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Volumn 67, Issue 1, 2005, Pages 1-9

KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis

Author keywords

HIV; Mutagenesis; Novel nucleoside analog

Indexed keywords

5 AZA 5,6 DIHYDRO 2' DEOXYCYTIDINE; ABACAVIR; KP 1212; LAMIVUDINE; MITOCHONDRIAL DNA; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; UNCLASSIFIED DRUG; ZIDOVUDINE;

EID: 20444414897     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.antiviral.2005.03.004     Document Type: Article
Times cited : (90)

References (32)
  • 1
    • 85033050931 scopus 로고    scopus 로고
    • Nonclinical toxicology studies with zidovudine: Genetic toxicity tests and carcinogenicity bioassays in mice and rats
    • K.M. Ayers, D. Clive, W.E. Tucker Jr., G. Hajian, and P. de Miranda Nonclinical toxicology studies with zidovudine: genetic toxicity tests and carcinogenicity bioassays in mice and rats Fundam. Appl. Toxicol. 32 1996 148 158
    • (1996) Fundam. Appl. Toxicol. , vol.32 , pp. 148-158
    • Ayers, K.M.1    Clive, D.2    Tucker Jr., W.E.3    Hajian, G.4    De Miranda, P.5
  • 2
    • 0034990846 scopus 로고    scopus 로고
    • Exploitation of the low fidelity of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and the nucleotide composition bias in the HIV-1 genome to alter the drug resistance development of HIV
    • J. Balzarini, M.J. Camarasa, M.J. Pérez-Pérez, A. San-Félix, S. Velazquez, C.F. Perno, E. De Clercq, J.N. Anderson, and A. Karlsson Exploitation of the low fidelity of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and the nucleotide composition bias in the HIV-1 genome to alter the drug resistance development of HIV J. Virol. 75 2001 5772 5777
    • (2001) J. Virol. , vol.75 , pp. 5772-5777
    • Balzarini, J.1    Camarasa, M.J.2    Pérez-Pérez, M.J.3    San-Félix, A.4    Velazquez, S.5    Perno, C.F.6    De Clercq, E.7    Anderson, J.N.8    Karlsson, A.9
  • 3
    • 0036174438 scopus 로고    scopus 로고
    • Assessment of mitochondrial toxicity in human cells treated with tenofovir: Comparison with other nucleoside reverse transcriptase inhibitors
    • G. Birkus, M.J.M. Hitchcock, and T. Cihlar Assessment of mitochondrial toxicity in human cells treated with tenofovir: comparison with other nucleoside reverse transcriptase inhibitors Antimicrob. Agents Chemother. 46 2002 716 723
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 716-723
    • Birkus, G.1    Hitchcock, M.J.M.2    Cihlar, T.3
  • 4
    • 0028952146 scopus 로고
    • HIV population dynamics in vivo: Implications for genetic variation, pathogenesis, and therapy
    • J.M. Coffin HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy Science 267 1995 483 489
    • (1995) Science , vol.267 , pp. 483-489
    • Coffin, J.M.1
  • 5
    • 0023035969 scopus 로고
    • Differences in DNA damage produced by incorporation of 5-aza-2′-deoxycytidine or 5,6-dihydro-5-azacytidine into DNA of mammalian cells
    • J.M. Covey, M. D'Incalci, E.J. Tilchen, D.S. Zaharko, and K.W. Kohn Differences in DNA damage produced by incorporation of 5-aza-2′- deoxycytidine or 5,6-dihydro-5-azacytidine into DNA of mammalian cells Cancer Res. 46 1986 5511 5517
    • (1986) Cancer Res. , vol.46 , pp. 5511-5517
