P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain

Journal of Neuroscience

Volumn 28, Issue 11, 2008, Pages 2892-2902

  Kobayashi, Kimiko ^a   Yamanaka, Hiroki ^a   Fukuoka, Tetsuo ^a   Dai, Yi ^a   Obata, Koichi ^a   Noguchi, Koichi ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

ADP; ATP; Microglia; Neuropathic pain; P2Y12; p38 MAPK; Spinal cord

Indexed keywords

2 (METHYTHIO)ADENOSINE 5' DIPHOSPHATE TRISODIUM; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PURINERGIC P2Y12 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PURINERGIC RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG; MEMBRANE PROTEIN; P2Y12 PROTEIN, RAT; PURINERGIC P2 RECEPTOR;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HYPERALGESIA; IMMUNOHISTOCHEMISTRY; MALE; MICROGLIA; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SCIATIC NERVE; SIGNAL TRANSDUCTION; SPINAL CORD; UPREGULATION; ANIMAL; BIOSYNTHESIS; COMPARATIVE STUDY; DRUG ANTAGONISM; GENETICS; METABOLISM; METHODOLOGY; NEURALGIA; PAIN ASSESSMENT; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; MALE; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; MICROGLIA; NEURALGIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2; UP-REGULATION;

EID: 40849089273     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5589-07.2008     Document Type: Article

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