Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir

Lancet

Volumn 359, Issue 9308, 2002, Pages 727-732

  Mallal, S ^a,b   Nolan, D ^a   Witt, C ^a,b   Masel, G ^a,b   Martin, A M ^a   Moore, C ^a   Sayer, D ^a,b   Castley, A ^a,b   Mamotte, C ^a,b   Maxwell, D ^a   James, I ^a   Christiansen, F T ^b,c  

^a MURDOCH UNIVERSITY   (Australia)

^b ROYAL PERTH HOSPITAL   (Australia)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ABACAVIR; HLA B ANTIGEN; HLA DQ ANTIGEN; HLA DR7 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; DRUG HYPERSENSITIVITY; DRUG TOLERANCE; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; MOLECULAR TYPING; POLYMORPHIC LOCUS; PREDICTION; PREVALENCE; PRIORITY JOURNAL;

EID: 0037006623     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(02)07873-X     Document Type: Article

References (22)

1. Hypersensitivity reactions during therapy with the nucleoside reverse transcriptase inhibitor abacavir
2. Abacavir rechallenge has to be avoided in case of hypersensitivity reaction
3. Risk factor analysis of hypersensitivity reactions to abacavir: Retrospective analysis of 25 clinical trials]
4. Hypersensitivity related to abacavir in two members of a family
5. Metabolic activation in drug allergies
6. HLA-restricted processing- and metabolism-independent pathway of drug recognition by human αβ T lymphocytes
7. Recognition of sulfamethoxazole and its reactive metabolites by drug-specific CD4+ T cells from allergic individuals
8. Disease associations with complotypes supratypes and haplotypes
9. High-resolution haplotype structure in the human genome
10. Studies of MHC haplotypes by pulsed field gel electrophoresis
11. Single base change in the human tumour necrosis factor alpha (TNFA) gene detectable by NcoI restriction of PCR product
12. Localization of central MHC genes influencing type I diabetes
13. Trinucleotide repeat polymorphism within exon 5 of the MICA gene (MHC class I chain-related gene A): Allele frequency data in the nine population groups Japanese, Northern Han, Hui, Uygur, Kazakhstan, Iranian, Saudi Arabian, Greek and Italian
14. HLA and disease associations: Detecting the strongest association
15. TNFalpha promoter region gene polymorphisms in carbamazepine-hypersensitive patients
16. Ankylosing spondylitis and HLA-B27
17. Unique intracellular activation of the potent anti-human immunodeficiency virus agent 1592U89
18. The role of heat shock proteins in the stimulation of an immune response
19. Eukaryotic heat shock proteins as molecular links in innate and adaptive immune responses: Hsp60-mediated activation of cytotoxic T cells
20. Haplotype tagging for the identification of common disease genes
21. Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase
22. Mitochondrial toxicity and HIV therapy