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Volumn 57, Issue 14, 2009, Pages 1469-1479

Microglia and neuropathic pain

Author keywords

Chemokine receptors; Cytokines; Microglia; Neuropathic pain; Protein kinases; Purinergic receptors

Indexed keywords

A 438079; A 740003; ANTISENSE OLIGONUCLEOTIDE; BUPIVACAINE; CANGRELOR; CANNABINOID 2 RECEPTOR; CANNABINOID 2 RECEPTOR AGONIST; CANNABINOID RECEPTOR AGONIST; CELL SURFACE RECEPTOR; CHEMOKINE; CLOPIDOGREL; FIBRONECTIN RECEPTOR; FRACTALKINE; GELATINASE B; LIDOCAINE; MACROPHAGE DERIVED CHEMOKINE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; MRS 2395; PURINERGIC P2X RECEPTOR; PURINERGIC P2X4 RECEPTOR; PURINERGIC P2X7 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PURINERGIC RECEPTOR P2X12 BLOCKING AGENT; PURINERGIC RECEPTOR P2X7 BLOCKING AGENT; SYNAPTOPHYSIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 4 BLOCKING AGENT; UNCLASSIFIED DRUG;

EID: 70450212126     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.20871     Document Type: Review
Times cited : (241)

References (128)
  • 2
    • 36448994709 scopus 로고    scopus 로고
    • Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
    • DOI 10.1038/nn2014, PII NN2014
    • Ajami B, Bennett JL, Krieger C, Tetzlaff W, Rossi FM. 2007. Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat Neurosci 10:1538-1543. (Pubitemid 350175883)
    • (2007) Nature Neuroscience , vol.10 , Issue.12 , pp. 1538-1543
    • Ajami, B.1    Bennett, J.L.2    Krieger, C.3    Tetzlaff, W.4    Rossi, F.M.V.5
  • 3
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signaling
    • Akira S, Takeda K. 2004. Toll-like receptor signaling. Nat Rev Immunol 4:499-511.
    • (2004) Nat Rev Immunol , vol.4 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 4
    • 32244442392 scopus 로고    scopus 로고
    • Mechanisms of disease: Neuropathic pain - A clinical perspective
    • DOI 10.1038/ncpneuro0113, PII N0113
    • Baron R. 2006. Mechanisms of disease: Neuropathic pain - A clinical perspective. Nat Clin Pract Neurol 2:95-106. (Pubitemid 43210250)
    • (2006) Nature Clinical Practice Neurology , vol.2 , Issue.2 , pp. 95-106
    • Baron, R.1
  • 5
    • 34249731465 scopus 로고    scopus 로고
    • Stereological and somatotopic analysis of the spinal microglial response to peripheral nerve injury
    • DOI 10.1016/j.bbi.2006.10.017, PII S0889159106003539, Neuropathic Pain, Glia and Cytokines
    • Beggs S, Salter MW. 2007. Stereological and somatotopic analysis of the spinal microglial response to peripheral nerve injury. Brain Behav Immun 21:624-633. (Pubitemid 46829774)
    • (2007) Brain, Behavior, and Immunity , vol.21 , Issue.5 , pp. 624-633
    • Beggs, S.1    Salter, M.W.2
  • 6
    • 51349166320 scopus 로고    scopus 로고
    • Glial TLR4 receptor as new target to treat neuropathic pain: Efficacy of a new receptor antagonist in a model of peripheral nerve injury in mice
    • Bettoni I, Comelli F, Rossini C, Granucci F, Giagnoni G, Peri F, Costa B. 2008. Glial TLR4 receptor as new target to treat neuropathic pain: Efficacy of a new receptor antagonist in a model of peripheral nerve injury in mice. Glia 56:1312-1319.
    • (2008) Glia , vol.56 , pp. 1312-1319
    • Bettoni, I.1    Comelli, F.2    Rossini, C.3    Granucci, F.4    Giagnoni, G.5    Peri, F.6    Costa, B.7
  • 7
    • 0036260089 scopus 로고    scopus 로고
    • Targeting leukocyte MMPs and transmigration minocycline as a potential therapy for multiple sclerosis
    • Brundula V, Rewcastle NB, Metz LM, Bernard CC, Yong VW. 2002. Targeting leukocyte MMPs and transmigration: Minocycline as a potential therapy for multiple sclerosis. Brain 125 (Part 6):1297-1308. (Pubitemid 34587139)
    • (2002) Brain , vol.125 , Issue.6 , pp. 1297-1308
    • Brundula, V.1    Rewcastle, N.B.2    Metz, L.M.3    Bernard, C.C.4    Yong, V.W.5
  • 8
    • 46449134214 scopus 로고    scopus 로고
    • Purinergic signalling and disorders of the central nervous system
    • DOI 10.1038/nrd2605, PII NRD2605
    • Burnstock G. 2008. Purinergic signaling and disorders of the central nervous system. Nat Rev Drug Discov 7:575-590. (Pubitemid 351927723)
    • (2008) Nature Reviews Drug Discovery , vol.7 , Issue.7 , pp. 575-590
    • Burnstock, G.1
  • 9
    • 34249667153 scopus 로고    scopus 로고
    • Cytokine regulation of MMP-9 in peripheral glia: Implications for pathological processes and pain in injured nerve
    • DOI 10.1016/j.bbi.2006.10.015, PII S0889159106003515, Neuropathic Pain, Glia and Cytokines
    • Chattopadhyay S, Myers RR, Janes J, Shubayev V. 2007. Cytokine regulation of MMP-9 in peripheral glia: Implications for pathological processes and pain in injured nerve. Brain Behav Immun 21:561-568. (Pubitemid 46829772)
    • (2007) Brain, Behavior, and Immunity , vol.21 , Issue.5 , pp. 561-568
    • Chattopadhyay, S.1    Myers, R.R.2    Janes, J.3    Shubayev, V.4
  • 13
    • 0030859754 scopus 로고    scopus 로고
    • Dissociation of microglial activation and neuropathic pain behaviors following peripheral nerve injury in the rat
    • DOI 10.1016/S0165-5728(97)00119-7, PII S0165572897001197
    • Colburn RW, DeLeo JA, Rickman AJ, Yeager MP, Kwon P, Hickey WF. 1997. Dissociation of microglial activation and neuropathic pain behaviors following peripheral nerve injury in the rat. J Neuroimmunol 79:163-175. (Pubitemid 27502035)
    • (1997) Journal of Neuroimmunology , vol.79 , Issue.2 , pp. 163-175
    • Colburn, R.W.1    Deleo, J.A.2    Rickman, A.J.3    Yeager, M.P.4    Kwon, P.5    Hickey, W.F.6
  • 14
    • 0032978701 scopus 로고    scopus 로고
    • The effect of site and type of nerve injury on spinal glial activation and neuropathic pain behavior
    • DOI 10.1006/exnr.1999.7065
    • Colburn RW, Rickman AJ, DeLeo JA. 1999. The effect of site and type of nerve injury on spinal glial activation and neuropathic pain behavior. Exp Neurol 157:289-304. (Pubitemid 29260737)
    • (1999) Experimental Neurology , vol.157 , Issue.2 , pp. 289-304
    • Colburn, R.W.1    Rickman, A.J.2    Deleo, J.A.3
  • 15
    • 0033080919 scopus 로고    scopus 로고
    • Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteins
    • Combs CK, Johnson DE, Cannady SB, Lehman TM, Landreth GE. 1999. Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteins. J Neurosci 19:928-939.
