Mechanism of action of 1-β-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-β-D-dioxolane guanosine

Antimicrobial Agents and Chemotherapy

Volumn 45, Issue 1, 2001, Pages 158-165

  Furman, P A ^a   Jeffrey, J ^a   Kiefer, L L ^a   Feng, J Y ^a   Anderson, K S ^a   Borroto Esoda, K ^a   Hill, E ^a   Copeland, W C ^a   Chu, C K ^a   Sommadossi, J P ^a   Liberman, I ^a   Schinazi, R F ^a   Painter, G R ^a  

^a Triangle Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 DIOXOLANE DERIVATIVE; 1BETA DEXTRO 2,6 DIAMINOPURINE DIOXOLANE; 2,6 DIAMINOPURINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DNA SYNTHESIS; DRUG MECHANISM; DRUG METABOLISM; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; PRIORITY JOURNAL;

ADENOSINE DEAMINASE; ANTI-HIV AGENTS; BONE MARROW CELLS; CELLS, CULTURED; DIOXOLANES; DNA, VIRAL; DNA-DIRECTED DNA POLYMERASE; DRUG RESISTANCE, MICROBIAL; ENZYME INHIBITORS; GUANOSINE; HIV-1; HUMANS; LACTIC ACID; MICROSCOPY, ELECTRON; MITOCHONDRIA; PRODRUGS; PURINE NUCLEOSIDES; REVERSE TRANSCRIPTASE INHIBITORS;

EID: 0035162759     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.45.1.158-165.2001     Document Type: Article

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