메뉴 건너뛰기




Volumn 10, Issue 11, 2007, Pages 1361-1368

The neuropathic pain triad: Neurons, immune cells and glia

Author keywords

[No Author keywords available]

Indexed keywords

ETANERCEPT; FLUOROCITRIC ACID; MINOCYCLINE; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PROPENTOFYLLINE; TERIFLUNOMIDE; THALIDOMIDE;

EID: 35548937457     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn1992     Document Type: Review
Times cited : (1480)

References (100)
  • 1
    • 0345445898 scopus 로고    scopus 로고
    • Advances in neuropathic pain: Diagnosis, mechanisms, and treatment recommendations
    • Dworkin, R.H. et al. Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations. Arch. Neurol. 60, 1524-1534 (2003).
    • (2003) Arch. Neurol , vol.60 , pp. 1524-1534
    • Dworkin, R.H.1
  • 2
    • 0036847816 scopus 로고    scopus 로고
    • Microglia as neuroprotective, immunocompetent cells of the CNS
    • Streit, W.J. Microglia as neuroprotective, immunocompetent cells of the CNS. Glia 40, 133-139 (2002).
    • (2002) Glia , vol.40 , pp. 133-139
    • Streit, W.J.1
  • 3
    • 33846571886 scopus 로고    scopus 로고
    • The origin and cell lineage of microglia: New concepts
    • Chan, W.Y., Kohsaka, S. & Rezaie, P. The origin and cell lineage of microglia: new concepts. Brain Res. Rev. 53, 344-354 (2007).
    • (2007) Brain Res. Rev , vol.53 , pp. 344-354
    • Chan, W.Y.1    Kohsaka, S.2    Rezaie, P.3
  • 4
    • 19444382923 scopus 로고    scopus 로고
    • Satellite glial cells in sensory ganglia: From form to function
    • Hanani, M. Satellite glial cells in sensory ganglia: from form to function. Brain Res. Brain Res. Rev. 48, 457-476 (2005).
    • (2005) Brain Res. Brain Res. Rev , vol.48 , pp. 457-476
    • Hanani, M.1
  • 5
    • 0034669221 scopus 로고    scopus 로고
    • Hyperalgesia due to nerve injury: Role of neutrophils
    • Perkins, N.M. & Tracey, D.J. Hyperalgesia due to nerve injury: role of neutrophils. Neuroscience 101, 745-757 (2000).
    • (2000) Neuroscience , vol.101 , pp. 745-757
    • Perkins, N.M.1    Tracey, D.J.2
  • 6
    • 0035180566 scopus 로고    scopus 로고
    • Rapid response of identified resident endoneurial macrophages to nerve injury
    • Mueller, M. et al. Rapid response of identified resident endoneurial macrophages to nerve injury. Am. J. Pathol. 159, 2187-2197 (2001).
    • (2001) Am. J. Pathol , vol.159 , pp. 2187-2197
    • Mueller, M.1
  • 7
    • 16844365105 scopus 로고    scopus 로고
    • Involvement of monocyte chemoattractant protein-1,macrophage inflammatory protein-1α and interleukin-1β in Wallerian degeneration
    • Perrin, F.E., Lacroix, S., Aviles-Trigueros, M. & David, S. Involvement of monocyte chemoattractant protein-1,macrophage inflammatory protein-1α and interleukin-1β in Wallerian degeneration. Brain 128, 854-866 (2005).
    • (2005) Brain , vol.128 , pp. 854-866
    • Perrin, F.E.1    Lacroix, S.2    Aviles-Trigueros, M.3    David, S.4
  • 8
    • 33644830621 scopus 로고    scopus 로고
    • TNFα-induced MMP-9 promotes macrophage recruitment into injured peripheral nerve
    • Shubayev, V.I. et al. TNFα-induced MMP-9 promotes macrophage recruitment into injured peripheral nerve. Mol. Cell. Neurosci. 31, 407-415 (2006).
    • (2006) Mol. Cell. Neurosci , vol.31 , pp. 407-415
    • Shubayev, V.I.1
  • 9
    • 0032905963 scopus 로고    scopus 로고
    • Evidence for nitric oxide and nitric oxide synthase activity in proximal stumps of transected peripheral nerves
    • Zochodne, D.W. et al. Evidence for nitric oxide and nitric oxide synthase activity in proximal stumps of transected peripheral nerves. Neuroscience 91, 1515-1527 (1999).
    • (1999) Neuroscience , vol.91 , pp. 1515-1527
    • Zochodne, D.W.1
  • 10
    • 0036130317 scopus 로고    scopus 로고
    • Degeneration and regeneration of the peripheral nervous system: From Augustus Waller's observations to neuroinflammation
    • Stoll, G., Jander, S. & Myers, R.R. Degeneration and regeneration of the peripheral nervous system: from Augustus Waller's observations to neuroinflammation. J. Peripher. Nerv. Syst. 7, 13-27 (2002).
    • (2002) J. Peripher. Nerv. Syst , vol.7 , pp. 13-27
    • Stoll, G.1    Jander, S.2    Myers, R.R.3
  • 11
    • 16344380422 scopus 로고    scopus 로고
    • Microanatomy of axon/ glial signaling during Wallerian degeneration
    • Guertin, A.D., Zhang, D.P., Mak, K.S., Alberta, J.A. & Kim, H.A.Microanatomy of axon/ glial signaling during Wallerian degeneration. J. Neurosci. 25, 3478-3487 (2005).