    • (1999) J Neurosci , vol.19 , pp. 928-939
    • Combs, C.K.1    Johnson, D.E.2    Cannady, S.B.3    Lehman, T.M.4    Landreth, G.E.5
  • 16
    • 30744439794 scopus 로고    scopus 로고
    • BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
    • DOI 10.1038/nature04223, PII NATURE04223
    • Coull JA, Beggs S, Boudreau D, Boivin D, Tsuda M, Inoue K, Gravel C, Salter MW, De Koninck Y. 2005. BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature 438:1017-1021. (Pubitemid 43093974)
    • (2005) Nature , vol.438 , Issue.7070 , pp. 1017-1021
    • Coull, J.A.M.1    Beggs, S.2    Boudreau, D.3    Boivin, D.4    Tsuda, M.5    Inoue, K.6    Gravel, C.7    Salter, M.W.8    De Koninck, Y.9
  • 17
    • 0032079675 scopus 로고    scopus 로고
    • Partial peripheral nerve injury leads to activation of astroglia and microglia which parallels the development of allodynic behavior
    • Coyle DE. 1998. Partial peripheral nerve injury leads to activation of astroglia and microglia which parallels the development of allodynic behavior. Glia 23:75-83.
    • (1998) Glia , vol.23 , pp. 75-83
    • Coyle, D.E.1
  • 20
    • 0035252354 scopus 로고    scopus 로고
    • The role of neuroinflammation and neuroimmune activation in persistent pain
    • DeLeo JA, Yezierski RP. 2001. The role of neuroinflammation and neuroimmune activation in persistent pain. Pain 90:1-6.
    • (2001) Pain , vol.90 , pp. 1-6
    • Deleo, J.A.1    Yezierski, R.P.2
  • 21
    • 38849178118 scopus 로고    scopus 로고
    • Characterization of cell proliferation in rat spinal cord following peripheral nerve injury and the relationship with neuropathic pain
    • DOI 10.1016/j.pain.2007.05.002, PII S0304395907002473
    • Echeverry S, Shi XQ, Zhang J. 2008. Characterization of cell proliferation in rat spinal cord following peripheral nerve injury and the relationship with neuropathic pain. Pain 135:37-47. (Pubitemid 351193080)
    • (2008) Pain , vol.135 , Issue.1-2 , pp. 37-47
    • Echeverry, S.1    Shi, X.Q.2    Zhang, J.3
  • 22
    • 0027428024 scopus 로고
    • A quantitative analysis of the microglial cell reaction in central primary sensory projection territories following peripheral nerve injury in the adult rat
    • Eriksson NP, Persson JK, Svensson M, Arvidsson J, Molander C, Aldskogius H. 1993. A quantitative analysis of the microglial cell reaction in central primary sensory projection territories following peripheral nerve injury in the adult rat. Exp Brain Res 96:19-27. (Pubitemid 23332175)
    • (1993) Experimental Brain Research , vol.96 , Issue.1 , pp. 19-27
    • Eriksson, N.P.1    Persson, J.K.E.2    Svensson, N.3    Arvidsson, J.4    Molander, C.5    Aldskogius, H.6
  • 23
    • 0029068714 scopus 로고
    • Microglial turnover in the injured CNS: Activated microglia undergo delayed DNA fragmentation following peripheral nerve injury
    • Gehrmann J, Banati RB. 1995. Microglial turnover in the injured CNS: Activated microglia undergo delayed DNA fragmentation following peripheral nerve injury. J Neuropathol Exp Neurol 54:680-688.
    • (1995) J Neuropathol Exp Neurol , vol.54 , pp. 680-688
    • Gehrmann, J.1    Banati, R.B.2
  • 25
    • 28244464861 scopus 로고    scopus 로고
    • Constitutive expression of CCR2 chemokine receptor and inhibition by MCP-1/CCL2 of GABA-induced currents in spinal cord neurones
    • DOI 10.1111/j.1471-4159.2005.03431.x
    • Gosselin RD, Varela C, Banisadr G, Mechighel P, Rostene W, Kitabgi P, Melik-Parsadaniantz S. 2005. Constitutive expression of CCR2 chemokine receptor and inhibition by MCP-1/CCL2 of GABA-induced currents in spinal cord neurones. J Neurochem 95:1023-1034. (Pubitemid 41713487)
    • (2005) Journal of Neurochemistry , vol.95 , Issue.4 , pp. 1023-1034
    • Gosselin, R.D.1    Varela, C.2    Banisadr, G.3    Mechighel, P.4    Rostene, W.5    Kitabgi, P.6    Melik-Parsadaniantz, S.7
  • 27
    • 38349023011 scopus 로고    scopus 로고
    • Attenuating phosphorylation of p38 MAPK in the activated microglia: A new mechanism for intrathecal lidocaine reversing tactile allodynia following chronic constriction injury in rats
    • Gu YW, Su DS, Tian J, Wang XR. 2008. Attenuating phosphorylation of p38 MAPK in the activated microglia: A new mechanism for intrathecal lidocaine reversing tactile allodynia following chronic constriction injury in rats. Neurosci Lett 431:129-134.
    • (2008) Neurosci Lett , vol.431 , pp. 129-134
    • Gu, Y.W.1    Su, D.S.2    Tian, J.3    Wang, X.R.4
  • 28
    • 38349119715 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptors: A therapeutic target for the treatment of inflammatory and neuropathic pain
    • Guindon J, Hohmann AG. 2008. Cannabinoid CB2 receptors: A therapeutic target for the treatment of inflammatory and neuropathic pain. Br J Pharmacol 153:319-334.
    • (2008) Br J Pharmacol , vol.153 , pp. 319-334
    • Guindon, J.1    Hohmann, A.G.2
  • 29
    • 34247594364 scopus 로고    scopus 로고
    • The innate immunity of the central nervous system in chronic pain: The role of Toll-like receptors
    • DOI 10.1007/s00018-007-6494-3
    • Guo LH, Schluesener HJ. 2007. The innate immunity of the central nervous system in chronic pain: The role of Toll-like receptors. Cell Mol Life Sci 64:1128-1136. (Pubitemid 46684548)
    • (2007) Cellular and Molecular Life Sciences , vol.64 , Issue.9 , pp. 1128-1136
    • Guo, L.-H.1    Schluesener, H.J.2
  • 30
    • 33646439133 scopus 로고    scopus 로고
    • Activated microglia contribute to the maintenance of chronic pain after spinal cord injury
    • DOI 10.1523/JNEUROSCI.0003-06.2006
    • Hains BC, Waxman SG. 2006. Activated microglia contribute to the maintenance of chronic pain after spinal cord injury. J Neurosci 26:4308-4317. (Pubitemid 44315390)
    • (2006) Journal of Neuroscience , vol.26 , Issue.16 , pp. 4308-4317
    • Hains, B.C.1    Waxman, S.G.2
  • 37
    • 34147159585 scopus 로고    scopus 로고
    • Long-term potentiation of neuronal excitation by neuron-glia interactions in the rat spinal dorsal horn
    • DOI 10.1111/j.1460-9568.2007.05386.x
    • Ikeda H, Tsuda M, Inoue K, Murase K. 2007. Long-term potentiation of neuronal excitation by neuron-glia interactions in the rat spinal dorsal horn. Eur J Neurosci 25:1297-1306. (Pubitemid 46568758)
    • (2007) European Journal of Neuroscience , vol.25 , Issue.5 , pp. 1297-1306
    • Ikeda, H.1    Tsuda, M.2    Inoue, K.3    Murase, K.4
  • 38
    • 0036848882 scopus 로고    scopus 로고
    • Microglial activation by purines and pyrimidines
    • Inoue K. 2002. Microglial activation by purines and pyrimidines. Glia 40:156-163.
