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Volumn 13, Issue 6, 2008, Pages 789-797

Effect of nucleoside and nucleotide reverse transcriptase inhibitors of HIV on endogenous nucleotide pools

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 7 [1 (2 FLUOROPHENYL) 2 HYDROXYETHYL] 3,5 DIHYDRO 4H PYRROLO[3,2 D]PYRIMIDIN 4 ONE; ABACAVIR; ANTIMETABOLITE; ANTIRETROVIRUS AGENT; DEOXYCYTIDINE PHOSPHATE DEAMINASE; DEOXYGUANOSINE; DEOXYGUANOSINE TRIPHOSPHATE; DEOXYRIBONUCLEOSIDE TRIPHOSPHATE; DIDANOSINE; HYDROXYUREA; LAMIVUDINE; METHOTREXATE; NUCLEOTIDE REVERSE TRANSCRIPTASE INHIBITOR; PNP 405; PURINE NUCLEOSIDE PHOSPHORYLASE; PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITOR; RIBAVIRIN; RNA DIRECTED DNA POLYMERASE INHIBITOR; TENOFOVIR; THYMIDINE; THYMIDINE TRIPHOSPHATE; THYMINE; UNCLASSIFIED DRUG; ZIDOVUDINE;

EID: 53149133921     PISSN: 13596535     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (16)

References (49)
  • 1
    • 23144439258 scopus 로고    scopus 로고
    • Intracellular interactions between nucleos(t)ide inhibitors of HIV reverse transcriptase
    • Ray AS. Intracellular interactions between nucleos(t)ide inhibitors of HIV reverse transcriptase. AIDS Rev 2005; 7:113-125.
    • (2005) AIDS Rev , vol.7 , pp. 113-125
    • Ray, A.S.1
  • 2
    • 0023266214 scopus 로고
    • The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial
    • Richman DD, Fischl MA, Grieco MH, et al. The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial. N Engl J Med 1987; 317:192-197.
    • (1987) N Engl J Med , vol.317 , pp. 192-197
    • Richman, D.D.1    Fischl, M.A.2    Grieco, M.H.3
  • 3
    • 30944468562 scopus 로고    scopus 로고
    • Tenofovir DF, emtricitabine, and efavirenz vs. zidovudine, lamivudine, and efavirenz; for HIV
    • Gallant JE, DeJesus E, Arrihas JR, et al. Tenofovir DF, emtricitabine, and efavirenz vs. zidovudine, lamivudine, and efavirenz; for HIV. N Engl J Med 2006; 354:251-260.
    • (2006) N Engl J Med , vol.354 , pp. 251-260
    • Gallant, J.E.1    DeJesus, E.2    Arrihas, J.R.3
  • 4
    • 4744372267 scopus 로고    scopus 로고
    • Phosphorylation of thymidine and AZT in heart mitochondria: Elucidation of a novel mechanism of AZT cardiotoxicity
    • McKee EE, Bentley AT, Hatch M, Gingerich J, Susan-Resiga D. Phosphorylation of thymidine and AZT in heart mitochondria: elucidation of a novel mechanism of AZT cardiotoxicity. Cardiovasc Toxicol 2004; 4:155-167.
    • (2004) Cardiovasc Toxicol , vol.4 , pp. 155-167
    • McKee, E.E.1    Bentley, A.T.2    Hatch, M.3    Gingerich, J.4    Susan-Resiga, D.5
  • 5
    • 33744915313 scopus 로고    scopus 로고
    • 3′-Azido-3′-deoxythymidine (AZT) is a competitive inhibitor of thymidine phosphorylation in isolated rat heart and liver mitochondria
    • Lynx MD, McKee EE. 3′-Azido-3′-deoxythymidine (AZT) is a competitive inhibitor of thymidine phosphorylation in isolated rat heart and liver mitochondria. Biochem Pharmacol 2006; 72:239-243.
