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Volumn 4, Issue 3, 2009, Pages 164-182

Recent patents reveal microtubules as persistent promising target for novel drug development for cancers

Author keywords

Anti tubulin drugs; Cancer; Noscapine; Patents; Taxanes; Vincas

Indexed keywords

3 HALOACETAMIDO BENZOYL ETHYL ESTER; 6 SHOGAOL; 9,10 DIDEHYDROEPOTHILONE D; \D 24851; \SC 2 71; ALKALOID DERIVATIVE; ANTINEOPLASTIC AGENT; BENZOYLPHENYLUREA DERIVATIVE; BETA TUBULIN; COLCHICINE; COMBRESTATIN A4 PHOSPHATE; CREMOPHOR; CYTOTOXIC AGENT; D 24851; DOCETAXEL; DOXORUBICIN; E 7820; EPOTHILONE B; EPOTHILONE DERIVATIVE; FLUOROURACIL; IXABEPILONE; N (3 CYANO 4 METHYL 1H INDOLE 7 YL) 3 CYANOBENZENE SULFONAMIDE; NAVELBINE; NOSCAPINE; PACLITAXEL; SC 2 71; TAXANE DERIVATIVE; THALIDOMIDE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULAR TARGETING AGENT; VINCRISTINE; VINDESINE; VINFLUNINE;

EID: 70350776966     PISSN: 1574891X     EISSN: None     Source Type: Journal    
DOI: 10.2174/157489109789318532     Document Type: Article
Times cited : (14)