    • (2002) Glia , vol.40 , pp. 156-163
    • Inoue, K.1
  • 39
    • 28444486336 scopus 로고    scopus 로고
    • The function of microglia through purinergic receptors: Neuropathic pain and cytokine release
    • DOI 10.1016/j.pharmthera.2005.07.001, PII S0163725805001567
    • Inoue K. 2006. The function of microglia through purinergic receptors: Neuropathic pain and cytokine release. Pharmacol Ther 109:210-226. (Pubitemid 41740822)
    • (2006) Pharmacology and Therapeutics , vol.109 , Issue.1-2 , pp. 210-226
    • Inoue, K.1
  • 40
    • 34547886861 scopus 로고    scopus 로고
    • The role of nucleotides in the neuron-glia communication responsible for the brain functions
    • DOI 10.1111/j.1471-4159.2007.04824.x
    • Inoue K, Koizumi S, Tsuda M. 2007. The role of nucleotides in the neuron-glia communication responsible for the brain functions. J Neurochem 102:1447-1458. (Pubitemid 47256211)
    • (2007) Journal of Neurochemistry , vol.102 , Issue.5 , pp. 1447-1458
    • Inoue, K.1    Koizumi, S.2    Tsuda, M.3
  • 42
    • 33846232608 scopus 로고    scopus 로고
    • Glial phosphorylated p38 MAP kinase mediates pain in a rat model of lumbar disc herniation and induces motor dysfunction in a rat model of lumbar spinal canal stenosis
    • DOI 10.1097/01.brs.0000251437.10545.e9, PII 0000763220070115000004
    • Ito T, Ohtori S, Inoue G, Koshi T, Doya H, Ozawa T, Saito T, Moriya H, Takahashi K. 2007. Glial phosphorylated p38 MAP kinase mediates pain in a rat model of lumbar disc herniation and induces motor dysfunction in a rat model of lumbar spinal canal stenosis. Spine 32:159-167. (Pubitemid 46105802)
    • (2007) Spine , vol.32 , Issue.2 , pp. 159-167
    • Ito, T.1    Ohtori, S.2    Inoue, G.3    Koshi, T.4    Doya, H.5    Ozawa, T.6    Saito, T.7    Moriya, H.8    Takahashi, K.9
  • 43
    • 34447502253 scopus 로고    scopus 로고
    • Possible role of spinal astrocytes in maintaining chronic pain sensitization: Review of current evidence with focus on bFGF/JNK pathway
    • DOI 10.1017/S1740925X07000403, PII S1740925X07000403
    • Ji RR, Kawasaki Y, Zhuang ZY, Wen YR, Decosterd I. 2006. Possible role of spinal astrocytes in maintaining chronic pain sensitization: Review of current evidence with focus on bFGF/JNK pathway. Neuron Glia Biol 2:259-269. (Pubitemid 47074743)
    • (2006) Neuron Glia Biology , vol.2 , Issue.4 , pp. 259-269
    • Ji, R.-R.1    Kawasaki, Y.2    Zhuang, Z.-Y.3    Wen, Y.-R.4    Decosterd, I.5
  • 44
    • 38049119409 scopus 로고    scopus 로고
    • P38 MAPK, microglial signaling, and neuropathic pain
    • Ji RR, Suter MR. 2007. p38 MAPK, microglial signaling, and neuropathic pain. Mol Pain 3:33
    • (2007) Mol Pain , vol.3 , pp. 33
    • Ji, R.R.1    Suter, M.R.2
  • 45
    • 0037705314 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain
    • Jin SX, Zhuang ZY, Woolf CJ, Ji RR. 2003. p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain. J Neurosci 23:4017-4022.
    • (2003) J Neurosci , vol.23 , pp. 4017-4022
    • Jin, S.X.1    Zhuang, Z.Y.2    Woolf, C.J.3    Ji, R.R.4
  • 46
    • 48249124939 scopus 로고    scopus 로고
    • Transforming growth factor-activated kinase 1 induced in spinal astrocytes contributes to mechanical hypersensitivity after nerve injury
    • Katsura H, Obata K, Miyoshi K, Kondo T, Yamanaka H, Kobayashi K, Dai Y, Fukuoka T, Sakagami M, Noguchi K. 2008. Transforming growth factor-activated kinase 1 induced in spinal astrocytes contributes to mechanical hypersensitivity after nerve injury. Glia 56:723-733.
    • (2008) Glia , vol.56 , pp. 723-733
    • Katsura, H.1    Obata, K.2    Miyoshi, K.3    Kondo, T.4    Yamanaka, H.5    Kobayashi, K.6    Dai, Y.7    Fukuoka, T.8    Sakagami, M.9    Noguchi, K.10
  • 49
    • 45549090676 scopus 로고    scopus 로고
    • Cytokine mechanisms of central sensitization: Distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord
    • Kawasaki Y, Zhang L, Cheng JK, Ji RR. 2008b. Cytokine mechanisms of central sensitization: Distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord. J Neurosci 28:5189-5194.
    • (2008) J Neurosci , vol.28 , pp. 5189-5194
    • Kawasaki, Y.1    Zhang, L.2    Cheng, J.K.3    Ji, R.R.4
  • 50
    • 36549088202 scopus 로고    scopus 로고
    • Transformation of the output of spinal lamina I neurons after nerve injury and microglia stimulation underlying neuropathic pain
    • DOI 10.1186/1744-8069-3-27
    • Keller AF, Beggs S, Salter MW, De Koninck Y. 2007. Transformation of the output of spinal lamina I neurons after nerve injury and microglia stimulation underlying neuropathic pain. Mol Pain 3:27 (Pubitemid 350182638)
    • (2007) Molecular Pain , vol.3 , pp. 27
    • Keller, A.F.1    Beggs, S.2    Salter, M.W.3    De Koninck, Y.4
  • 51
    • 33746701380 scopus 로고    scopus 로고
    • P2X receptors as cell-surface ATP sensors in health and disease
    • Khakh BS, North RA. 2006. P2X receptors as cell-surface ATP sensors in health and disease. Nature 442:527-532.
    • (2006) Nature , vol.442 , pp. 527-532
    • Khakh, B.S.1    North, R.A.2
  • 53
    • 57549088119 scopus 로고    scopus 로고
    • Minocycline and neurodegenerative diseases
    • Kim HS, Suh YH. 2009. Minocycline and neurodegenerative diseases. Behav Brain Res 196:168-179.
    • (2009) Behav Brain Res , vol.196 , pp. 168-179
    • Kim, H.S.1    Suh, Y.H.2
  • 54
    • 40849089273 scopus 로고    scopus 로고
    • P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain
    • Kobayashi K, Yamanaka H, Fukuoka T, Dai Y, Obata K, Noguchi K. 2008. P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain. J Neurosci 28:2892-2902.