    • (2006) Biochem Pharmacol , vol.72 , pp. 239-243
    • Lynx, M.D.1    McKee, E.E.2
  • 6
    • 33645124958 scopus 로고    scopus 로고
    • 3′-Azido-3′-deoxythymidine, (AZT) inhibits thymidine phosphorylation in isolated rat liver mitochondria: A possible mechanism of AZT hepatotoxicity
    • Lynx MD, Bentley AT, McKee EE. 3′-Azido-3′-deoxythymidine, (AZT) inhibits thymidine phosphorylation in isolated rat liver mitochondria: a possible mechanism of AZT hepatotoxicity. Biochem Pharmacol 2006; 71:1342-1348.
    • (2006) Biochem Pharmacol , vol.71 , pp. 1342-1348
    • Lynx, M.D.1    Bentley, A.T.2    McKee, E.E.3
  • 7
    • 0024353932 scopus 로고
    • Cellular pharmacology of 3′-azido-3′-deoxythymidine with evidence of incorporation into DNA of human bone marrow cells
    • Sommadossi JP, Carlisle R, Zhou Z. Cellular pharmacology of 3′-azido-3′-deoxythymidine with evidence of incorporation into DNA of human bone marrow cells. Mol Pharmacol 1989; 36:9-14.
    • (1989) Mol Pharmacol , vol.36 , pp. 9-14
    • Sommadossi, J.P.1    Carlisle, R.2    Zhou, Z.3
  • 8
    • 0025143813 scopus 로고
    • Incorporation of 3′-azido-3′-deoxythymidine into cellular DNA and its removal in a human leukemic cell line
    • Vazquez-Padua MA, Starnes MC, Cheng YC. Incorporation of 3′-azido-3′-deoxythymidine into cellular DNA and its removal in a human leukemic cell line. Cancer Commun 1990; 2:55-62.
    • (1990) Cancer Commun , vol.2 , pp. 55-62
    • Vazquez-Padua, M.A.1    Starnes, M.C.2    Cheng, Y.C.3
  • 9
    • 0027157404 scopus 로고
    • Inhibition of mammalian DNA polymerase-associated 3′ to 5′ exonuclease activity by 5′-monophosphates of 3′-azido-3′-deoxythymidine and 3′-amino-3′-deoxythymidine
    • Bridges EG, Faraj A, Sommadossi JP. Inhibition of mammalian DNA polymerase-associated 3′ to 5′ exonuclease activity by 5′-monophosphates of 3′-azido-3′-deoxythymidine and 3′-amino-3′-deoxythymidine. Biochem Pharmacol 1993; 45:1571-1576.
    • (1993) Biochem Pharmacol , vol.45 , pp. 1571-1576
    • Bridges, E.G.1    Faraj, A.2    Sommadossi, J.P.3
  • 10
    • 0027451533 scopus 로고
    • Reduction of 3′-azido-2′,3′-dideoxymideosides to their 3′-amino metabolite is mediated by cytochrome P-450 and NADPH-cytochrome P-450 reductase in rat liver microsomes
    • Cretton EM, Sommadossi JR Reduction of 3′-azido-2′,3′-dideoxymideosides to their 3′-amino metabolite is mediated by cytochrome P-450 and NADPH-cytochrome P-450 reductase in rat liver microsomes. Drug Metab Dispos 1993; 21:946-950.
    • (1993) Drug Metab Dispos , vol.21 , pp. 946-950
    • Cretton, E.M.1    Sommadossi, J.R.2
  • 12
    • 0022996630 scopus 로고
    • Phosphorylation of 3′-azido-3′-deoxythymidine and selective interaction of the Y-triphosphate with human immunodeficiency virus reverse transcriptase
    • Furman PA, Fyfe JA, St Clair MH, et al. Phosphorylation of 3′-azido-3′-deoxythymidine and selective interaction of the Y-triphosphate with human immunodeficiency virus reverse transcriptase. Proc Natl Acad Sci U S A 1986; 83:8333-8337.
    • (1986) Proc Natl Acad Sci U S A , vol.83 , pp. 8333-8337
    • Furman, P.A.1    Fyfe, J.A.2    St Clair, M.H.3
  • 13
    • 0034452004 scopus 로고    scopus 로고
    • Purine nucleoside phosphorylases: Properties, functions, and clinical aspects
    • Bzowska A, Kulikowska E, Shugar D. Purine nucleoside phosphorylases: properties, functions, and clinical aspects. Pharmacol Ther 2000; 88:349-425.
