Complement induction in spinal cord microglia results in anaphylatoxin C5a-mediated pain hypersensitivity

Journal of Neuroscience

Volumn 27, Issue 32, 2007, Pages 8699-8708

  Griffin, Robert S ^a   Costigan, Michael ^a   Brenner, Gary J ^a   Ma, Chi Him Eddie ^a   Scholz, Joachim ^a   Moss, Andrew ^a   Allchorne, Andrew J ^a   Stahl, Gregory L ^b   Woolf, Clifford J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Complement cascade; Dorsal horn; Immunity; Microarray; Microglia; Neuropathic pain; Pain; Spinal cord

Indexed keywords

COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C4; COMPLEMENT COMPONENT C5 INHIBITOR; COMPLEMENT COMPONENT C5A; COMPLEMENT COMPONENT C5A RECEPTOR; COMPLEMENT COMPONENT C6;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPLEMENT DEFICIENCY; CONTROLLED STUDY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC REGULATION; GENETIC TRANSCRIPTION; MALE; MICROARRAY ANALYSIS; MICROGLIA; MOUSE; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PERIPHERAL NERVE INJURY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN INDUCTION; RAT; RECEPTOR UPREGULATION; SPINAL CORD DORSAL HORN;

ANAPHYLATOXINS; ANIMALS; CELLS, CULTURED; COMPLEMENT C5A; GENE EXPRESSION REGULATION; HYPERALGESIA; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICROGLIA; PAIN; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, COMPLEMENT; SPINAL CORD;

EID: 34547865012     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2018-07.2007     Document Type: Article

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