    • (2008) J Neurosci , vol.28 , pp. 2892-2902
    • Kobayashi, K.1    Yamanaka, H.2    Fukuoka, T.3    Dai, Y.4    Obata, K.5    Noguchi, K.6
  • 55
    • 0037419533 scopus 로고    scopus 로고
    • Propentofylline protects beta-amyloid protein-induced apoptosis in cultured rat hippocampal neurons
    • DOI 10.1016/S0014-2999(02)02789-9, PII S0014299902027899
    • Koriyama Y, Chiba K, Mohri T. 2003. Propentofylline protects beta-amyloid protein-induced apoptosis in cultured rat hippocampal neurons. Eur J Pharmacol 458:235-241. (Pubitemid 36009462)
    • (2003) European Journal of Pharmacology , vol.458 , Issue.3 , pp. 235-241
    • Koriyama, Y.1    Chiba, K.2    Mohri, T.3
  • 56
    • 0034107999 scopus 로고    scopus 로고
    • Evaluation of neurotoxicity of Alzheimer's amyloid beta protein (beta42) in cultured hippocampal cells and its prevention by propentofylline
    • DOI 10.1254/jjp.82.301
    • Koriyama Y, Yamazaki M, Chiba K, Mohri T. 2000. Evaluation of neurotoxicity of alzheimer's amyloid beta protein (beta42) in cultured hippocampal cells and its prevention by propentofylline. Jpn J Pharmacol 82:301-306. (Pubitemid 30301569)
    • (2000) Japanese Journal of Pharmacology , vol.82 , Issue.4 , pp. 301-306
    • Koriyama, Y.1    Yamazaki, M.2    Chiba, K.3    Mohri, T.4
  • 57
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: A sensor for pathological events in the CNS
    • Kreutzberg GW. 1996. Microglia: A sensor for pathological events in the CNS. Trends Neurosci 19:312-318.
    • (1996) Trends Neurosci , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 58
    • 21544469729 scopus 로고    scopus 로고
    • Induction of CX3CL1 expression in astrocytes and CX3CR1 in microglia in the spinal cord of a rat model of neuropathic pain
    • DOI 10.1016/j.jpain.2005.02.001, PII S1526590005004189
    • Lindia JA, McGowan E, Jochnowitz N, Abbadie C. 2005. Induction of CX3CL1 expression in astrocytes and CX3CR1 in microglia in the spinal cord of a rat model of neuropathic pain. J Pain 6:434-438. (Pubitemid 40922694)
    • (2005) Journal of Pain , vol.6 , Issue.7 , pp. 434-438
    • Lindia, J.A.1    McGowan, E.2    Jochnowitz, N.3    Abbadie, C.4
  • 59
    • 0034014321 scopus 로고    scopus 로고
    • Glial cell proliferation in the spinal cord after dorsal rhizotomy or sciatic nerve transection in the adult rat
    • Liu L, Rudin M, Kozlova EN. 2000. Glial cell proliferation in the spinal cord after dorsal rhizotomy or sciatic nerve transection in the adult rat. Exp Brain Res 131:64-73. (Pubitemid 30137817)
    • (2000) Experimental Brain Research , vol.131 , Issue.1 , pp. 64-73
    • Liu, L.1    Rudin, M.2    Kozlova, E.N.3
  • 66
    • 0034866550 scopus 로고    scopus 로고
    • Microglia: Activation and their significance in the central nervous system
    • Nakajima K, Kohsaka S. 2001. Microglia: Activation and their significance in the central nervous system. J Biochem (Tokyo) 130:169-175. (Pubitemid 32785862)
    • (2001) Journal of Biochemistry , vol.130 , Issue.2 , pp. 169-175
    • Nakajima, K.1    Kohsaka, S.2
  • 67
    • 33646567454 scopus 로고    scopus 로고
    • Direct evidence for spinal cord microglia in the development of a neuropathic pain-like state in mice
    • DOI 10.1111/j.1471-4159.2006.03808.x
    • Narita M, Yoshida T, Nakajima M, Narita M, Miyatake M, Takagi T, Yajima Y, Suzuki T. 2006. Direct evidence for spinal cord microglia in the development of a neuropathic pain-like state in mice. J Neurochem 97:1337-1348. (Pubitemid 43725573)
    • (2006) Journal of Neurochemistry , vol.97 , Issue.5 , pp. 1337-1348
    • Narita, M.1    Yoshida, T.2    Nakajima, M.3    Narita, M.4    Miyatake, M.5    Takagi, T.6    Yajima, Y.7    Suzuki, T.8
  • 68
    • 33646259685 scopus 로고    scopus 로고
    • Possible involvement of increase in spinal fibronectin following peripheral nerve injury in upregulation of microglial P2X(4), a key molecule for mechanical allodynia
    • Nasu-Tada K, Koizumi S, Tsuda M, Kunifusa E, Inoue K. 2006. Possible involvement of increase in spinal fibronectin following peripheral nerve injury in upregulation of microglial P2X(4), a key molecule for mechanical allodynia. Glia 53:769-775.
    • (2006) Glia , vol.53 , pp. 769-775
    • Nasu-Tada, K.1    Koizumi, S.2    Tsuda, M.3    Kunifusa, E.4    Inoue, K.5
  • 69
    • 19744380563 scopus 로고    scopus 로고
    • Neuroscience: Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • DOI 10.1126/science.1110647
    • Nimmerjahn A, Kirchhoff F, Helmchen F. 2005. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308:1314-1318. (Pubitemid 40746128)
    • (2005) Science , vol.308 , Issue.5726 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 70
    • 0032510831 scopus 로고    scopus 로고
    • Localization of fractalkine and CX3CR1 mRNAs in rat brain: Does fractalkine play a role in signaling from neuron to microglia?
    • Nishiyori A, Minami M, Ohtani Y, Takami S, Yamamoto J, Kawaguchi N, Kume T, Akaike A, Satoh M. 1998. Localization of fractalkine and CX3CR1 mRNAs in rat brain: Does fractalkine play a role in signaling from neuron to microglia? FEBS Lett 429:167-172.
    • (1998) FEBS Lett , vol.429 , pp. 167-172
    • Nishiyori, A.1    Minami, M.2    Ohtani, Y.3    Takami, S.4    Yamamoto, J.5    Kawaguchi, N.6    Kume, T.7    Akaike, A.8    Satoh, M.9
  • 72
    • 34547889515 scopus 로고    scopus 로고
    • Roles of extracellular signal-regulated protein kinases 5 in spinal microglia and primary sensory neurons for neuropathic pain
    • DOI 10.1111/j.1471-4159.2007.04656.x
    • Obata K, Katsura H, Mizushima T, Sakurai J, Kobayashi K, Yamanaka H, Dai Y, Fukuoka T, Noguchi K. 2007. Roles of extracellular signal-regulated protein kinases 5 in spinal microglia and primary sensory neurons for neuropathic pain. J Neurochem 102:1569-1584. (Pubitemid 47256198)
    • (2007) Journal of Neurochemistry , vol.102 , Issue.5 , pp. 1569-1584
    • Obata, K.1    Katsura, H.2    Mizushima, T.3    Sakurai, J.4    Kobayashi, K.5    Yamanaka, H.6    Dai, Y.7    Fukuoka, T.8    Noguchi, K.9
  • 73
    • 33751534869 scopus 로고    scopus 로고
    • Intravenous paclitaxel administration in the rat induces a peripheral sensory neuropathy characterized by macrophage infiltration and injury to sensory neurons and their supporting cells
    • Peters CM, Jimenez-Andrade JM, Jonas BM, Sevcik MA, Koewler NJ, Ghilardi JR, Wong GY, Mantyh PW. 2007. Intravenous paclitaxel administration in the rat induces a peripheral sensory neuropathy characterized by macrophage infiltration and injury to sensory neurons and their supporting cells. Exp Neurol 203:42-54.
    • (2007) Exp Neurol , vol.203 , pp. 42-54
    • Peters, C.M.1    Jimenez-Andrade, J.M.2    Jonas, B.M.3    Sevcik, M.A.4    Koewler, N.J.5    Ghilardi, J.R.6    Wong, G.Y.7    Mantyh, P.W.8
  • 74
    • 33644993675 scopus 로고    scopus 로고
    • Activation of glia and microglial p38 MAPK in medullary dorsal horn contributes to tactile hypersensitivity following trigeminal sensory nerve injury
    • Piao ZG, Cho IH, Park CK, Hong JP, Choi SY, Lee SJ, Lee S, Park K, Kim JS, Oh SB. 2006. Activation of glia and microglial p38 MAPK in medullary dorsal horn contributes to tactile hypersensitivity following trigeminal sensory nerve injury. Pain 121:219-231.