    • (2000) Pharmacol Ther , vol.88 , pp. 349-425
    • Bzowska, A.1    Kulikowska, E.2    Shugar, D.3
  • 14
    • 1642461500 scopus 로고    scopus 로고
    • Role of purine nucleoside p hosphorylase in interactions between 2′,3′-dideoxyinosine and allogerinol, ganciclovir, or tenofovir
    • Ray AS, Olson L, Fridland A. Role of purine nucleoside p hosphorylase in interactions between 2′,3′-dideoxyinosine and allogerinol, ganciclovir, or tenofovir. Antimicrob Agents ther 2004; 48:1089-1095.
    • (2004) Antimicrob Agents ther , vol.48 , pp. 1089-1095
    • Ray, A.S.1    Olson, L.2    Fridland, A.3
  • 15
    • 11244277325 scopus 로고    scopus 로고
    • CD4 cell decline with didanosine and tenofovir and failure of triple nucleoside/nucleotide regimens may be related
    • Kakuda TN, Anderson PL, Becker SL. CD4 cell decline with didanosine and tenofovir and failure of triple nucleoside/nucleotide regimens may be related. AIDS 2004; 18:2442-2444.
    • (2004) AIDS , vol.18 , pp. 2442-2444
    • Kakuda, T.N.1    Anderson, P.L.2    Becker, S.L.3
  • 16
    • 0038730672 scopus 로고    scopus 로고
    • Mechanism of inhibition of T-acute lymphoblastic leukemia cells by PNP inhibitor-BCX-1777
    • Bantia S, Ananth SL, Parker CD, Horn LL, Upshaw R. Mechanism of inhibition of T-acute lymphoblastic leukemia cells by PNP inhibitor-BCX-1777. Int Immunopharmacol 2003; 3:879-887.
    • (2003) Int Immunopharmacol , vol.3 , pp. 879-887
    • Bantia, S.1    Ananth, S.L.2    Parker, C.D.3    Horn, L.L.4    Upshaw, R.5
  • 17
    • 12144286268 scopus 로고    scopus 로고
    • Unexpected CD4 cell count decline in patients receiving didanosine and tenofovir-based regimens despite undetectable viral load
    • Negredo E, Molto J, Burger D, et al. Unexpected CD4 cell count decline in patients receiving didanosine and tenofovir-based regimens despite undetectable viral load. AIDS 2004; 18:459-463.
    • (2004) AIDS , vol.18 , pp. 459-463
    • Negredo, E.1    Molto, J.2    Burger, D.3
  • 18
    • 20244390456 scopus 로고    scopus 로고
    • + T-cell decline in HIV-infected patients with complete virus suppression taking tenofovir and didanosine
    • + T-cell decline in HIV-infected patients with complete virus suppression taking tenofovir and didanosine. AIDS 2005; 19:569-575.
    • (2005) AIDS , vol.19 , pp. 569-575
    • Barrios, A.1    Rendon, A.2    Negredo, E.3
  • 19
    • 0038369913 scopus 로고    scopus 로고
    • A randomized trial to study first-line combination therapy with or without a protease inhibitor in HIV-1-infected patients
    • van Leeuwen R, Katlama C, Murphy RL, et al. A randomized trial to study first-line combination therapy with or without a protease inhibitor in HIV-1-infected patients. AIDS 2003; 17:987-999.
    • (2003) AIDS , vol.17 , pp. 987-999
    • van Leeuwen, R.1    Katlama, C.2    Murphy, R.L.3
  • 20
    • 0142125266 scopus 로고    scopus 로고
    • Low efficacy and high frequency of adverse events in a randomized trial of the triple nucleoside regimen abacavir, stavudine and didanosine
    • Gerstoft J, Kirk O, Obel N, et al. Low efficacy and high frequency of adverse events in a randomized trial of the triple nucleoside regimen abacavir, stavudine and didanosine. AIDS 2003; 17:2045-2052.
