메뉴 건너뛰기




Volumn 41, Issue 5, 1997, Pages 1099-1107

Unique intracellular activation of the potent anti-human immunodeficiency virus agent 1592U89

Author keywords

[No Author keywords available]

Indexed keywords

9 (2 HYDROXY 3 NONYL)ADENINE; ABACAVIR; CARBOVIR; MYCOPHENOLIC ACID; PHOSPHOTRANSFERASE; RNA DIRECTED DNA POLYMERASE;

EID: 0030903443     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.41.5.1099     Document Type: Article
Times cited : (226)

References (50)
  • 1
    • 0020375548 scopus 로고
    • Inhibitors of adenosine deaminase
    • Agarwal, R. P. 1982. Inhibitors of adenosine deaminase. Pharm. Ther. 17: 399-429.
    • (1982) Pharm. Ther. , vol.17 , pp. 399-429
    • Agarwal, R.P.1
  • 3
    • 0028205185 scopus 로고
    • Metabolism and mechanism of action of purine and pyrimidine derivatives
    • Balzarini, J. 1994. Metabolism and mechanism of action of purine and pyrimidine derivatives. Pharm. World Sci. 16:113-126.
    • (1994) Pharm. World Sci. , vol.16 , pp. 113-126
    • Balzarini, J.1
  • 4
    • 0025165466 scopus 로고
    • Metabolism of the carbocyclic nucleoside analogue carbovir, an inhibitor of human immunodeficiency virus, in human lymphoid cells
    • Bondoc, L. L., Jr., W. M. Shannon, J. A. Secrist III, R. Vince, and A. Fridland. 1990. Metabolism of the carbocyclic nucleoside analogue carbovir, an inhibitor of human immunodeficiency virus, in human lymphoid cells. Biochemistry 29:9839-9843.
    • (1990) Biochemistry , vol.29 , pp. 9839-9843
    • Bondoc Jr., L.L.1    Shannon, W.M.2    Secrist III, J.A.3    Vince, R.4    Fridland, A.5
  • 5
    • 0026336729 scopus 로고
    • Modulation of metabolism and anti-HIV-1 activity of purine 2′,3′-dideoxynucleosides by IMP dehydrogenase inhibitors
    • Bondoc, L. L., Jr., B. L. Robbins, G. S. Ahluwalia, H. Mitsuya, D. G. Johns, and A. Fridland. 1991. Modulation of metabolism and anti-HIV-1 activity of purine 2′,3′-dideoxynucleosides by IMP dehydrogenase inhibitors. Adv. Exp. Med. Biol. 309A:49-53.
    • (1991) Adv. Exp. Med. Biol. , vol.309 A , pp. 49-53
    • Bondoc Jr., L.L.1    Robbins, B.L.2    Ahluwalia, G.S.3    Mitsuya, H.4    Johns, D.G.5    Fridland, A.6
  • 6
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 8
    • 0342297401 scopus 로고
    • Nonclinical toxicology and in vitro toxicity studies with the novel anti-HIV agent (1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol (1592U89) succinate
    • abstr. I88. American Society for Microbiology, Washington, D.C.
    • Ching, S. V., K. M. Ayers, R. E. Dornsife, G. L. Grebe, and J. L. Howard. 1994. Nonclinical toxicology and in vitro toxicity studies with the novel anti-HIV agent (1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol (1592U89) succinate, abstr. I88, p. 92. In Abstracts of the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
    • (1994) Abstracts of the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy , pp. 92
    • Ching, S.V.1    Ayers, K.M.2    Dornsife, R.E.3    Grebe, G.L.4    Howard, J.L.5
  • 12
    • 0026523623 scopus 로고
    • HIV inhibitors targeted at the reverse transcriptase
    • De Clercq, E. 1992. HIV inhibitors targeted at the reverse transcriptase. AIDS Res. Hum. Retroviruses 8:19-134.