    • Covey, J.M.1    D'Incalci, M.2    Tilchen, E.J.3    Zaharko, D.S.4    Kohn, K.W.5
  • 6
    • 0027285909 scopus 로고
    • A phase II study of 5,6-dihydro-5-azacytidine hydrochloride in disseminated malignant melanoma
    • E.T. Creagan, D.J. Schaid, L.C. Hartmann, and C.L. Loprinzi A phase II study of 5,6-dihydro-5-azacytidine hydrochloride in disseminated malignant melanoma Am. J. Clin. Oncol. 16 1993 243 244
    • (1993) Am. J. Clin. Oncol. , vol.16 , pp. 243-244
    • Creagan, E.T.1    Schaid, D.J.2    Hartmann, L.C.3    Loprinzi, C.L.4
  • 8
    • 0035811016 scopus 로고    scopus 로고
    • RNA virus error catastrophe: Direct molecular test by using ribavirin
    • S. Crotty, C.E. Cameron, and R. Andino RNA virus error catastrophe: direct molecular test by using ribavirin Proc. Natl. Acad. Sci. U.S.A. 98 2001 6895 6900
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 6895-6900
    • Crotty, S.1    Cameron, C.E.2    Andino, R.3
  • 10
    • 0038621386 scopus 로고    scopus 로고
    • Stealth nucleosides: Mode of action and potential use in the treatment of viral diseases
    • R. Daifuku Stealth nucleosides: mode of action and potential use in the treatment of viral diseases BioDrugs 17 2003 169 177
    • (2003) BioDrugs , vol.17 , pp. 169-177
    • Daifuku, R.1
  • 11
    • 0027222068 scopus 로고
    • Viral quasispecies
    • M. Eigen Viral quasispecies Sci. Am. 269 1993 42 49
    • (1993) Sci. Am. , vol.269 , pp. 42-49
    • Eigen, M.1
  • 12
    • 0035968250 scopus 로고    scopus 로고
    • Insights into the molecular mechanism of mitochondrial toxicity by AIDS drugs
    • J.Y. Feng, A.A. Johnson, K.A. Johnson, and K.S. Anderson Insights into the molecular mechanism of mitochondrial toxicity by AIDS drugs J. Biol. Chem. 276 2001 23832 23837
    • (2001) J. Biol. Chem. , vol.276 , pp. 23832-23837
    • Feng, J.Y.1    Johnson, A.A.2    Johnson, K.A.3    Anderson, K.S.4
  • 13
    • 0037223513 scopus 로고    scopus 로고
    • Mutation rate and the efficacy of antimicrobial drug treatment
    • P.J. Gerrish, and J.G. Garcia-Lerma Mutation rate and the efficacy of antimicrobial drug treatment Lancet Infect. Dis. 3 2003 28 32
    • (2003) Lancet Infect. Dis. , vol.3 , pp. 28-32
    • Gerrish, P.J.1    Garcia-Lerma, J.G.2
  • 15
    • 0035173377 scopus 로고    scopus 로고
    • Human immunodeficiency virus reverse transcriptase and protease sequence database: An expanded data model integrating natural language text and sequence analysis programs
    • R. Kantor, R. Machekano, M.J. Gonzales, K. Dupnik, J.M. Schapiro, and R.W. Shafer Human immunodeficiency virus reverse transcriptase and protease sequence database: an expanded data model integrating natural language text and sequence analysis programs Nucleic Acids Res. 29 2001 296 299
    • (2001) Nucleic Acids Res. , vol.29 , pp. 296-299
    • Kantor, R.1    MacHekano, R.2    Gonzales, M.J.3    Dupnik, K.4    Schapiro, J.M.5    Shafer, R.W.6
  • 16
    • 0028959324 scopus 로고
    • Biochemical pharmacology and DNA methylation studies of arabinosyl 5-azacytidine and 5,6-dihydro-5-azacytidine in two human leukemia cell lines PER-145 and PER-163
