Toxicity of Antiviral Nucleoside Analogs and the Human Mitochondrial DNA Polymerase

Journal of Biological Chemistry

Volumn 276, Issue 44, 2001, Pages 40847-40857

  Johnson, Allison A ^a   Ray, Adrian S ^b   Hanes, Jeremiah ^a   Suo, Zucai ^c   Colacino, Joseph M ^c   Anderson, Karen S ^b   Johnson, Kenneth A ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MUTAGENESIS; PHOSPHATES; TOXICITY; VIRUSES;

MITOCHONDRIA;

BIOCHEMISTRY;

ABACAVIR; CARBOVIR; DIDANOSINE; DNA POLYMERASE; FIALURIDINE; LAMIVUDINE; NUCLEOSIDE ANALOG; TENOFOVIR; ZALCITABINE; ZIDOVUDINE; DNA DIRECTED DNA POLYMERASE; DNA DIRECTED DNA POLYMERASE GAMMA; PRIMER DNA; PRODRUG; RECOMBINANT PROTEIN; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; BASE PAIRING; CATALYSIS; DIABETES MELLITUS; DRUG ACTIVITY; DRUG BINDING; DRUG TOXICITY; ENZYME KINETICS; ENZYME SPECIFICITY; FOOD AND DRUG ADMINISTRATION; HUMAN; HYPERTROPHIC CARDIOMYOPATHY; LACTIC ACIDOSIS; LIVER FAILURE; MITOCHONDRION; MUTAGENESIS; MYOPATHY; PANCREATITIS; PANCYTOPENIA; PERCEPTION DEAFNESS; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; SIDEROBLASTIC ANEMIA; DRUG EFFECT; ENZYMOLOGY; KINETICS; METABOLISM; NUCLEOTIDE SEQUENCE;

BASE SEQUENCE; DNA PRIMERS; DNA-DIRECTED DNA POLYMERASE; HUMANS; KINETICS; MITOCHONDRIA; PRODRUGS; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE INHIBITORS;

EID: 0035798566     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M106743200     Document Type: Article

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