    • (1992) AIDS Res. Hum. Retroviruses , vol.8 , pp. 19-134
    • De Clercq, E.1
  • 13
    • 0026032318 scopus 로고
    • Anti-human immunodeficiency virus synergism by zidovudine (3′-azidothymidine) and didanosine (dideoxyinosine) contrasts with their additive inhibition of normal human marrow progenitor cells
    • Dornsife, R. E., M. H. St. Clair, A. T. Huang, T. J. Panella, G. W. Koszalka, C. L. Burns, and D. R. Averett. 1991. Anti-human immunodeficiency virus synergism by zidovudine (3′-azidothymidine) and didanosine (dideoxyinosine) contrasts with their additive inhibition of normal human marrow progenitor cells. Antimicrob. Agents Chemother. 35:322-328.
    • (1991) Antimicrob. Agents Chemother. , vol.35 , pp. 322-328
    • Dornsife, R.E.1    St. Clair, M.H.2    Huang, A.T.3    Panella, T.J.4    Koszalka, G.W.5    Burns, C.L.6    Averett, D.R.7
  • 14
    • 0342732427 scopus 로고
    • Unique intracellular activation of a new anti-HIV agent (1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol (1592U89) in the human T-lymphoblastoid cell line CEM-T4
    • abstr. I84, American Society for Microbiology, Washington, D.C.
    • Faletto, M. B., W. H. Miller, E. P. Garvey, J. E. Reardon, and S. S. Good. 1994. Unique intracellular activation of a new anti-HIV agent (1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol (1592U89) in the human T-lymphoblastoid cell line CEM-T4, abstr. I84, p. 92. In Abstracts of the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
    • (1994) Abstracts of the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy , pp. 92
    • Faletto, M.B.1    Miller, W.H.2    Garvey, E.P.3    Reardon, J.E.4    Good, S.S.5
  • 16
    • 0016378181 scopus 로고
    • Subcellular fractionation of rat liver
    • Fleischer, S., and M. Kervina. 1974. Subcellular fractionation of rat liver. Methods Enzymol. 31:6-41.
    • (1974) Methods Enzymol. , vol.31 , pp. 6-41
    • Fleischer, S.1    Kervina, M.2
  • 18
    • 0019322677 scopus 로고
    • Adenosine deaminase and adenylate deaminase: Comparative kinetic studies with transition state and ground state analog inhibitors
    • Frieden, C., L. C. Kurz, and H. R. Gilbert. 1980. Adenosine deaminase and adenylate deaminase: comparative kinetic studies with transition state and ground state analog inhibitors. Biochemistry 19:5303-5309.
    • (1980) Biochemistry , vol.19 , pp. 5303-5309
    • Frieden, C.1    Kurz, L.C.2    Gilbert, H.R.3
  • 20
    • 0023787694 scopus 로고
    • Spectrum of antiviral activity and mechanism of action of zidovudine. An overview
    • Furman, P. A., and D. W. Barry. 1988. Spectrum of antiviral activity and mechanism of action of zidovudine. An overview. Am. J. Med. 85(Suppl. 2A):176-181.
    • (1988) Am. J. Med. , vol.85 , Issue.SUPPL. 2A , pp. 176-181
    • Furman, P.A.1    Barry, D.W.2
  • 22
    • 0026634744 scopus 로고
    • A novel human phosphotransferase highly specific for adenosine
    • Garvey, E., and T. A. Krenitsky. 1992. A novel human phosphotransferase highly specific for adenosine. Arch. Biochem. Biophys. 296:161-169.
    • (1992) Arch. Biochem. Biophys. , vol.296 , pp. 161-169
    • Garvey, E.1    Krenitsky, T.A.2
  • 23
    • 0013580709 scopus 로고
    • Disposition in monkeys and mice of (1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol (1592U89) succinate, a potent inhibitor of HIV
    • abstr. I86, American Society for Microbiology, Washington, D.C.