    • (2006) Pain , vol.121 , pp. 219-231
    • Piao, Z.G.1    Cho, I.H.2    Park, C.K.3    Hong, J.P.4    Choi, S.Y.5    Lee, S.J.6    Lee, S.7    Park, K.8    Kim, J.S.9    Oh, S.B.10
  • 75
    • 36549041874 scopus 로고    scopus 로고
    • 4 receptors by lysosomal targeting, glycan protection and exocytosis
    • DOI 10.1242/jcs.010348
    • Qureshi OS, Paramasivam A, Yu JC, Murrell-Lagnado RD. 2007. Regulation of P2X4 receptors by lysosomal targeting, glycan protection and exocytosis. J Cell Sci 120 (Part 21):3838-3849. (Pubitemid 350187365)
    • (2007) Journal of Cell Science , vol.120 , Issue.21 , pp. 3838-3849
    • Qureshi, O.S.1    Paramasivam, A.2    Yu, J.C.H.3    Murrell-Lagnado, R.D.4
  • 76
    • 0037622717 scopus 로고    scopus 로고
    • Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy
    • DOI 10.1124/jpet.103.052407
    • Raghavendra V, Tanga F, DeLeo JA. 2003. Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy. J Pharmacol Exp Ther 306:624-630. (Pubitemid 36886161)
    • (2003) Journal of Pharmacology and Experimental Therapeutics , vol.306 , Issue.2 , pp. 624-630
    • Raghavendra, V.1    Tanga, F.2    Deleo, J.A.3
  • 77
    • 0032814562 scopus 로고    scopus 로고
    • Neuroglial activation repertoire in the injured brain: Graded response, molecular mechanisms and cues to physiological function
    • DOI 10.1016/S0165-0173(99)00007-7, PII S0165017399000077
    • Raivich G, Bohatschek M, Kloss C, Werner A, Jones LL, Kreutzberg GW. 1999. Neuroglial activation repertoire in the injured brain: Graded response, molecular mechanisms and cues to physiological function. Brain Res Brain Res Rev 30:77-105. (Pubitemid 29331517)
    • (1999) Brain Research Reviews , vol.30 , Issue.1 , pp. 77-105
    • Raivich, G.1    Bohatschek, M.2    Kloss, C.U.A.3    Werner, A.4    Jones, L.L.5    Kreutzberg, G.W.6
  • 78
    • 0033835476 scopus 로고    scopus 로고
    • Intrathecally administered endotoxin or cytokines produce allodynia, hyperalgesia and changes in spinal cord neuronal responses to nociceptive stimuli in the rat
    • Reeve AJ, Patel S, Fox A, Walker K, Urban L. 2000. Intrathecally administered endotoxin or cytokines produce allodynia, hyperalgesia and changes in spinal cord neuronal responses to nociceptive stimuli in the rat. Eur J Pain 4:247-257.
    • (2000) Eur J Pain , vol.4 , pp. 247-257
    • Reeve, A.J.1    Patel, S.2    Fox, A.3    Walker, K.4    Urban, L.5
  • 79
    • 41149137558 scopus 로고    scopus 로고
    • Spinal microglial and perivascular cell cannabinoid receptor type 2 activation reduces behavioral hypersensitivity without tolerance after peripheral nerve injury
    • Romero-Sandoval A, Nutile-McMenemy N, DeLeo JA. 2008. Spinal microglial and perivascular cell cannabinoid receptor type 2 activation reduces behavioral hypersensitivity without tolerance after peripheral nerve injury. Anesthesiology 108:722-734.
    • (2008) Anesthesiology , vol.108 , pp. 722-734
    • Romero-Sandoval, A.1    Nutile-McMenemy, N.2    Deleo, J.A.3
  • 80
    • 1842731881 scopus 로고    scopus 로고
    • SRC kinases: A hub for NMDA receptor regulation
    • Salter MW, Kalia LV. 2004. Src kinases: A hub for NMDA receptor regulation. Nat Rev Neurosci 5:317-328. (Pubitemid 38478658)
    • (2004) Nature Reviews Neuroscience , vol.5 , Issue.4 , pp. 317-328
    • Salter, M.W.1    Kalia, L.V.2
  • 81
    • 0345701254 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons
    • Schafers M, Svensson CI, Sommer C, Sorkin LS. 2003. Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons. J Neurosci 23:2517-2521. (Pubitemid 36418584)
    • (2003) Journal of Neuroscience , vol.23 , Issue.7 , pp. 2517-2521
    • Schafers, M.1    Svensson, C.I.2    Sommer, C.3    Sorkin, L.S.4
  • 82
    • 0036829011 scopus 로고    scopus 로고
    • Can we conquer pain?
    • Schulz J, Woolf CJ. 2002. Can we conquer pain? Nat Neurosci 5 Suppl: 1062-1067.
    • (2002) Nat Neurosci , vol.5 , Issue.SUPPL. , pp. 1062-1067
    • Schulz, J.1    Woolf, C.J.2
  • 83
    • 35548937457 scopus 로고    scopus 로고
    • The neuropathic pain triad: Neurons, immune cells and glia
    • Schulz J, Woolf CJ. 2007. The neuropathic pain triad: Neurons, immune cells and glia. Nat Neurosci 10:1361-1368.
    • (2007) Nat Neurosci , vol.10 , pp. 1361-1368
    • Schulz, J.1    Woolf, C.J.2
  • 84
    • 1842689293 scopus 로고    scopus 로고
    • Amyloid precursor protein mediates proinflammatory activation of monocytic lineage cells
    • Sondag CM, Combs CK. 2004. Amyloid precursor protein mediates proinflammatory activation of monocytic lineage cells. J Biol Chem 279:14456-14463.