    • (2003) AIDS , vol.17 , pp. 2045-2052
    • Gerstoft, J.1    Kirk, O.2    Obel, N.3
  • 21
    • 2342537759 scopus 로고    scopus 로고
    • Triple-nucleoside regimens versus efavirenz-containing repimens for the initial treatment of HIV-1 infection
    • Gulick RM, Ribaudo HJ, Shikuma CM, et al. Triple-nucleoside regimens versus efavirenz-containing repimens for the initial treatment of HIV-1 infection. N Eng J Med 2004; 350:1850-1861.
    • (2004) N Eng J Med , vol.350 , pp. 1850-1861
    • Gulick, R.M.1    Ribaudo, H.J.2    Shikuma, C.M.3
  • 22
    • 2142657848 scopus 로고    scopus 로고
    • Which nucleoside and nucleotide backbone combinations select for the K65R mutation in HIV-1 reverse transcriptase
    • Winston A, Pozniak A, Mandalia S, Gazzard B, Pillay D, Nelson M. Which nucleoside and nucleotide backbone combinations select for the K65R mutation in HIV-1 reverse transcriptase. AIDS 2004; 18:949-951.
    • (2004) AIDS , vol.18 , pp. 949-951
    • Winston, A.1    Pozniak, A.2    Mandalia, S.3    Gazzard, B.4    Pillay, D.5    Nelson, M.6
  • 23
    • 3142682708 scopus 로고    scopus 로고
    • Poor virologic responses and early emergence of resistance in treatment naive, HIV-infected patients receiving a once daily triple nucleoside regimen of didanosine, lamivudine, and tenofovir DF
    • 8-11 February, San Francisco, CA, USA. Abstract 51
    • Jemsek Hutcherson P, Harper E. Poor virologic responses and early emergence of resistance in treatment naive, HIV-infected patients receiving a once daily triple nucleoside regimen of didanosine, lamivudine, and tenofovir DF. 11th Conference on Retroviruses and Opportunistic Infections. 8-11 February 2004, San Francisco, CA, USA. Abstract 51.
    • (2004) 11th Conference on Retroviruses and Opportunistic Infections
    • Jemsek Hutcherson, P.1    Harper, E.2
  • 24
    • 27944472569 scopus 로고    scopus 로고
    • Early virologic nonresponse to tenofovir, abacavir, and lamivudine in HIV-infected antiretroviral-naive subjects
    • Gallant JE, Rodriguez AE, Weinberg WG, et al. Early virologic nonresponse to tenofovir, abacavir, and lamivudine in HIV-infected antiretroviral-naive subjects. J Infect Dis 2005; 192:1921-1930.
    • (2005) J Infect Dis , vol.192 , pp. 1921-1930
    • Gallant, J.E.1    Rodriguez, A.E.2    Weinberg, W.G.3
  • 25
    • 53149102969 scopus 로고    scopus 로고
    • Panel on Antiretroviral Guidelines for Adults and Adolescents. dolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services. (Updated 29 January 2008. Accessed 24 April 2008.) Available from http://aidsinfo.nih.gov/ContentFiles/AdultandAdeloscentGL.pdf
    • Panel on Antiretroviral Guidelines for Adults and Adolescents. dolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services. (Updated 29 January 2008. Accessed 24 April 2008.) Available from http://aidsinfo.nih.gov/ContentFiles/AdultandAdeloscentGL.pdf
  • 26
    • 0037144629 scopus 로고    scopus 로고
    • An efficient and large-scale enantioselective synthesis of PNP405: A purine nucleoside phosphorylase inhibitor
    • Prashad M, Hat D, Chen L, Kim HY, Repic O, Blacklock TJ. An efficient and large-scale enantioselective synthesis of PNP405: a purine nucleoside phosphorylase inhibitor. J Org Chem 2002; 67:6612-6617.
    • (2002) J Org Chem , vol.67 , pp. 6612-6617
    • Prashad, M.1    Hat, D.2    Chen, L.3    Kim, H.Y.4    Repic, O.5    Blacklock, T.J.6
  • 27
    • 33947430923 scopus 로고    scopus 로고
    • Simultaneous quantitation of the nucleotide analog adefovir, its phosphorylated anabolites and 2′-deoxyadenosine triphosyhate by ion-pairing LC/MS/MS
    • Vela E, Olson LY, Huang A, Fridland A, Ray AS. Simultaneous quantitation of the nucleotide analog adefovir, its phosphorylated anabolites and 2′-deoxyadenosine triphosyhate by ion-pairing LC/MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci 2007; 848:335-343.