    • (2005) J. Neurosci , vol.25 , pp. 3478-3487
    • Guertin, A.D.1    Zhang, D.P.2    Mak, K.S.3    Alberta, J.A.4    Kim, H.A.5
  • 12
    • 0031039847 scopus 로고    scopus 로고
    • Expression of neuregulins and their putative receptors, ErbB2 and ErbB3, is induced during Wallerian degeneration
    • Carroll, S.L., Miller, M.L., Frohnert, P.W., Kim, S.S. & Corbett, J.A. Expression of neuregulins and their putative receptors, ErbB2 and ErbB3, is induced during Wallerian degeneration. J. Neurosci. 17, 1642-1659 (1997).
    • (1997) J. Neurosci , vol.17 , pp. 1642-1659
    • Carroll, S.L.1    Miller, M.L.2    Frohnert, P.W.3    Kim, S.S.4    Corbett, J.A.5
  • 13
    • 3042793949 scopus 로고    scopus 로고
    • Rapid axoglial signaling mediated by neuregulin and neurotrophic factors
    • Esper, R.M. & Loeb, J.A. Rapid axoglial signaling mediated by neuregulin and neurotrophic factors. J. Neurosci. 24, 6218-6227 (2004).
    • (2004) J. Neurosci , vol.24 , pp. 6218-6227
    • Esper, R.M.1    Loeb, J.A.2
  • 14
    • 33748126653 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor family members sensitize nociceptors in vitro and produce thermal hyperalgesia in vivo
    • Malin, S.A. et al. Glial cell line-derived neurotrophic factor family members sensitize nociceptors in vitro and produce thermal hyperalgesia in vivo. J. Neurosci. 26, 8588-8599 (2006).
    • (2006) J. Neurosci , vol.26 , pp. 8588-8599
    • Malin, S.A.1
  • 15
    • 1642398098 scopus 로고    scopus 로고
    • Cyclooxygenase 2 in infiltrating inflammatory cells in injured nerve is universally up-regulated following various types of peripheral nerve injury
    • Ma, W. & Eisenach, J.C. Cyclooxygenase 2 in infiltrating inflammatory cells in injured nerve is universally up-regulated following various types of peripheral nerve injury. Neuroscience 121, 691-704 (2003).
    • (2003) Neuroscience , vol.121 , pp. 691-704
    • Ma, W.1    Eisenach, J.C.2
  • 16
    • 0036703899 scopus 로고    scopus 로고
    • Denervated Schwann cells attract macrophages by secretion of leukemia inhibitory factor (LIF) and monocyte chemoattractant protein-1 in a process regulated by interleukin-6 and LIF
    • Tofaris, G.K., Patterson, P.H., Jessen, K.R. & Mirsky, R. Denervated Schwann cells attract macrophages by secretion of leukemia inhibitory factor (LIF) and monocyte chemoattractant protein-1 in a process regulated by interleukin-6 and LIF. J. Neurosci. 22, 6696-6703 (2002).
    • (2002) J. Neurosci , vol.22 , pp. 6696-6703
    • Tofaris, G.K.1    Patterson, P.H.2    Jessen, K.R.3    Mirsky, R.4
  • 17
    • 15444377583 scopus 로고    scopus 로고
    • A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1
    • Zhang, N. et al. A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1. Proc. Natl. Acad. Sci. USA 102, 4536-4541 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 4536-4541
    • Zhang, N.1
  • 18
    • 0035878073 scopus 로고    scopus 로고
    • Chemokines and glycoprotein120 produce pain hypersensitivity by directly exciting primary nociceptive neurons
    • Oh, S.B. et al. Chemokines and glycoprotein120 produce pain hypersensitivity by directly exciting primary nociceptive neurons. J. Neurosci. 21, 5027-5035 (2001).
    • (2001) J. Neurosci , vol.21 , pp. 5027-5035
    • Oh, S.B.1
  • 19
    • 33646247398 scopus 로고    scopus 로고
    • Spatially distinct and functionally independent mechanisms of axonal degeneration in a model of HIV-ssociated sensory neuropathy
    • Melli, G., Keswani, S.C., Fischer, A., Chen, W. & Hoke, A. Spatially distinct and functionally independent mechanisms of axonal degeneration in a model of HIV-ssociated sensory neuropathy. Brain 129, 1330-1338 (2006).
    • (2006) Brain , vol.129 , pp. 1330-1338
    • Melli, G.1    Keswani, S.C.2    Fischer, A.3    Chen, W.4    Hoke, A.5
  • 20
    • 0042837947 scopus 로고    scopus 로고
    • Schwann cell chemokine receptors mediate HIV-1 gp120 toxicity to sensory neurons
    • Keswani, S.C. et al. Schwann cell chemokine receptors mediate HIV-1 gp120 toxicity to sensory neurons. Ann. Neurol. 54, 287-296 (2003).
    • (2003) Ann. Neurol , vol.54 , pp. 287-296
    • Keswani, S.C.1
  • 21
    • 13444306159 scopus 로고    scopus 로고
    • A cascade of cytokines mediates mechanical inflammatory hypernociception in mice
    • Cunha, T.M. et al. A cascade of cytokines mediates mechanical inflammatory hypernociception in mice. Proc. Natl. Acad. Sci. USA 102, 1755-1760 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 1755-1760
    • Cunha, T.M.1
  • 22
    • 17144451153 scopus 로고    scopus 로고
    • Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligation
    • Schafers, M., Lee, D.H., Brors, D., Yaksh, T.L. & Sorkin, L.S. Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligation. J. Neurosci. 23, 3028-3038 (2003).
