Effect of β-enantiomeric and racemic nucleoside analogues on mitochondrial functions in HepG2 cells. Implications for predicting drug hepatotoxicity

Biochemical Pharmacology

Volumn 52, Issue 10, 1996, Pages 1577-1584

  Cui, Lixin ^a   Schinazi, Raymond F ^b,c   Gosselin, Gilles ^d   Imbach, Jean Louis ^d   Chu, Chung K ^e   Rando, Robert F ^f   Revankar, Ganapathi R ^f   Sommadossi, Jean Pierre ^a,g  

^a University of Alabama at Birmingham   (United States)

^b ATLANTA VA MEDICAL CENTER   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIV MONTPELLIER   (France)

^e UNIVERSITY OF GEORGIA   (United States)

^f Antigenics Inc   (United States)

^g UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

hepatitis B; hepatotoxicity; mitochondria; nucleoside analogues; stereoisomerism

Indexed keywords

2 HYDROXYMETHYL 5 (2,6 DIAMINOPURIN 9 YL) 1,3 DIOXOLANE; 2 HYDROXYMETHYL 5 (5 FLUOROCYTOSIN 1 YL) 1,3 DIOXOLANE; 2',3' DIDEOXY 5 FLUOROCYTIDINE; 2,4 DIAMINO 2 DEOXY 2 FLUOROPYRROLO[2,3 D]PYRIMIDINE 7 ARABINOSIDE; 2,4 DIAMINO 2,3 DIDEOXY 2 FLUOROPYRROLO[2,3 D]PYRIMIDINE 7 ARABINOSIDE; 4 AMINO 2 DEOXY 2 FLUOROPYRROLO[2,3 D]PYRIMIDINE 7 ARABINOSIDE; 4 AMINO 2 DEOXY 2 FLUOROPYRROLO[2,3 D]PYRIMIDINE 7 ARABINOSIDE 5 THIOCARBOXAMIDE; ANTIVIRUS AGENT; EMTRICITABINE; LACTIC ACID; LAMIVUDINE; NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CELL LINE; CONTROLLED STUDY; CYTOCHEMISTRY; ENANTIOMER; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL; MITOCHONDRION; PRIORITY JOURNAL;

ANTIVIRAL AGENTS; CELL DIVISION; CELL LINE; DNA, MITOCHONDRIAL; DRUG EVALUATION, PRECLINICAL; HEPATITIS B; HUMANS; LACTIC ACID; MICROSCOPY, ELECTRON; MITOCHONDRIA, LIVER; MOLECULAR STRUCTURE; NUCLEOSIDES; STEREOISOMERISM;

EID: 0030598407     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(96)00562-X     Document Type: Article

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