Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): Increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase

Biochemistry

Volumn 37, Issue 45, 1998, Pages 15908-15917

  Arion, Dominique ^a   Kaushik, Neerja ^a   McCormick, Suzanne ^a   Borkow, Gadi ^a   Parniak, Michael A ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PYROPHOSPHATE; RNA DIRECTED DNA POLYMERASE; ZIDOVUDINE;

ARTICLE; DISSOCIATION CONSTANT; DRUG RESISTANCE; HUMAN IMMUNODEFICIENCY VIRUS 1; MICHAELIS CONSTANT; NONHUMAN; PHENOTYPE; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERIZATION; PRIORITY JOURNAL; TIME; VIRUS MUTATION; VIRUS REPLICATION; VIRUS RESISTANCE;

CATALYSIS; DIPHOSPHATES; DNA, VIRAL; DRUG RESISTANCE, MICROBIAL; FOSCARNET; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; MUTAGENESIS, SITE-DIRECTED; PEPTIDE CHAIN TERMINATION, TRANSLATIONAL; PHENOTYPE; POLYMERS; PROTEIN PROCESSING, POST-TRANSLATIONAL; REVERSE TRANSCRIPTASE INHIBITORS; TEMPLATES, GENETIC; ZIDOVUDINE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0032506055     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi981200e     Document Type: Article

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