    • (2003) J. Neurosci , vol.23 , pp. 3028-3038
    • Schafers, M.1    Lee, D.H.2    Brors, D.3    Yaksh, T.L.4    Sorkin, L.S.5
  • 23
    • 31644436766 scopus 로고    scopus 로고
    • Genetic impairment of interleukin-1 signaling attenuates neuropathic pain, autotomy, and spontaneous ectopic neuronal activity, following nerve injury in mice
    • Wolf, G., Gabay, E., Tal, M., Yirmiya, R. & Shavit, Y. Genetic impairment of interleukin-1 signaling attenuates neuropathic pain, autotomy, and spontaneous ectopic neuronal activity, following nerve injury in mice. Pain 120, 315-324 (2006).
    • (2006) Pain , vol.120 , pp. 315-324
    • Wolf, G.1    Gabay, E.2    Tal, M.3    Yirmiya, R.4    Shavit, Y.5
  • 24
    • 0345701254 scopus 로고    scopus 로고
    • Tumor necrosis factor-α induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons
    • Schäfers, M., Svensson, C.I., Sommer, C. & Sorkin, L.S. Tumor necrosis factor-α induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons. J. Neurosci. 23, 2517-2521 (2003).
    • (2003) J. Neurosci , vol.23 , pp. 2517-2521
    • Schäfers, M.1    Svensson, C.I.2    Sommer, C.3    Sorkin, L.S.4
  • 25
    • 85047692516 scopus 로고    scopus 로고
    • Signalling pathways of the TNF superfamily: A double-edged sword
    • Aggarwal, B.B. Signalling pathways of the TNF superfamily: a double-edged sword. Nat. Rev. Immunol. 3, 745-756 (2003).
    • (2003) Nat. Rev. Immunol , vol.3 , pp. 745-756
    • Aggarwal, B.B.1
  • 26
    • 32444451323 scopus 로고    scopus 로고
    • The role of neuroinflammation in neuropathic pain: Mechanisms and therapeutic targets
    • Myers, R.R., Campana, W.M. & Shubayev, V.I. The role of neuroinflammation in neuropathic pain: mechanisms and therapeutic targets. Drug Discov. Today 11, 8-20 (2006).
    • (2006) Drug Discov. Today , vol.11 , pp. 8-20
    • Myers, R.R.1    Campana, W.M.2    Shubayev, V.I.3
  • 27
    • 0023471275 scopus 로고
    • Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve
    • Lindholm, D., Heumann, R., Meyer, M. & Thoenen, H. Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve. Nature 330, 658-659 (1987).
    • (1987) Nature , vol.330 , pp. 658-659
    • Lindholm, D.1    Heumann, R.2    Meyer, M.3    Thoenen, H.4
  • 28
    • 0035195636 scopus 로고    scopus 로고
    • Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene
    • Mack, T.G. et al. Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene. Nat. Neurosci. 4, 1199-1206 (2001).
    • (2001) Nat. Neurosci , vol.4 , pp. 1199-1206
    • Mack, T.G.1
  • 29
    • 0032536413 scopus 로고    scopus 로고
    • Painful mononeuropathy in C57BL/Wld mice with delayed wallerian degeneration: Differential effects of cytokine production and nerve regeneration on thermal and mechanical hypersensitivity
    • Sommer, C. & Schafers, M. Painful mononeuropathy in C57BL/Wld mice with delayed wallerian degeneration: differential effects of cytokine production and nerve regeneration on thermal and mechanical hypersensitivity. Brain Res. 784, 154-162 (1998).
    • (1998) Brain Res , vol.784 , pp. 154-162
    • Sommer, C.1    Schafers, M.2
  • 30
    • 34249717859 scopus 로고    scopus 로고
    • Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine
    • Zhuang, Z.Y. et al. Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine. Brain Behav. Immun. 21, 642-651 (2007).
    • (2007) Brain Behav. Immun , vol.21 , pp. 642-651
    • Zhuang, Z.Y.1
  • 31
    • 33847685669 scopus 로고    scopus 로고
    • Neutrophils invade lumbar dorsal root ganglia after chronic constriction injury of the sciatic nerve
    • Morin, N. et al. Neutrophils invade lumbar dorsal root ganglia after chronic constriction injury of the sciatic nerve. J. Neuroimmunol. 184, 164-171 (2007).
    • (2007) J. Neuroimmunol , vol.184 , pp. 164-171
    • Morin, N.1
  • 32
    • 25444490392 scopus 로고    scopus 로고
    • Excitatory monocyte chemoattractant protein-1 signaling is up-regulated in sensory neurons after chronic compression of the dorsal root ganglion
    • White, F.A. et al. Excitatory monocyte chemoattractant protein-1 signaling is up-regulated in sensory neurons after chronic compression of the dorsal root ganglion. Proc. Natl. Acad. Sci. USA 102, 14092-14097 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 14092-14097
    • White, F.A.1
  • 33
    • 33645850108 scopus 로고    scopus 로고
    • Spatial and temporal relationship between monocyte chemoattractant protein-1 expression and spinal glial activation following peripheral nerve injury
    • Zhang, J. & De Koninck, Y. Spatial and temporal relationship between monocyte chemoattractant protein-1 expression and spinal glial activation following peripheral nerve injury. J. Neurochem. 97, 772-783 (2006).
    • (2006) J. Neurochem , vol.97 , pp. 772-783
    • Zhang, J.1    De Koninck, Y.2
  • 34
    • 0842299503 scopus 로고    scopus 로고
    • Distinct functional types of macrophage in dorsal root ganglia and spinal nerves proximal to sciatic and spinal nerve transections in the rat
    • Hu, P. & McLachlan, E.M. Distinct functional types of macrophage in dorsal root ganglia and spinal nerves proximal to sciatic and spinal nerve transections in the rat. Exp. Neurol. 184, 590-605 (2003).