    • (2004) J Biol Chem , vol.279 , pp. 14456-14463
    • Sondag, C.M.1    Combs, C.K.2
  • 85
    • 0032937860 scopus 로고    scopus 로고
    • The role of microglia and macrophages in the pathophysiology of the CNS
    • DOI 10.1016/S0301-0082(98)00083-5, PII S0301008298000835
    • Stoll G, Jander S. 1999. The role of microglia and macrophages in the pathophysiology of the CNS. Prog Neurobiol 58:233-247. (Pubitemid 29193056)
    • (1999) Progress in Neurobiology , vol.58 , Issue.3 , pp. 233-247
    • Stollg, G.1    Jander, S.2
  • 86
    • 0034705679 scopus 로고    scopus 로고
    • Microglial proliferation in the spinal cord of aged rats with a sciatic nerve injury
    • DOI 10.1016/S0304-3940(00)01142-3, PII S0304394000011423
    • Stuesse SL, Cruce WL, Lovell JA, McBurney DL, Crisp T. 2000. Microglial proliferation in the spinal cord of aged rats with a sciatic nerve injury. Neurosci Lett 287:121-124. (Pubitemid 30353062)
    • (2000) Neuroscience Letters , vol.287 , Issue.2 , pp. 121-124
    • Stuesse, S.L.1    Cruce, W.L.R.2    Lovell, J.A.3    McBurney, D.L.4    Crisp, T.5
  • 88
    • 0842322759 scopus 로고    scopus 로고
    • 7 Receptor-Activated Microglia
    • DOI 10.1523/JNEUROSCI.3792-03.2004
    • Suzuki T, Hide I, Ido K, Kohsaka S, Inoue K, Nakata Y. 2004. Production and release of neuroprotective tumor necrosis factor by P2X7 receptor-activated microglia. J Neurosci 24:1-7. (Pubitemid 38181664)
    • (2004) Journal of Neuroscience , vol.24 , Issue.1 , pp. 1-7
    • Suzuki, T.1    Hide, I.2    Ido, K.3    Kohsaka, S.4    Inoue, K.5    Nakata, Y.6
  • 89
    • 0035018058 scopus 로고    scopus 로고
    • Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain
    • Sweitzer SM, Schubert P, DeLeo JA. 2001. Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain. J Pharmacol Exp Ther 297:1210-1217. (Pubitemid 32472523)
    • (2001) Journal of Pharmacology and Experimental Therapeutics , vol.297 , Issue.3 , pp. 1210-1217
    • Sweitzer, S.M.1    Schubert, P.2    Deleo, J.A.3
  • 90
    • 0036228048 scopus 로고    scopus 로고
    • The differential role of spinal MHC class II and cellular adhesion molecules in peripheral inflammatory versus neuropathic pain in rodents
    • DOI 10.1016/S0165-5728(02)00036-X, PII S016557280200036X
    • Sweitzer SM, White KA, Dutta C, DeLeo JA. 2002. The differential role of spinal MHC class II, cellular adhesion molecules in peripheral inflammatory versus neuropathic pain in rodents. J Neuroimmunol 125:82-93. (Pubitemid 34327457)
    • (2002) Journal of Neuroimmunology , vol.125 , Issue.1-2 , pp. 82-93
    • Sweitzer, S.M.1    White, K.A.2    Dutta, C.3    Deleo, J.A.4
  • 91
    • 0034711317 scopus 로고    scopus 로고
    • CD45 inhibits CD40L-induced microglial activation via negative regulation of the Src/p44/42 MAPK pathway
    • DOI 10.1074/jbc.M002006200
    • Tan J, Town T, Mullan M. 2000. CD45 inhibits CD40L-induced microglial activation via negative regulation of the Src/p44/42 MAPK pathway. J Biol Chem 275:37224-37231. (Pubitemid 32002143)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.47 , pp. 37224-37231
    • Tan, J.1    Town, T.2    Mullan, M.3
  • 92
    • 1642404488 scopus 로고    scopus 로고
    • Enhanced production of monocyte chemoattractant protein-1 in the dorsal root ganglia in a rat model of neuropathic pain: Possible involvement in the development of neuropathic pain
    • DOI 10.1016/j.neures.2004.01.004, PII S0168010204000070
    • Tanaka T, Minami M, Nakagawa T, Satoh M. 2004. Enhanced production of monocyte chemoattractant protein-1 in the dorsal root ganglia in a rat model of neuropathic pain: Possible involvement in the development of neuropathic pain. Neurosci Res 48:463-469. (Pubitemid 38369344)
    • (2004) Neuroscience Research , vol.48 , Issue.4 , pp. 463-469
    • Tanaka, T.1    Minami, M.2    Nakagawa, T.3    Satoh, M.4
  • 94
    • 0347814979 scopus 로고    scopus 로고
    • Quantitative real-time RT-PCR assessment of spinal microglial and astrocytic activation markers in a rat model of neuropathic pain
    • DOI 10.1016/j.neuint.2003.06.002, PII S0197018603003024
    • Tanga FY, Raghavendra V, DeLeo JA. 2004. Quantitative real-time RT-PCR assessment of spinal microglial and astrocytic activation markers in a rat model of neuropathic pain. Neurochem Int 45:397-407. (Pubitemid 38625630)
    • (2004) Neurochemistry International , vol.45 , Issue.2-3 , pp. 397-407
    • Tanga, F.Y.1    Raghavendra, V.2    Deleo, J.A.3
  • 95
    • 33845961213 scopus 로고    scopus 로고
    • Efficacy of propentofylline, a glial modulating agent, on existing mechanical allodynia following peripheral nerve injury
    • DOI 10.1016/j.bbi.2006.07.001, PII S0889159106002583
    • Tawfik VL, Nutile-McMenemy N, Lacroix-Fralish ML, Deleo JA. 2007. Efficacy of propentofylline, a glial modulating agent, on existing mechanical allodynia following peripheral nerve injury. Brain Behav Immun 21:238-246. (Pubitemid 46038912)
    • (2007) Brain, Behavior, and Immunity , vol.21 , Issue.2 , pp. 238-246
    • Tawfik, V.L.1    Nutile-McMenemy, N.2    Lacroix-Fralish, M.L.3    Deleo, J.A.4
  • 96
    • 43949146604 scopus 로고    scopus 로고
    • Activation of microglia and p38 mitogen-activated protein kinase in the dorsal column nucleus contributes to tactile allodynia following peripheral nerve injury
    • Terayama R, Omura S, Fujisawa N, Yamaai T, Ichikawa H, Sugimoto T. 2008. Activation of microglia and p38 mitogen-activated protein kinase in the dorsal column nucleus contributes to tactile allodynia following peripheral nerve injury. Neuroscience 153:1245-1255.
    • (2008) Neuroscience , vol.153 , pp. 1245-1255
    • Terayama, R.1    Omura, S.2    Fujisawa, N.3    Yamaai, T.4    Ichikawa, H.5    Sugimoto, T.6
  • 98
    • 44949147139 scopus 로고    scopus 로고
    • P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury
    • Tozaki-Saitoh H, Tsuda M, Miyata H, Ueda K, Kohsaka S, Inoue K. 2008. P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury. J Neurosci 28:4949-4956.
    • (2008) J Neurosci , vol.28 , pp. 4949-4956
    • Tozaki-Saitoh, H.1    Tsuda, M.2    Miyata, H.3    Ueda, K.4    Kohsaka, S.5    Inoue, K.6
  • 99
    • 13144276331 scopus 로고    scopus 로고
    • Neuropathic pain and spinal microglia: A big problem from molecules in ''small'' glia
    • Tsuda M, Inoue K, Salter MW. 2005. Neuropathic pain and spinal microglia: A big problem from molecules in ''small'' glia. Trends Neurosci 28:101-107.
    • (2005) Trends Neurosci , vol.28 , pp. 101-107
    • Tsuda, M.1    Inoue, K.2    Salter, M.W.3
  • 100
    • 0346655315 scopus 로고    scopus 로고
    • Activation of p38 Mitogen-Activated Protein Kinase in Spinal Hyperactive Microglia Contributes to Pain Hypersensitivity Following Peripheral Nerve Injury
    • DOI 10.1002/glia.10308
    • Tsuda M, Mizokoshi A, Shigemoto-Mogami Y, Koizumi S, Inoue K. 2004. Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury. Glia 45:89-95. (Pubitemid 38076231)
    • (2004) GLIA , vol.45 , Issue.1 , pp. 89-95
    • Tsuda, M.1    Mizokoshi, A.2    Shigemoto-Mogami, Y.3    Koizumi, S.4    Inoue, K.5
  • 101
    • 0042968804 scopus 로고    scopus 로고
    • 4 receptors induced in spinal microglia gate tactile allodynia after nerve injury
    • DOI 10.1038/nature01786
    • Tsuda M, Shigemoto-Mogami Y, Koizumi S, Mizokoshi A, Kohsaka S, Salter MW, Inoue K. 2003. P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature 424:778-783. (Pubitemid 37021707)
    • (2003) Nature , vol.424 , Issue.6950 , pp. 778-783
    • Tsuda, M.1    Shigemoto-Mogami, Y.2    Koizumi, S.3    Mizokoshi, A.4    Kohsaka, S.5    Salter, M.W.6    Inoue, K.7
  • 102
  • 103
    • 36448966388 scopus 로고    scopus 로고
    • 4 receptor upregulation and neuropathic pain after peripheral nerve injury
    • DOI 10.1002/glia.20591
    • Tsuda M, Tozaki-Saitoh H, Masuda T, Toyomitsu E, Tezuka T, Yamamoto T, Inoue K. 2008b. Lyn tyrosine kinase is required for P2X(4) receptor upregulation and neuropathic pain after peripheral nerve injury. Glia 56:50-58. (Pubitemid 350172730)
    • (2008) GLIA , vol.56 , Issue.1 , pp. 50-58
    • Tsuda, M.1    Tozaki-Saitoh, H.2    Masuda, T.3    Toyomitsu, E.4    Tezuka, T.5    Yamamoto, T.6    Inoue, K.7
  • 104
    • 38949212281 scopus 로고    scopus 로고
    • Activation of dorsal horn microglia contributes to diabetes-induced tactile allodynia via extracellular signal-regulated protein kinase signaling
    • Tsuda M, Ueno H, Kataoka A, Tozaki-Saitoh H, Inoue K. 2008c. Activation of dorsal horn microglia contributes to diabetes-induced tactile allodynia via extracellular signal-regulated protein kinase signaling. Glia 56:378-386.
