcriptase inhibitor for the treatment of HIV infection that is refractory to existing drugs
-
Cox S., and Southby J. Apricitabine-a novel nucleoside reverse transcriptase inhibitor for the treatment of HIV infection that is refractory to existing drugs. Exp. Opin. Investig. Drugs 18 (2009) 199-209
-
(2009)
Exp. Opin. Investig. Drugs
, vol.18
, pp. 199-209
-
-
Cox, S.1
Southby, J.2
-
44
-
-
65649128150
-
Genotypic analysis of patients enrolled in study AVX-201 and treated with apricitabine for 24 weeks
-
Cox S., Southby S., and Moore J. Genotypic analysis of patients enrolled in study AVX-201 and treated with apricitabine for 24 weeks. Antiviral Ther. 13 Suppl. 3 (2008) A22
-
(2008)
Antiviral Ther.
, vol.13
, Issue.SUPPL. 3
-
-
Cox, S.1
Southby, S.2
Moore, J.3
-
45
-
-
0027451533
-
Reduction of 3′-azido-2′,3′-dideoxynucleosides to their 3′-amino metabolite is mediated by cytochrome P-450 and NADPH-cytochrome P-450 reductase in rat liver microsomes
-
Cretton E.M., and Sommadossi J.P. Reduction of 3′-azido-2′,3′-dideoxynucleosides to their 3′-amino metabolite is mediated by cytochrome P-450 and NADPH-cytochrome P-450 reductase in rat liver microsomes. Drug Metab. Dispos. 21 (1993) 946-950
-
(1993)
Drug Metab. Dispos.
, vol.21
, pp. 946-950
-
-
Cretton, E.M.1
Sommadossi, J.P.2
-
46
-
-
0027321002
-
In vitro and in vivo disposition and metabolism of 3′-deoxy-2′,3′-didehydrothymidine
-
Cretton E.M., Zhou Z., Kidd L.B., McClure H.M., Kaul S., Hitchcock M.J., and Sommadossi J.P. In vitro and in vivo disposition and metabolism of 3′-deoxy-2′,3′-didehydrothymidine. Antimicrob. Agents Chemother. 37 (1993) 1816-1825
-
(1993)
Antimicrob. Agents Chemother.
, vol.37
, pp. 1816-1825
-
-
Cretton, E.M.1
Zhou, Z.2
Kidd, L.B.3
McClure, H.M.4
Kaul, S.5
Hitchcock, M.J.6
Sommadossi, J.P.7
-
47
-
-
0030598407
-
Effect of beta-enantiomeric and racemic nucleoside analogues on mitochondrial functions in HepG2 cells. Implications for predicting drug hepatotoxicity
-
Cui L., Schinazi R.F., Gosselin G., Imbach J.L., Chu C.K., Rando R.F., Revankar G.R., and Sommadossi J.P. Effect of beta-enantiomeric and racemic nucleoside analogues on mitochondrial functions in HepG2 cells. Implications for predicting drug hepatotoxicity. Biochem. Pharmacol. 52 (1996) 1577-1584
-
(1996)
Biochem. Pharmacol.
, vol.52
, pp. 1577-1584
-
-
Cui, L.1
Schinazi, R.F.2
Gosselin, G.3
Imbach, J.L.4
Chu, C.K.5
Rando, R.F.6
Revankar, G.R.7
Sommadossi, J.P.8
-
48
-
-
0025274663
-
Mitochondrial myopathy caused by long-term zidovudine therapy
-
Dalakas M.C., Illa I., Pezeshkpour G.H., Laukaitis J.P., Cohen B., and Griffin J.L. Mitochondrial myopathy caused by long-term zidovudine therapy. N. Engl. J. Med. 322 (1990) 1098-1105
-
(1990)
N. Engl. J. Med.
, vol.322
, pp. 1098-1105
-
-
Dalakas, M.C.1
Illa, I.2
Pezeshkpour, G.H.3
Laukaitis, J.P.4
Cohen, B.5
Griffin, J.L.6
-
49
-
-
34547421241
-
Effects of apricitabine and other nucleoside reverse transcriptase inhibitors on replication of mitochondrial DNA in HepG2 cells
-
de Baar M.P., de Rooij E.R., Smolders K.G., van Schijndel H.B., Timmermans E.C., and Bethell R. Effects of apricitabine and other nucleoside reverse transcriptase inhibitors on replication of mitochondrial DNA in HepG2 cells. Antiviral Res. 76 (2007) 68-74
-
(2007)
Antiviral Res.
, vol.76
, pp. 68-74
-
-
de Baar, M.P.1
de Rooij, E.R.2
Smolders, K.G.3
van Schijndel, H.B.4
Timmermans, E.C.5
Bethell, R.6
-
50
-
-
25144470707
-
Antiviral potential of a new generation of acyclic nucleoside phosphonates, the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines
-
De Clercq E., Andrei G., Balzarini J., Leyssen P., Naesens L., Neyts J., Pannecouque C., Snoeck R., Ying C., Hockova D., and Holy A. Antiviral potential of a new generation of acyclic nucleoside phosphonates, the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines. Nucleosides Nucleotides Nucleic Acids 24 (2005) 331-341
-
(2005)
Nucleosides Nucleotides Nucleic Acids
, vol.24
, pp. 331-341
-
-
De Clercq, E.1
Andrei, G.2
Balzarini, J.3
Leyssen, P.4
Naesens, L.5
Neyts, J.6
Pannecouque, C.7
Snoeck, R.8
Ying, C.9
Hockova, D.10
Holy, A.11
-
51
-
-
0032819048
-
Anti-human immunodeficiency virus type 1 activity, intracellular metabolism, and pharmacokinetic evaluation of 2′-deoxy-3′-oxa-4′-thiocytidine
-
de Muys J.M., Gourdeau H., Nguyen-Ba N., Taylor D.L., Ahmed P.S., Mansour T., Locas C., Richard N., Wainberg M.A., and Rando R.F. Anti-human immunodeficiency virus type 1 activity, intracellular metabolism, and pharmacokinetic evaluation of 2′-deoxy-3′-oxa-4′-thiocytidine. Antimicrob. Agents Chemother. 43 (1999) 1835-1844
-
(1999)
Antimicrob. Agents Chemother.
, vol.43
, pp. 1835-1844
-
-
de Muys, J.M.1
Gourdeau, H.2
Nguyen-Ba, N.3
Taylor, D.L.4
Ahmed, P.S.5
Mansour, T.6
Locas, C.7
Richard, N.8
Wainberg, M.A.9
Rando, R.F.10
-
52
-
-
64149101991
-
Elvucitabine phase II 48 week interim results show safety and efficacy profiles similar to lamivudine in treatment naïve HIV-1 infected patients with a unique pharmacokinetic profile
-
Washington, DC, USA
-
DeJesus E.D., Saple D., Morales-Ramirez J., Kumarasamy N., Jefferson T., Bellos N., Wade B., Gugliotti R., Robinson H., and Olek E. Elvucitabine phase II 48 week interim results show safety and efficacy profiles similar to lamivudine in treatment naïve HIV-1 infected patients with a unique pharmacokinetic profile. 48th Interscience Conference on Antimicrobial Agents and Chemotherapy, Abstract H-892. Washington, DC, USA (2008)
-
(2008)
48th Interscience Conference on Antimicrobial Agents and Chemotherapy, Abstract H-892
-
-
DeJesus, E.D.1
Saple, D.2
Morales-Ramirez, J.3
Kumarasamy, N.4
Jefferson, T.5
Bellos, N.6
Wade, B.7
Gugliotti, R.8
Robinson, H.9
Olek, E.10
-
53
-
-
73549087233
-
Pharmacokinetics and drug-drug interactions of antiretrovirals: an update
-
Dickinson L., Khoo S., and Back D. Pharmacokinetics and drug-drug interactions of antiretrovirals: an update. Antiviral Res. 85 (2010) 176-189
-
(2010)
Antiviral Res.
, vol.85
, pp. 176-189
-
-
Dickinson, L.1
Khoo, S.2
Back, D.3
-
54
-
-
0030040315
-
In vitro potency of inhibition by antiviral drugs of hematopoietic progenitor colony formation correlates with exposure at hemotoxic levels in human immunodeficiency virus-positive humans
-
Dornsife R.E., and Averett D.R. In vitro potency of inhibition by antiviral drugs of hematopoietic progenitor colony formation correlates with exposure at hemotoxic levels in human immunodeficiency virus-positive humans. Antimicrob. Agents Chemother. 40 (1996) 514-519
-
(1996)
Antimicrob. Agents Chemother.
, vol.40
, pp. 514-519
-
-
Dornsife, R.E.1
Averett, D.R.2
-
55
-
-
0032518398
-
Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution
-
Doublie S., Tabor S., Long A.M., Richardson C.C., and Ellenberger T. Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution. Nature 391 (1998) 251-258
-
(1998)
Nature
, vol.391
, pp. 251-258
-
-
Doublie, S.1
Tabor, S.2
Long, A.M.3
Richardson, C.C.4
Ellenberger, T.5
-
56
-
-
17344362757
-
Elvucitabine: potent antiviral activity demonstrated in multidrug-resistant HIV infection
-
ACH-006 Study Team
-
Dunkle L.M., Gathe J.C., Pedevillano D.E., Robison H.G., Rice W.G., Pottage J.C., and ACH-006 Study Team. Elvucitabine: potent antiviral activity demonstrated in multidrug-resistant HIV infection. Antivir. Ther. 8 (2003) 85
-
(2003)
Antivir. Ther.
, vol.8
, pp. 85
-
-
Dunkle, L.M.1
Gathe, J.C.2
Pedevillano, D.E.3
Robison, H.G.4
Rice, W.G.5
Pottage, J.C.6
-
57
-
-
0031836316
-
Metabolism of 2′,3′-dideoxy-2′,3′-didehydro-beta-L(-)-5-fluorocytidine and its activity in combination with clinically approved anti-human immunodeficiency virus beta-D(+) nucleoside analogs in vitro
-
Dutschman G.E., Bridges E.G., Liu S.H., Gullen E., Guo X., Kukhanova M., and Cheng Y.C. Metabolism of 2′,3′-dideoxy-2′,3′-didehydro-beta-L(-)-5-fluorocytidine and its activity in combination with clinically approved anti-human immunodeficiency virus beta-D(+) nucleoside analogs in vitro. Antimicrob. Agents Chemother. 42 (1998) 1799-1804
-
(1998)
Antimicrob. Agents Chemother.
, vol.42
, pp. 1799-1804
-
-
Dutschman, G.E.1
Bridges, E.G.2
Liu, S.H.3
Gullen, E.4
Guo, X.5
Kukhanova, M.6
Cheng, Y.C.7
-
58
-
-
2142713068
-
Novel 4′-substituted stavudine analog with improved anti-human immunodeficiency virus activity and decreased cytotoxicity
-
Dutschman G.E., Grill S.P., Gullen E.A., Haraguchi K., Takeda S., Tanaka H., Baba M., and Cheng Y.C. Novel 4′-substituted stavudine analog with improved anti-human immunodeficiency virus activity and decreased cytotoxicity. Antimicrob. Agents Chemother. 48 (2004) 1640-1646
-
(2004)
Antimicrob. Agents Chemother.
, vol.48
, pp. 1640-1646
-
-
Dutschman, G.E.1
Grill, S.P.2
Gullen, E.A.3
Haraguchi, K.4
Takeda, S.5
Tanaka, H.6
Baba, M.7
Cheng, Y.C.8
-
59
-
-
73549097325
-
Efficacy and safety of raltegravir plus etravirine and darunavir/ritonavir in treatment-experienced patients with multidrug-resistant virus: 48-week results from the ANRS 139 TRIO trial
-
Cape Town, South Africa
-
Fagard C., Descamps D., Dubar V., Colin C., Taburet A.M., Roquebert B., Katlama C., Jacomet C., Piketty C., Molina J.M., Chene G., and Yazdanpanah Y. Efficacy and safety of raltegravir plus etravirine and darunavir/ritonavir in treatment-experienced patients with multidrug-resistant virus: 48-week results from the ANRS 139 TRIO trial. 4th IAS Conference on Pathogenesis, Treatment, and Prevention, Abstract TUPDB204. Cape Town, South Africa (2009)
-
(2009)
4th IAS Conference on Pathogenesis, Treatment, and Prevention, Abstract TUPDB204
-
-
Fagard, C.1
Descamps, D.2
Dubar, V.3
Colin, C.4
Taburet, A.M.5
Roquebert, B.6
Katlama, C.7
Jacomet, C.8
Piketty, C.9
Molina, J.M.10
Chene, G.11
Yazdanpanah, Y.12
-
60
-
-
0030903443
-
Unique intracellular activation of the potent anti-human immunodeficiency virus agent 1592U89
-
Faletto M.B., Miller W.H., Garvey E.P., St. Clair M.H., Daluge S.M., and Good S.S. Unique intracellular activation of the potent anti-human immunodeficiency virus agent 1592U89. Antimicrob. Agents Chemother. 41 (1997) 1099-1107
-
(1997)
Antimicrob. Agents Chemother.
, vol.41
, pp. 1099-1107
-
-
Faletto, M.B.1
Miller, W.H.2
Garvey, E.P.3
St. Clair, M.H.4
Daluge, S.M.5
Good, S.S.6
-
61
-
-
0029915098
-
Selective protection of toxicity of 2′,3′-dideoxypyrimidine nucleoside analogs by beta-D-uridine in human granulocyte-macrophage progenitor cells
-
Faraj A., Schinazi R.F., Xie M.Y., Gosselin G., Perigaud C., Imbach J.L., and Sommadossi J.P. Selective protection of toxicity of 2′,3′-dideoxypyrimidine nucleoside analogs by beta-D-uridine in human granulocyte-macrophage progenitor cells. Antiviral Res. 29 (1996) 261-267
-
(1996)
Antiviral Res.
, vol.29
, pp. 261-267
-
-
Faraj, A.1
Schinazi, R.F.2
Xie, M.Y.3
Gosselin, G.4
Perigaud, C.5
Imbach, J.L.6
Sommadossi, J.P.7
-
62
-
-
0033524447
-
Mechanistic studies comparing the incorporation of (+) and (-) isomers of 3TCTP by HIV-1 reverse transcriptase
-
Feng J.Y., and Anderson K.S. Mechanistic studies comparing the incorporation of (+) and (-) isomers of 3TCTP by HIV-1 reverse transcriptase. Biochemistry 38 (1999) 55-63
-
(1999)
Biochemistry
, vol.38
, pp. 55-63
-
-
Feng, J.Y.1
Anderson, K.S.2
-
63
-
-
0032829089
-
Mechanistic studies show that (-)-FTC-TP is a better inhibitor of HIV-1 reverse transcriptase than 3TC-TP
-
Feng J.Y., Shi J., Schinazi R.F., and Anderson K.S. Mechanistic studies show that (-)-FTC-TP is a better inhibitor of HIV-1 reverse transcriptase than 3TC-TP. FASEB J. 13 (1999) 1511-1517
-
(1999)
FASEB J.
, vol.13
, pp. 1511-1517
-
-
Feng, J.Y.1
Shi, J.2
Schinazi, R.F.3
Anderson, K.S.4
-
64
-
-
1642420304
-
Relationship between antiviral activity and host toxicity: comparison of the incorporation efficiencies of 2′,3′-dideoxy-5-fluoro-3′-thiacytidine-triphosphate analogs by human immunodeficiency virus type 1 reverse transcriptase and human mitochondrial DNA polymerase
-
Feng J.Y., Murakami E., Zorca S.M., Johnson A.A., Johnson K.A., Schinazi R.F., Furman P.A., and Anderson K.S. Relationship between antiviral activity and host toxicity: comparison of the incorporation efficiencies of 2′,3′-dideoxy-5-fluoro-3′-thiacytidine-triphosphate analogs by human immunodeficiency virus type 1 reverse transcriptase and human mitochondrial DNA polymerase. Antimicrob. Agents Chemother. 48 (2004) 1300-1306
-
(2004)
Antimicrob. Agents Chemother.
, vol.48
, pp. 1300-1306
-
-
Feng, J.Y.1
Murakami, E.2
Zorca, S.M.3
Johnson, A.A.4
Johnson, K.A.5
Schinazi, R.F.6
Furman, P.A.7
Anderson, K.S.8
-
65
-
-
4644357529
-
Anabolism of amdoxovir: phosphorylation of dioxolane guanosine and its 5′-phosphates by mammalian phosphotransferases
-
Feng J.Y., Parker W.B., Krajewski M.L., Deville-Bonne D., Veron M., Krishnan P., Cheng Y.C., and Borroto-Esoda K. Anabolism of amdoxovir: phosphorylation of dioxolane guanosine and its 5′-phosphates by mammalian phosphotransferases. Biochem. Pharmacol. 68 (2004) 1879-1888
-
(2004)
Biochem. Pharmacol.