    • (2003) Exp. Neurol , vol.184 , pp. 590-605
    • Hu, P.1    McLachlan, E.M.2
  • 35
    • 0034717839 scopus 로고    scopus 로고
    • Delayed loss of small dorsal root ganglion cells after transection of the rat sciatic nerve
    • Tandrup, T., Woolf, C.J. & Coggeshall, R.E. Delayed loss of small dorsal root ganglion cells after transection of the rat sciatic nerve. J. Comp. Neurol. 422, 172-180 (2000).
    • (2000) J. Comp. Neurol , vol.422 , pp. 172-180
    • Tandrup, T.1    Woolf, C.J.2    Coggeshall, R.E.3
  • 36
    • 0035898266 scopus 로고    scopus 로고
    • Effect of peripheral nerve injury on dorsal root ganglion neurons in the C57 BL/6J mouse: Marked changes both in cell numbers and neuropeptide expression
    • Shi, T.J. et al. Effect of peripheral nerve injury on dorsal root ganglion neurons in the C57 BL/6J mouse: marked changes both in cell numbers and neuropeptide expression. Neuroscience 105, 249-263 (2001).
    • (2001) Neuroscience , vol.105 , pp. 249-263
    • Shi, T.J.1
  • 37
    • 0037175326 scopus 로고    scopus 로고
    • Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury
    • Costigan, M. et al. Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury. BMC Neurosci. [online] 3, 16 (2002).
    • (2002) BMC Neurosci. [online] , vol.3 , pp. 16
    • Costigan, M.1
  • 38
    • 0034613224 scopus 로고    scopus 로고
    • Intrathecal anti-IL-6 antibody and IgG attenuates peripheral nerve injury-induced mechanical allodynia in the rat: Possible immune modulation in neuropathic pain
    • Arruda, J.L., Sweitzer, S., Rutkowski, M.D. & DeLeo, J.A. Intrathecal anti-IL-6 antibody and IgG attenuates peripheral nerve injury-induced mechanical allodynia in the rat: possible immune modulation in neuropathic pain. Brain Res. 879, 216-225 (2000).
    • (2000) Brain Res , vol.879 , pp. 216-225
    • Arruda, J.L.1    Sweitzer, S.2    Rutkowski, M.D.3    DeLeo, J.A.4
  • 39
    • 30644463076 scopus 로고    scopus 로고
    • Acute p38-mediated modulation of tetrodotoxin-resistant sodium channels in mouse sensory neurons by tumor necrosis factor-α
    • Jin, X. & Gereau, R.W. Acute p38-mediated modulation of tetrodotoxin-resistant sodium channels in mouse sensory neurons by tumor necrosis factor-α. J. Neurosci. 26, 246-255 (2006).
    • (2006) J. Neurosci , vol.26 , pp. 246-255
    • Jin, X.1    Gereau, R.W.2
  • 40
    • 34248576759 scopus 로고    scopus 로고
    • Physiology and pathophysiology of purinergic neurotransmission
    • Burnstock, G. Physiology and pathophysiology of purinergic neurotransmission. Physiol. Rev. 87, 659-797 (2007).
    • (2007) Physiol. Rev , vol.87 , pp. 659-797
    • Burnstock, G.1
  • 41
    • 0035287474 scopus 로고    scopus 로고
    • Molecular physiology of P2X receptors and ATP signalling at synapses
    • Khakh, B.S. Molecular physiology of P2X receptors and ATP signalling at synapses. Nat. Rev. Neurosci. 2, 165-174 (2001).
    • (2001) Nat. Rev. Neurosci , vol.2 , pp. 165-174
    • Khakh, B.S.1
  • 42
    • 12444274856 scopus 로고    scopus 로고
    • Differential expression patterns of mRNAs for P2X receptor subunits in neurochemically characterized dorsal root ganglion neurons in the rat
    • Kobayashi, K. et al. Differential expression patterns of mRNAs for P2X receptor subunits in neurochemically characterized dorsal root ganglion neurons in the rat. J. Comp. Neurol. 481, 377-390 (2005).
    • (2005) J. Comp. Neurol , vol.481 , pp. 377-390
    • Kobayashi, K.1
  • 43
    • 33747189475 scopus 로고    scopus 로고
    • Neurons and glial cells differentially express P2Y receptor mRNAs in the rat dorsal root ganglion and spinal cord
    • Kobayashi, K. et al. Neurons and glial cells differentially express P2Y receptor mRNAs in the rat dorsal root ganglion and spinal cord. J. Comp. Neurol. 498, 443-454 (2006).
    • (2006) J. Comp. Neurol , vol.498 , pp. 443-454
    • Kobayashi, K.1
  • 44
    • 0035253835 scopus 로고    scopus 로고
    • Nucleotide receptors: An emerging family of regulatory molecules in blood cells
    • Di Virgilio, F. et al. Nucleotide receptors: an emerging family of regulatory molecules in blood cells. Blood 97, 587-600 (2001).
    • (2001) Blood , vol.97 , pp. 587-600
    • Di Virgilio, F.1
  • 45
    • 34547483582 scopus 로고    scopus 로고
    • Neuronal somatic ATP release triggers neuron-satellite glial cell communication in dorsal root ganglia
    • Zhang, X., Chen, Y., Wang, C. & Huang, L.Y. Neuronal somatic ATP release triggers neuron-satellite glial cell communication in dorsal root ganglia. Proc. Natl. Acad. Sci. USA 104, 9864-9869 (2007).