    • Good, S. S., B. S. Owens, M. B. Faletto, W. B. Mahony, and B. A. Domin. 1994. Disposition in monkeys and mice of (1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol (1592U89) succinate, a potent inhibitor of HIV, abstr. I86, p. 92. In Abstracts of the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
    • (1994) Abstracts of the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy , pp. 92
    • Good, S.S.1    Owens, B.S.2    Faletto, M.B.3    Mahony, W.B.4    Domin, B.A.5
  • 25
    • 0025773889 scopus 로고
    • Inhibitors of IMP dehydrogenase stimulate the phosphorylation of the anti-human immunodeficiency virus nucleosides 2′,3′-dideoxyadenosine and 2′,3′-dideoxyinosine
    • Hartman, N. R., G. S. Ahluwalia, D. A. Cooney, H. Mitsuya, S. Kageyama, A. Fridland, S. Broder, and D. G. Johns. 1991. Inhibitors of IMP dehydrogenase stimulate the phosphorylation of the anti-human immunodeficiency virus nucleosides 2′,3′-dideoxyadenosine and 2′,3′-dideoxyinosine. Mol. Pharmacol. 40:118-124.
    • (1991) Mol. Pharmacol. , vol.40 , pp. 118-124
    • Hartman, N.R.1    Ahluwalia, G.S.2    Cooney, D.A.3    Mitsuya, H.4    Kageyama, S.5    Fridland, A.6    Broder, S.7    Johns, D.G.8
  • 26
    • 0025758338 scopus 로고
    • The bioavailability and nonlinear clearance of (-)-carbovir in the rat
    • Huang, S.-H., R. P. Remmel, and C. L. Zimmerman. 1991. The bioavailability and nonlinear clearance of (-)-carbovir in the rat. Pharm. Res. 8:739-743.
    • (1991) Pharm. Res. , vol.8 , pp. 739-743
    • Huang, S.-H.1    Remmel, R.P.2    Zimmerman, C.L.3
  • 27
    • 0024435381 scopus 로고
    • Phosphorylation of 2′,3′-dideoxyinosine by cytosolic 5′-nucleotidase of human lymphoid cells
    • Johnson, M. A., and A. Fridland. 1989. Phosphorylation of 2′,3′-dideoxyinosine by cytosolic 5′-nucleotidase of human lymphoid cells. Mol. Pharmacol. 36:291-295.
    • (1989) Mol. Pharmacol. , vol.36 , pp. 291-295
    • Johnson, M.A.1    Fridland, A.2
  • 31
    • 0026511017 scopus 로고
    • Stability of carbovir, a potent inhibitor of HIV, to phosphorolysis by human purine nucleoside phosphorylase
    • Marr, C. L. P., and C. R. Penn. 1992. Stability of carbovir, a potent inhibitor of HIV, to phosphorolysis by human purine nucleoside phosphorylase. Antiviral Chem. Chemother. 3:121-124.
    • (1992) Antiviral Chem. Chemother. , vol.3 , pp. 121-124
    • Marr, C.L.P.1    Penn, C.R.2
  • 32
    • 0018786515 scopus 로고
    • Adenosine kinase from rabbit liver. 1. Purification by affinity chromatography and properties
    • Miller, R. L., D. L. Adamczyk, and W. H. Miller. 1979. Adenosine kinase from rabbit liver. 1. Purification by affinity chromatography and properties. J. Biol. Chem. 254:2339-2345.
    • (1979) J. Biol. Chem. , vol.254 , pp. 2339-2345
    • Miller, R.L.1    Adamczyk, D.L.2    Miller, W.H.3
  • 33
    • 84920293124 scopus 로고    scopus 로고
    • Unpublished results
    • Miller, W. Unpublished results.
    • Miller, W.1
  • 34
    • 0026701851 scopus 로고
    • Phosphorylation of carbovir enantiomers by cellular enzymes determines the stereoselectivity of antiviral activity
    • Miller, W. H., S. M. Daluge, E. P. Garvey, S. Hopkins, J. E. Reardon, F. L. Boyd, and R. L. Miller. 1992. Phosphorylation of carbovir enantiomers by cellular enzymes determines the stereoselectivity of antiviral activity. J. Biol. Chem. 267:21220-21224.