, vol.68
, pp. 1879-1888
-
-
Feng, J.Y.1
Parker, W.B.2
Krajewski, M.L.3
Deville-Bonne, D.4
Veron, M.5
Krishnan, P.6
Cheng, Y.C.7
Borroto-Esoda, K.8
-
66
-
-
33846596702
-
Randomized open-label trial of two simplified, class-sparing regimens following a first suppressive three or four-drug regimen
-
Fischl M.A., Collier A.C., Mukherjee A.L., Feinberg J.E., Demeter L.M., Tebas P., Giuliano M., Dehlinger M., Garren K., Brizz B., and Bassett R. Randomized open-label trial of two simplified, class-sparing regimens following a first suppressive three or four-drug regimen. AIDS 21 (2007) 325-333
-
(2007)
AIDS
, vol.21
, pp. 325-333
-
-
Fischl, M.A.1
Collier, A.C.2
Mukherjee, A.L.3
Feinberg, J.E.4
Demeter, L.M.5
Tebas, P.6
Giuliano, M.7
Dehlinger, M.8
Garren, K.9
Brizz, B.10
Bassett, R.11
-
67
-
-
0028007333
-
Relationship between plasma concentrations of 3′-deoxy-3′-fluorothymidine (alovudine) and antiretroviral activity in two concentration-controlled trials
-
Flexner C., van der Horst C., Jacobson M.A., Powderly W., Duncanson F., Ganes D., Barditch-Crovo P.A., Petty B.G., Baron P.A., Armstrong D., et al. Relationship between plasma concentrations of 3′-deoxy-3′-fluorothymidine (alovudine) and antiretroviral activity in two concentration-controlled trials. J. Infect. Dis. 170 (1994) 1394-1403
-
(1994)
J. Infect. Dis.
, vol.170
, pp. 1394-1403
-
-
Flexner, C.1
van der Horst, C.2
Jacobson, M.A.3
Powderly, W.4
Duncanson, F.5
Ganes, D.6
Barditch-Crovo, P.A.7
Petty, B.G.8
Baron, P.A.9
Armstrong, D.10
-
68
-
-
0022996630
-
Phosphorylation of 3′-azido-3′-deoxythymidine and selective interaction of the 5′-triphosphate with human immunodeficiency virus reverse transcriptase
-
Furman P.A., Fyfe J.A., St. Clair M.H., Weinhold K., Rideout J.L., Freeman G.A., Lehrman S.N., Bolognesi D.P., Broder S., Mitsuya H., et al. Phosphorylation of 3′-azido-3′-deoxythymidine and selective interaction of the 5′-triphosphate with human immunodeficiency virus reverse transcriptase. Proc. Natl. Acad. Sci. U.S.A. 83 (1986) 8333-8337
-
(1986)
Proc. Natl. Acad. Sci. U.S.A.
, vol.83
, pp. 8333-8337
-
-
Furman, P.A.1
Fyfe, J.A.2
St. Clair, M.H.3
Weinhold, K.4
Rideout, J.L.5
Freeman, G.A.6
Lehrman, S.N.7
Bolognesi, D.P.8
Broder, S.9
Mitsuya, H.10
-
69
-
-
0035162759
-
Mechanism of action of 1-beta-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-beta-D-dioxolane guanosine
-
Furman P.A., Jeffrey J., Kiefer L.L., Feng J.Y., Anderson K.S., Borroto-Esoda K., Hill E., Copeland W.C., Chu C.K., Sommadossi J.P., Liberman I., Schinazi R.F., and Painter G.R. Mechanism of action of 1-beta-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-beta-D-dioxolane guanosine. Antimicrob. Agents Chemother. 45 (2001) 158-165
-
(2001)
Antimicrob. Agents Chemother.
, vol.45
, pp. 158-165
-
-
Furman, P.A.1
Jeffrey, J.2
Kiefer, L.L.3
Feng, J.Y.4
Anderson, K.S.5
Borroto-Esoda, K.6
Hill, E.7
Copeland, W.C.8
Chu, C.K.9
Sommadossi, J.P.10
Liberman, I.11
Schinazi, R.F.12
Painter, G.R.13
-
70
-
-
55249115137
-
The 3-year renal safety of a tenofovir disoproxil fumarate vs. a thymidine analogue-containing regimen in antiretroviral-naive patients
-
Gallant J.E., Winston J.A., DeJesus E., Pozniak A.L., Chen S.S., Cheng A.K., and Enejosa J.V. The 3-year renal safety of a tenofovir disoproxil fumarate vs. a thymidine analogue-containing regimen in antiretroviral-naive patients. AIDS 22 (2008) 2155-2163
-
(2008)
AIDS
, vol.22
, pp. 2155-2163
-
-
Gallant, J.E.1
Winston, J.A.2
DeJesus, E.3
Pozniak, A.L.4
Chen, S.S.5
Cheng, A.K.6
Enejosa, J.V.7
-
71
-
-
3042848853
-
Efficacy and safety of tenofovir DF vs stavudine in combination therapy in antiretroviral-naive patients: a 3-year randomized trial
-
Gallant J.E., Staszewski S., Pozniak A.L., DeJesus E., Suleiman J.M., Miller M.D., Coakley D.F., Lu B., Toole J.J., and Cheng A.K. Efficacy and safety of tenofovir DF vs stavudine in combination therapy in antiretroviral-naive patients: a 3-year randomized trial. JAMA 292 (2004) 191-201
-
(2004)
JAMA
, vol.292
, pp. 191-201
-
-
Gallant, J.E.1
Staszewski, S.2
Pozniak, A.L.3
DeJesus, E.4
Suleiman, J.M.5
Miller, M.D.6
Coakley, D.F.7
Lu, B.8
Toole, J.J.9
Cheng, A.K.10
-
72
-
-
27944472569
-
Early virologic nonresponse to tenofovir, abacavir, and lamivudine in HIV-infected antiretroviral-naive subjects
-
ESS30009 Study
-
Gallant J.E., Rodriguez A.E., Weinberg W.G., Young B., Berger D.S., Lim M.L., Liao Q., Ross L., Johnson J., Shaefer M.S., and ESS30009 Study. Early virologic nonresponse to tenofovir, abacavir, and lamivudine in HIV-infected antiretroviral-naive subjects. J. Infect. Dis. 192 (2005) 1921-1930
-
(2005)
J. Infect. Dis.
, vol.192
, pp. 1921-1930
-
-
Gallant, J.E.1
Rodriguez, A.E.2
Weinberg, W.G.3
Young, B.4
Berger, D.S.5
Lim, M.L.6
Liao, Q.7
Ross, L.8
Johnson, J.9
Shaefer, M.S.10
-
73
-
-
30944468562
-
Tenofovir DF, emtricitabine, and efavirenz vs. zidovudine, lamivudine, and efavirenz for HIV
-
Gallant J.E., DeJesus E., Arribas J.R., Pozniak A.L., Gazzard B., Campo R.E., Lu B., McColl D., Chuck S., Enejosa J., Toole J.J., and Cheng A.K. Tenofovir DF, emtricitabine, and efavirenz vs. zidovudine, lamivudine, and efavirenz for HIV. N. Engl. J. Med. 354 (2006) 251-260
-
(2006)
N. Engl. J. Med.
, vol.354
, pp. 251-260
-
-
Gallant, J.E.1
DeJesus, E.2
Arribas, J.R.3
Pozniak, A.L.4
Gazzard, B.5
Campo, R.E.6
Lu, B.7
McColl, D.8
Chuck, S.9
Enejosa, J.10
Toole, J.J.11
Cheng, A.K.12
-
74
-
-
0021261510
-
Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS
-
Gallo R.C., Salahuddin S.Z., Popovic M., Shearer G.M., Kaplan M., Haynes B.F., Palker T.J., Redfield R., Oleske J., Safai B., et al. Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science 224 (1984) 500-503
-
(1984)
Science
, vol.224
, pp. 500-503
-
-
Gallo, R.C.1
Salahuddin, S.Z.2
Popovic, M.3
Shearer, G.M.4
Kaplan, M.5
Haynes, B.F.6
Palker, T.J.7
Redfield, R.8
Oleske, J.9
Safai, B.10
-
75
-
-
0027287973
-
Differential phosphorylation of azidothymidine, dideoxycytidine, and dideoxyinosine in resting and activated peripheral blood mononuclear cells
-
Gao W.Y., Shirasaka T., Johns D.G., Broder S., and Mitsuya H. Differential phosphorylation of azidothymidine, dideoxycytidine, and dideoxyinosine in resting and activated peripheral blood mononuclear cells. J. Clin. Invest. 91 (1993) 2326-2333
-
(1993)
J. Clin. Invest.
, vol.91
, pp. 2326-2333
-
-
Gao, W.Y.1
Shirasaka, T.2
Johns, D.G.3
Broder, S.4
Mitsuya, H.5
-
76
-
-
39849100140
-
Prevention of rectal SHIV transmission in macaques by daily or intermittent prophylaxis with emtricitabine and tenofovir
-
Garcia-Lerma J.G., Otten R.A., Qari S.H., Jackson E., Cong M.E., Masciotra S., Luo W., Kim C., Adams D.R., Monsour M., Lipscomb J., Johnson J.A., Delinsky D., Schinazi R.F., Janssen R., Folks T.M., and Heneine W. Prevention of rectal SHIV transmission in macaques by daily or intermittent prophylaxis with emtricitabine and tenofovir. PLoS Med. 5 (2008) e28
-
(2008)
PLoS Med.
, vol.5
-
-
Garcia-Lerma, J.G.1
Otten, R.A.2
Qari, S.H.3
Jackson, E.4
Cong, M.E.5
Masciotra, S.6
Luo, W.7
Kim, C.8
Adams, D.R.9
Monsour, M.10
Lipscomb, J.11
Johnson, J.A.12
Delinsky, D.13
Schinazi, R.F.14
Janssen, R.15
Folks, T.M.16
Heneine, W.17
-
77
-
-
0142125266
-
Low efficacy and high frequency of adverse events in a randomized trial of the triple nucleoside regimen abacavir, stavudine and didanosine
-
Gerstoft J., Kirk O., Obel N., Pedersen C., Mathiesen L., Nielsen H., Katzenstein T.L., and Lundgren J.D. Low efficacy and high frequency of adverse events in a randomized trial of the triple nucleoside regimen abacavir, stavudine and didanosine. Aids 17 (2003) 2045-2052
-
(2003)
Aids
, vol.17
, pp. 2045-2052
-
-
Gerstoft, J.1
Kirk, O.2
Obel, N.3
Pedersen, C.4
Mathiesen, L.5
Nielsen, H.6
Katzenstein, T.L.7
Lundgren, J.D.8
-
78
-
-
34250359868
-
Antiviral activity of low-dose alovudine in antiretroviral-experienced patients: results from a 4-week randomized, double-blind, placebo-controlled dose-ranging trial
-
Ghosn J., Quinson A.M., Sabo N., Cotte L., Piketty C., Dorleacq N., Bravo M.L., Mayers D., Harmenberg J., Mardh G., Valdez H., and Katlama C. Antiviral activity of low-dose alovudine in antiretroviral-experienced patients: results from a 4-week randomized, double-blind, placebo-controlled dose-ranging trial. HIV Med. 8 (2007) 142-147
-
(2007)
HIV Med.
, vol.8
, pp. 142-147
-
-
Ghosn, J.1
Quinson, A.M.2
Sabo, N.3
Cotte, L.4
Piketty, C.5
Dorleacq, N.6
Bravo, M.L.7
Mayers, D.8
Harmenberg, J.9
Mardh, G.10
Valdez, H.11
Katlama, C.12
-
79
-
-
33747785298
-
Amdoxovir versus placebo with enfuvirtide plus optimized background therapy for HIV-1-infected subjects failing current therapy (AACTG A5118)
-
Gripshover B.M., Ribaudo H., Santana J., Gerber J.G., Campbell T.B., Hogg E., Jarocki B., Hammer S.M., and Kuritzkes D.R. Amdoxovir versus placebo with enfuvirtide plus optimized background therapy for HIV-1-infected subjects failing current therapy (AACTG A5118). Antiviral Ther. 11 (2006) 619-623
-
(2006)
Antiviral Ther.
, vol.11
, pp. 619-623
-
-
Gripshover, B.M.1
Ribaudo, H.2
Santana, J.3
Gerber, J.G.4
Campbell, T.B.5
Hogg, E.6
Jarocki, B.7
Hammer, S.M.8
Kuritzkes, D.R.9
-
80
-
-
0032823357
-
Mechanism of action and in vitro activity of 1′,3′-dioxolanylpurine nucleoside analogues against sensitive and drug-resistant human immunodeficiency virus type 1 variants
-
Gu Z., Wainberg M.A., Nguyen-Ba N., L′Heureux L., de Muys J.M., Bowlin T.L., and Rando R.F. Mechanism of action and in vitro activity of 1′,3′-dioxolanylpurine nucleoside analogues against sensitive and drug-resistant human immunodeficiency virus type 1 variants. Antimicrob. Agents Chemother. 43 (1999) 2376-2382
-
(1999)
Antimicrob. Agents Chemother.
, vol.43
, pp. 2376-2382
-
-
Gu, Z.1
Wainberg, M.A.2
Nguyen-Ba, N.3
LHeureux, L.4
de Muys, J.M.5
Bowlin, T.L.6
Rando, R.F.7
-
81
-
-
31944441500
-
In vitro antiretroviral activity and in vitro toxicity profile of SPD754, a new deoxycytidine nucleoside reverse transcriptase inhibitor for treatment of human immunodeficiency virus infection
-
Gu Z., Allard B., de Muys J.M., Lippens J., Rando R.F., Nguyen-Ba N., Ren C., McKenna P., Taylor D.L., and Bethell R.C. In vitro antiretroviral activity and in vitro toxicity profile of SPD754, a new deoxycytidine nucleoside reverse transcriptase inhibitor for treatment of human immunodeficiency virus infection. Antimicrob. Agents Chemother. 50 (2006) 625-631
-
(2006)
Antimicrob. Agents Chemother.
, vol.50
, pp. 625-631
-
-
Gu, Z.1
Allard, B.2
de Muys, J.M.3
Lippens, J.4
Rando, R.F.5
Nguyen-Ba, N.6
Ren, C.7
McKenna, P.8
Taylor, D.L.9
Bethell, R.C.10
-
82
-
-
2342537759
-
Triple-nucleoside regimens versus efavirenz-containing regimens for the initial treatment of HIV-1 infection
-
Gulick R.M., Ribaudo H.J., Shikuma C.M., Lustgarten S., Squires K.E., Meyer W.A.3r., Acosta E.P., Schackman B.R., Pilcher C.D., Murphy R.L., Maher W.E., Witt M.D., Reichman R.C., Snyder S., Klingman K.L., and Kuritzkes D.R. Triple-nucleoside regimens versus efavirenz-containing regimens for the initial treatment of HIV-1 infection. N. Engl. J. Med. 350 (2004) 1850-1861
-
(2004)
N. Engl. J. Med.
, vol.350
, pp. 1850-1861
-
-
Gulick, R.M.1
Ribaudo, H.J.2
Shikuma, C.M.3
Lustgarten, S.4
Squires, K.E.5
Meyer, W.A.3r.6
Acosta, E.P.7
Schackman, B.R.8
Pilcher, C.D.9
Murphy, R.L.10
Maher, W.E.11
Witt, M.D.12
Reichman, R.C.13
Snyder, S.14
Klingman, K.L.15
Kuritzkes, D.R.16
-
83
-
-
0042531890
-
MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2′,3′-dideoxycytidine and 9′-(2′-phosphonylmethoxyethyl)adenine
-
Guo Y., Kotova E., Chen Z.S., Lee K., Hopper-Borge E., Belinsky M.G., and Kruh G.D. MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2′,3′-dideoxycytidine and 9′-(2′-phosphonylmethoxyethyl)adenine. J. Biol. Chem. 278 (2003) 29509-29514
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 29509-29514
-
-
Guo, Y.1
Kotova, E.2
Chen, Z.S.3
Lee, K.4
Hopper-Borge, E.5
Belinsky, M.G.6
Kruh, G.D.7
-
84
-
-
24144440751
-
In vitro selection and analysis of human immunodeficiency virus type 1 resistant to derivatives of beta-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine
-
Hammond J.L., Parikh U.M., Koontz D.L., Schlueter-Wirtz S., Chu C.K., Bazmi H.Z., Schinazi R.F., and Mellors J.W. In vitro selection and analysis of human immunodeficiency virus type 1 resistant to derivatives of beta-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine. Antimicrob. Agents Chemother. 49 (2005) 3930-3932
-
(2005)
Antimicrob. Agents Chemother.
, vol.49
, pp. 3930-3932
-
-
Hammond, J.L.1
Parikh, U.M.2
Koontz, D.L.3
Schlueter-Wirtz, S.4
Chu, C.K.5
Bazmi, H.Z.6
Schinazi, R.F.7
Mellors, J.W.8
-
85
-
-
37849030691
-
Exonuclease removal of dideoxycytidine (zalcitabine) by the human mitochondrial DNA polymerase
-
Hanes J.W., and Johnson K.A. Exonuclease removal of dideoxycytidine (zalcitabine) by the human mitochondrial DNA polymerase. Antimicrob. Agents Chemother. 52 (2008) 253-258
-
(2008)
Antimicrob. Agents Chemother.
