Age-related changes in the spinal cord microglial and astrocytic response profile to nerve injury

Brain, Behavior, and Immunity

Volumn 21, Issue 5, 2007, Pages 617-623

  Vega Avelaira, David ^a   Moss, Andrew ^a   Fitzgerald, Maria ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Activation; Astrocytes; GFAP; IBA 1; Microglia; Neonate; Neuropathic; OX 42; Pain; Spinal cord

Indexed keywords

BINDING PROTEIN; CYTOKINE; GAMMA INTERFERON; GLIAL FIBRILLARY ACIDIC PROTEIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INTERLEUKIN 1; INTERLEUKIN 6; IONIZED BINDING CALCIUM ADAPTER PROTEIN; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

AGING; ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; MALE; MICROGLIA; NERVE INJURY; NEUROPATHIC PAIN; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPINAL CORD; WESTERN BLOTTING;

AGING; ANALYSIS OF VARIANCE; ANIMALS; ASTROCYTES; CALCIUM-BINDING PROTEINS; DISEASE MODELS, ANIMAL; MALE; MICROGLIA; POSTERIOR HORN CELLS; RATS; RATS, SPRAGUE-DAWLEY; SCIATIC NERVE; SCIATIC NEUROPATHY; SPINAL CORD; TIME FACTORS;

EID: 34249714208     PISSN: 08891591     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbi.2006.10.007     Document Type: Article

References (23)

1. Anand P., and Birch R. Restoration of sensory function and lack of long-term chronic pain syndromes after brachial plexus injury in human neonates. Brain 125 (2002) 113-122
2. Bailey A.L., and Ribeiro-da-Silva A. Transient loss of terminals from non-peptidergic nociceptive fibers in the substantia gelatinosa of spinal cord following chronic constriction injury of the sciatic nerve. Neuroscience 138 (2006) 675-690
3. Caggiano A.O., and Kraig R.P. Eicosanoids and nitric oxide influence induction of reactive gliosis from spreading depression in microglia but not astrocytes. J. Comp. Neurol. 369 (1996) 93-108
4. De Leo J.A., Tawfik V.L., and LaCroix-Fralish M.L. The tetrapartite synapse: path to CNS sensitization and chronic pain. Pain 122 (2006) 17-21
5. De Leo J.A., and Yezierski R.P. The role of neuroinflammation and neuroimmune activation in persistent pain. Pain 90 (2001) 1-6
6. Decosterd I., and Woolf C.J. Spared nerve injury: an animal model of persistent peripheral neuropathic pain. Pain 87 (2000) 149-158
7. Hansson E. Could chronic pain and spread of pain sensation be induced and maintained by glial activation?. Acta Physiol. (Oxford) 187 (2006) 321-327
8. Howard R.F. Current status of pain management in children. JAMA 290 (2003) 2464-2469
9. Howard R.F., Walker S.M., Mota P.M., and Fitzgerald M. The ontogeny of neuropathic pain: postnatal onset of mechanical allodynia in rat spared nerve injury (SNI) and chronic constriction injury (CCI) models. Pain 115 (2005) 382-389
10. Ito D., Imai Y., Ohsawa K., Nakajima K., Fukuuchi Y., and Kohsaka S. Microglia-specific localisation of a novel calcium binding protein, Iba1. Brain Res. Mol. Brain Res. 57 (1998) 1-9
11. Ji, R.R., Strichartz, G., 2004. Cell signaling and the genesis of neuropathic pain. Sci STKE 2004, reE14.
12. Jin S.X., Zhuang Z.Y., Woolf C.J., and Ji R.R. p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain. J. Neurosci. 23 (2003) 4017-4022
13. Lee D.H., and Chung J.M. Neuropathic pain in neonatal rats. Neurosci. Lett. 209 (1996) 140-142
14. Moss, A., Beggs, S., Vega-Avelaira, D., Costigan, M., Hathway, G.J., Salter, M.W., Fitzgerald, M. Spinal microglia and neuropathic pain in young rats, Pain (2006), doi:10.1016/j.pain.2006.09.018, in press.
15. Piao Z.G., Cho I.H., Park C.K., Hong J.P., Choi S.Y., Lee S.J., Lee S., Park K., Kim J.S., and Oh S.B. Activation of glia and microglial p38 MAPK in medullary dorsal horn contributes to tactile hypersensitivity following trigeminal sensory nerve injury. Pain 121 (2006) 219-231
16. Reeves S.A., Helman L.J., Allison A., and Israel M.A. Molecular cloning and primary structure of human glial fibrillary acidic protein. Proc. Natl. Acad. Sci. USA 86 (1989) 5178-5182
17. Ririe D.G., and Eisenach J.C. Age-dependent responses to nerve injury-induced mechanical allodynia. Anesthesiology 104 (2006) 344-350
18. Sweitzer S.M., Schubert P., and Deleo J.A. Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain. J. Pharmacol. Exp. Ther. 297 (2001) 1210-1217
19. Tanga F.Y., Raghavendra V., Nutile-McMenemy N., Marks A., and Deleo J.A. Role of astrocytic S100beta in behavioral hypersensitivity in rodent models of neuropathic pain. Neuroscience 140 (2006) 1003-1010
20. Watkins L.R., and Maier S.F. Implications of immune-to-brain communication for sickness and pain. Proc. Natl. Acad. Sci. USA 96 (1999) 7710-7713
21. Wieseler-Frank J., Maier S.F., and Watkins LR. Central proinflammatory cytokines and pain enhancement. Neurosignals 14 (2005) 166-174
22. Woolf C.J., and Salter M.W. Neuronal plasticity: increasing the gain in pain. Science 288 (2000) 1765-1769
23. Zhuang Z.Y., Wen Y.R., Zhang D.R., Borsello T., Bonny C., Strichartz G.R., Decosterd I., and Ji R.R. A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance. J. Neurosci. 26 (2006) 3551-3560