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 9864-9869
    • Zhang, X.1    Chen, Y.2    Wang, C.3    Huang, L.Y.4
  • 46
    • 28644433892 scopus 로고    scopus 로고
    • Mechanisms underlying enhanced P2X receptor-mediated responses in the neuropathic pain state
    • Chen, Y., Li, G.W., Wang, C., Gu, Y. & Huang, L.Y. Mechanisms underlying enhanced P2X receptor-mediated responses in the neuropathic pain state. Pain 119, 38-48 (2005).
    • (2005) Pain , vol.119 , pp. 38-48
    • Chen, Y.1    Li, G.W.2    Wang, C.3    Gu, Y.4    Huang, L.Y.5
  • 47
    • 0037168683 scopus 로고    scopus 로고
    • A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat
    • Jarvis, M.F. et al. A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat. Proc. Natl. Acad. Sci. USA 99, 17179-17184 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 17179-17184
    • Jarvis, M.F.1
  • 48
    • 0042968804 scopus 로고    scopus 로고
    • P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury
    • Tsuda, M. et al. P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature 424, 778-783 (2003).
    • (2003) Nature , vol.424 , pp. 778-783
    • Tsuda, M.1
  • 49
    • 20144375454 scopus 로고    scopus 로고
    • Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain
    • Chessell, I.P. et al. Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain. Pain 114, 386-396 (2005).
    • (2005) Pain , vol.114 , pp. 386-396
    • Chessell, I.P.1
  • 50
    • 34249099764 scopus 로고    scopus 로고
    • P2X7-related modulation of pathological nociception in rats
    • McGaraughty, S. et al. P2X7-related modulation of pathological nociception in rats. Neuroscience 146, 1817-1828 (2007).
    • (2007) Neuroscience , vol.146 , pp. 1817-1828
    • McGaraughty, S.1
  • 51
    • 33845631301 scopus 로고    scopus 로고
    • v1.9 is an effector of peripheral inflammatory pain hypersensitivity
    • v1.9 is an effector of peripheral inflammatory pain hypersensitivity. J. Neurosci. 26, 12852-12860 (2006).
    • (2006) J. Neurosci , vol.26 , pp. 12852-12860
    • Amaya, F.1
  • 52
    • 33746032539 scopus 로고    scopus 로고
    • 2/3 receptors in neuropathic pain following chronic constriction injury in the rat: An electrophysiological study
    • 2/3 receptors in neuropathic pain following chronic constriction injury in the rat: an electrophysiological study. Br. J. Pharmacol. 148, 845-852 (2006).
    • (2006) Br. J. Pharmacol , vol.148 , pp. 845-852
    • Sharp, C.J.1
  • 53
    • 0031795813 scopus 로고    scopus 로고
    • Spinal nerve lesion-induced mechanoallodynia and adrenergic sprouting in sensory ganglia are attenuated in interleukin-6 knockout mice
    • Ramer, M.S., Murphy, P.G., Richardson, P.M. & Bisby, M.A. Spinal nerve lesion-induced mechanoallodynia and adrenergic sprouting in sensory ganglia are attenuated in interleukin-6 knockout mice. Pain 78, 115-121 (1998).
    • (1998) Pain , vol.78 , pp. 115-121
    • Ramer, M.S.1    Murphy, P.G.2    Richardson, P.M.3    Bisby, M.A.4
  • 54
    • 34547432764 scopus 로고    scopus 로고
    • Isolation and characterization of neural crest progenitors from adult dorsal root ganglia
    • Li, H.Y., Say, E.H. & Zhou, X.F. Isolation and characterization of neural crest progenitors from adult dorsal root ganglia. Stem Cells 25, 2053-2065 (2007).
    • (2007) Stem Cells , vol.25 , pp. 2053-2065
    • Li, H.Y.1    Say, E.H.2    Zhou, X.F.3
  • 55
    • 34249661663 scopus 로고    scopus 로고
    • Immune cell involvement in dorsal root ganglia and spinal cord after chronic constriction or transection of the rat sciatic nerve
    • Hu, P., Bembrick, A.L., Keay, K.A. & McLachlan, E.M. Immune cell involvement in dorsal root ganglia and spinal cord after chronic constriction or transection of the rat sciatic nerve. Brain Behav. Immun. 21, 599-616 (2007).
    • (2007) Brain Behav. Immun , vol.21 , pp. 599-616
    • Hu, P.1    Bembrick, A.L.2    Keay, K.A.3    McLachlan, E.M.4
  • 56
    • 34249731465 scopus 로고    scopus 로고
    • Stereological and somatotopic analysis of the spinal microglial response to peripheral nerve injury
    • Beggs, S. & Salter, M.W. Stereological and somatotopic analysis of the spinal microglial response to peripheral nerve injury. Brain Behav. Immun. 21, 624-633 (2007).
    • (2007) Brain Behav. Immun , vol.21 , pp. 624-633
    • Beggs, S.1    Salter, M.W.2
  • 58
    • 13144276331 scopus 로고    scopus 로고
    • Neuropathic pain and spinal microglia: A big problem from molecules in "small" glia
    • Tsuda, M., Inoue, K. & Salter, M.W. Neuropathic pain and spinal microglia: a big problem from molecules in "small" glia. Trends Neurosci. 28, 101-107 (2005).
    • (2005) Trends Neurosci , vol.28 , pp. 101-107
    • Tsuda, M.1    Inoue, K.2    Salter, M.W.3
  • 59
    • 0036788082 scopus 로고    scopus 로고
    • Beyond neurons: Evidence that immune and glial cells contribute to pathological pain states
    • Watkins, L.R. & Maier, S.F. Beyond neurons: evidence that immune and glial cells contribute to pathological pain states. Physiol. Rev. 82, 981-1011 (2002).