, vol.52
, pp. 253-258
-
-
Hanes, J.W.1
Johnson, K.A.2
-
86
-
-
0141545085
-
Synthesis of a highly active new anti-HIV agent 2′,3′-didehydro-3′-deoxy-4′-ethynylthymidine
-
Haraguchi K., Takeda S., Tanaka H., Nitanda T., Baba M., Dutschman G.E., and Cheng Y.C. Synthesis of a highly active new anti-HIV agent 2′,3′-didehydro-3′-deoxy-4′-ethynylthymidine. Bioorg. Med. Chem. Lett. 13 (2003) 3775-3777
-
(2003)
Bioorg. Med. Chem. Lett.
, vol.13
, pp. 3775-3777
-
-
Haraguchi, K.1
Takeda, S.2
Tanaka, H.3
Nitanda, T.4
Baba, M.5
Dutschman, G.E.6
Cheng, Y.C.7
-
87
-
-
41149166259
-
Synthesis and anti-HIV activity of 4′-substituted 4′-thiothymidines: a new entry based on nucleophilic substitution of the 4′-acetoxy group
-
Haraguchi K., Shimada H., Tanaka H., Hamasaki T., Baba M., Gullen E.A., Dutschman G.E., and Cheng Y.C. Synthesis and anti-HIV activity of 4′-substituted 4′-thiothymidines: a new entry based on nucleophilic substitution of the 4′-acetoxy group. J. Med. Chem. 51 (2008) 1885-1893
-
(2008)
J. Med. Chem.
, vol.51
, pp. 1885-1893
-
-
Haraguchi, K.1
Shimada, H.2
Tanaka, H.3
Hamasaki, T.4
Baba, M.5
Gullen, E.A.6
Dutschman, G.E.7
Cheng, Y.C.8
-
88
-
-
73549111832
-
Studies of FLG as a potent and selective inhibitor of hepatitis B virus replication in vitro and in vivo
-
San Diego, CA, USA
-
Harmenberg J., Ageland H., Borg N., Bottiger D., Johansson N.G., Lofgren B., Oberg B., Pelcman N., Schroder I., Stahle L., Vrang L., Zhang H., and Zhou X. Studies of FLG as a potent and selective inhibitor of hepatitis B virus replication in vitro and in vivo. 11th International Conference on Antiviral Research, Abstract 90. San Diego, CA, USA (1998)
-
(1998)
11th International Conference on Antiviral Research, Abstract 90
-
-
Harmenberg, J.1
Ageland, H.2
Borg, N.3
Bottiger, D.4
Johansson, N.G.5
Lofgren, B.6
Oberg, B.7
Pelcman, N.8
Schroder, I.9
Stahle, L.10
Vrang, L.11
Zhang, H.12
Zhou, X.13
-
89
-
-
26644440388
-
Pharmacokinetic evaluation of the hepatitis B nucleoside analogue MIV-210 in human volunteers
-
Prague, Czech Republic
-
Harmenberg J., Larsson T., Bottiger D., Augustsson E., Mardh G., and Oberg B. Pharmacokinetic evaluation of the hepatitis B nucleoside analogue MIV-210 in human volunteers. 15th International Conference on Antiviral Research, Abstract 150. Prague, Czech Republic (2002)
-
(2002)
15th International Conference on Antiviral Research, Abstract 150
-
-
Harmenberg, J.1
Larsson, T.2
Bottiger, D.3
Augustsson, E.4
Mardh, G.5
Oberg, B.6
-
90
-
-
0037165904
-
Intracellular carbovir triphosphate levels in patients taking abacavir once a day
-
Harris M., Back D., Kewn S., Jutha S., Marina R., and Montaner J.S. Intracellular carbovir triphosphate levels in patients taking abacavir once a day. AIDS 16 (2002) 1196-1197
-
(2002)
AIDS
, vol.16
, pp. 1196-1197
-
-
Harris, M.1
Back, D.2
Kewn, S.3
Jutha, S.4
Marina, R.5
Montaner, J.S.6
-
91
-
-
20444414897
-
KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis
-
Harris K.S., Brabant W., Styrchak S., Gall A., and Daifuku R. KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis. Antiviral Res. 67 (2005) 1-9
-
(2005)
Antiviral Res.
, vol.67
, pp. 1-9
-
-
Harris, K.S.1
Brabant, W.2
Styrchak, S.3
Gall, A.4
Daifuku, R.5
-
92
-
-
0025773889
-
Inhibitors of IMP dehydrogenase stimulate the phosphorylation of the anti-human immunodeficiency virus nucleosides 2′,3′-dideoxyadenosine and 2′,3′-dideoxyinosine
-
Hartman N.R., Ahluwalia G.S., Cooney D.A., Mitsuya H., Kageyama S., Fridland A., Broder S., and Johns D.G. Inhibitors of IMP dehydrogenase stimulate the phosphorylation of the anti-human immunodeficiency virus nucleosides 2′,3′-dideoxyadenosine and 2′,3′-dideoxyinosine. Mol. Pharmacol. 40 (1991) 118-124
-
(1991)
Mol. Pharmacol.
, vol.40
, pp. 118-124
-
-
Hartman, N.R.1
Ahluwalia, G.S.2
Cooney, D.A.3
Mitsuya, H.4
Kageyama, S.5
Fridland, A.6
Broder, S.7
Johns, D.G.8
-
93
-
-
73549088565
-
Potent activity of a nucleoside reverse transcriptase inhibitor, 4′-ethynyl-2-fluoro-2′-deoxyadenosine, against HIV-1 infection in Hu-PBMC-NOD/SCID/JAK3null (NOJ) mouse model
-
(June 22; Epub ahead of print)
-
Hattori S., Ide K., Nakata H., Harada H., Suzu S., Ashida N., Kohgo S., Hayakawa H., Mitsuya H., and Okada S. Potent activity of a nucleoside reverse transcriptase inhibitor, 4′-ethynyl-2-fluoro-2′-deoxyadenosine, against HIV-1 infection in Hu-PBMC-NOD/SCID/JAK3null (NOJ) mouse model. Antimicrob. Agents Chemother. (2009) (June 22; Epub ahead of print)
-
(2009)
Antimicrob. Agents Chemother.
-
-
Hattori, S.1
Ide, K.2
Nakata, H.3
Harada, H.4
Suzu, S.5
Ashida, N.6
Kohgo, S.7
Hayakawa, H.8
Mitsuya, H.9
Okada, S.10
-
94
-
-
67651096095
-
Metabolic outcomes in a randomized trial of nucleoside, nonnucleoside and protease inhibitor-sparing regimens for initial HIV treatment
-
Haubrich R.H., Riddler S.A., DiRienzo A.G., Komarow L., Powderly W.G., Klingman K., Garren K.W., Butcher D.L., Rooney J.F., Haas D.W., Mellors J.W., and Havlir D.V. Metabolic outcomes in a randomized trial of nucleoside, nonnucleoside and protease inhibitor-sparing regimens for initial HIV treatment. AIDS 23 (2009) 1109-1118
-
(2009)
AIDS
, vol.23
, pp. 1109-1118
-
-
Haubrich, R.H.1
Riddler, S.A.2
DiRienzo, A.G.3
Komarow, L.4
Powderly, W.G.5
Klingman, K.6
Garren, K.W.7
Butcher, D.L.8
Rooney, J.F.9
Haas, D.W.10
Mellors, J.W.11
Havlir, D.V.12
-
95
-
-
0033914469
-
In vivo antagonism with zidovudine plus stavudine combination therapy
-
Havlir D.V., Tierney C., Friedland G.H., Pollard R.B., Smeaton L., Sommadossi J.P., Fox L., Kessler H., Fife K.H., and Richman D.D. In vivo antagonism with zidovudine plus stavudine combination therapy. J. Infect. Dis. 182 (2000) 321-325
-
(2000)
J. Infect. Dis.
, vol.182
, pp. 321-325
-
-
Havlir, D.V.1
Tierney, C.2
Friedland, G.H.3
Pollard, R.B.4
Smeaton, L.5
Sommadossi, J.P.6
Fox, L.7
Kessler, H.8
Fife, K.H.9
Richman, D.D.10
-
96
-
-
73549101316
-
Understanding and managing the adverse effects of HAART
-
Hawkins T. Understanding and managing the adverse effects of HAART. Antiviral Res. 85 (2010) 201-209
-
(2010)
Antiviral Res.
, vol.85
, pp. 201-209
-
-
Hawkins, T.1
-
97
-
-
22344455482
-
Intracellular pharmacokinetics of tenofovir diphosphate, carbovir triphosphate, and lamivudine triphosphate in patients receiving triple-nucleoside regimens
-
Hawkins T., Veikley W., St. Claire III R.L., Guyer B., Clark N., and Kearney B.P. Intracellular pharmacokinetics of tenofovir diphosphate, carbovir triphosphate, and lamivudine triphosphate in patients receiving triple-nucleoside regimens. J. Acquir. Immune Defic. Syndr. 39 (2005) 406-411
-
(2005)
J. Acquir. Immune Defic. Syndr.
, vol.39
, pp. 406-411
-
-
Hawkins, T.1
Veikley, W.2
St. Claire III, R.L.3
Guyer, B.4
Clark, N.5
Kearney, B.P.6
-
98
-
-
4344602617
-
Potential of 4′-C-substituted nucleosides for the treatment of HIV-1
-
Hayakawa H., Kohgo S., Kitano K., Ashida N., Kodama E., Mitsuya H., and Ohrui H. Potential of 4′-C-substituted nucleosides for the treatment of HIV-1. Antiviral Chem. Chemother. 15 (2004) 169-187
-
(2004)
Antiviral Chem. Chemother.
, vol.15
, pp. 169-187
-
-
Hayakawa, H.1
Kohgo, S.2
Kitano, K.3
Ashida, N.4
Kodama, E.5
Mitsuya, H.6
Ohrui, H.7
-
99
-
-
1242340323
-
The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteinsIntroduction
-
Hediger M.A., Romero M.F., Peng J.B., Rolfs A., Takanaga H., and Bruford E.A. The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteinsIntroduction. Pflugers Arch. 447 (2004) 465-468
-
(2004)
Pflugers Arch.
, vol.447
, pp. 465-468
-
-
Hediger, M.A.1
Romero, M.F.2
Peng, J.B.3
Rolfs, A.4
Takanaga, H.5
Bruford, E.A.6
-
100
-
-
0023713363
-
Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides
-
Herdewijn P., Balzarini J., Baba M., Pauwels R., Van Aerschot A., Janssen G., and De Clercq E. Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides. J. Med. Chem. 31 (1988) 2040-2048
-
(1988)
J. Med. Chem.
, vol.31
, pp. 2040-2048
-
-
Herdewijn, P.1
Balzarini, J.2
Baba, M.3
Pauwels, R.4
Van Aerschot, A.5
Janssen, G.6
De Clercq, E.7
-
101
-
-
21444447772
-
Safety, pharmacokinetics, and efficacy of (+/-)-beta-2′,3′-dideoxy-5-fluoro-3′-thiacytidine with efavirenz and stavudine in antiretroviral-naive human immunodeficiency virus-infected patients
-
Herzmann C., Arasteh K., Murphy R.L., Schulbin H., Kreckel P., Drauz D., Schinazi R.F., Beard A., Cartee L., and Otto M.J. Safety, pharmacokinetics, and efficacy of (+/-)-beta-2′,3′-dideoxy-5-fluoro-3′-thiacytidine with efavirenz and stavudine in antiretroviral-naive human immunodeficiency virus-infected patients. Antimicrob. Agents Chemother. 49 (2005) 2828-2833
-
(2005)
Antimicrob. Agents Chemother.
, vol.49
, pp. 2828-2833
-
-
Herzmann, C.1
Arasteh, K.2
Murphy, R.L.3
Schulbin, H.4
Kreckel, P.5
Drauz, D.6
Schinazi, R.F.7
Beard, A.8
Cartee, L.9
Otto, M.J.10
-
102
-
-
0024405549
-
Cellular pharmacology of 2′,3′-dideoxy-2′,3′-didehydrothymidine, a nucleoside analog active against human immunodeficiency virus
-
Ho H.T., and Hitchcock M.J. Cellular pharmacology of 2′,3′-dideoxy-2′,3′-didehydrothymidine, a nucleoside analog active against human immunodeficiency virus. Antimicrob. Agents Chemother. 33 (1989) 844-849
-
(1989)
Antimicrob. Agents Chemother.
, vol.33
, pp. 844-849
-
-
Ho, H.T.1
Hitchcock, M.J.2
-
103
-
-
0242299576
-
5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity
-
Hockova D., Holy A., Masojidkova M., Andrei G., Snoeck R., De Clercq E., and Balzarini J. 5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity. J. Med. Chem. 46 (2003) 5064-5073
-
(2003)
J. Med. Chem.
, vol.46
, pp. 5064-5073
-
-
Hockova, D.1
Holy, A.2
Masojidkova, M.3
Andrei, G.4
Snoeck, R.5
De Clercq, E.6
Balzarini, J.7
-
104
-
-
67349157073
-
Alkoxyalkyl prodrugs of acyclic nucleoside phosphonates enhance oral antiviral activity and reduce toxicity: current state of the art
-
Hostetler K.Y. Alkoxyalkyl prodrugs of acyclic nucleoside phosphonates enhance oral antiviral activity and reduce toxicity: current state of the art. Antiviral Res. 82 (2009) A84-A98
-
(2009)
Antiviral Res.
, vol.82
-
-
Hostetler, K.Y.1
-
105
-
-
70349769521
-
Association of abacavir and impaired endothelial function in treated and suppressed HIV-infected patients
-
Hsue P.Y., Hunt P.W., Wu Y., Schnell A., Ho J.E., Hatano H., Xie Y., Martin J.N., Ganz P., and Deeks S.G. Association of abacavir and impaired endothelial function in treated and suppressed HIV-infected patients. AIDS (2009)
-
(2009)
AIDS
-
-
Hsue, P.Y.1
Hunt, P.W.2
Wu, Y.3
Schnell, A.4
Ho, J.E.5
Hatano, H.6
Xie, Y.7
Martin, J.N.8
Ganz, P.9
Deeks, S.G.10
-
106
-
-
0032573488
-
Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance
-
Huang H., Chopra R., Verdine G.L., and Harrison S.C. Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance. Science 282 (1998) 1669-1675
-
(1998)
Science
, vol.282
, pp. 1669-1675
-
-
Huang, H.1
Chopra, R.2
Verdine, G.L.3
Harrison, S.C.4
-
107
-
-
20444368420
-
The 5′-nucleotidases as regulators of nucleotide and drug metabolism
-
Hunsucker S.A., Mitchell B.S., and Spychala J. The 5′-nucleotidases as regulators of nucleotide and drug metabolism. Pharmacol. Ther. 107 (2005) 1-30
-
(2005)
Pharmacol. Ther.
, vol.107
, pp. 1-30
-
-
Hunsucker, S.A.1
Mitchell, B.S.2
Spychala, J.3
-
108
-
-
33846420624
-
Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir
-
Imaoka T., Kusuhara H., Adachi M., Schuetz J.D., Takeuchi K., and Sugiyama Y. Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir. Mol. Pharmacol. 71 (2007) 619-627
-
(2007)
Mol. Pharmacol.
, vol.71
, pp. 619-627
-
-
Imaoka, T.1
Kusuhara, H.2
Adachi, M.3
Schuetz, J.D.4
Takeuchi, K.5
Sugiyama, Y.6
-
109
-
-
0029689120
-
Structure-activity relationships for phosphorylation of nucleoside analogs to monophosphates by nucleoside kinases
-
Johansson N.G., and Eriksson S. Structure-activity relationships for phosphorylation of nucleoside analogs to monophosphates by nucleoside kinases. Acta Biochim. Pol. 43 (1996) 143-160
-
(1996)
Acta Biochim. Pol.
, vol.43
, pp. 143-160
-
-
Johansson, N.G.1
Eriksson, S.2
-
110
-
-
0024435381
-
Phosphorylation of 2′,3′-dideoxyinosine by cytosolic 5′-nucleotidase of human lymphoid cells
-
Johnson M.A., and Fridland A. Phosphorylation of 2′,3′-dideoxyinosine by cytosolic 5′-nucleotidase of human lymphoid cells. Mol. Pharmacol. 36 (1989) 291-295
-
(1989)
Mol. Pharmacol.