    • (2008) Glia , vol.56 , pp. 378-386
    • Tsuda, M.1    Ueno, H.2    Kataoka, A.3    Tozaki-Saitoh, H.4    Inoue, K.5
  • 105
    • 14944376107 scopus 로고    scopus 로고
    • Activation of the spinal cord complement cascade might contribute to mechanical allodynia induced by three animal models of spinal sensitization
    • DOI 10.1016/j.jpain.2004.11.011
    • Twining CM, Sloane EM, Schoeniger DK, Milligan ED, Martin D, Marsh H, Maier SF, Watkins LR. 2005. Activation of the spinal cord complement cascade might contribute to mechanical allodynia induced by three animal models of spinal sensitization. J Pain 6:174-183. (Pubitemid 40365021)
    • (2005) Journal of Pain , vol.6 , Issue.3 , pp. 174-183
    • Twining, C.M.1    Sloane, E.M.2    Schoeniger, D.K.3    Milligan, E.D.4    Martin, D.5    Marsh, H.6    Maier, S.F.7    Watkins, L.R.8
  • 106
    • 34249714208 scopus 로고    scopus 로고
    • Age-related changes in the spinal cord microglial and astrocytic response profile to nerve injury
    • DOI 10.1016/j.bbi.2006.10.007, PII S0889159106003461, Neuropathic Pain, Glia and Cytokines
    • Vega-Avelaira D, Moss A, Fitzgerald M. 2007. Age-related changes in the spinal cord microglial and astrocytic response profile to nerve injury. Brain Behav Immun 21:617-623. (Pubitemid 46829770)
    • (2007) Brain, Behavior, and Immunity , vol.21 , Issue.5 , pp. 617-623
    • Vega-Avelaira, D.1    Moss, A.2    Fitzgerald, M.3
  • 107
    • 4544252839 scopus 로고    scopus 로고
    • Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions
    • Verge GM, Milligan ED, Maier SF, Watkins LR, Naeve GS, Foster AC. 2004. Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions. Eur J Neurosci 20:1150-1160.
    • (2004) Eur J Neurosci , vol.20 , pp. 1150-1160
    • Verge, G.M.1    Milligan, E.D.2    Maier, S.F.3    Watkins, L.R.4    Naeve, G.S.5    Foster, A.C.6
  • 109
    • 0033621660 scopus 로고    scopus 로고
    • Interleukin-1beta inhibits gamma-aminobutyric acid type a (GABA(A)) receptor current in cultured hippocampal neurons
    • Wang S, Cheng Q, Malik S, Yang J. 2000. Interleukin-1beta inhibits gamma-aminobutyric acid type A (GABA(A)) receptor current in cultured hippocampal neurons. J Pharmacol Exp Ther 292:497-504. (Pubitemid 30067411)
    • (2000) Journal of Pharmacology and Experimental Therapeutics , vol.292 , Issue.2 , pp. 497-504
    • Wang, S.1    Cheng, Q.2    Malik, S.3    Yang, J.4
  • 111
    • 36049011866 scopus 로고    scopus 로고
    • "Listening" and "talking" to neurons: Implications of immune activation for pain control and increasing the efficacy of opioids
    • Watkins LR, Hutchinson MR, Milligan ED, Maier SF. 2007. "Listening" and "talking" to neurons: Implications of immune activation for pain control and increasing the efficacy of opioids. Brain Res Rev 56:148-169.
    • (2007) Brain Res Rev , vol.56 , pp. 148-169
    • Watkins, L.R.1    Hutchinson, M.R.2    Milligan, E.D.3    Maier, S.F.4
  • 112
    • 0035426434 scopus 로고    scopus 로고
    • Glial activation: A driving force for pathological pain
    • Watkins LR, Milligan ED, Maier SF. 2001. Glial activation: A driving force for pathological pain. Trends Neurosci 24:450-455.
    • (2001) Trends Neurosci , vol.24 , pp. 450-455
    • Watkins, L.R.1    Milligan, E.D.2    Maier, S.F.3
  • 113
    • 34547563162 scopus 로고    scopus 로고
    • Nerve conduction blockade in the sciatic nerve prevents but does not reverse the activation of p38 mitogen-activated protein kinase in spinal microglia in the rat spared nerve injury model
    • DOI 10.1097/01.anes.0000270759.11086.e7, PII 0000054220070800000020
    • Wen YR, Suter MR, Kawasaki Y, Huang J, Pertin M, Kohno T, Berde CB, Decosterd I, Ji RR. 2007. Nerve conduction blockade in the sciatic nerve prevents but does not reverse the activation of p38 mitogen- activated protein kinase in spinal microglia in the rat spared nerve injury model. Anesthesiology 107:312-321. (Pubitemid 47196496)
    • (2007) Anesthesiology , vol.107 , Issue.2 , pp. 312-321
    • Wen, Y.-R.1    Suter, M.R.2    Kawasaki, Y.3    Huang, J.4    Pertin, M.5    Kohno, T.6    Berde, C.B.7    Decosterd, I.8    Ji, R.-R.9
  • 115
    • 0037195594 scopus 로고    scopus 로고
    • Nerve root injury severity differentially modulates spinal glial activation in a rat lumbar radiculopathy model: Considerations for persistent pain
    • Winkelstein BA, DeLeo JA. 2002. Nerve root injury severity differentially modulates spinal glial activation in a rat lumbar radiculopathy model: Considerations for persistent pain. Brain Res 956:294-301.
    • (2002) Brain Res , vol.956 , pp. 294-301
    • Winkelstein, B.A.1    Deleo, J.A.2
  • 116
    • 0033526651 scopus 로고    scopus 로고
    • Neuropathic pain: Aetiology, symptoms, mechanisms, and management
    • DOI 10.1016/S0140-6736(99)01307-0
    • Woolf CJ, Mannion RJ. 1999. Neuropathic pain: Aetiology, symptoms, mechanisms, and management. Lancet 353:1959-1964. (Pubitemid 29255720)
    • (1999) Lancet , vol.353 , Issue.9168 , pp. 1959-1964
    • Woolf, C.J.1    Mannion, R.J.2
  • 117
    • 0034625770 scopus 로고    scopus 로고
    • Neuronal plasticity: Increasing the gain in pain
    • Woolf CJ, Salter MW. 2000. Neuronal plasticity: Increasing the gain in pain. Science 288:1765-1769.