    • (2002) Physiol. Rev , vol.82 , pp. 981-1011
    • Watkins, L.R.1    Maier, S.F.2
  • 60
    • 0037705314 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain
    • Jin, S.X., Zhuang, Z.Y., Woolf, C.J. & Ji, R.R. p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain. J. Neurosci. 23, 4017-4022 (2003).
    • (2003) J. Neurosci , vol.23 , pp. 4017-4022
    • Jin, S.X.1    Zhuang, Z.Y.2    Woolf, C.J.3    Ji, R.R.4
  • 61
    • 33748279280 scopus 로고    scopus 로고
    • Activation of Src-family kinases in spinal microglia contributes to mechanical hypersensitivity after nerve injury
    • Katsura, H. et al. Activation of Src-family kinases in spinal microglia contributes to mechanical hypersensitivity after nerve injury. J. Neurosci. 26, 8680-8690 (2006).
    • (2006) J. Neurosci , vol.26 , pp. 8680-8690
    • Katsura, H.1
  • 62
    • 15244340126 scopus 로고    scopus 로고
    • Spinal p38β isoform mediates tissue injury-induced hyperalgesia and spinal sensitization
    • Svensson, C.I. et al. Spinal p38β isoform mediates tissue injury-induced hyperalgesia and spinal sensitization. J. Neurochem. 92, 1508-1520 (2005).
    • (2005) J. Neurochem , vol.92 , pp. 1508-1520
    • Svensson, C.I.1
  • 63
    • 14044252008 scopus 로고    scopus 로고
    • ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model
    • Zhuang, Z.Y., Gerner, P., Woolf, C.J. & Ji, R.R. ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model. Pain 114, 149-159 (2005).
    • (2005) Pain , vol.114 , pp. 149-159
    • Zhuang, Z.Y.1    Gerner, P.2    Woolf, C.J.3    Ji, R.R.4
  • 64
    • 4544252839 scopus 로고    scopus 로고
    • Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions
    • Verge, G.M. et al. Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions. Eur. J. Neurosci. 20, 1150-1160 (2004).
    • (2004) Eur. J. Neurosci , vol.20 , pp. 1150-1160
    • Verge, G.M.1
  • 66
    • 34447503938 scopus 로고    scopus 로고
    • A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity
    • Kim, D. et al. A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity. J. Biol. Chem. 282, 14975-14983 (2007).
    • (2007) J. Biol. Chem , vol.282 , pp. 14975-14983
    • Kim, D.1
  • 67
    • 17644414137 scopus 로고    scopus 로고
    • The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy
    • Tanga, F.Y., Nutile-McMenemy, N. & DeLeo, J.A. The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy. Proc. Natl. Acad. Sci. USA 102, 5856-5861 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 5856-5861
    • Tanga, F.Y.1    Nutile-McMenemy, N.2    DeLeo, J.A.3
  • 69
    • 8144221210 scopus 로고    scopus 로고
    • Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats
    • Milligan, E.D. et al. Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats. Eur. J. Neurosci. 20, 2294-2302 (2004).
    • (2004) Eur. J. Neurosci , vol.20 , pp. 2294-2302
    • Milligan, E.D.1
  • 70
    • 0037934294 scopus 로고    scopus 로고
    • Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2
    • Abbadie, C. et al. Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2. Proc. Natl. Acad. Sci. USA 100, 7947-7952 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 7947-7952
    • Abbadie, C.1
  • 71
    • 33847183077 scopus 로고    scopus 로고
    • Cooperation of Toll-like receptor signals in innate immune defence
    • Trinchieri, G. & Sher, A. Cooperation of Toll-like receptor signals in innate immune defence. Nat. Rev. Immunol. 7, 179-190 (2007).
    • (2007) Nat. Rev. Immunol , vol.7 , pp. 179-190
    • Trinchieri, G.1    Sher, A.2
  • 72
    • 33750369226 scopus 로고    scopus 로고
    • Toll-like receptors in systemic autoimmune disease
    • Marshak-Rothstein, A. Toll-like receptors in systemic autoimmune disease. Nat. Rev. Immunol. 6, 823-835 (2006).
    • (2006) Nat. Rev. Immunol , vol.6 , pp. 823-835
    • Marshak-Rothstein, A.1
  • 73
    • 23744437312 scopus 로고    scopus 로고
    • Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibition in lamina II of the dorsal horn after peripheral nerve injury
    • Scholz, J. et al. Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibition in lamina II of the dorsal horn after peripheral nerve injury. J. Neurosci. 25, 7317-7323 (2005).
    • (2005) J. Neurosci , vol.25 , pp. 7317-7323
    • Scholz, J.1
  • 74
    • 38849178118 scopus 로고    scopus 로고
    • Characterization of cell proliferation in rat spinal cord following peripheral nerve injury and the relationship with neuropathic pain
    • June, doi:10.1016/j.pain.2007.05.002
    • Echeverry, S., Shi, X.Q. & Zhang, J. Characterization of cell proliferation in rat spinal cord following peripheral nerve injury and the relationship with neuropathic pain. Pain, published online 8, June 2007 (doi:10.1016/j.pain.2007.05.002).
    • (2007) Pain, published online , vol.8
    • Echeverry, S.1    Shi, X.Q.2    Zhang, J.3
  • 75
    • 30744439794 scopus 로고    scopus 로고
    • BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
    • Coull, J.A. et al. BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature 438, 1017-1021 (2005).