, vol.36
, pp. 291-295
-
-
Johnson, M.A.1
Fridland, A.2
-
111
-
-
0035798566
-
Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase
-
Johnson A.A., Ray A.S., Hanes J., Suo Z., Colacino J.M., Anderson K.S., and Johnson K.A. Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase. J. Biol. Chem. 276 (2001) 40847-40857
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 40847-40857
-
-
Johnson, A.A.1
Ray, A.S.2
Hanes, J.3
Suo, Z.4
Colacino, J.M.5
Anderson, K.S.6
Johnson, K.A.7
-
112
-
-
48749086685
-
Minority HIV-1 drug resistance mutations are present in antiretroviral treatment-naive populations and associate with reduced treatment efficacy
-
Johnson J.A., Li J.F., Wei X., Lipscomb J., Irlbeck D., Craig C., Smith A., Bennett D.E., Monsour M., Sandstrom P., Lanier E.R., and Heneine W. Minority HIV-1 drug resistance mutations are present in antiretroviral treatment-naive populations and associate with reduced treatment efficacy. PLoS Med. 5 (2008) e158
-
(2008)
PLoS Med.
, vol.5
-
-
Johnson, J.A.1
Li, J.F.2
Wei, X.3
Lipscomb, J.4
Irlbeck, D.5
Craig, C.6
Smith, A.7
Bennett, D.E.8
Monsour, M.9
Sandstrom, P.10
Lanier, E.R.11
Heneine, W.12
-
113
-
-
8544278025
-
DNA polymerase fidelity: kinetics, structure, and checkpoints
-
Joyce C.M., and Benkovic S.J. DNA polymerase fidelity: kinetics, structure, and checkpoints. Biochemistry 43 (2004) 14317-14324
-
(2004)
Biochemistry
, vol.43
, pp. 14317-14324
-
-
Joyce, C.M.1
Benkovic, S.J.2
-
114
-
-
73849128498
-
Antiretroviral prophylaxis for the prevention of HIV infection: future implementation challenges
-
Karim S., and Baxter C. Antiretroviral prophylaxis for the prevention of HIV infection: future implementation challenges. HIV Ther. 3 (2009) 3-6
-
(2009)
HIV Ther.
, vol.3
, pp. 3-6
-
-
Karim, S.1
Baxter, C.2
-
116
-
-
3042693911
-
MIV-310 reduces HIV viral load in patients failing multiple antiretroviral therapy: results from a 4-week phase II study
-
Katlama C., Ghosn J., Tubiana R., Wirden M., Valantin M.A., Harmenberg J., Mardh G., Oberg B., and Calvez V. MIV-310 reduces HIV viral load in patients failing multiple antiretroviral therapy: results from a 4-week phase II study. AIDS 18 (2004) 1299-1304
-
(2004)
AIDS
, vol.18
, pp. 1299-1304
-
-
Katlama, C.1
Ghosn, J.2
Tubiana, R.3
Wirden, M.4
Valantin, M.A.5
Harmenberg, J.6
Mardh, G.7
Oberg, B.8
Calvez, V.9
-
117
-
-
48349089930
-
2′-Deoxy-4′-C-ethynyl-2-halo-adenosines active against drug-resistant human immunodeficiency virus type 1 variants
-
Kawamoto A., Kodama E., Sarafianos S.G., Sakagami Y., Kohgo S., Kitano K., Ashida N., Iwai Y., Hayakawa H., Nakata H., Mitsuya H., Arnold E., and Matsuoka M. 2′-Deoxy-4′-C-ethynyl-2-halo-adenosines active against drug-resistant human immunodeficiency virus type 1 variants. Int. J. Biochem. Cell. Biol. 40 (2008) 2410-2420
-
(2008)
Int. J. Biochem. Cell. Biol.
, vol.40
, pp. 2410-2420
-
-
Kawamoto, A.1
Kodama, E.2
Sarafianos, S.G.3
Sakagami, Y.4
Kohgo, S.5
Kitano, K.6
Ashida, N.7
Iwai, Y.8
Hayakawa, H.9
Nakata, H.10
Mitsuya, H.11
Arnold, E.12
Matsuoka, M.13
-
118
-
-
0032578396
-
Drug concentration heterogeneity facilitates the evolution of drug resistance
-
Kepler T.B., and Perelson A.S. Drug concentration heterogeneity facilitates the evolution of drug resistance. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 11514-11519
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 11514-11519
-
-
Kepler, T.B.1
Perelson, A.S.2
-
119
-
-
0001140507
-
Regiospecific and highly stereoselective electrophilic addition to furanoid glycals: synthesis of phosphonate nucleotide analogues with potent activity against HIV
-
Kim C.U., Luh B.Y., and Martin J.C. Regiospecific and highly stereoselective electrophilic addition to furanoid glycals: synthesis of phosphonate nucleotide analogues with potent activity against HIV. J. Org. Chem. 56 (1991) 2642-2647
-
(1991)
J. Org. Chem.
, vol.56
, pp. 2642-2647
-
-
Kim, C.U.1
Luh, B.Y.2
Martin, J.C.3
-
120
-
-
0035794282
-
Anti-HIV type 1 activity of 3′-fluoro-3′-deoxythymidine for several different multidrug-resistant mutants
-
Kim E.Y., Vrang L., Oberg B., and Merigan T.C. Anti-HIV type 1 activity of 3′-fluoro-3′-deoxythymidine for several different multidrug-resistant mutants. AIDS Res. Hum. Retroviruses 17 (2001) 401-407
-
(2001)
AIDS Res. Hum. Retroviruses
, vol.17
, pp. 401-407
-
-
Kim, E.Y.1
Vrang, L.2
Oberg, B.3
Merigan, T.C.4
-
121
-
-
38349171607
-
The effect of lopinavir/ritonavir on the renal clearance of tenofovir in HIV-infected patients
-
Kiser J.J., Carten M.L., Aquilante C.L., Anderson P.L., Wolfe P., King T.M., Delahunty T., Bushman L.R., and Fletcher C.V. The effect of lopinavir/ritonavir on the renal clearance of tenofovir in HIV-infected patients. Clin. Pharmacol. Ther. 83 (2008) 265-272
-
(2008)
Clin. Pharmacol. Ther.
, vol.83
, pp. 265-272
-
-
Kiser, J.J.1
Carten, M.L.2
Aquilante, C.L.3
Anderson, P.L.4
Wolfe, P.5
King, T.M.6
Delahunty, T.7
Bushman, L.R.8
Fletcher, C.V.9
-
122
-
-
38349194473
-
2′-Deoxy-4′-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2′-alpha-hydroxyl groups
-
Klumpp K., Kalayanov G., Ma H., Le Pogam S., Leveque V., Jiang W.R., Inocencio N., De Witte A., Rajyaguru S., Tai E., Chanda S., Irwin M.R., Sund C., Winqist A., Maltseva T., Eriksson S., Usova E., Smith M., Alker A., Najera I., Cammack N., Martin J.A., Johansson N.G., and Smith D.B. 2′-Deoxy-4′-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2′-alpha-hydroxyl groups. J. Biol. Chem. 283 (2008) 2167-2175
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 2167-2175
-
-
Klumpp, K.1
Kalayanov, G.2
Ma, H.3
Le Pogam, S.4
Leveque, V.5
Jiang, W.R.6
Inocencio, N.7
De Witte, A.8
Rajyaguru, S.9
Tai, E.10
Chanda, S.11
Irwin, M.R.12
Sund, C.13
Winqist, A.14
Maltseva, T.15
Eriksson, S.16
Usova, E.17
Smith, M.18
Alker, A.19
Najera, I.20
Cammack, N.21
Martin, J.A.22
Johansson, N.G.23
Smith, D.B.24
more..
-
123
-
-
73549112033
-
2′-Deoxynucleoside analogs can be potent dual inhibitors of HCV and HIV replication with selectivity against human polymerases
-
Miami Beach, FL, USA
-
Klumpp K., Su G., Leveque V., Deval J., Heilek G., Rajyaguru S., Li Y., Hang J.Q., Ma H., Inocencio N., Kalayanov G., Winqist A., Smith D.B., Cammack N., Johansson N.G., and Najera I. 2′-Deoxynucleoside analogs can be potent dual inhibitors of HCV and HIV replication with selectivity against human polymerases. 22nd International Conference on Antiviral Research, Abstract 16. Miami Beach, FL, USA (2009)
-
(2009)
22nd International Conference on Antiviral Research, Abstract 16
-
-
Klumpp, K.1
Su, G.2
Leveque, V.3
Deval, J.4
Heilek, G.5
Rajyaguru, S.6
Li, Y.7
Hang, J.Q.8
Ma, H.9
Inocencio, N.10
Kalayanov, G.11
Winqist, A.12
Smith, D.B.13
Cammack, N.14
Johansson, N.G.15
Najera, I.16
-
124
-
-
0026509422
-
Comparisons of anti-human immunodeficiency virus activities, cellular transport, and plasma and intracellular pharmacokinetics of 3′-fluoro-3′-deoxythymidine and 3′-azido-3′-deoxythymidine
-
Kong X.B., Zhu Q.Y., Vidal P.M., Watanabe K.A., Polsky B., Armstrong D., Ostrander M., Lang Jr. S.A., Muchmore E., and Chou T.C. Comparisons of anti-human immunodeficiency virus activities, cellular transport, and plasma and intracellular pharmacokinetics of 3′-fluoro-3′-deoxythymidine and 3′-azido-3′-deoxythymidine. Antimicrob. Agents Chemother. 36 (1992) 808-818
-
(1992)
Antimicrob. Agents Chemother.
, vol.36
, pp. 808-818
-
-
Kong, X.B.1
Zhu, Q.Y.2
Vidal, P.M.3
Watanabe, K.A.4
Polsky, B.5
Armstrong, D.6
Ostrander, M.7
Lang Jr., S.A.8
Muchmore, E.9
Chou, T.C.10
-
125
-
-
0037085269
-
Phosphorylation of pyrimidine deoxynucleoside analog diphosphates: selective phosphorylation of L-nucleoside analog diphosphates by 3-phosphoglycerate kinase
-
Krishnan P., Fu Q., Lam W., Liou J.Y., Dutschman G., and Cheng Y.C. Phosphorylation of pyrimidine deoxynucleoside analog diphosphates: selective phosphorylation of L-nucleoside analog diphosphates by 3-phosphoglycerate kinase. J. Biol. Chem. 277 (2002) 5453-5459
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 5453-5459
-
-
Krishnan, P.1
Fu, Q.2
Lam, W.3
Liou, J.Y.4
Dutschman, G.5
Cheng, Y.C.6
-
126
-
-
0347712943
-
Prevalence of mutations associated with resistance to antiretroviral therapy from 1999-2002
-
Boston, MA, USA
-
Lanier E., Scott J., Ait-Khaled M., Craig C., Alcorn T., Irlbeck D., Gerondelis P., Burgess R., and Underwood M. Prevalence of mutations associated with resistance to antiretroviral therapy from 1999-2002. 10th Conference on Retroviruses and Opportunistic Infections, Abstract 635. Boston, MA, USA (2003)
-
(2003)
10th Conference on Retroviruses and Opportunistic Infections, Abstract 635
-
-
Lanier, E.1
Scott, J.2
Ait-Khaled, M.3
Craig, C.4
Alcorn, T.5
Irlbeck, D.6
Gerondelis, P.7
Burgess, R.8
Underwood, M.9
-
127
-
-
73549086796
-
-
Lanier, E., Scott, J., Ait-Khaled, M., Craig, C., Alcorn, T., Irlbeck, D., Gerondelis, P., Burgess, R., Underwood, M., 2003b. Prevalence of mutations associated with resistance to antiretroviral therapy from 1999-2002. In: 10th Conference on Retroviruses and Opportunistic Infections, Abstr. 635 Boston MA USA.
-
Lanier, E., Scott, J., Ait-Khaled, M., Craig, C., Alcorn, T., Irlbeck, D., Gerondelis, P., Burgess, R., Underwood, M., 2003b. Prevalence of mutations associated with resistance to antiretroviral therapy from 1999-2002. In: 10th Conference on Retroviruses and Opportunistic Infections, Abstr. 635 Boston MA USA.
-
-
-
-
128
-
-
67349095246
-
Hexadecyloxypropyl tenofovir associates directly with HIV and subsequently inhibits viral replication in untreated cells
-
Montreal, Canada
-
Lanier R., Lampert B., Robertson A., Almond M., and Painter G. Hexadecyloxypropyl tenofovir associates directly with HIV and subsequently inhibits viral replication in untreated cells. 16th Conference on retroviruses and Opportunistic Infections, Abstract 556. Montreal, Canada (2009)
-
(2009)
16th Conference on retroviruses and Opportunistic Infections, Abstract 556
-
-
Lanier, R.1
Lampert, B.2
Robertson, A.3
Almond, M.4
Painter, G.5
-
129
-
-
73549103653
-
Development of hexadecyloxypropyl tenofovir (CMX157) for HIV: potential for use as a microbicide and therapeutic
-
Miami Beach, FL, USA
-
Lanier R., Lampert B., Trosta L., Almonda M., and Painter G. Development of hexadecyloxypropyl tenofovir (CMX157) for HIV: potential for use as a microbicide and therapeutic. 22th International Conference on Antiviral Research, Abstract 89. Miami Beach, FL, USA (2009)
-
(2009)
22th International Conference on Antiviral Research, Abstract 89
-
-
Lanier, R.1
Lampert, B.2
Trosta, L.3
Almonda, M.4
Painter, G.5
-
130
-
-
73549085453
-
High-resolution crystallographic analysis of the competitive binding of a novel nucleotide analog GS-9148-diphosphate to HIV-1 reverse transcriptase
-
Montreal, Canada
-
Lansdon E., Samuel D., Lagpacan L., White K., Boojamra C., Mackman R., Cihlar T., Ray A., McGrath M., and Swaminathan S. High-resolution crystallographic analysis of the competitive binding of a novel nucleotide analog GS-9148-diphosphate to HIV-1 reverse transcriptase. 16th Conference on Retroviruses and Opportunistic Infections, Abstract 66LB. Montreal, Canada (2009)
-
(2009)
16th Conference on Retroviruses and Opportunistic Infections, Abstract 66LB
-
-
Lansdon, E.1
Samuel, D.2
Lagpacan, L.3
White, K.4
Boojamra, C.5
Mackman, R.6
Cihlar, T.7
Ray, A.8
McGrath, M.9
Swaminathan, S.10
-
131
-
-
18244398917
-
Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor tenofovir leads to preferential distribution and accumulation in lymphatic tissue
-
Lee W.A., He G.X., Eisenberg E., Cihlar T., Swaminathan S., Mulato A., and Cundy K.C. Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor tenofovir leads to preferential distribution and accumulation in lymphatic tissue. Antimicrob. Agents Chemother. 49 (2005) 1898-1906
-
(2005)
Antimicrob. Agents Chemother.
, vol.49
, pp. 1898-1906
-
-
Lee, W.A.1
He, G.X.2
Eisenberg, E.3
Cihlar, T.4
Swaminathan, S.5
Mulato, A.6
Cundy, K.C.7
-
132
-
-
34250215650
-
Biochemical studies on the mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to 1-(beta-D-dioxolane)thymine triphosphate
-
Lennerstrand J., Chu C.K., and Schinazi R.F. Biochemical studies on the mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to 1-(beta-D-dioxolane)thymine triphosphate. Antimicrob. Agents Chemother. 51 (2007) 2078-2084
-
(2007)
Antimicrob. Agents Chemother.
, vol.51
, pp. 2078-2084
-
-
Lennerstrand, J.1
Chu, C.K.2
Schinazi, R.F.3
-
133
-
-
0026046254
-
Mitochondrial ultrastructural and molecular changes induced by zidovudine in rat hearts
-
Lewis W., Papoian T., Gonzalez B., Louie H., Kelly D.P., Payne R.M., and Grody W.W. Mitochondrial ultrastructural and molecular changes induced by zidovudine in rat hearts. Lab. Invest. 65 (1991) 228-236
-
(1991)
Lab. Invest.
, vol.65
, pp. 228-236
-
-
Lewis, W.1
Papoian, T.2
Gonzalez, B.3
Louie, H.4
Kelly, D.P.5
Payne, R.M.6
Grody, W.W.7
-
134
-
-
32844455838
-
Phosphoramidate and phosphate prodrugs of (-)-beta-D-(2R,4R)-dioxolane-thymine: synthesis, anti-HIV activity and stability studies
-
Liang Y., Narayanasamy J., Schinazi R.F., and Chu C.K. Phosphoramidate and phosphate prodrugs of (-)-beta-D-(2R,4R)-dioxolane-thymine: synthesis, anti-HIV activity and stability studies. Bioorg. Med. Chem. 14 (2006) 2178-2189
-
(2006)
Bioorg. Med. Chem.