    • U.R. Kees, and V.I. Avramis Biochemical pharmacology and DNA methylation studies of arabinosyl 5-azacytidine and 5,6-dihydro-5-azacytidine in two human leukemia cell lines PER-145 and PER-163 Anticancer Drugs 6 1995 303 310
    • (1995) Anticancer Drugs , vol.6 , pp. 303-310
    • Kees, U.R.1    Avramis, V.I.2
  • 17
    • 0025138304 scopus 로고
    • Susceptibilities of zidovudine-susceptible and -resistant human immunodeficiency virus isolates to antiviral agents determined by using a quantitative plaque reduction assay
    • B.A. Larder, B. Chesebro, and D.D. Richman Susceptibilities of zidovudine-susceptible and -resistant human immunodeficiency virus isolates to antiviral agents determined by using a quantitative plaque reduction assay Antimicrob. Agents Chemother. 34 1990 436 441
    • (1990) Antimicrob. Agents Chemother. , vol.34 , pp. 436-441
    • Larder, B.A.1    Chesebro, B.2    Richman, D.D.3
  • 18
    • 0026042638 scopus 로고
    • Zidovudine-resistant human immunodeficiency virus selected by passage in cell culture
    • B.A. Larder, K.E. Coates, and S.D. Kemp Zidovudine-resistant human immunodeficiency virus selected by passage in cell culture J. Virol. 65 1991 5232 5236
    • (1991) J. Virol. , vol.65 , pp. 5232-5236
    • Larder, B.A.1    Coates, K.E.2    Kemp, S.D.3
  • 21
    • 20444429765 scopus 로고    scopus 로고
    • Mechanism of action of a novel viral mutagenic covert nucleotide: Molecular interactions with HIV-1 reverse transcriptase and host cell DNA polymerases
    • Murakami, E., Basavapathruni, A., Bradley, W., Anderson, K.S., 2005. Mechanism of action of a novel viral mutagenic covert nucleotide: molecular interactions with HIV-1 reverse transcriptase and host cell DNA polymerases. Antiviral Res.
    • (2005) Antiviral Res.
    • Murakami, E.1    Basavapathruni, A.2    Bradley, W.3    Anderson, K.S.4
  • 22
    • 0024974481 scopus 로고
    • Error thresholds of replication in finite populations mutation frequencies and the onset of Muller's ratchet
    • M. Nowak, and P. Schuster Error thresholds of replication in finite populations mutation frequencies and the onset of Muller's ratchet J. Theor. Biol. 137 1989 375 395
    • (1989) J. Theor. Biol. , vol.137 , pp. 375-395
    • Nowak, M.1    Schuster, P.2
  • 23
    • 0033780046 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 spinoculation enhances infection through virus binding
    • U. O'Doherty, W.J. Swiggard, and M.H. Malim Human immunodeficiency virus type 1 spinoculation enhances infection through virus binding J. Virol. 74 2000 10074 10080
    • (2000) J. Virol. , vol.74 , pp. 10074-10080
    • O'Doherty, U.1    Swiggard, W.J.2    Malim, M.H.3
  • 24
    • 0017673058 scopus 로고
    • A quantitative assay of mutation induction at the hypoxanthine-guanine phosphoribosyl transferase locus in Chinese hamster ovary cells (CHO/HGPRT system): Development and definition of the system
    • J.P. O'Neill, P.A. Brimer, R. Machanoff, G.P. Hirsch, and A.W. Hsie A quantitative assay of mutation induction at the hypoxanthine-guanine phosphoribosyl transferase locus in Chinese hamster ovary cells (CHO/HGPRT system): development and definition of the system Mutat. Res. 45 1977 91 101
    • (1977) Mutat. Res. , vol.45 , pp. 91-101
    • O'Neill, J.P.1    Brimer, P.A.2    MacHanoff, R.3    Hirsch, G.P.4    Hsie, A.W.5