    • (1992) J. Biol. Chem. , vol.267 , pp. 21220-21224
    • Miller, W.H.1    Daluge, S.M.2    Garvey, E.P.3    Hopkins, S.4    Reardon, J.E.5    Boyd, F.L.6    Miller, R.L.7
  • 35
    • 0025779083 scopus 로고
    • Targeted therapy of human immunodeficiency virus-related disease
    • Mitsuya, H., R. Yarchoan, S. Kageyama, and S. Broder. 1991. Targeted therapy of human immunodeficiency virus-related disease. FASEB J. 5: 2369-2381.
    • (1991) FASEB J. , vol.5 , pp. 2369-2381
    • Mitsuya, H.1    Yarchoan, R.2    Kageyama, S.3    Broder, S.4
  • 36
    • 0026731822 scopus 로고
    • DNA chain termination activity and inhibition of human immunodeficiency virus reverse transcriptase by carbocyclic 2′,3′-dideoxyguanosine triphosphate
    • Orr, D. C., H. T. Figueiredo, C.-L. Mo, C. R. Penn, and J. M. Cameron. 1992. DNA chain termination activity and inhibition of human immunodeficiency virus reverse transcriptase by carbocyclic 2′,3′-dideoxyguanosine triphosphate. J. Biol. Chem. 267:4177-4182.
    • (1992) J. Biol. Chem. , vol.267 , pp. 4177-4182
    • Orr, D.C.1    Figueiredo, H.T.2    Mo, C.-L.3    Penn, C.R.4    Cameron, J.M.5
  • 37
    • 0026078484 scopus 로고
    • Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase and human DNA polymcrases α, β, and γ by the 5′-triphosphates of carbovir, 3′-azido-3′-deoxythymidine, 2′,3′-dideoxyguanosine, and 3′-deoxythymidine
    • Parker, W. B., E. L. White, S. C. Shaddix, L. J. Ross, R. W. Buckheit, Jr., J. M. Germany, J. A. Secrist III, R. Vince, and W. M. Shannon. 1991. Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase and human DNA polymcrases α, β, and γ by the 5′-triphosphates of carbovir, 3′-azido-3′-deoxythymidine, 2′,3′-dideoxyguanosine, and 3′-deoxythymidine. J. Biol. Chem. 266:1754-1762.
    • (1991) J. Biol. Chem. , vol.266 , pp. 1754-1762
    • Parker, W.B.1    White, E.L.2    Shaddix, S.C.3    Ross, L.J.4    Buckheit Jr., R.W.5    Germany, J.M.6    Secrist III, J.A.7    Vince, R.8    Shannon, W.M.9
  • 39
    • 84920293123 scopus 로고    scopus 로고
    • Personal communication
    • Prus, K. L. (Glaxo Wellcome Inc., Research Triangle Park, N.C.). Personal communication.
    • Prus, K.L.1
  • 40
    • 0026775786 scopus 로고
    • Altered kinetics of AMP deaminase by myosin binding
    • Rundell, K. W., P. C. Tullson, and R. L. Terjung. 1992. Altered kinetics of AMP deaminase by myosin binding. Am. J. Physiol. 263:C294-C299.
    • (1992) Am. J. Physiol. , vol.263
    • Rundell, K.W.1    Tullson, P.C.2    Terjung, R.L.3
  • 41
    • 0021165906 scopus 로고
    • In vitro metabolism of deoxycoformycin in human T lymphoblastoid cells
    • Siaw, M. F. E., and M. S. Coleman. 1984. In vitro metabolism of deoxycoformycin in human T lymphoblastoid cells. J. Biol. Chem. 259:9426-9433.