, vol.14
, pp. 2178-2189
-
-
Liang, Y.1
Narayanasamy, J.2
Schinazi, R.F.3
Chu, C.K.4
-
135
-
-
58949101282
-
5′-O-Aliphatic and amino acid ester prodrugs of (-)-beta-D-(2R,4R)-dioxolane-thymine (DOT): synthesis, anti-HIV activity, cytotoxicity and stability studies
-
Liang Y., Sharon A., Grier J.P., Rapp K.L., Schinazi R.F., and Chu C.K. 5′-O-Aliphatic and amino acid ester prodrugs of (-)-beta-D-(2R,4R)-dioxolane-thymine (DOT): synthesis, anti-HIV activity, cytotoxicity and stability studies. Bioorg. Med. Chem. 17 (2009) 1404-1409
-
(2009)
Bioorg. Med. Chem.
, vol.17
, pp. 1404-1409
-
-
Liang, Y.1
Sharon, A.2
Grier, J.P.3
Rapp, K.L.4
Schinazi, R.F.5
Chu, C.K.6
-
136
-
-
0029881506
-
Design and synthesis of 2′,3′-dideoxy-2′,3′-didehydro-beta-L-cytidine (beta-L-d4C) and 2′,3′-dideoxy 2′,3′-didehydro-beta-L-5-fluorocytidine (beta-L-Fd4C), two exceptionally potent inhibitors of human hepatitis B virus (HBV) and potent inhibitors of human immunodeficiency virus (HIV) in vitro
-
Lin T.S., Luo M.Z., Liu M.C., Zhu Y.L., Gullen E., Dutschman G.E., and Cheng Y.C. Design and synthesis of 2′,3′-dideoxy-2′,3′-didehydro-beta-L-cytidine (beta-L-d4C) and 2′,3′-dideoxy 2′,3′-didehydro-beta-L-5-fluorocytidine (beta-L-Fd4C), two exceptionally potent inhibitors of human hepatitis B virus (HBV) and potent inhibitors of human immunodeficiency virus (HIV) in vitro. J. Med. Chem. 39 (1996) 1757-1759
-
(1996)
J. Med. Chem.
, vol.39
, pp. 1757-1759
-
-
Lin, T.S.1
Luo, M.Z.2
Liu, M.C.3
Zhu, Y.L.4
Gullen, E.5
Dutschman, G.E.6
Cheng, Y.C.7
-
137
-
-
0037043652
-
Antiretroviral-drug resistance among patients recently infected with HIV
-
Little S.J., Holte S., Routy J.P., Daar E.S., Markowitz M., Collier A.C., Koup R.A., Mellors J.W., Connick E., Conway B., Kilby M., Wang L., Whitcomb J.M., Hellmann N.S., and Richman D.D. Antiretroviral-drug resistance among patients recently infected with HIV. N. Engl. J. Med. 347 (2002) 385-394
-
(2002)
N. Engl. J. Med.
, vol.347
, pp. 385-394
-
-
Little, S.J.1
Holte, S.2
Routy, J.P.3
Daar, E.S.4
Markowitz, M.5
Collier, A.C.6
Koup, R.A.7
Mellors, J.W.8
Connick, E.9
Conway, B.10
Kilby, M.11
Wang, L.12
Whitcomb, J.M.13
Hellmann, N.S.14
Richman, D.D.15
-
138
-
-
43149125347
-
Steady-state pharmacokinetics (PK) of tenofovir (TDF) and fosamprenavir (FPV) after once daily (QD) TDF with unboosted or ritonavir (R)-boosted twice daily (BID) FPV in healthy volunteers
-
Glasgow, UK
-
Luber A., Slowinski D., Andrews M., Olson K., Peloquin C., Pakes G., Pappa K., Shelton M., and Condoluci D. Steady-state pharmacokinetics (PK) of tenofovir (TDF) and fosamprenavir (FPV) after once daily (QD) TDF with unboosted or ritonavir (R)-boosted twice daily (BID) FPV in healthy volunteers. 8th International Congress on Drug Therapy in HIV Infection. Glasgow, UK (2006)
-
(2006)
8th International Congress on Drug Therapy in HIV Infection
-
-
Luber, A.1
Slowinski, D.2
Andrews, M.3
Olson, K.4
Peloquin, C.5
Pakes, G.6
Pappa, K.7
Shelton, M.8
Condoluci, D.9
-
139
-
-
0026740250
-
Synthesis and anti-HIV activity of 4′-azido- and 4′-methoxynucleosides
-
Maag H., Rydzewski R.M., McRoberts M.J., Crawford-Ruth D., Verheyden J.P., and Prisbe E.J. Synthesis and anti-HIV activity of 4′-azido- and 4′-methoxynucleosides. J. Med. Chem. 35 (1992) 1440-1451
-
(1992)
J. Med. Chem.
, vol.35
, pp. 1440-1451
-
-
Maag, H.1
Rydzewski, R.M.2
McRoberts, M.J.3
Crawford-Ruth, D.4
Verheyden, J.P.5
Prisbe, E.J.6
-
140
-
-
33745114091
-
Severe liver disease associated with prolonged exposure to antiretroviral drugs
-
Maida I., Nunez M., Rios M.J., Martin-Carbonero L., Sotgiu G., Toro C., Rivas P., Barreiro P., Mura M.S., Babudieri S., Garcia-Samaniego J., Gonzalez-Lahoz J., and Soriano V. Severe liver disease associated with prolonged exposure to antiretroviral drugs. J. Acquir. Immune Defic. Syndr. 42 (2006) 177-182
-
(2006)
J. Acquir. Immune Defic. Syndr.
, vol.42
, pp. 177-182
-
-
Maida, I.1
Nunez, M.2
Rios, M.J.3
Martin-Carbonero, L.4
Sotgiu, G.5
Toro, C.6
Rivas, P.7
Barreiro, P.8
Mura, M.S.9
Babudieri, S.10
Garcia-Samaniego, J.11
Gonzalez-Lahoz, J.12
Soriano, V.13
-
141
-
-
0037006623
-
Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir
-
Mallal S., Nolan D., Witt C., Masel G., Martin A.M., Moore C., Sayer D., Castley A., Mamotte C., Maxwell D., James I., and Christiansen F.T. Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir. Lancet 359 (2002) 727-732
-
(2002)
Lancet
, vol.359
, pp. 727-732
-
-
Mallal, S.1
Nolan, D.2
Witt, C.3
Masel, G.4
Martin, A.M.5
Moore, C.6
Sayer, D.7
Castley, A.8
Mamotte, C.9
Maxwell, D.10
James, I.11
Christiansen, F.T.12
-
142
-
-
73549085006
-
Biochemical mechanism of HIV-1 reverse transcriptase inhibition and resistance to translocation-deficient RT inhibitors
-
Boston, MA, USA
-
Marchand B., Michailidis L., Fopoussi A., Kodama E., Matsuoka M., Ashida N., Nagy E., Parniak M., Mitsuya H., and Sarafianos S. Biochemical mechanism of HIV-1 reverse transcriptase inhibition and resistance to translocation-deficient RT inhibitors. 15th Conference on Retroviruses and Opportunistic Infections, Abstract 726a. Boston, MA, USA (2008)
-
(2008)
15th Conference on Retroviruses and Opportunistic Infections, Abstract 726a
-
-
Marchand, B.1
Michailidis, L.2
Fopoussi, A.3
Kodama, E.4
Matsuoka, M.5
Ashida, N.6
Nagy, E.7
Parniak, M.8
Mitsuya, H.9
Sarafianos, S.10
-
143
-
-
34648831495
-
The use of beta-D-2,6-diaminopurine dioxolane with or without mycophenolate mofetil in drug-resistant HIV infection
-
Margolis D.M., Mukherjee A.L., Fletcher C.V., Hogg E., Ogata-Arakaki D., Petersen T., Rusin D., Martinez A., and Mellors J.W. The use of beta-D-2,6-diaminopurine dioxolane with or without mycophenolate mofetil in drug-resistant HIV infection. AIDS 21 (2007) 2025-2032
-
(2007)
AIDS
, vol.21
, pp. 2025-2032
-
-
Margolis, D.M.1
Mukherjee, A.L.2
Fletcher, C.V.3
Hogg, E.4
Ogata-Arakaki, D.5
Petersen, T.6
Rusin, D.7
Martinez, A.8
Mellors, J.W.9
-
144
-
-
0028148674
-
Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis
-
Martin J.L., Brown C.E., Matthews-Davis N., and Reardon J.E. Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis. Antimicrob. Agents Chemother. 38 (1994) 2743-2749
-
(1994)
Antimicrob. Agents Chemother.
, vol.38
, pp. 2743-2749
-
-
Martin, J.L.1
Brown, C.E.2
Matthews-Davis, N.3
Reardon, J.E.4
-
145
-
-
12144287198
-
Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant
-
Martin A.M., Nolan D., Gaudieri S., Almeida C.A., Nolan R., James I., Carvalho F., Phillips E., Christiansen F.T., Purcell A.W., McCluskey J., and Mallal S. Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 4180-4185
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 4180-4185
-
-
Martin, A.M.1
Nolan, D.2
Gaudieri, S.3
Almeida, C.A.4
Nolan, R.5
James, I.6
Carvalho, F.7
Phillips, E.8
Christiansen, F.T.9
Purcell, A.W.10
McCluskey, J.11
Mallal, S.12
-
146
-
-
73549101337
-
Abacavir stimulates Hsp70 redistribution in antigen presenting cells of patients with hypersensitivity: association with type I alcohol dehydrogenase activity
-
Boston, MA, USA
-
Martin A., Almeida C., Nolan D., Cameron P., James I., Purcell A., McCluskey J., and Phillips E.S.M. Abacavir stimulates Hsp70 redistribution in antigen presenting cells of patients with hypersensitivity: association with type I alcohol dehydrogenase activity. 12th Conference on Retroviruses and Opportunistic Infections, Abstract 834. Boston, MA, USA (2005)
-
(2005)
12th Conference on Retroviruses and Opportunistic Infections, Abstract 834
-
-
Martin, A.1
Almeida, C.2
Nolan, D.3
Cameron, P.4
James, I.5
Purcell, A.6
McCluskey, J.7
Phillips, E.S.M.8
-
147
-
-
73549122138
-
A brief history of the first generation nucleoside HIV reverse transcriptase inhibitors
-
Martin J., Hitchcock M.J., De Clercq E., and Prusoff W. A brief history of the first generation nucleoside HIV reverse transcriptase inhibitors. Antiviral Res. 85 (2010) 34-38
-
(2010)
Antiviral Res.
, vol.85
, pp. 34-38
-
-
Martin, J.1
Hitchcock, M.J.2
De Clercq, E.3
Prusoff, W.4
-
148
-
-
70350179571
-
GS-9350: a pharmaco-enhancer without anti-HIV activity
-
Montreal, Canada
-
Mathias A., Lee M., Callebaut C., Xu L., Tsai L., Murray B., Liu H., Yale K., Warren D., and Kearney B. GS-9350: a pharmaco-enhancer without anti-HIV activity. 15th Conference on Retroviruses and Opportunistic Infections, Abstract 40. Montreal, Canada (2009)
-
(2009)
15th Conference on Retroviruses and Opportunistic Infections, Abstract 40
-
-
Mathias, A.1
Lee, M.2
Callebaut, C.3
Xu, L.4
Tsai, L.5
Murray, B.6
Liu, H.7
Yale, K.8
Warren, D.9
Kearney, B.10
-
149
-
-
42149172733
-
Prevalence, genotypic associations and phenotypic characterization of K65R, L74V and other HIV-1 RT resistance mutations in a commercial database
-
McColl D.J., Chappey C., Parkin N.T., and Miller M.D. Prevalence, genotypic associations and phenotypic characterization of K65R, L74V and other HIV-1 RT resistance mutations in a commercial database. Antiviral Ther. 13 (2008) 189-197
-
(2008)
Antiviral Ther.
, vol.13
, pp. 189-197
-
-
McColl, D.J.1
Chappey, C.2
Parkin, N.T.3
Miller, M.D.4
-
150
-
-
0032585875
-
Pharmacokinetics of [(14)C]abacavir, a human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitor, administered in a single oral dose to HIV-1-infected adults: a mass balance study
-
McDowell J.A., Chittick G.E., Ravitch J.R., Polk R.E., Kerkering T.M., and Stein D.S. Pharmacokinetics of [(14)C]abacavir, a human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitor, administered in a single oral dose to HIV-1-infected adults: a mass balance study. Antimicrob. Agents Chemother. 43 (1999) 2855-2861
-
(1999)
Antimicrob. Agents Chemother.
, vol.43
, pp. 2855-2861
-
-
McDowell, J.A.1
Chittick, G.E.2
Ravitch, J.R.3
Polk, R.E.4
Kerkering, T.M.5
Stein, D.S.6
-
151
-
-
0034045094
-
Pharmacokinetic interaction of abacavir (1592U89) and ethanol in human immunodeficiency virus-infected adults
-
McDowell J.A., Chittick G.E., Stevens C.P., Edwards K.D., and Stein D.S. Pharmacokinetic interaction of abacavir (1592U89) and ethanol in human immunodeficiency virus-infected adults. Antimicrob. Agents Chemother. 44 (2000) 1686-1690
-
(2000)
Antimicrob. Agents Chemother.
, vol.44
, pp. 1686-1690
-
-
McDowell, J.A.1
Chittick, G.E.2
Stevens, C.P.3
Edwards, K.D.4
Stein, D.S.5
-
152
-
-
4744372267
-
Phosphorylation of thymidine and AZT in heart mitochondria: elucidation of a novel mechanism of AZT cardiotoxicity
-
McKee E.E., Bentley A.T., Hatch M., Gingerich J., and Susan-Resiga D. Phosphorylation of thymidine and AZT in heart mitochondria: elucidation of a novel mechanism of AZT cardiotoxicity. Cardiovasc. Toxicol. 4 (2004) 155-167
-
(2004)
Cardiovasc. Toxicol.
, vol.4
, pp. 155-167
-
-
McKee, E.E.1
Bentley, A.T.2
Hatch, M.3
Gingerich, J.4
Susan-Resiga, D.5
-
153
-
-
0028817865
-
Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B
-
McKenzie R., Fried M.W., Sallie R., Conjeevaram H., Di Bisceglie A.M., Park Y., Savarese B., Kleiner D., Tsokos M., Luciano C., et al. Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B. N. Engl. J. Med. 333 (1995) 1099-1105
-
(1995)
N. Engl. J. Med.
, vol.333
, pp. 1099-1105
-
-
McKenzie, R.1
Fried, M.W.2
Sallie, R.3
Conjeevaram, H.4
Di Bisceglie, A.M.5
Park, Y.6
Savarese, B.7
Kleiner, D.8
Tsokos, M.9
Luciano, C.10
-
154
-
-
73549088708
-
Molecular basis of human immunodeficiency virus drug resistance: an update
-
Menendez-Arias L. Molecular basis of human immunodeficiency virus drug resistance: an update. Antiviral Res. 85 (2010) 210-231
-
(2010)
Antiviral Res.
, vol.85
, pp. 210-231
-
-
Menendez-Arias, L.1
-
155
-
-
0036156325
-
Dioxolane guanosine, the active form of the prodrug diaminopurine dioxolane, is a potent inhibitor of drug-resistant HIV-1 isolates from patients for whom standard nucleoside therapy fails
-
Mewshaw J.P., Myrick F.T., Wakefield D.A., Hooper B.J., Harris J.L., McCreedy B., and Borroto-Esoda K. Dioxolane guanosine, the active form of the prodrug diaminopurine dioxolane, is a potent inhibitor of drug-resistant HIV-1 isolates from patients for whom standard nucleoside therapy fails. J. Acquir. Immune Defic. Syndr. 29 (2002) 11-20
-
(2002)
J. Acquir. Immune Defic. Syndr.
, vol.29
, pp. 11-20
-
-
Mewshaw, J.P.1
Myrick, F.T.2
Wakefield, D.A.3
Hooper, B.J.4
Harris, J.L.5
McCreedy, B.6
Borroto-Esoda, K.7
-
156
-
-
0033165851
-
A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase
-
Meyer P.R., Matsuura S.E., Mian A.M., So A.G., and Scott W.A. A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase. Mol. Cell 4 (1999) 35-43
-
(1999)
Mol. Cell
, vol.4
, pp. 35-43
-
-
Meyer, P.R.1
Matsuura, S.E.2
Mian, A.M.3
So, A.G.4
Scott, W.A.5
-
157
-
-
70349146239
-
Profound antiviral effect of oral administration of MIV-210 on chronic hepadnaviral infection in the woodchuck model of hepatitis B
-
(June 29; Epub ahead of print)
-
Michalak T.I., Zhang H., Churchill N.D., Larsson T., Johansson N.G., and Oberg B. Profound antiviral effect of oral administration of MIV-210 on chronic hepadnaviral infection in the woodchuck model of hepatitis B. Antimicrob. Agents Chemother. (2009) (June 29; Epub ahead of print)
-
(2009)
Antimicrob. Agents Chemother.
-
-
Michalak, T.I.1
Zhang, H.2
Churchill, N.D.3
Larsson, T.4
Johansson, N.G.5
Oberg, B.6
-
158
-
-
2342661255
-
K65R, TAMs and tenofovir
-
Miller M.D. K65R, TAMs and tenofovir. AIDS Rev. 6 (2004) 22-33
-
(2004)
AIDS Rev.