    • (2005) Nature , vol.438 , pp. 1017-1021
    • Coull, J.A.1
  • 76
    • 0042860080 scopus 로고    scopus 로고
    • Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain
    • Coull, J.A. et al. Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain. Nature 424, 938-942 (2003).
    • (2003) Nature , vol.424 , pp. 938-942
    • Coull, J.A.1
  • 77
    • 0035449908 scopus 로고    scopus 로고
    • ATP P2X receptor-mediated enhancement of glutamate release and evoked EPSCs in dorsal horn neurons of the rat spinal cord
    • Nakatsuka, T. & Gu, J.G. ATP P2X receptor-mediated enhancement of glutamate release and evoked EPSCs in dorsal horn neurons of the rat spinal cord. J. Neurosci. 21, 6522-6531 (2001).
    • (2001) J. Neurosci , vol.21 , pp. 6522-6531
    • Nakatsuka, T.1    Gu, J.G.2
  • 78
    • 34547505414 scopus 로고    scopus 로고
    • Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain
    • Clark, A.K. et al. Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain. Proc. Natl. Acad. Sci. USA 104, 10655-10660 (2007).
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 10655-10660
    • Clark, A.K.1
  • 79
    • 0035888084 scopus 로고    scopus 로고
    • Nerve injury proximal or distal to the DRG induces similar spinal glial activation and selective cytokine expression but differential behavioral responses to pharmacologic treatment
    • Winkelstein, B.A., Rutkowski, M.D., Sweitzer, S.M., Pahl, J.L. & DeLeo, J.A. Nerve injury proximal or distal to the DRG induces similar spinal glial activation and selective cytokine expression but differential behavioral responses to pharmacologic treatment. J. Comp. Neurol. 439, 127-139 (2001).
    • (2001) J. Comp. Neurol , vol.439 , pp. 127-139
    • Winkelstein, B.A.1    Rutkowski, M.D.2    Sweitzer, S.M.3    Pahl, J.L.4    DeLeo, J.A.5
  • 80
    • 34547865012 scopus 로고    scopus 로고
    • Complement induction in spinal cord microglia results in anaphylatoxin C5a-mediated pain hypersensitivity
    • Griffin, R.S. et al. Complement induction in spinal cord microglia results in anaphylatoxin C5a-mediated pain hypersensitivity. J. Neurosci. 27, 8699-8708 (2007).
    • (2007) J. Neurosci , vol.27 , pp. 8699-8708
    • Griffin, R.S.1
  • 81
    • 0034707108 scopus 로고    scopus 로고
    • Intrathecal methylprednisolone for intractable postherpetic neuralgia
    • Kotani, N. et al. Intrathecal methylprednisolone for intractable postherpetic neuralgia. N. Engl. J. Med. 343, 1514-1519 (2000).
    • (2000) N. Engl. J. Med , vol.343 , pp. 1514-1519
    • Kotani, N.1
  • 82
    • 30844434168 scopus 로고    scopus 로고
    • The PINE study of epidural steroids and local anaesthetics to prevent postherpetic neuralgia: A randomised controlled trial
    • van Wijck, A.J. et al. The PINE study of epidural steroids and local anaesthetics to prevent postherpetic neuralgia: a randomised controlled trial. Lancet 367, 219-224 (2006).
    • (2006) Lancet , vol.367 , pp. 219-224
    • van Wijck, A.J.1
  • 83
    • 27744589586 scopus 로고    scopus 로고
    • A multicentre randomized controlled trial of epidural corticosteroid injections for sciatica: The WEST study
    • Arden, N.K. et al. A multicentre randomized controlled trial of epidural corticosteroid injections for sciatica: the WEST study. Rheumatology (Oxford) 44, 1399-1406 (2005).
    • (2005) Rheumatology (Oxford) , vol.44 , pp. 1399-1406
    • Arden, N.K.1
  • 84
    • 0347169249 scopus 로고    scopus 로고
    • Glia: A novel drug discovery target for clinical pain
    • Watkins, L.R. &Maier, S.F. Glia: a novel drug discovery target for clinical pain. Nat. Rev. Drug Discov. 2, 973-985 (2003).
    • (2003) Nat. Rev. Drug Discov , vol.2 , pp. 973-985
    • Watkins, L.R.1    Maier, S.F.2
  • 85
    • 33751513963 scopus 로고    scopus 로고
    • Role of spinal microglia in rat models of peripheral nerve injury and inflammation
    • Clark, A.K., Gentry, C., Bradbury, E.J., McMahon, S.B. & Malcangio, M. Role of spinal microglia in rat models of peripheral nerve injury and inflammation. Eur. J. Pain 11, 223-230 (2007).
    • (2007) Eur. J. Pain , vol.11 , pp. 223-230
    • Clark, A.K.1    Gentry, C.2    Bradbury, E.J.3    McMahon, S.B.4    Malcangio, M.5
  • 86
    • 33845961213 scopus 로고    scopus 로고
    • Efficacy of propentofylline, a glial modulating agent, on existing mechanical allodynia following peripheral nerve injury
    • Tawfik, V.L., Nutile-McMenemy, N., LaCroix-Fralish, M.L. & DeLeo, J.A. Efficacy of propentofylline, a glial modulating agent, on existing mechanical allodynia following peripheral nerve injury. Brain Behav. Immun. 21, 238-246 (2007).
    • (2007) Brain Behav. Immun , vol.21 , pp. 238-246
    • Tawfik, V.L.1    Nutile-McMenemy, N.2    LaCroix-Fralish, M.L.3    DeLeo, J.A.4
  • 87
    • 17044417657 scopus 로고    scopus 로고
    • Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation
    • Ledeboer, A. et al. Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation. Pain 115, 71-83 (2005).