    • (2007) J Chromatogr B Analyt Technol Biomed Life Sci , vol.848 , pp. 335-343
    • Vela, E.1    Olson, L.Y.2    Huang, A.3    Fridland, A.4    Ray, A.S.5
  • 28
    • 0028143584 scopus 로고
    • Physiological concentrations of purines and pyrimidines
    • Traut TW. Physiological concentrations of purines and pyrimidines. Mol Cell Biochem 1994; 140:1-22.
    • (1994) Mol Cell Biochem , vol.140 , pp. 1-22
    • Traut, T.W.1
  • 29
    • 0001707601 scopus 로고
    • 3′-Azido-3′-deoxythymidine (BW A509U): An antiviral agent that inhibits the infectivity and cyropathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro
    • Mitsuya H, Weinhold KJ, Furman PA, et al. 3′-Azido-3′-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cyropathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro. Proc Natl Acad Sci U S A 1985; 82:7096-7100.
    • (1985) Proc Natl Acad Sci U S A , vol.82 , pp. 7096-7100
    • Mitsuya, H.1    Weinhold, K.J.2    Furman, P.A.3
  • 30
    • 0025337365 scopus 로고
    • Relationship of deoxynucleotide changes to inhibition of DNA synthesis induced by the antiretroviral agent 3′-azido-3′-deoxythymidine and release of its monophosphate by human lymphoid cells (CCRF-CEM)
    • Fridland A, Connelly MC, Ashmun R. Relationship of deoxynucleotide changes to inhibition of DNA synthesis induced by the antiretroviral agent 3′-azido-3′-deoxythymidine and release of its monophosphate by human lymphoid cells (CCRF-CEM). Mol Pharmacol 1990; 37:665-670.
    • (1990) Mol Pharmacol , vol.37 , pp. 665-670
    • Fridland, A.1    Connelly, M.C.2    Ashmun, R.3
  • 31
    • 0021789719 scopus 로고
    • Relations between synthesis of deoxyribonucleotides and DNA replication in 3T6 fibroblasts
    • Nicander B, Reichard P. Relations between synthesis of deoxyribonucleotides and DNA replication in 3T6 fibroblasts. J Biol Chem 1985; 260:5376-5381.
    • (1985) J Biol Chem , vol.260 , pp. 5376-5381
    • Nicander, B.1    Reichard, P.2
  • 32
    • 0032702725 scopus 로고    scopus 로고
    • 9-(2-phosphonylmethoxyethyl) derivatives of purine nucleotide analogs: A comparison of their metabolism and interaction with cellular DNA synthesis
    • Kramata P, Downey KM. 9-(2-phosphonylmethoxyethyl) derivatives of purine nucleotide analogs: A comparison of their metabolism and interaction with cellular DNA synthesis. Mol Pharmacol 1999; 56:1262-1270.
    • (1999) Mol Pharmacol , vol.56 , pp. 1262-1270
    • Kramata, P.1    Downey, K.M.2
  • 33
    • 0025339708 scopus 로고
    • Selective action of 3′-azido-3′-deoxythymidine 5′-triphosphate on viral reverse transcriptases and human DNA polymerases
    • Huang P, Farquhar D, Plunkett W. Selective action of 3′-azido-3′-deoxythymidine 5′-triphosphate on viral reverse transcriptases and human DNA polymerases. J Biol Chem 1990; 265:11914-11918.
    • (1990) J Biol Chem , vol.265 , pp. 11914-11918
    • Huang, P.1    Farquhar, D.2    Plunkett, W.3
  • 34
    • 0026786397 scopus 로고
    • Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA
    • Copeland WC, Chen MS, Wang TS. Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA. J Biol Chem 1992; 267:21459-21464.