, vol.6
, pp. 22-33
-
-
Miller, M.D.1
-
159
-
-
0001707601
-
3′-Azido-3′-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro
-
Mitsuya H., Weinhold K.J., Furman P.A., St. Clair M.H., Lehrman S.N., Gallo R.C., Bolognesi D., Barry D.W., and Broder S. 3′-Azido-3′-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro. Proc. Natl. Acad. Sci. U.S.A. 82 (1985) 7096-7100
-
(1985)
Proc. Natl. Acad. Sci. U.S.A.
, vol.82
, pp. 7096-7100
-
-
Mitsuya, H.1
Weinhold, K.J.2
Furman, P.A.3
St. Clair, M.H.4
Lehrman, S.N.5
Gallo, R.C.6
Bolognesi, D.7
Barry, D.W.8
Broder, S.9
-
160
-
-
33750227103
-
A randomized comparative trial of tenofovir DF or abacavir as replacement for a thymidine analogue in persons with lipoatrophy
-
Moyle G.J., Sabin C.A., Cartledge J., Johnson M., Wilkins E., Churchill D., Hay P., Fakoya A., Murphy M., Scullard G., Leen C., and Reilly G. A randomized comparative trial of tenofovir DF or abacavir as replacement for a thymidine analogue in persons with lipoatrophy. AIDS 20 (2006) 2043-2050
-
(2006)
AIDS
, vol.20
, pp. 2043-2050
-
-
Moyle, G.J.1
Sabin, C.A.2
Cartledge, J.3
Johnson, M.4
Wilkins, E.5
Churchill, D.6
Hay, P.7
Fakoya, A.8
Murphy, M.9
Scullard, G.10
Leen, C.11
Reilly, G.12
-
162
-
-
1542404537
-
Investigating the effects of stereochemistry on incorporation and removal of 5-fluorocytidine analogs by mitochondrial DNA polymerase gamma: comparison of D- and L-D4FC-TP
-
Murakami E., Ray A.S., Schinazi R.F., and Anderson K.S. Investigating the effects of stereochemistry on incorporation and removal of 5-fluorocytidine analogs by mitochondrial DNA polymerase gamma: comparison of D- and L-D4FC-TP. Antiviral Res. 62 (2004) 57-64
-
(2004)
Antiviral Res.
, vol.62
, pp. 57-64
-
-
Murakami, E.1
Ray, A.S.2
Schinazi, R.F.3
Anderson, K.S.4
-
163
-
-
20444429765
-
Mechanism of action of a novel viral mutagenic covert nucleotide: molecular interactions with HIV-1 reverse transcriptase and host cell DNA polymerases
-
Murakami E., Basavapathruni A., Bradley W.D., and Anderson K.S. Mechanism of action of a novel viral mutagenic covert nucleotide: molecular interactions with HIV-1 reverse transcriptase and host cell DNA polymerases. Antiviral Res. 67 (2005) 10-17
-
(2005)
Antiviral Res.
, vol.67
, pp. 10-17
-
-
Murakami, E.1
Basavapathruni, A.2
Bradley, W.D.3
Anderson, K.S.4
-
164
-
-
66349117456
-
Pharmacokinetics and potent anti-HIV-1 activity of amdoxovir plus zidovudine in a randomized double-blind placebo-controlled study
-
Boston, MA
-
Murphy R., Zala C., Ochoa C., Tharnish P., Mathew J., Fromentin E., Asif G., Hurwitz S., Kivel N., and Schinazi R. Pharmacokinetics and potent anti-HIV-1 activity of amdoxovir plus zidovudine in a randomized double-blind placebo-controlled study. 15th Conference on Retroviruses and Opportunistic Infections, Abstract 794. Boston, MA (2008)
-
(2008)
15th Conference on Retroviruses and Opportunistic Infections, Abstract 794
-
-
Murphy, R.1
Zala, C.2
Ochoa, C.3
Tharnish, P.4
Mathew, J.5
Fromentin, E.6
Asif, G.7
Hurwitz, S.8
Kivel, N.9
Schinazi, R.10
-
165
-
-
34547620353
-
Activity against human immunodeficiency virus type 1, intracellular metabolism, and effects on human DNA polymerases of 4′-ethynyl-2-fluoro-2′-deoxyadenosine
-
Nakata H., Amano M., Koh Y., Kodama E., Yang G., Bailey C.M., Kohgo S., Hayakawa H., Matsuoka M., Anderson K.S., Cheng Y.C., and Mitsuya H. Activity against human immunodeficiency virus type 1, intracellular metabolism, and effects on human DNA polymerases of 4′-ethynyl-2-fluoro-2′-deoxyadenosine. Antimicrob. Agents Chemother. 51 (2007) 2701-2708
-
(2007)
Antimicrob. Agents Chemother.
, vol.51
, pp. 2701-2708
-
-
Nakata, H.1
Amano, M.2
Koh, Y.3
Kodama, E.4
Yang, G.5
Bailey, C.M.6
Kohgo, S.7
Hayakawa, H.8
Matsuoka, M.9
Anderson, K.S.10
Cheng, Y.C.11
Mitsuya, H.12
-
166
-
-
34249984379
-
The safety of tenofovir disoproxil fumarate for the treatment of HIV infection in adults: the first 4 years
-
Nelson M.R., Katlama C., Montaner J.S., Cooper D.A., Gazzard B., Clotet B., Lazzarin A., Schewe K., Lange J., Wyatt C., Curtis S., Chen S.S., Smith S., Bischofberger N., and Rooney J.F. The safety of tenofovir disoproxil fumarate for the treatment of HIV infection in adults: the first 4 years. AIDS 21 (2007) 1273-1281
-
(2007)
AIDS
, vol.21
, pp. 1273-1281
-
-
Nelson, M.R.1
Katlama, C.2
Montaner, J.S.3
Cooper, D.A.4
Gazzard, B.5
Clotet, B.6
Lazzarin, A.7
Schewe, K.8
Lange, J.9
Wyatt, C.10
Curtis, S.11
Chen, S.S.12
Smith, S.13
Bischofberger, N.14
Rooney, J.F.15
-
167
-
-
23044505480
-
Anti-human immunodeficiency virus type 1 activity and resistance profile of 2′,3′-didehydro-3′-deoxy-4′-ethynylthymidine in vitro
-
Nitanda T., Wang X., Kumamoto H., Haraguchi K., Tanaka H., Cheng Y.C., and Baba M. Anti-human immunodeficiency virus type 1 activity and resistance profile of 2′,3′-didehydro-3′-deoxy-4′-ethynylthymidine in vitro. Antimicrob. Agents Chemother. 49 (2005) 3355-3360
-
(2005)
Antimicrob. Agents Chemother.
, vol.49
, pp. 3355-3360
-
-
Nitanda, T.1
Wang, X.2
Kumamoto, H.3
Haraguchi, K.4
Tanaka, H.5
Cheng, Y.C.6
Baba, M.7
-
168
-
-
35848960087
-
Variations in reverse transcriptase and RNase H domain mutations in human immunodeficiency virus type 1 clinical isolates are associated with divergent phenotypic resistance to zidovudine
-
Ntemgwa M., Wainberg M.A., Oliveira M., Moisi D., Lalonde R., Micheli V., and Brenner B.G. Variations in reverse transcriptase and RNase H domain mutations in human immunodeficiency virus type 1 clinical isolates are associated with divergent phenotypic resistance to zidovudine. Antimicrob. Agents Chemother. 51 (2007) 3861-3869
-
(2007)
Antimicrob. Agents Chemother.
, vol.51
, pp. 3861-3869
-
-
Ntemgwa, M.1
Wainberg, M.A.2
Oliveira, M.3
Moisi, D.4
Lalonde, R.5
Micheli, V.6
Brenner, B.G.7
-
169
-
-
34948857943
-
Evaluation of hexadecyloxypropyl-9-R-[2-(phosphonomethoxy)propyl]-adenine, CMX157, as a potential treatment for human immunodeficiency virus type 1 and hepatitis B virus infections
-
Painter G.R., Almond M.R., Trost L.C., Lampert B.M., Neyts J., De Clercq E., Korba B.E., Aldern K.A., Beadle J.R., and Hostetler K.Y. Evaluation of hexadecyloxypropyl-9-R-[2-(phosphonomethoxy)propyl]-adenine, CMX157, as a potential treatment for human immunodeficiency virus type 1 and hepatitis B virus infections. Antimicrob. Agents Chemother. 51 (2007) 3505-3509
-
(2007)
Antimicrob. Agents Chemother.
, vol.51
, pp. 3505-3509
-
-
Painter, G.R.1
Almond, M.R.2
Trost, L.C.3
Lampert, B.M.4
Neyts, J.5
De Clercq, E.6
Korba, B.E.7
Aldern, K.A.8
Beadle, J.R.9
Hostetler, K.Y.10
-
170
-
-
35848929439
-
Intracellular metabolism and persistence of the anti-human immunodeficiency virus activity of 2′,3′-didehydro-3′-deoxy-4′-ethynylthymidine, a novel thymidine analog
-
Paintsil E., Dutschman G.E., Hu R., Grill S.P., Lam W., Baba M., Tanaka H., and Cheng Y.C. Intracellular metabolism and persistence of the anti-human immunodeficiency virus activity of 2′,3′-didehydro-3′-deoxy-4′-ethynylthymidine, a novel thymidine analog. Antimicrob. Agents Chemother. 51 (2007) 3870-3879
-
(2007)
Antimicrob. Agents Chemother.
, vol.51
, pp. 3870-3879
-
-
Paintsil, E.1
Dutschman, G.E.2
Hu, R.3
Grill, S.P.4
Lam, W.5
Baba, M.6
Tanaka, H.7
Cheng, Y.C.8
-
171
-
-
66349096006
-
Comparative study of the persistence of anti-HIV activity of deoxynucleoside HIV reverse transcriptase inhibitors after removal from culture
-
Paintsil E., Grill S.P., Dutschman G.E., and Cheng Y.C. Comparative study of the persistence of anti-HIV activity of deoxynucleoside HIV reverse transcriptase inhibitors after removal from culture. AIDS Res. Ther. 6 (2009) 5
-
(2009)
AIDS Res. Ther.
, vol.6
, pp. 5
-
-
Paintsil, E.1
Grill, S.P.2
Dutschman, G.E.3
Cheng, Y.C.4
-
172
-
-
73549090631
-
A Single-dose escalation study to evaluate the safety, tolerability, and pharmacokinetics of OBP-601, a novel NRTI, in healthy subjects
-
Montreal, Canada
-
Paintsil E., Mastuda T., Ross J., Schofield J., Cheng Y.C., and Urata Y. A Single-dose escalation study to evaluate the safety, tolerability, and pharmacokinetics of OBP-601, a novel NRTI, in healthy subjects. 16th Conference on Retroviruses and Opportunistic Infections, Abstract 568. Montreal, Canada (2009)
-
(2009)
16th Conference on Retroviruses and Opportunistic Infections, Abstract 568
-
-
Paintsil, E.1
Mastuda, T.2
Ross, J.3
Schofield, J.4
Cheng, Y.C.5
Urata, Y.6
-
173
-
-
62449261120
-
HIV preexposure prophylaxis in the United States: impact on lifetime infection risk, clinical outcomes, and cost-effectiveness
-
Paltiel A.D., Freedberg K.A., Scott C.A., Schackman B.R., Losina E., Wang B., Seage G.R.3r., Sloan C.E., Sax P.E., and Walensky R.P. HIV preexposure prophylaxis in the United States: impact on lifetime infection risk, clinical outcomes, and cost-effectiveness. Clin. Infect. Dis. 48 (2009) 806-815
-
(2009)
Clin. Infect. Dis.
, vol.48
, pp. 806-815
-
-
Paltiel, A.D.1
Freedberg, K.A.2
Scott, C.A.3
Schackman, B.R.4
Losina, E.5
Wang, B.6
Seage, G.R.3r.7
Sloan, C.E.8
Sax, P.E.9
Walensky, R.P.10
-
174
-
-
34250695989
-
Abcg2/Bcrp1 mediates the polarized transport of antiretroviral nucleosides abacavir and zidovudine
-
Pan G., Giri N., and Elmquist W.F. Abcg2/Bcrp1 mediates the polarized transport of antiretroviral nucleosides abacavir and zidovudine. Drug Metab. Dispos. 35 (2007) 1165-1173
-
(2007)
Drug Metab. Dispos.
, vol.35
, pp. 1165-1173
-
-
Pan, G.1
Giri, N.2
Elmquist, W.F.3
-
175
-
-
14744267571
-
In vitro activity of structurally diverse nucleoside analogs against human immunodeficiency virus type 1 with the K65R mutation in reverse transcriptase
-
Parikh U.M., Koontz D.L., Chu C.K., Schinazi R.F., and Mellors J.W. In vitro activity of structurally diverse nucleoside analogs against human immunodeficiency virus type 1 with the K65R mutation in reverse transcriptase. Antimicrob. Agents Chemother. 49 (2005) 1139-1144
-
(2005)
Antimicrob. Agents Chemother.
, vol.49
, pp. 1139-1144
-
-
Parikh, U.M.1
Koontz, D.L.2
Chu, C.K.3
Schinazi, R.F.4
Mellors, J.W.5
-
176
-
-
64349088125
-
Successful translation of pharmacogenetics into the clinic: the abacavir example
-
Phillips E., and Mallal S. Successful translation of pharmacogenetics into the clinic: the abacavir example. Mol. Diagn. Ther. 13 (2009) 1-9
-
(2009)
Mol. Diagn. Ther.
, vol.13
, pp. 1-9
-
-
Phillips, E.1
Mallal, S.2
-
177
-
-
4444227542
-
Pharmacokinetic properties of nucleoside/nucleotide reverse transcriptase inhibitors
-
Piliero P.J. Pharmacokinetic properties of nucleoside/nucleotide reverse transcriptase inhibitors. J. Acquir. Immune Defic. Syndr. 37 Suppl. 1 (2004) S2-S12
-
(2004)
J. Acquir. Immune Defic. Syndr.
, vol.37
, Issue.SUPPL. 1
-
-
Piliero, P.J.1
-
178
-
-
20944435946
-
Measurement of intracellular didanosine and tenofovir phosphorylated metabolites and possible interaction of the two drugs in human immunodeficiency virus-infected patients
-
Pruvost A., Negredo E., Benech H., Theodoro F., Puig J., Grau E., Garcia E., Molto J., Grassi J., and Clotet B. Measurement of intracellular didanosine and tenofovir phosphorylated metabolites and possible interaction of the two drugs in human immunodeficiency virus-infected patients. Antimicrob. Agents Chemother. 49 (2005) 1907-1914
-
(2005)
Antimicrob. Agents Chemother.
, vol.49
, pp. 1907-1914
-
-
Pruvost, A.1
Negredo, E.2
Benech, H.3
Theodoro, F.4
Puig, J.5
Grau, E.6
Garcia, E.7
Molto, J.8
Grassi, J.9
Clotet, B.10
-
179
-
-
23144439258
-
Intracellular interactions between nucleos(t)ide inhibitors of HIV reverse transcriptase
-
Ray A.S. Intracellular interactions between nucleos(t)ide inhibitors of HIV reverse transcriptase. AIDS Rev. 7 (2005) 113-125
-
(2005)
AIDS Rev.
, vol.7
, pp. 113-125
-
-
Ray, A.S.1
-
181
-
-
0037161286
-
Insights into the molecular mechanism of inhibition and drug resistance for HIV-1 RT with carbovir triphosphate
-
Ray A.S., Yang Z., Shi J., Hobbs A., Schinazi R.F., Chu C.K., and Anderson K.S. Insights into the molecular mechanism of inhibition and drug resistance for HIV-1 RT with carbovir triphosphate. Biochemistry 41 (2002) 5150-5162
-
(2002)
Biochemistry
, vol.41
, pp. 5150-5162
-
-
Ray, A.S.1
Yang, Z.2
Shi, J.3
Hobbs, A.4
Schinazi, R.F.5
Chu, C.K.6
Anderson, K.S.7
-
182
-
-
1642461500
-
Role of purine nucleoside phosphorylase in interactions between 2′,3′-dideoxyinosine and allopurinol, ganciclovir, or tenofovir
-
Ray A.S., Olson L., and Fridland A. Role of purine nucleoside phosphorylase in interactions between 2′,3′-dideoxyinosine and allopurinol, ganciclovir, or tenofovir. Antimicrob. Agents Chemother. 48 (2004) 1089-1095
-
(2004)
Antimicrob. Agents Chemother.
, vol.48
, pp. 1089-1095
-
-
Ray, A.S.1
Olson, L.2
Fridland, A.3
-
183
-
-
33749531758
-
Mechanism of active renal tubular efflux of tenofovir
-
Ray A.S., Cihlar T., Robinson K.L., Tong L., Vela J.E., Fuller M.D., Wieman L.M., Eisenberg E.J., and Rhodes G.R. Mechanism of active renal tubular efflux of tenofovir. Antimicrob. Agents Chemother. 50 (2006) 3297-3304
-
(2006)
Antimicrob. Agents Chemother.