    • (2000) Science , vol.288 , pp. 1765-1769
    • Woolf, C.J.1    Salter, M.W.2
  • 118
    • 33847325194 scopus 로고    scopus 로고
    • P38 activation in uninjured primary afferent neurons and in spinal microglia contributes to the development of neuropathic pain induced by selective motor fiber injury
    • DOI 10.1016/j.expneurol.2006.11.016, PII S0014488606006261
    • Xu JT, Xin WJ, Wei XH, Wu CY, Ge YX, Liu YL, Zang Y, Zhang T, Li YY, Liu XG. 2007. p38 activation in uninjured primary afferent neurons and in spinal microglia contributes to the development of neuropathic pain induced by selective motor fiber injury. Exp Neurol 204:355-365. (Pubitemid 46330283)
    • (2007) Experimental Neurology , vol.204 , Issue.1 , pp. 355-365
    • Xu, J.-T.1    Xin, W.-J.2    Wei, X.-H.3    Wu, C.-Y.4    Ge, Y.-X.5    Liu, Y.-L.6    Zang, Y.7    Zhang, T.8    Li, Y.-Y.9    Liu, X.-G.10
  • 119
    • 39749122600 scopus 로고    scopus 로고
    • Involvement of central cannabinoid CB2 receptor in reducing mechanical allodynia in a mouse model of neuropathic pain
    • Yamamoto W, Mikami T, Iwamura H. 2008. Involvement of central cannabinoid CB2 receptor in reducing mechanical allodynia in a mouse model of neuropathic pain. Eur J Pharmacol 583:56-61.
    • (2008) Eur J Pharmacol , vol.583 , pp. 56-61
    • Yamamoto, W.1    Mikami, T.2    Iwamura, H.3
  • 120
    • 0035940298 scopus 로고    scopus 로고
    • Development of rolipram-sensitive, cyclic AMP phosphodiesterase (PDE4) in rat primary neuronal cultures
    • DOI 10.1016/S0165-3806(01)00219-X, PII S016538060100219X
    • Ye Y, Jackson K, Houslay MD, Chandler LJ, O'Donnell JM. 2001. Development of rolipram-sensitive, cyclic AMP phosphodiesterase (PDE4) in rat primary neuronal cultures. Brain Res Dev Brain Res 130:115-121. (Pubitemid 32830979)
    • (2001) Developmental Brain Research , vol.130 , Issue.1 , pp. 115-121
    • Ye, Y.1    Jackson, K.2    Houslay, M.D.3    Chandler, L.J.4    O'Donnell, J.M.5
  • 121
    • 33645850108 scopus 로고    scopus 로고
    • Spatial and temporal relationship between monocyte chemoattractant protein-1 expression and spinal glial activation following peripheral nerve injury
    • Zhang J, De Koninck Y. 2006. Spatial and temporal relationship between monocyte chemoattractant protein-1 expression and spinal glial activation following peripheral nerve injury. J Neurochem 97:772-783.
    • (2006) J Neurochem , vol.97 , pp. 772-783
    • Zhang, J.1    De Koninck, Y.2
  • 122
    • 0038684167 scopus 로고    scopus 로고
    • Induction of CB2 receptor expression in the rat spinal cord of neuropathic but not inflammatory chronic pain models
    • DOI 10.1046/j.1460-9568.2003.02704.x
    • Zhang J, Hoffert C, Vu HK, Groblewski T, Ahmad S, O'Donnell D. 2003. Induction of CB2 receptor expression in the rat spinal cord of neuropathic but not inflammatory chronic pain models. Eur J Neurosci 17:2750-2754. (Pubitemid 36819300)
    • (2003) European Journal of Neuroscience , vol.17 , Issue.12 , pp. 2750-2754
    • Zhang, J.1    Hoffert, C.2    Vu, H.K.3    Groblewski, T.4    Ahmad, S.5    O'Donnell, D.6
  • 123
    • 36048991728 scopus 로고    scopus 로고
    • Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain
    • DOI 10.1523/JNEUROSCI.3016-07.2007
    • Zhang J, Shi XQ, Echeverry S, Mogil JS, De Koninck Y, Rivest S. 2007. Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain. J Neurosci 27:12396-12406. (Pubitemid 350085465)
    • (2007) Journal of Neuroscience , vol.27 , Issue.45 , pp. 12396-12406
    • Zhang, J.1    Xiang, Q.S.2    Echeverry, S.3    Mogil, J.S.4    De Koninck, Y.5    Rivest, S.6
  • 124
    • 27644537034 scopus 로고    scopus 로고
    • Spinal glial activation in a new rat model of bone cancer pain produced by prostate cancer cell inoculation of the tibia
    • DOI 10.1016/j.pain.2005.08.001, PII S0304395905003830
    • Zhang RX, Liu B, Wang L, Ren K, Qiao JT, Berman BM, Lao L. 2005. Spinal glial activation in a new rat model of bone cancer pain produced by prostate cancer cell inoculation of the tibia. Pain 118:125-136. (Pubitemid 41566591)
    • (2005) Pain , vol.118 , Issue.1-2 , pp. 125-136
    • Zhang, R.-X.1    Liu, B.2    Wang, L.3    Ren, K.4    Qiao, J.-T.5    Berman, B.M.6    Lao, L.7
  • 125
    • 33847337984 scopus 로고    scopus 로고
    • 2 contributes to pain after spinal cord injury
    • DOI 10.1523/JNEUROSCI.0138-07.2007
    • Zhao P, Waxman SG, Hains BC. 2007. Extracellular signal-regulated kinase-regulated microglia-neuron signaling by prostaglandin E2 contributes to pain after spinal cord injury. J Neurosci 27:2357-2368. (Pubitemid 46340975)
    • (2007) Journal of Neuroscience , vol.27 , Issue.9 , pp. 2357-2368
    • Zhao, P.1    Waxman, S.G.2    Hains, B.C.3
  • 126
    • 14044252008 scopus 로고    scopus 로고
    • ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model
    • DOI 10.1016/j.pain.2004.12.022
    • Zhuang ZY, Gerner P, Woolf CJ, Ji RR. 2005. ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model. Pain 114:149-159. (Pubitemid 40279096)
    • (2005) Pain , vol.114 , Issue.1-2 , pp. 149-159
    • Zhuang, Z.-Y.1    Gerner, P.2    Woolf, C.J.3    Ji, R.-R.4
  • 127
    • 34249717859 scopus 로고    scopus 로고
    • Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine
    • DOI 10.1016/j.bbi.2006.11.003, PII S0889159106003540, Neuropathic Pain, Glia and Cytokines
    • Zhuang ZY, Kawasaki Y, Tan PH, Wen YR, Huang J, Ji RR. 2007. Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine. Brain Behav Immun 21:642-651. (Pubitemid 46830963)
    • (2007) Brain, Behavior, and Immunity , vol.21 , Issue.5 , pp. 642-651
    • Zhuang, Z.-Y.1    Kawasaki, Y.2    Tan, P.-H.3    Wen, Y.-R.4    Huang, J.5    Ji, R.-R.6
  • 128
    • 33645460235 scopus 로고    scopus 로고
    • A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: Respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance
    • Zhuang ZY, Wen YR, Zhang DR, Borsello T, Bonny C, Strichartz GR, Decosterd I, Ji RR. 2006. A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: Respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance. J Neurosci 26:3551-3560.
    • (2006) J Neurosci , vol.26 , pp. 3551-3560
    • Zhuang, Z.Y.1    Wen, Y.R.2    Zhang, D.R.3    Borsello, T.4    Bonny, C.5    Strichartz, G.R.6    Decosterd, I.7    Ji, R.R.8


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