    • (1992) J Biol Chem , vol.267 , pp. 21459-21464
    • Copeland, W.C.1    Chen, M.S.2    Wang, T.S.3
  • 35
    • 0026604666 scopus 로고
    • Interactions of azidothymidine triphosphate with the cellular DNA polymerases alpha, delta, and epsilon and with DNA primase
    • Nickel W, Austermann S, Bialek G, Grosse E, Interactions of azidothymidine triphosphate with the cellular DNA polymerases alpha, delta, and epsilon and with DNA primase. J Biol Chem 1992; 267:848-854.
    • (1992) J Biol Chem , vol.267 , pp. 848-854
    • Nickel, W.1    Austermann, S.2    Bialek, G.3    Grosse, E.4
  • 36
    • 0035798566 scopus 로고    scopus 로고
    • Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase
    • Johnson AA, Ray AS, Hanes J, et al. Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase. J Biol Chem 2001; 276:40847-40857.
    • (2001) J Biol Chem , vol.276 , pp. 40847-40857
    • Johnson, A.A.1    Ray, A.S.2    Hanes, J.3
  • 37
    • 0037220313 scopus 로고    scopus 로고
    • Assessment of the effect of phosphorylated metabolites of anti-human immunodeficiency virus and anti-hepatitis B virus pyrimidine analogs on the behavior of human deoxycytidylate deaminase
    • Liou JY, Krishnan P, Hsieh CC, Dutschman GE, Cheng YC. Assessment of the effect of phosphorylated metabolites of anti-human immunodeficiency virus and anti-hepatitis B virus pyrimidine analogs on the behavior of human deoxycytidylate deaminase. Mol Pharmacol 2003; 63:105-110.
    • (2003) Mol Pharmacol , vol.63 , pp. 105-110
    • Liou, J.Y.1    Krishnan, P.2    Hsieh, C.C.3    Dutschman, G.E.4    Cheng, Y.C.5
  • 38
    • 0042357238 scopus 로고    scopus 로고
    • Achieving the ultimate physiological goal in transition state analogue inhibitors for purine nucleoside phosphorylase
    • Lewandowicz A, Tyler PC, Evans GB, Furneaux RH, Schramm VL. Achieving the ultimate physiological goal in transition state analogue inhibitors for purine nucleoside phosphorylase. J Biol Chem 2003; 278:31465-31468.
    • (2003) J Biol Chem , vol.278 , pp. 31465-31468
    • Lewandowicz, A.1    Tyler, P.C.2    Evans, G.B.3    Furneaux, R.H.4    Schramm, V.L.5
  • 40
    • 0031916651 scopus 로고    scopus 로고
    • Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl) adenine (PMPA), bis(isopropyloxymethylcarbonyl)PMPA
    • Robbins BL, Srinivas RV, Kim C, Bischofberger N, Fridland A. Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl) adenine (PMPA), bis(isopropyloxymethylcarbonyl)PMPA. Antimicrob Agents Chemother 1998; 42:612-617.
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 612-617
    • Robbins, B.L.1    Srinivas, R.V.2    Kim, C.3    Bischofberger, N.4    Fridland, A.5
  • 41
    • 0034806946 scopus 로고    scopus 로고
    • Phase I/ II trial of the pharmacokinetics, safety, and antiretroviral activity of tenofovir disoproxil fumarate in human immunodeficiency virus-infected adults
    • Barditch-Crovo P, Deeks SG, Collier A, et al. Phase I/ II trial of the pharmacokinetics, safety, and antiretroviral activity of tenofovir disoproxil fumarate in human immunodeficiency virus-infected adults. Antimicrob Agents Chemother 2001; 45:2733-2739.
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 2733-2739
    • Barditch-Crovo, P.1    Deeks, S.G.2    Collier, A.3
  • 42
    • 0038012639 scopus 로고    scopus 로고
    • Metabolism of tenofovir and didanosine in quiescent or stimulated human peripheral blood mononuclear cells
    • Robbins BL, Wilcox CK, Fridland A, Rodman JH. Metabolism of tenofovir and didanosine in quiescent or stimulated human peripheral blood mononuclear cells. Pharmacotherapy 2003; 23:695-701.