, vol.50
, pp. 3297-3304
-
-
Ray, A.S.1
Cihlar, T.2
Robinson, K.L.3
Tong, L.4
Vela, J.E.5
Fuller, M.D.6
Wieman, L.M.7
Eisenberg, E.J.8
Rhodes, G.R.9
-
184
-
-
38649131311
-
Intracellular metabolism of the nucleotide prodrug GS-9131, a potent anti-human immunodeficiency virus agent
-
Ray A.S., Vela J.E., Boojamra C.G., Zhang L., Hui H., Callebaut C., Stray K., Lin K.Y., Gao Y., Mackman R.L., and Cihlar T. Intracellular metabolism of the nucleotide prodrug GS-9131, a potent anti-human immunodeficiency virus agent. Antimicrob. Agents Chemother. 52 (2008) 648-654
-
(2008)
Antimicrob. Agents Chemother.
, vol.52
, pp. 648-654
-
-
Ray, A.S.1
Vela, J.E.2
Boojamra, C.G.3
Zhang, L.4
Hui, H.5
Callebaut, C.6
Stray, K.7
Lin, K.Y.8
Gao, Y.9
Mackman, R.L.10
Cihlar, T.11
-
185
-
-
56549108946
-
Lack of evidence for an effect of lopinavir/ritonavir on tenofovir renal clearance
-
(Author reply 661)
-
Ray A.S., Wright M.R., and Rhodes G.R. Lack of evidence for an effect of lopinavir/ritonavir on tenofovir renal clearance. Clin. Pharmacol. Ther. 84 660 (2008) (Author reply 661)
-
(2008)
Clin. Pharmacol. Ther.
, vol.84
, Issue.660
-
-
Ray, A.S.1
Wright, M.R.2
Rhodes, G.R.3
-
186
-
-
0026735812
-
Human immunodeficiency virus reverse transcriptase: steady-state and pre-steady-state kinetics of nucleotide incorporation
-
Reardon J.E. Human immunodeficiency virus reverse transcriptase: steady-state and pre-steady-state kinetics of nucleotide incorporation. Biochemistry 31 (1992) 4473-4479
-
(1992)
Biochemistry
, vol.31
, pp. 4473-4479
-
-
Reardon, J.E.1
-
187
-
-
0024577652
-
Glucuronidation of 3′-azido-3′-deoxythymidine: human and rat enzyme specificity
-
Resetar A., and Spector T. Glucuronidation of 3′-azido-3′-deoxythymidine: human and rat enzyme specificity. Biochem. Pharmacol. 38 (1989) 1389-1393
-
(1989)
Biochem. Pharmacol.
, vol.38
, pp. 1389-1393
-
-
Resetar, A.1
Spector, T.2
-
188
-
-
73549114477
-
Fosalvudine tidoxil, a novel alovudine-derived prodrug is activated and inhibits the replication of HIV-1 in human PBMC
-
Toronto, Canada
-
Reuss F., Kulke M., Braspenning J., Heckl-Östreicher B., and Opitz H.G. Fosalvudine tidoxil, a novel alovudine-derived prodrug is activated and inhibits the replication of HIV-1 in human PBMC. 16th International AIDS Conference, Abstract ThPE0025. Toronto, Canada (2006)
-
(2006)
16th International AIDS Conference, Abstract ThPE0025
-
-
Reuss, F.1
Kulke, M.2
Braspenning, J.3
Heckl-Östreicher, B.4
Opitz, H.G.5
-
189
-
-
31044456584
-
Pharmacogenetics of plasma efavirenz exposure after treatment discontinuation: an Adult AIDS Clinical Trials Group Study
-
Ribaudo H.J., Haas D.W., Tierney C., Kim R.B., Wilkinson G.R., Gulick R.M., Clifford D.B., Marzolini C., Fletcher C.V., Tashima K.T., Kuritzkes D.R., and Acosta E.P. Pharmacogenetics of plasma efavirenz exposure after treatment discontinuation: an Adult AIDS Clinical Trials Group Study. Clin. Infect. Dis. 42 (2006) 401-407
-
(2006)
Clin. Infect. Dis.
, vol.42
, pp. 401-407
-
-
Ribaudo, H.J.1
Haas, D.W.2
Tierney, C.3
Kim, R.B.4
Wilkinson, G.R.5
Gulick, R.M.6
Clifford, D.B.7
Marzolini, C.8
Fletcher, C.V.9
Tashima, K.T.10
Kuritzkes, D.R.11
Acosta, E.P.12
-
190
-
-
3142660152
-
The prevalence of antiretroviral drug resistance in the United States
-
Richman D.D., Morton S.C., Wrin T., Hellmann N., Berry S., Shapiro M.F., and Bozzette S.A. The prevalence of antiretroviral drug resistance in the United States. AIDS 18 (2004) 1393-1401
-
(2004)
AIDS
, vol.18
, pp. 1393-1401
-
-
Richman, D.D.1
Morton, S.C.2
Wrin, T.3
Hellmann, N.4
Berry, S.5
Shapiro, M.F.6
Bozzette, S.A.7
-
191
-
-
62249095476
-
The challenge of finding a cure for HIV infection
-
Richman D.D., Margolis D.M., Delaney M., Greene W.C., Hazuda D., and Pomerantz R.J. The challenge of finding a cure for HIV infection. Science 323 (2009) 1304-1307
-
(2009)
Science
, vol.323
, pp. 1304-1307
-
-
Richman, D.D.1
Margolis, D.M.2
Delaney, M.3
Greene, W.C.4
Hazuda, D.5
Pomerantz, R.J.6
-
192
-
-
43549094732
-
Class-sparing regimens for initial treatment of HIV-1 infection
-
Riddler S.A., Haubrich R., DiRienzo A.G., Peeples L., Powderly W.G., Klingman K.L., Garren K.W., George T., Rooney J.F., Brizz B., Lalloo U.G., Murphy R.L., Swindells S., Havlir D., and Mellors J.W. Class-sparing regimens for initial treatment of HIV-1 infection. N. Engl. J. Med. 358 (2008) 2095-2106
-
(2008)
N. Engl. J. Med.
, vol.358
, pp. 2095-2106
-
-
Riddler, S.A.1
Haubrich, R.2
DiRienzo, A.G.3
Peeples, L.4
Powderly, W.G.5
Klingman, K.L.6
Garren, K.W.7
George, T.8
Rooney, J.F.9
Brizz, B.10
Lalloo, U.G.11
Murphy, R.L.12
Swindells, S.13
Havlir, D.14
Mellors, J.W.15
-
193
-
-
0024273119
-
The accuracy of reverse transcriptase from HIV-1
-
Roberts J.D., Bebenek K., and Kunkel T.A. The accuracy of reverse transcriptase from HIV-1. Science 242 (1988) 1171-1173
-
(1988)
Science
, vol.242
, pp. 1171-1173
-
-
Roberts, J.D.1
Bebenek, K.2
Kunkel, T.A.3
-
194
-
-
34047228643
-
Prevalence of antiretroviral drug resistance and resistance-associated mutations in antiretroviral therapy-naive HIV-infected individuals from 40 United States cities
-
Ross L., Lim M.L., Liao Q., Wine B., Rodriguez A.E., Weinberg W., and Shaefer M. Prevalence of antiretroviral drug resistance and resistance-associated mutations in antiretroviral therapy-naive HIV-infected individuals from 40 United States cities. HIV Clin. Trials 8 (2007) 1-8
-
(2007)
HIV Clin. Trials
, vol.8
, pp. 1-8
-
-
Ross, L.1
Lim, M.L.2
Liao, Q.3
Wine, B.4
Rodriguez, A.E.5
Weinberg, W.6
Shaefer, M.7
-
195
-
-
42649130015
-
Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the D:A:D study: a multi-cohort collaboration
-
Sabin C.A., Worm S.W., Weber R., Reiss P., El-Sadr W., Dabis F., De Wit S., Law M., D′Arminio Monforte A., Friis-Moller N., Kirk O., Pradier C., Weller I., Phillips A.N., and Lundgren J.D. Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the D:A:D study: a multi-cohort collaboration. Lancet 371 (2008) 1417-1426
-
(2008)
Lancet
, vol.371
, pp. 1417-1426
-
-
Sabin, C.A.1
Worm, S.W.2
Weber, R.3
Reiss, P.4
El-Sadr, W.5
Dabis, F.6
De Wit, S.7
Law, M.8
DArminio Monforte, A.9
Friis-Moller, N.10
Kirk, O.11
Pradier, C.12
Weller, I.13
Phillips, A.N.14
Lundgren, J.D.15
-
196
-
-
0033621167
-
Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids
-
Sarafianos S.G., Das K., Clark Jr. A.D., Ding J., Boyer P.L., Hughes S.H., and Arnold E. Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 10027-10032
-
(1999)
Proc. Natl. Acad. Sci. U.S.A.
, vol.96
, pp. 10027-10032
-
-
Sarafianos, S.G.1
Das, K.2
Clark Jr., A.D.3
Ding, J.4
Boyer, P.L.5
Hughes, S.H.6
Arnold, E.7
-
197
-
-
58149133507
-
Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition
-
Sarafianos S.G., Marchand B., Das K., Himmel D.M., Parniak M.A., Hughes S.H., and Arnold E. Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition. J. Mol. Biol. 385 (2009) 693-713
-
(2009)
J. Mol. Biol.
, vol.385
, pp. 693-713
-
-
Sarafianos, S.G.1
Marchand, B.2
Das, K.3
Himmel, D.M.4
Parniak, M.A.5
Hughes, S.H.6
Arnold, E.7
-
198
-
-
0030930760
-
Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism
-
Sawaya M.R., Prasad R., Wilson S.H., Kraut J., and Pelletier H. Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism. Biochemistry 36 (1997) 11205-11215
-
(1997)
Biochemistry
, vol.36
, pp. 11205-11215
-
-
Sawaya, M.R.1
Prasad, R.2
Wilson, S.H.3
Kraut, J.4
Pelletier, H.5
-
199
-
-
33846971989
-
Renal safety of tenofovir disoproxil fumarate
-
Sax P.E., Gallant J.E., and Klotman P.E. Renal safety of tenofovir disoproxil fumarate. AIDS Read. 17 (2007) 102-103
-
(2007)
AIDS Read.
, vol.17
, pp. 102-103
-
-
Sax, P.E.1
Gallant, J.E.2
Klotman, P.E.3
-
200
-
-
0026480950
-
Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
-
Schinazi R.F., McMillan A., Cannon D., Mathis R., Lloyd R.M., Peck A., Sommadossi J.P., St. Clair M., Wilson J., Furman P.A., et al. Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine. Antimicrob. Agents Chemother. 36 (1992) 2423-2431
-
(1992)
Antimicrob. Agents Chemother.
, vol.36
, pp. 2423-2431
-
-
Schinazi, R.F.1
McMillan, A.2
Cannon, D.3
Mathis, R.4
Lloyd, R.M.5
Peck, A.6
Sommadossi, J.P.7
St. Clair, M.8
Wilson, J.9
Furman, P.A.10
-
201
-
-
0027409698
-
Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides
-
Schinazi R.F., Lloyd Jr. R.M., Nguyen M.H., Cannon D.L., McMillan A., Ilksoy N., Chu C.K., Liotta D.C., Bazmi H.Z., and Mellors J.W. Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides. Antimicrob. Agents Chemother. 37 (1993) 875-881
-
(1993)
Antimicrob. Agents Chemother.
, vol.37
, pp. 875-881
-
-
Schinazi, R.F.1
Lloyd Jr., R.M.2
Nguyen, M.H.3
Cannon, D.L.4
McMillan, A.5
Ilksoy, N.6
Chu, C.K.7
Liotta, D.C.8
Bazmi, H.Z.9
Mellors, J.W.10
-
202
-
-
21444440281
-
Molecular properties of HIV-1 resistant to (+)-enantiomers and racemates of oxathiolane cytosine nucleosides and their potential for the treatment of HIV and HBV infections
-
Schinazi R.F., McMillan A., Lloyd R.L., Schlueter-Wirtz S., Liotta D.C., and Chu C.K. Molecular properties of HIV-1 resistant to (+)-enantiomers and racemates of oxathiolane cytosine nucleosides and their potential for the treatment of HIV and HBV infections. Antiviral Res. 34 (1997) A42
-
(1997)
Antiviral Res.
, vol.34
-
-
Schinazi, R.F.1
McMillan, A.2
Lloyd, R.L.3
Schlueter-Wirtz, S.4
Liotta, D.C.5
Chu, C.K.6
-
203
-
-
0031964879
-
Inhibition of human and duck hepatitis B virus by 2′,3′-dideoxy-3′-fluoroguanosine in vitro
-
Schroder I., Holmgren B., Oberg M., and Lofgren B. Inhibition of human and duck hepatitis B virus by 2′,3′-dideoxy-3′-fluoroguanosine in vitro. Antiviral Res. 37 (1998) 57-66
-
(1998)
Antiviral Res.
, vol.37
, pp. 57-66
-
-
Schroder, I.1
Holmgren, B.2
Oberg, M.3
Lofgren, B.4
-
204
-
-
0032879904
-
MRP4: a previously unidentified factor in resistance to nucleoside-based antiviral drugs
-
Schuetz J.D., Connelly M.C., Sun D., Paibir S.G., Flynn P.M., Srinivas R.V., Kumar A., and Fridland A. MRP4: a previously unidentified factor in resistance to nucleoside-based antiviral drugs. Nat. Med. 5 (1999) 1048-1051
-
(1999)
Nat. Med.
, vol.5
, pp. 1048-1051
-
-
Schuetz, J.D.1
Connelly, M.C.2
Sun, D.3
Paibir, S.G.4
Flynn, P.M.5
Srinivas, R.V.6
Kumar, A.7
Fridland, A.8
-
205
-
-
35548933763
-
P-glycoprotein-mediated active efflux of the anti-HIV1 nucleoside abacavir limits cellular accumulation and brain distribution
-
Shaik N., Giri N., Pan G., and Elmquist W.F. P-glycoprotein-mediated active efflux of the anti-HIV1 nucleoside abacavir limits cellular accumulation and brain distribution. Drug Metab. Dispos. 35 (2007) 2076-2085
-
(2007)
Drug Metab. Dispos.
, vol.35
, pp. 2076-2085
-
-
Shaik, N.1
Giri, N.2
Pan, G.3
Elmquist, W.F.4
-
206
-
-
0027417199
-
Affinity of the antiviral enantiomers of oxathiolane cytosine nucleosides for human 2′-deoxycytidine kinase
-
Shewach D.S., Liotta D.C., and Schinazi R.F. Affinity of the antiviral enantiomers of oxathiolane cytosine nucleosides for human 2′-deoxycytidine kinase. Biochem. Pharmacol. 45 (1993) 1540-1543
-
(1993)
Biochem. Pharmacol.
, vol.45
, pp. 1540-1543
-
-
Shewach, D.S.1
Liotta, D.C.2
Schinazi, R.F.3
-
207
-
-
60649109560
-
Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients
-
SMART, and DAD. Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients. AIDS 22 (2008) F17-F24
-
(2008)
AIDS
, vol.22
-
-
SMART1
DAD2
-
209
-
-
68649086238
-
Randomized, double-blind, placebo-matched, multicenter trial of abacavir/lamivudine or tenofovir/emtricitabine with lopinavir/ritonavir for initial HIV treatment
-
Smith K.Y., Patel P., Fine D., Bellos N., Sloan L., Lackey P., Kumar P.N., Sutherland-Phillips D.H., Vavro C., Yau L., Wannamaker P., and Shaefer M.S. Randomized, double-blind, placebo-matched, multicenter trial of abacavir/lamivudine or tenofovir/emtricitabine with lopinavir/ritonavir for initial HIV treatment. AIDS 23 (2009) 1547-1556
-
(2009)
AIDS
, vol.23
, pp. 1547-1556
-
-
Smith, K.Y.1
Patel, P.2
Fine, D.3
Bellos, N.4
Sloan, L.5
Lackey, P.6
Kumar, P.N.7
Sutherland-Phillips, D.H.8
Vavro, C.9
Yau, L.10
Wannamaker, P.11
Shaefer, M.S.12
-
210
-
-
3142630463
-
Cellular nucleoside pharmacokinetics and pharmacology: a potentially important determinant of antiretroviral efficacy
-
Sommadossi J.P. Cellular nucleoside pharmacokinetics and pharmacology: a potentially important determinant of antiretroviral efficacy. AIDS 12 Suppl. 3 (1998) S1-S8
-
(1998)
AIDS
, vol.12
, Issue.SUPPL. 3
-
-
Sommadossi, J.P.1
-
211
-
-
34147115118
-
APOBEC3G and HIV-1: strike and counterstrike
-
Soros V.B., and Greene W.C. APOBEC3G and HIV-1: strike and counterstrike. Curr. HIV/AIDS Rep. 4 (2007) 3-9
-
(2007)
Curr. HIV/AIDS Rep.