    • (1984) J. Biol. Chem. , vol.259 , pp. 9426-9433
    • Siaw, M.F.E.1    Coleman, M.S.2
  • 42
    • 0020617884 scopus 로고
    • Conversion of 2,6-diamino-9-(2-hydroxyethoxymethyl)purine to acyclovir as catalyzed by adenosine deaminase
    • Spector, T., T. E. Jones, and L. M. Beacham III. 1983. Conversion of 2,6-diamino-9-(2-hydroxyethoxymethyl)purine to acyclovir as catalyzed by adenosine deaminase. Biochem. Pharmacol. 32:2505-2509.
    • (1983) Biochem. Pharmacol. , vol.32 , pp. 2505-2509
    • Spector, T.1    Jones, T.E.2    Beacham III, L.M.3
  • 43
    • 0030945276 scopus 로고    scopus 로고
    • Combination of mutations in human immunodeficiency virus type 1 reverse transcriptase required for resistance to the carbocyclic nucleoside 1592U89
    • Tisdale, M., T. Alnadof, and D. Cousens. 1997. Combination of mutations in human immunodeficiency virus type 1 reverse transcriptase required for resistance to the carbocyclic nucleoside 1592U89. Antimicrob. Agents Chemother. 41:1094-1098.
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 1094-1098
    • Tisdale, M.1    Alnadof, T.2    Cousens, D.3
  • 45
    • 84920293122 scopus 로고    scopus 로고
    • Personal communication
    • Trennery, P. (Medicines Safety Evaluation, Glaxo Wellcome plc, Ware, United Kingdom). Personal communication.
    • Trennery, P.1
  • 46
    • 0021260691 scopus 로고
    • Effects of acyclovir and its metabolites on purine nucleoside phosphorylase
    • Tuttle, J. V., and T. A. Krenitsky. 1984. Effects of acyclovir and its metabolites on purine nucleoside phosphorylase. J. Biol. Chem. 259:4065-4069.
    • (1984) J. Biol. Chem. , vol.259 , pp. 4065-4069
    • Tuttle, J.V.1    Krenitsky, T.A.2
  • 47
    • 0018539672 scopus 로고
    • The metabolism of 2′-deoxycoformycin by L1210 cells in vitro
    • Venner, P. M., and R. I. Glazer. 1979. The metabolism of 2′-deoxycoformycin by L1210 cells in vitro. Biochem. Pharmacol. 28:3239-3242.
    • (1979) Biochem. Pharmacol. , vol.28 , pp. 3239-3242
    • Venner, P.M.1    Glazer, R.I.2
  • 49
    • 0025322824 scopus 로고
    • Resolution of racemic carbovir and selective inhibition of human immunodeficiency virus by the (-)-enantiomer
    • Vince, R., and J. Brownell. 1990. Resolution of racemic carbovir and selective inhibition of human immunodeficiency virus by the (-)-enantiomer. Biochem. Biophys. Res. Commun. 168:912-916.
    • (1990) Biochem. Biophys. Res. Commun. , vol.168 , pp. 912-916
    • Vince, R.1    Brownell, J.2
  • 50
    • 0024354118 scopus 로고
    • Comparison of the effect of carbovir, AZT, and dideoxynucleoside triphosphates on the activity of human immunodeficiency virus reverse transcriptase and selected human polymerases
    • White, E. L., W. B. Parker, L. J. Macy, S. C. Shaddix, G. McCaleb, J. A. Secrist III, R. Vince, and W. M. Shannon. 1989. Comparison of the effect of carbovir, AZT, and dideoxynucleoside triphosphates on the activity of human immunodeficiency virus reverse transcriptase and selected human polymerases. Biochem. Biophys. Res. Commun. 161:393-398.
    • (1989) Biochem. Biophys. Res. Commun. , vol.161 , pp. 393-398
    • White, E.L.1    Parker, W.B.2    Macy, L.J.3    Shaddix, S.C.4    McCaleb, G.5    Secrist III, J.A.6    Vince, R.7    Shannon, W.M.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.