Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease

PLoS ONE

Volumn 4, Issue 11, 2009, Pages

  Willuweit, Antje ^a   Velden, Joachim ^a,e   Godemann, Robert ^a   Manook, Andre ^b   Jetzek, Fritz ^c   Tintrup, Hartmut ^d,f   Kauselmann, Gunther ^d   Zevnik, Branko ^d   Henriksen, Gjermund ^b   Drzezga, Alexander ^b   Pohlner, Johannes ^a,g   Schoor, Michael ^d   Kemp, John A ^a   von der Kammer, Heinz ^a  

^a Evotec Neurosciences GmbH   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c Evotec Technologies GmbH   (Germany)

^d TaconicArtemis GmbH   (Germany)

^e UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^f Lonza Cologne GmbH   (Germany)

^g Bionamics GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; PRESENILIN 1; PRESENILIN 2;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE MUTATION; GENETIC VARIABILITY; GLIA CELL; HOMOZYGOSITY; IMMUNOREACTIVITY; INTRON; MOUSE; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; PROMOTER REGION; PROTEIN BINDING; TRANSGENE; AMYLOIDOSIS; ANIMAL; DISEASE MODEL; GENETICS; HOMOZYGOTE; HUMAN; MALE; METABOLISM; MUTATION; NERVE CELL; PATHOLOGY; TRANSGENIC MOUSE;

ANIMALIA; MUS; MUS MUSCULUS;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOIDOSIS; ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; HOMOZYGOTE; HUMANS; MALE; MICE; MICE, TRANSGENIC; MUTATION; NEURONS; PRESENILIN-1; PROMOTER REGIONS, GENETIC;

EID: 70949102175     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0007931     Document Type: Article

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