    • (2005) Pain , vol.115 , pp. 71-83
    • Ledeboer, A.1
  • 88
    • 0037622717 scopus 로고    scopus 로고
    • Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy
    • Raghavendra, V., Tanga, F. & DeLeo, J.A. Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy. J. Pharmacol. Exp. Ther. 306, 624-630 (2003).
    • (2003) J. Pharmacol. Exp. Ther , vol.306 , pp. 624-630
    • Raghavendra, V.1    Tanga, F.2    DeLeo, J.A.3
  • 89
    • 0036796293 scopus 로고    scopus 로고
    • The active metabolite of leflunomide, an immunosuppressive agent, reduces mechanical sensitivity in a rat mononeuropathy model
    • Sweitzer, S.M. & DeLeo, J.A. The active metabolite of leflunomide, an immunosuppressive agent, reduces mechanical sensitivity in a rat mononeuropathy model. J. Pain 3, 360-368 (2002).
    • (2002) J. Pain , vol.3 , pp. 360-368
    • Sweitzer, S.M.1    DeLeo, J.A.2
  • 90
    • 33645278343 scopus 로고    scopus 로고
    • Toxicology of fluoroacetate: A review, with possible directions for therapy research
    • Goncharov, N.V., Jenkins, R.O. & Radilov, A.S. Toxicology of fluoroacetate: a review, with possible directions for therapy research. J. Appl. Toxicol. 26, 148-161 (2006).
    • (2006) J. Appl. Toxicol , vol.26 , pp. 148-161
    • Goncharov, N.V.1    Jenkins, R.O.2    Radilov, A.S.3
  • 91
    • 0032561712 scopus 로고    scopus 로고
    • Differential regulation of microglial activation by propentofylline via cAMP signaling
    • Si, Q., Nakamura, Y., Ogata, T., Kataoka, K. & Schubert, P. Differential regulation of microglial activation by propentofylline via cAMP signaling. Brain Res. 812, 97-104 (1998).
    • (1998) Brain Res , vol.812 , pp. 97-104
    • Si, Q.1    Nakamura, Y.2    Ogata, T.3    Kataoka, K.4    Schubert, P.5
  • 92
    • 11244317215 scopus 로고    scopus 로고
    • The potential of minocycline for neuroprotection in human neurologic disease
    • Zemke, D. & Majid, A. The potential of minocycline for neuroprotection in human neurologic disease. Clin. Neuropharmacol. 27, 293-298 (2004).
    • (2004) Clin. Neuropharmacol , vol.27 , pp. 293-298
    • Zemke, D.1    Majid, A.2
  • 94
    • 30744455257 scopus 로고    scopus 로고
    • Antinociceptive properties of a non-nucleotide P2X3/ P2X2/3 receptor antagonist
    • McGaraughty, S. & Jarvis, M.F. Antinociceptive properties of a non-nucleotide P2X3/ P2X2/3 receptor antagonist. Drug News Perspect. 18, 501-507 (2005).
    • (2005) Drug News Perspect , vol.18 , pp. 501-507
    • McGaraughty, S.1    Jarvis, M.F.2
  • 95
    • 34347333404 scopus 로고    scopus 로고
    • 7 receptor function and indicates a role in chronic pain states
    • 7 receptor function and indicates a role in chronic pain states. Br. J. Pharmacol. 151, 571-579 (2007).
    • (2007) Br. J. Pharmacol , vol.151 , pp. 571-579
    • Donnelly-Roberts, D.L.1    Jarvis, M.F.2
  • 96
    • 9644268887 scopus 로고    scopus 로고
    • Cannabinoid signaling in glial cells
    • Stella, N. Cannabinoid signaling in glial cells. Glia 48, 267-277 (2004).
    • (2004) Glia , vol.48 , pp. 267-277
    • Stella, N.1
  • 97
    • 20144388149 scopus 로고    scopus 로고
    • Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy
    • Valenzano, K.J. et al. Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy. Neuropharmacology 48, 658-672 (2005).
    • (2005) Neuropharmacology , vol.48 , pp. 658-672
    • Valenzano, K.J.1
  • 98
    • 33750991074 scopus 로고    scopus 로고
    • Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain
    • Milligan, E.D. et al. Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain. Pain 126, 294-308 (2006).
    • (2006) Pain , vol.126 , pp. 294-308
    • Milligan, E.D.1
  • 99
    • 0034578906 scopus 로고    scopus 로고
    • Thalidomide treatment in chronic constrictive neuropathy decreases endoneurial tumor necrosis factor-α, increases interleukin-10 and has long-term effects on spinal cord dorsal horn met-enkephalin
    • George, A., Marziniak, M., Schafers, M., Toyka, K.V. & Sommer, C. Thalidomide treatment in chronic constrictive neuropathy decreases endoneurial tumor necrosis factor-α, increases interleukin-10 and has long-term effects on spinal cord dorsal horn met-enkephalin. Pain 88, 267-275 (2000).
    • (2000) Pain , vol.88 , pp. 267-275
    • George, A.1    Marziniak, M.2    Schafers, M.3    Toyka, K.V.4    Sommer, C.5
  • 100
    • 0031884593 scopus 로고    scopus 로고
    • The effect of thalidomide treatment on vascular pathology and hyperalgesia caused by chronic constriction injury of rat nerve
    • Sommer, C., Marziniak, M. & Myers, R.R. The effect of thalidomide treatment on vascular pathology and hyperalgesia caused by chronic constriction injury of rat nerve. Pain 74, 83-91 (1998).
    • (1998) Pain , vol.74 , pp. 83-91
    • Sommer, C.1    Marziniak, M.2    Myers, R.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.