Nerve root injury severity differentially modulates spinal glial activation in a rat lumbar radiculopathy model: Considerations for persistent pain

Brain Research

Volumn 956, Issue 2, 2002, Pages 294-301

  Winkelstein, Beth A ^a,c   DeLeo, Joyce A ^a,b  

^a DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

^b Neurology Department Dartmouth Hitchcock Medical Center   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Astrocyte; Biomechanics; Microglia; Nerve root; Pain; Radiculopathy

Indexed keywords

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; CELL ACTIVATION; CONTROLLED STUDY; DISEASE SEVERITY; GLIA CELL; IMAGE ANALYSIS; IN VIVO STUDY; INJURY SCALE; MALE; MICROGLIA; MODULATION; NERVE LIGATION; NERVE ROOT COMPRESSION; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL ROOT; SUTURING METHOD;

ANIMALS; ASTROCYTES; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; INJURY SEVERITY SCORE; LUMBOSACRAL REGION; MALE; MICROGLIA; PAIN; RADICULOPATHY; RATS; RATS, SPRAGUE-DAWLEY; SPINAL NERVE ROOTS; TIME FACTORS;

EID: 0037195594     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)03560-6     Document Type: Article

References (26)

1. Colburn R.W., DeLeo J.A., Rickman A.J., Yeager M.P., Kwon P., Hickey W.F. Dissociation of microglial activation and neuropathic pain behaviors following peripheral nerve injury in the rat. J. Neuroimmunol. 79:1997;163-175.
2. Colburn R., Rickman A., DeLeo J.A. The effect of site and type of nerve injury on spinal glial activation and neuropathic pain behavior. Exp. Neurol. 157:1999;289-304.
3. DeLeo J.A., Yezierski R.P. The role of neuroinflammation and neuroimmune activation in persistent pain. Pain. 91:2001;1-6.
4. Fung Y.C. Foundations of Solid Mechanics. 1965;Prentice-Hall, Inc, Englewood Cliffs, NJ.
5. Hanai F., Matsui N., Hongo N. Changes in responses of wide dynamic range neurons in the spinal dorsal horn after dorsal root or dorsal root ganglion compression. Spine. 21:1996;1408-1415.
6. Hashizume H., DeLeo J.A., Colburn R.W., Weinstein J.N. Spinal glial activation and cytokine expression after lumbar root injury in the rat. Spine. 25:2000;1206-1217.
7. Hollingworth W., Dixon A.K., Todd C.J., Bell M., Antoun N., Arafat Q., Girling S., Karia K., Laing R. Self reported health status and magnetic resonance imaging findings in patients with low back pain. Eur. Spine J. 7:1998;369-375.
8. Kawakami M., Weinstein J.N., Chatani K., Spratt K., Meller S., Gebhart G. Experimental lumbar radiculopathy. Behavioral and histologic changes in a model of radicular pain after spinal nerve root irritation with chromic gut ligatures in the rat. Spine. 19:1994;1795-1802.
9. Kettenmann H., Ransom B.R. Neuroglia. 1995;Oxford University Press, New York.
10. Kim S., Chung J. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain. 50:1992;355-363.
11. Kreutzberg G.W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 19:1886;312-318.
12. Lundborg G., Myers R., Powell H. Nerve compression injury and increased endoneurial fluid pressure: a 'miniature compartment syndrome'. J. Neurol. Neurosurg. Psych. 45:1983;1119-1124.
13. Olmarker K., Rydevik B., Holm S. Edema formation in spinal nerve roots induced by experimental, graded compression. An experimental study on the pig cauda equina with special reference to differences in effects between rapid and slow onset of compression. Spine. 14:1989;569-573.
14. Olmarker K., Rydevik B., Nordborg C. Autologous nucleus pulposus induces neurophysiologic and histologic changes in the porcine cauda equina nerve roots. Spine. 18:1993;1425-1432.
15. Pedowitz R., Garfin S., Massie J., Hargens A., Swenson M., Myers R., Rydevik B. Effects of magnitude and duration of compression on spinal nerve root conduction. Spine. 17:1992;194-199.
16. Rutkowski M.R., Winkelstein B.A., Hickey W.F., Pahl J.L., DeLeo J.A. Lumbar nerve root injury induces CNS neuroimmune activation and neuroinflammation in the rat: relationship to painful radiculopathy. Spine. 27:2002;1604-1613.
17. Sweitzer S., White K.A., Dutta C., DeLeo J.A. The differential role of spinal MHC class II and cellular adhesion molecules in inflammatory versus neuropathic pain. J. Neuroimmunol. 125:2002;82-93.
18. Vucetic N., Astrand P., Guntner P., Svensson O. Diagnosis and prognosis in lumbar disc herniation. Clin. Orthop. 361:1999;116-122.
19. Watkins L.R., Maier S.F. The pain of being sick: implications of immune-to-brain communication for understanding pain. Ann. Rev. Psych. 51:2000;29-57.
20. Watkins L.R., Milligan E.D., Maier S.F. Glial activation: a driving force for pathological pain. Trends Neurosci. 24:2001;450-455.
21. Watkins L.R., Milligan E.D., Maier S.F. Spinal cord glia: new players in pain. Pain. 93:2001;201-205.
22. Winkelstein B.A., Rutkowski M.D., Sweitzer S.M., Pahl J.L., DeLeo J.A. Nerve injury proximal or distal to the DRG induces similar spinal glial activation and selective cytokine expression but differential behavioral responses to pharmacological treatment. J. Comp. Neurol. 438:2001;127-139.
23. Winkelstein B.A., Rutkowski M.D., Weinstein J.N., DeLeo J.A. Quantification of neural tissue injury in a rat radiculopathy model: comparison of local deformation, behavioral outcomes, and spinal cytokine mRNA for two surgeons. J. Neurosci. Meth. 111:2001;49-57.
24. Winkelstein B.A., Weinstein J.N., DeLeo J.A. The role of mechanical deformation in lumbar radiculopathy: an in vivo model. Spine. 27:2002;27-33.
25. Yamaguchi K., Murakami M., Takahashi K., Moriya H., Tatsuoka H., Chiba T. Behavioral and morphological studies of the chronically compressed cauda equina. Experimental model of lumbar spinal stenosis in the rat. Spine. 24:1999;845-851.
26. Yoshizawa H., Kobayashi S., Kubota K. Effects of compression on intraradicular blood flow in dogs. Spine. 14:1989;1220-1225.