, vol.4
, pp. 3-9
-
-
Soros, V.B.1
Greene, W.C.2
-
212
-
-
0035174783
-
Phosphorylation of nucleoside analog antiretrovirals: a review for clinicians
-
Stein D.S., and Moore K.H. Phosphorylation of nucleoside analog antiretrovirals: a review for clinicians. Pharmacotherapy 21 (2001) 11-34
-
(2001)
Pharmacotherapy
, vol.21
, pp. 11-34
-
-
Stein, D.S.1
Moore, K.H.2
-
213
-
-
0033581011
-
DNA polymerases: structural diversity and common mechanisms
-
Steitz T.A. DNA polymerases: structural diversity and common mechanisms. J. Biol. Chem. 274 (1999) 17395-17398
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 17395-17398
-
-
Steitz, T.A.1
-
214
-
-
0028606031
-
A unified polymerase mechanism for nonhomologous DNA and RNA polymerases
-
Steitz T.A., Smerdon S.J., Jager J., and Joyce C.M. A unified polymerase mechanism for nonhomologous DNA and RNA polymerases. Science 266 (1994) 2022-2025
-
(1994)
Science
, vol.266
, pp. 2022-2025
-
-
Steitz, T.A.1
Smerdon, S.J.2
Jager, J.3
Joyce, C.M.4
-
215
-
-
4544321053
-
Intracellular pharmacology of emtricitabine and tenofovir
-
877-878 (Author reply 878-879)
-
Stevens R.C., Blum M.R., Rousseau F.S., and Kearney B.P. Intracellular pharmacology of emtricitabine and tenofovir. Clin. Infect. Dis. 39 (2004) 877-878 (Author reply 878-879)
-
(2004)
Clin. Infect. Dis.
, vol.39
-
-
Stevens, R.C.1
Blum, M.R.2
Rousseau, F.S.3
Kearney, B.P.4
-
216
-
-
0018879146
-
Human erythrocytic purine nucleoside phosphorylase: reaction with sugar-modified nucleoside substrates
-
Stoeckler J.D., Cambor C., and Parks Jr. R.E. Human erythrocytic purine nucleoside phosphorylase: reaction with sugar-modified nucleoside substrates. Biochemistry 19 (1980) 102-107
-
(1980)
Biochemistry
, vol.19
, pp. 102-107
-
-
Stoeckler, J.D.1
Cambor, C.2
Parks Jr., R.E.3
-
217
-
-
0032538456
-
Selective inhibition of HIV-1 reverse transcriptase by an antiviral inhibitor, (R)-9-(2-phosphonylmethoxypropyl)adenine
-
Suo Z., and Johnson K.A. Selective inhibition of HIV-1 reverse transcriptase by an antiviral inhibitor, (R)-9-(2-phosphonylmethoxypropyl)adenine. J. Biol. Chem. 273 (1998) 27250-27258
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 27250-27258
-
-
Suo, Z.1
Johnson, K.A.2
-
218
-
-
27144445999
-
Short-term safety and pharmacodynamics of amdoxovir in HIV-infected patients
-
Thompson M.A., Kessler H.A., Eron Jr. J.J., Jacobson J.M., Adda N., Shen G., Zong J., Harris J., Moxham C., and Rousseau F.S. Short-term safety and pharmacodynamics of amdoxovir in HIV-infected patients. AIDS 19 (2005) 1607-1615
-
(2005)
AIDS
, vol.19
, pp. 1607-1615
-
-
Thompson, M.A.1
Kessler, H.A.2
Eron Jr., J.J.3
Jacobson, J.M.4
Adda, N.5
Shen, G.6
Zong, J.7
Harris, J.8
Moxham, C.9
Rousseau, F.S.10
-
219
-
-
34948854765
-
Effects of human immunodeficiency virus protease inhibitors on the intestinal absorption of tenofovir disoproxil fumarate in vitro
-
Tong L., Phan T.K., Robinson K.L., Babusis D., Strab R., Bhoopathy S., Hidalgo I.J., Rhodes G.R., and Ray A.S. Effects of human immunodeficiency virus protease inhibitors on the intestinal absorption of tenofovir disoproxil fumarate in vitro. Antimicrob. Agents Chemother. 51 (2007) 3498-3504
-
(2007)
Antimicrob. Agents Chemother.
, vol.51
, pp. 3498-3504
-
-
Tong, L.1
Phan, T.K.2
Robinson, K.L.3
Babusis, D.4
Strab, R.5
Bhoopathy, S.6
Hidalgo, I.J.7
Rhodes, G.R.8
Ray, A.S.9
-
220
-
-
0033987078
-
Mechanism of inhibition of the human immunodeficiency virus type 1 reverse transcriptase by d4TTP: an equivalent incorporation efficiency relative to the natural substrate dTTP
-
Vaccaro J.A., Parnell K.M., Terezakis S.A., and Anderson K.S. Mechanism of inhibition of the human immunodeficiency virus type 1 reverse transcriptase by d4TTP: an equivalent incorporation efficiency relative to the natural substrate dTTP. Antimicrob. Agents Chemother. 44 (2000) 217-221
-
(2000)
Antimicrob. Agents Chemother.
, vol.44
, pp. 217-221
-
-
Vaccaro, J.A.1
Parnell, K.M.2
Terezakis, S.A.3
Anderson, K.S.4
-
221
-
-
0033796942
-
Phosphorylation of nucleosides and nucleoside analogs by mammalian nucleoside monophosphate kinases
-
Van Rompay A.R., Johansson M., and Karlsson A. Phosphorylation of nucleosides and nucleoside analogs by mammalian nucleoside monophosphate kinases. Pharmacol. Ther. 87 (2000) 189-198
-
(2000)
Pharmacol. Ther.
, vol.87
, pp. 189-198
-
-
Van Rompay, A.R.1
Johansson, M.2
Karlsson, A.3
-
222
-
-
0030888216
-
In vitro screening of nucleoside analog combinations for potential use in anti-HIV therapy
-
Veal G.J., Barry M.G., Khoo S.H., and Back D.J. In vitro screening of nucleoside analog combinations for potential use in anti-HIV therapy. AIDS Res. Hum. Retroviruses 13 (1997) 481-484
-
(1997)
AIDS Res. Hum. Retroviruses
, vol.13
, pp. 481-484
-
-
Veal, G.J.1
Barry, M.G.2
Khoo, S.H.3
Back, D.J.4
-
223
-
-
53149133921
-
Effect of nucleoside and nucleotide reverse transcriptase inhibitors of HIV on endogenous nucleotide pools
-
Vela J.E., Miller M.D., Rhodes G.R., and Ray A.S. Effect of nucleoside and nucleotide reverse transcriptase inhibitors of HIV on endogenous nucleotide pools. Antivir. Ther. 13 (2008) 789-797
-
(2008)
Antivir. Ther.
, vol.13
, pp. 789-797
-
-
Vela, J.E.1
Miller, M.D.2
Rhodes, G.R.3
Ray, A.S.4
-
224
-
-
67649997342
-
Mitochondrial DNA depletion in rat liver induced by fosalvudine tidoxil, a novel nucleoside reverse transcriptase inhibitor prodrug
-
Venhoff A.C., Lebrecht D., Reuss F.U., Heckl-Ostreicher B., Wehr R., Walker U.A., and Venhoff N. Mitochondrial DNA depletion in rat liver induced by fosalvudine tidoxil, a novel nucleoside reverse transcriptase inhibitor prodrug. Antimicrob. Agents Chemother. 53 (2009) 2748-2751
-
(2009)
Antimicrob. Agents Chemother.
, vol.53
, pp. 2748-2751
-
-
Venhoff, A.C.1
Lebrecht, D.2
Reuss, F.U.3
Heckl-Ostreicher, B.4
Wehr, R.5
Walker, U.A.6
Venhoff, N.7
-
225
-
-
2942560805
-
The impact of the M184V substitution on drug resistance and viral fitness
-
Wainberg M.A. The impact of the M184V substitution on drug resistance and viral fitness. Exp. Rev. Anti-Infect. Ther. 2 (2004) 147-151
-
(2004)
Exp. Rev. Anti-Infect. Ther.
, vol.2
, pp. 147-151
-
-
Wainberg, M.A.1
-
226
-
-
3142717936
-
Pharmacokinetic and pharmacodynamic characteristics of emtricitabine support its once daily dosing for the treatment of HIV infection
-
Wang L.H., Begley J., St. Claire III R.L., Harris J., Wakeford C., and Rousseau F.S. Pharmacokinetic and pharmacodynamic characteristics of emtricitabine support its once daily dosing for the treatment of HIV infection. AIDS Res. Hum. Retroviruses 20 (2004) 1173-1182
-
(2004)
AIDS Res. Hum. Retroviruses
, vol.20
, pp. 1173-1182
-
-
Wang, L.H.1
Begley, J.2
St. Claire III, R.L.3
Harris, J.4
Wakeford, C.5
Rousseau, F.S.6
-
227
-
-
67749095978
-
Study of the retention of metabolites of 4′-Ed4T, a novel anti-HIV-1 thymidine analog, in cells
-
Wang X., Tanaka H., Baba M., and Cheng Y.C. Study of the retention of metabolites of 4′-Ed4T, a novel anti-HIV-1 thymidine analog, in cells. Antimicrob. Agents Chemother. 53 (2009) 3317-3324
-
(2009)
Antimicrob. Agents Chemother.
, vol.53
, pp. 3317-3324
-
-
Wang, X.1
Tanaka, H.2
Baba, M.3
Cheng, Y.C.4
-
228
-
-
34547768666
-
Abacavir plasma pharmacokinetics in the absence and presence of atazanavir/ritonavir or lopinavir/ritonavir and vice versa in HIV-infected patients
-
Waters L.J., Moyle G., Bonora S., D′Avolio A., Else L., Mandalia S., Pozniak A., Nelson M., Gazzard B., Back D., and Boffito M. Abacavir plasma pharmacokinetics in the absence and presence of atazanavir/ritonavir or lopinavir/ritonavir and vice versa in HIV-infected patients. Antiviral Ther. 12 (2007) 825-830
-
(2007)
Antiviral Ther.
, vol.12
, pp. 825-830
-
-
Waters, L.J.1
Moyle, G.2
Bonora, S.3
DAvolio, A.4
Else, L.5
Mandalia, S.6
Pozniak, A.7
Nelson, M.8
Gazzard, B.9
Back, D.10
Boffito, M.11
-
229
-
-
73549122403
-
Drug susceptibility profile of OBP-601, a novel NRTI, using a comprehensive panel of NRTI- or NNRTI-resistant viruses
-
Boston, MA
-
Weber J., Weberova J., Vazquez A., Urata Y., Matsuda T., Shafer R., Arts E., and Quinones-Mateu M. Drug susceptibility profile of OBP-601, a novel NRTI, using a comprehensive panel of NRTI- or NNRTI-resistant viruses. 15th Conference on Retroviruses and Opportunistic Infections, Abstract 726b. Boston, MA (2008)
-
(2008)
15th Conference on Retroviruses and Opportunistic Infections, Abstract 726b
-
-
Weber, J.1
Weberova, J.2
Vazquez, A.3
Urata, Y.4
Matsuda, T.5
Shafer, R.6
Arts, E.7
Quinones-Mateu, M.8
-
230
-
-
0034956253
-
Mitochondrial toxicity and HIV therapy
-
White A.J. Mitochondrial toxicity and HIV therapy. Sex. Transm. Infect. 77 (2001) 158-173
-
(2001)
Sex. Transm. Infect.
, vol.77
, pp. 158-173
-
-
White, A.J.1
-
231
-
-
0036839746
-
Molecular mechanisms of resistance to human immunodeficiency virus type 1 with reverse transcriptase mutations K65R and K65R + M184V and their effects on enzyme function and viral replication capacity
-
White K.L., Margot N.A., Wrin T., Petropoulos C.J., Miller M.D., and Naeger L.K. Molecular mechanisms of resistance to human immunodeficiency virus type 1 with reverse transcriptase mutations K65R and K65R + M184V and their effects on enzyme function and viral replication capacity. Antimicrob. Agents Chemother. 46 (2002) 3437-3446
-
(2002)
Antimicrob. Agents Chemother.
, vol.46
, pp. 3437-3446
-
-
White, K.L.1
Margot, N.A.2
Wrin, T.3
Petropoulos, C.J.4
Miller, M.D.5
Naeger, L.K.6
-
232
-
-
2142657848
-
Which nucleoside and nucleotide backbone combinations select for the K65R mutation in HIV-1 reverse transcriptase
-
Winston A., Pozniak A., Mandalia S., Gazzard B., Pillay D., and Nelson M. Which nucleoside and nucleotide backbone combinations select for the K65R mutation in HIV-1 reverse transcriptase. Aids 18 (2004) 949-951
-
(2004)
Aids
, vol.18
, pp. 949-951
-
-
Winston, A.1
Pozniak, A.2
Mandalia, S.3
Gazzard, B.4
Pillay, D.5
Nelson, M.6
-
233
-
-
17144400727
-
Deoxythreosyl phosphonate nucleosides as selective anti-HIV agents
-
Wu T., Froeyen M., Kempeneers V., Pannecouque C., Wang J., Busson R., De Clercq E., and Herdewijn P. Deoxythreosyl phosphonate nucleosides as selective anti-HIV agents. J. Am. Chem. Soc. 127 (2005) 5056-5065
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 5056-5065
-
-
Wu, T.1
Froeyen, M.2
Kempeneers, V.3
Pannecouque, C.4
Wang, J.5
Busson, R.6
De Clercq, E.7
Herdewijn, P.8
-
234
-
-
33847027993
-
Highly selective action of triphosphate metabolite of 4′-ethynyl D4T: a novel anti-HIV compound against HIV-1 RT
-
Yang G., Dutschman G.E., Wang C.J., Tanaka H., Baba M., Anderson K.S., and Cheng Y.C. Highly selective action of triphosphate metabolite of 4′-ethynyl D4T: a novel anti-HIV compound against HIV-1 RT. Antiviral Res. 73 (2007) 185-191
-
(2007)
Antiviral Res.
, vol.73
, pp. 185-191
-
-
Yang, G.1
Dutschman, G.E.2
Wang, C.J.3
Tanaka, H.4
Baba, M.5
Anderson, K.S.6
Cheng, Y.C.7
-
235
-
-
14744274964
-
Novel acyclic nucleoside phosphonate analogues with potent anti-hepatitis B virus activities
-
Ying C., Holy A., Hockova D., Havlas Z., De Clercq E., and Neyts J. Novel acyclic nucleoside phosphonate analogues with potent anti-hepatitis B virus activities. Antimicrob. Agents Chemother. 49 (2005) 1177-1180
-
(2005)
Antimicrob. Agents Chemother.
, vol.49
, pp. 1177-1180
-
-
Ying, C.1
Holy, A.2
Hockova, D.3
Havlas, Z.4
De Clercq, E.5
Neyts, J.6
-
236
-
-
30844452341
-
Inhibition of multiple drug resistant (MRD) HIV-1 by 3′-fluoro-2′,3′-dideoxyguanosine (FLG)
-
San Diego, CA, USA
-
Zhang H., Oberg B., Harmenberg J., Vrang L., Zhou X., Larsson T., and Samuelsson B. Inhibition of multiple drug resistant (MRD) HIV-1 by 3′-fluoro-2′,3′-dideoxyguanosine (FLG). 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy, Abstract H-182. San Diego, CA, USA (2002)
-
(2002)
42nd Interscience Conference on Antimicrobial Agents and Chemotherapy, Abstract H-182
-
-
Zhang, H.1
Oberg, B.2
Harmenberg, J.3
Vrang, L.4
Zhou, X.5
Larsson, T.6
Samuelsson, B.7
-
237
-
-
73549118619
-
PPI-801, a nucleoside analogue causing chain termination by penultimate incorporation into HIV DNA
-
Palm Springs, CA, USA
-
Zhang H., Bottiger D., Haffar O., Samuelsson B., Vrang L., and Oberg B. PPI-801, a nucleoside analogue causing chain termination by penultimate incorporation into HIV DNA. 15th International Conference on Antiviral Research, Abstract LB-03. Palm Springs, CA, USA (2007)
-
(2007)
15th International Conference on Antiviral Research, Abstract LB-03
-
-
Zhang, H.1
Bottiger, D.2
Haffar, O.3
Samuelsson, B.4
Vrang, L.5
Oberg, B.6
-
238
-
-
0026729643
-
5′-Nucleotidase: molecular structure and functional aspects
-
Zimmermann H. 5′-Nucleotidase: molecular structure and functional aspects. Biochem. J. 285 (1992) 345-365
-
(1992)
Biochem. J.
, vol.285
, pp. 345-365
-
-
Zimmermann, H.1
|