Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with β-branched amino acids

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 18, 1999, Pages 10027-10032

  Sarafianos, Stefan G ^a   Das, Kalyan ^a   Clark Jr , Arthur D ^a   Ding, Jianping ^a   Boyer, Paul L ^b   Hughes, Stephen H ^b   Arnold, Edward ^a  

^a RUTGERS UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA AMINO ACID; LAMIVUDINE; PRIMER DNA; RNA DIRECTED DNA POLYMERASE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; COMPLEX FORMATION; DNA TEMPLATE; DRUG RESISTANCE; DRUG STRUCTURE; ENANTIOMER; ENZYME STRUCTURE; HEPATITIS B; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; STEREOCHEMISTRY;

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CONSERVED SEQUENCE; DIMERIZATION; DRUG RESISTANCE, MICROBIAL; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; LAMIVUDINE; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; POINT MUTATION; PROTEIN CONFORMATION; RNA, VIRAL; TEMPLATES, GENETIC;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0033621167     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.18.10027     Document Type: Article

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