  • 25
    • 0017718690 scopus 로고
    • Chemical mutagenesis of mammalian cells can be quantified
    • J.P. O'Neill, and A.W. Hsie Chemical mutagenesis of mammalian cells can be quantified Nature 269 1977 815 817
    • (1977) Nature , vol.269 , pp. 815-817
    • O'Neill, J.P.1    Hsie, A.W.2
  • 26
    • 0034813056 scopus 로고    scopus 로고
    • Efficient virus extinction by combinations of a mutagen and antiviral inhibitors
    • N. Pariente, S. Sierra, P.R. Lowenstein, and E. Domingo Efficient virus extinction by combinations of a mutagen and antiviral inhibitors J. Virol. 75 2001 9723 9730
    • (2001) J. Virol. , vol.75 , pp. 9723-9730
    • Pariente, N.1    Sierra, S.2    Lowenstein, P.R.3    Domingo, E.4
  • 27
    • 0024267430 scopus 로고
    • Fidelity of HIV-1 reverse transcriptase
    • B.D. Preston, B.J. Poiesz, and L.A. Loeb Fidelity of HIV-1 reverse transcriptase Science 242 1988 1168 1171
    • (1988) Science , vol.242 , pp. 1168-1171
    • Preston, B.D.1    Poiesz, B.J.2    Loeb, L.A.3
  • 28
    • 0024273119 scopus 로고
    • The accuracy of reverse transcriptase from HIV-1
    • J.D. Roberts, K. Bebenek, and T.A. Kunkel The accuracy of reverse transcriptase from HIV-1 Science 242 1988 1171 1173
    • (1988) Science , vol.242 , pp. 1171-1173
    • Roberts, J.D.1    Bebenek, K.2    Kunkel, T.A.3
  • 29
    • 0032522949 scopus 로고    scopus 로고
    • Dihydro-5-azacytidine and cisplatin in the treatment of malignant mesothelioma: A phase II study by the cancer and leukemia group B
    • B.L. Samuels, J.E. Herndon II, D.C. Harmon, R. Carey, J. Aisner, J.M. Corson, Y. Suzuki, M.R. Green, and N.J. Vogelzang Dihydro-5-azacytidine and cisplatin in the treatment of malignant mesothelioma: a phase II study by the cancer and leukemia group B Cancer 82 1998 1578 1584
    • (1998) Cancer , vol.82 , pp. 1578-1584
    • Samuels, B.L.1    Herndon II, J.E.2    Harmon, D.C.3    Carey, R.4    Aisner, J.5    Corson, J.M.6    Suzuki, Y.7    Green, M.R.8    Vogelzang, N.J.9
  • 30
    • 0032830814 scopus 로고    scopus 로고
    • Genotoxicity of 3′-azido-3′-deoxythymidine in the human lymphoblastoid cell line, TK6: Relationships between DNA incorporation, mutant frequency, and spectrum of deletion mutations in HPRT
    • H.E. Sussman, O.A. Olivero, Q. Meng, S.M. Pietras, M.C. Poirie, J.P. O'Neill, B.A. Finette, M.J. Bauer, and V.E. Walker Genotoxicity of 3′-azido-3′-deoxythymidine in the human lymphoblastoid cell line, TK6: relationships between DNA incorporation, mutant frequency, and spectrum of deletion mutations in HPRT Mutat. Res. 429 1999 249 259
    • (1999) Mutat. Res. , vol.429 , pp. 249-259
    • Sussman, H.E.1    Olivero, O.A.2    Meng, Q.3    Pietras, S.M.4    Poirie, M.C.5    O'Neill, J.P.6    Finette, B.A.7    Bauer, M.J.8    Walker, V.E.9
  • 31
    • 0032565577 scopus 로고    scopus 로고
    • Mutagenicity and repair of oxidative DNA damage: Insights from studies using defined lesions
    • D. Wang, D.A. Kreutzer, and J.M. Essigmann Mutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions Mutat. Res. 400 1998 99 115
    • (1998) Mutat. Res. , vol.400 , pp. 99-115
    • Wang, D.1    Kreutzer, D.A.2    Essigmann, J.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.