5′-O-Aliphatic and amino acid ester prodrugs of (-)-β-d-(2R,4R)-dioxolane-thymine (DOT): Synthesis, anti-HIV activity, cytotoxicity and stability studies

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 3, 2009, Pages 1404-1409

  Liang, Yuzeng ^a   Sharon, Ashoke ^a   Grier, Jason P ^b   Rapp, Kimberly L ^b   Schinazi, Raymond F ^b   Chu, Chung K ^a  

^a UNIVERSITY OF GEORGIA   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

5 O aliphatic acid esters; 5 O amino acid esters; Anti HIV activity; Dioxolane thymine (DOT); Nucleoside prodrugs

Indexed keywords

ALIPHATIC CARBOXYLIC ACID; AMINO ACID DERIVATIVE; BETA DEXTRO DIOXOLANE THYMINE 5' O ALIPHATIC ACID ESTER DERIVATIVE; DIOXOLANE THYMINE 5' O DODECANOIC; DIOXOLANE THYMINE 5' O OCTANOIC ESTER; DIOXOLANE THYMINE 5' O VALERIC ESTER; ESTERASE; PRODRUG; UNCLASSIFIED DRUG; 1,3 DIOXOLANE DERIVATIVE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; DIOXOLANE THYMINE; DIOXOLANE-THYMINE; DRUG DERIVATIVE; THYMINE;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG HALF LIFE; DRUG POTENCY; DRUG STABILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROLYSIS; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; ANIMAL; CELL LINE; CERCOPITHECUS; CHEMISTRY; DRUG EFFECT; HALF LIFE TIME; MONONUCLEAR CELL; STEREOISOMERISM; VERO CELL;

HUMAN IMMUNODEFICIENCY VIRUS 1; SUS;

ANIMALS; ANTI-HIV AGENTS; CELL LINE; CERCOPITHECUS AETHIOPS; DIOXOLANES; DRUG STABILITY; HALF-LIFE; HUMANS; LEUKOCYTES, MONONUCLEAR; PRODRUGS; STEREOISOMERISM; THYMINE; VERO CELLS;

EID: 58949101282     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.10.078     Document Type: Article

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