    • (2003) Pharmacotherapy , vol.23 , pp. 695-701
    • Robbins, B.L.1    Wilcox, C.K.2    Fridland, A.3    Rodman, J.H.4
  • 43
    • 20944435946 scopus 로고    scopus 로고
    • Measurement of intracellular didanosine and tenofovir phosphorylated metabolites and possible interaction of the two drugs in human immunodeficiency virus-infected patients
    • Pruvost A, Negredo E, Benech H, et al. Measurement of intracellular didanosine and tenofovir phosphorylated metabolites and possible interaction of the two drugs in human immunodeficiency virus-infected patients. Antimicrob Agents Chemother 2005; 49:1907-1914.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 1907-1914
    • Pruvost, A.1    Negredo, E.2    Benech, H.3
  • 44
    • 20444483684 scopus 로고    scopus 로고
    • Lack of a metabolic and antiviral drug interaction between tenofovir, abacavir and lamivudine
    • Ray AS, Myrick F, Vela JE, et al. Lack of a metabolic and antiviral drug interaction between tenofovir, abacavir and lamivudine. Antivir Ther 2005; 10:451-457.
    • (2005) Antivir Ther , vol.10 , pp. 451-457
    • Ray, A.S.1    Myrick, F.2    Vela, J.E.3
  • 45
    • 22344455482 scopus 로고    scopus 로고
    • Intracellular pharmacokinetics of tenofovir diphosphate, carbovir triphosphate, and lamivudine triphosphate in patients receiving triple-nucleoside regimens
    • Hawkins T, Veikley W, St Claire RL, III, Guyer B, Clark N, Kearney BP. Intracellular pharmacokinetics of tenofovir diphosphate, carbovir triphosphate, and lamivudine triphosphate in patients receiving triple-nucleoside regimens. J Acquir Immune Defic Syndr 2005; 39:406-411.
    • (2005) J Acquir Immune Defic Syndr , vol.39 , pp. 406-411
    • Hawkins, T.1    Veikley, W.2    St Claire III, R.L.3    Guyer, B.4    Clark, N.5    Kearney, B.P.6
  • 46
    • 0035819909 scopus 로고    scopus 로고
    • Abacavirlamivudine-zidovudine vs indinavir-lamivudine-zidovudine in antiretroviral-naive HIV-infected adults: A randomized equivalence trial
    • Staszewski S, Keiser P, Montaner J, et al. Abacavirlamivudine-zidovudine vs indinavir-lamivudine-zidovudine in antiretroviral-naive HIV-infected adults: A randomized equivalence trial. JAMA 2001; 285:1155-1163.
    • (2001) JAMA , vol.285 , pp. 1155-1163
    • Staszewski, S.1    Keiser, P.2    Montaner, J.3
  • 47
    • 0038369024 scopus 로고    scopus 로고
    • K65R with and without S68: A new resistance profile in vivo detected in most patients failing abacavir, didanosine and stavudine
    • Roge BT, Katzenstein TL, Obel N, et al. K65R with and without S68: a new resistance profile in vivo detected in most patients failing abacavir, didanosine and stavudine. Antivir, Ther 2003; 8:173-182.
    • (2003) Antivir, Ther , vol.8 , pp. 173-182
    • Roge, B.T.1    Katzenstein, T.L.2    Obel, N.3
  • 48
    • 33745450105 scopus 로고    scopus 로고
    • Virological response to a triple nucleoside/nucleotide analogue regimen over 48 weeks in HIV-1-infected adults in Africa
    • DART Virology Group and Trial Team
    • DART Virology Group and Trial Team. Virological response to a triple nucleoside/nucleotide analogue regimen over 48 weeks in HIV-1-infected adults in Africa. AIDS 2006; 20:1391-1399.
    • (2006) AIDS , vol.20 , pp. 1391-1399
  • 49
    • 33644511106 scopus 로고    scopus 로고
    • An open-label, randomized comparative pilot study of a single-class quadruple therapy regimen versus a 2-class triple therapy regimen for individuals initiating antiretroviral therapy
    • Moyle G, Higgs C, Teague A, et al. An open-label, randomized comparative pilot study of a single-class quadruple therapy regimen versus a 2-class triple therapy regimen for individuals initiating antiretroviral therapy. Antivir Ther 2006; 11:73-78.
    • (2006) Antivir Ther , vol.11 , pp. 73-78
    • Moyle, G.1    Higgs, C.2    Teague, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.