References (187)
  • 1
    • 70350764573 scopus 로고    scopus 로고
    • zur Hausen H. Viral oncogenesis. Microbes and malignancy. Infection as a cause of human cancer. J Parsonnet New York: Oxford Univ Press 1999; 107-130.
    • zur Hausen H. Viral oncogenesis. Microbes and malignancy. Infection as a cause of human cancer. J Parsonnet New York: Oxford Univ Press 1999; 107-130.
  • 2
    • 44949256213 scopus 로고    scopus 로고
    • Novel human polyomaviruses-re-emergence of a well known virus family as possible human carcinogens
    • zur Hausen H. Novel human polyomaviruses-re-emergence of a well known virus family as possible human carcinogens. Int J Cancer 2008; 123: 247-250.
    • (2008) Int J Cancer , vol.123 , pp. 247-250
    • zur Hausen, H.1
  • 3
    • 59349121140 scopus 로고    scopus 로고
    • Papillomaviruses in the causation of human cancers -a brief historical account
    • zur Hausen H. Papillomaviruses in the causation of human cancers -a brief historical account. Virology 2009; 384: 260-265.
    • (2009) Virology , vol.384 , pp. 260-265
    • zur Hausen, H.1
  • 4
    • 38149091718 scopus 로고    scopus 로고
    • Evolution of robotic surgery in the treatment of localized prostate cancer
    • Zorn KC, Gofrit ON, Steinberg GD, et al. Evolution of robotic surgery in the treatment of localized prostate cancer. Curr Treat Options Oncol 2007; 8: 197-210.
    • (2007) Curr Treat Options Oncol , vol.8 , pp. 197-210
    • Zorn, K.C.1    Gofrit, O.N.2    Steinberg, G.D.3
  • 6
    • 33646582004 scopus 로고    scopus 로고
    • Video-assisted thoracic surgery - the past, present status and the future
    • Luh SP, Liu HP. Video-assisted thoracic surgery - the past, present status and the future. J Zhejiang Univ Sci B 2006; 7: 118-128.
    • (2006) J Zhejiang Univ Sci B , vol.7 , pp. 118-128
    • Luh, S.P.1    Liu, H.P.2
  • 7
    • 58149355456 scopus 로고    scopus 로고
    • Recent advances in radiation therapy
    • Gerber DE, Chan TA. Recent advances in radiation therapy. Am Fam Physician 2008; 78: 1254-1262.
    • (2008) Am Fam Physician , vol.78 , pp. 1254-1262
    • Gerber, D.E.1    Chan, T.A.2
  • 8
    • 0033052777 scopus 로고    scopus 로고
    • Mechanisms of action of and resistance to antitubulin agents: Microtubule dynamics, drug transport, and cell death
    • Dumontet C, Sikic BI. Mechanisms of action of and resistance to antitubulin agents: Microtubule dynamics, drug transport, and cell death. J Clin Oncol 1999; 17: 1061-1070.
    • (1999) J Clin Oncol , vol.17 , pp. 1061-1070
    • Dumontet, C.1    Sikic, B.I.2
  • 9
    • 0037350545 scopus 로고    scopus 로고
    • Immunotherapy: Past, present and future
    • Waldmann TA. Immunotherapy: Past, present and future. Nat Med 2003; 9: 269-277.
    • (2003) Nat Med , vol.9 , pp. 269-277
    • Waldmann, T.A.1
  • 10
    • 0015791561 scopus 로고
    • Human X mouse somatic cell hybrid clone secreting immunoglobulins of both parental types
    • Schwaber J, Cohen EP. Human X mouse somatic cell hybrid clone secreting immunoglobulins of both parental types. Nature 1973; 244: 444-447.
    • (1973) Nature , vol.244 , pp. 444-447
    • Schwaber, J.1    Cohen, E.P.2
  • 11
    • 0035524114 scopus 로고    scopus 로고
    • Improving the efficacy of antibody-based cancer therapies
    • Carter P. Improving the efficacy of antibody-based cancer therapies. Nat Rev Cancer 2001; 1: 118-129.
    • (2001) Nat Rev Cancer , vol.1 , pp. 118-129
    • Carter, P.1
  • 12
    • 17144455839 scopus 로고    scopus 로고
    • IDEC-C2B8: Results of a phase I multiple-dose trial in patients with relapsed non-Hodgkin's lymphoma
    • Maloney DG, Grillo-López AJ, Bodkin DJ, et al. IDEC-C2B8: Results of a phase I multiple-dose trial in patients with relapsed non-Hodgkin's lymphoma. J Clin Oncol 1997; 15: 3266-274.
    • (1997) J Clin Oncol , vol.15 , pp. 3266-3274
    • Maloney, D.G.1    Grillo-López, A.J.2    Bodkin, D.J.3
  • 13
    • 0242624620 scopus 로고    scopus 로고
    • Biologic and therapeutic role of HER2 in cancer
    • Ménard S, Pupa SM, Campiglio M, et al. Biologic and therapeutic role of HER2 in cancer. Oncogene 2003; 22: 6570-6578.
    • (2003) Oncogene , vol.22 , pp. 6570-6578
    • Ménard, S.1    Pupa, S.M.2    Campiglio, M.3
  • 14
    • 0242694519 scopus 로고    scopus 로고
    • HER-2-targeted therapy: Lessons learned and futuredirections
    • Nahta R, Esteva FJ. HER-2-targeted therapy: lessons learned and futuredirections. Clin Cancer Res 2003; 9: 5078-5084.
    • (2003) Clin Cancer Res , vol.9 , pp. 5078-5084
    • Nahta, R.1    Esteva, F.J.2
  • 15
    • 0028266553 scopus 로고
    • Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin 2
    • Rosenberg SA, Yang JC, Topalian SL, et al. Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin 2. JAMA 1994; 271: 907-913.
    • (1994) JAMA , vol.271 , pp. 907-913
    • Rosenberg, S.A.1    Yang, J.C.2    Topalian, S.L.3
  • 16
    • 0022525650 scopus 로고
    • Treatment of hairy cell leukemia with recombinant alpha-interferon
    • Quesada JR, Hersh EM, Manning J, et al. Treatment of hairy cell leukemia with recombinant alpha-interferon. Blood 1986; 68: 493-497.
    • (1986) Blood , vol.68 , pp. 493-497
    • Quesada, J.R.1    Hersh, E.M.2    Manning, J.3
  • 17
    • 38449104646 scopus 로고    scopus 로고
    • Cancer vaccines: A new frontier in prevention and treatment
    • Giarelli E. Cancer vaccines: A new frontier in prevention and treatment. Oncology (Williston Park) 2007; 21: 11-17.
    • (2007) Oncology (Williston Park) , vol.21 , pp. 11-17
    • Giarelli, E.1
  • 18
    • 45949108923 scopus 로고    scopus 로고
    • Cancer vaccines: Accomplishments and challenges
    • Pejawar-Gaddy S, Finn OJ. Cancer vaccines: Accomplishments and challenges. Crit Rev Oncol Hematol 2008; 67: 93-102.
    • (2008) Crit Rev Oncol Hematol , vol.67 , pp. 93-102
    • Pejawar-Gaddy, S.1    Finn, O.J.2
  • 20
    • 0030965103 scopus 로고    scopus 로고
    • Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. Taiwan Childhood Hepatoma Study Group
    • Chang MH, Chen CJ, Lai MS, et al. Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. Taiwan Childhood Hepatoma Study Group. N Engl J Med 1997; 336: 1855-1859.
    • (1997) N Engl J Med , vol.336 , pp. 1855-1859
    • Chang, M.H.1    Chen, C.J.2    Lai, M.S.3
  • 21
    • 33644698390 scopus 로고    scopus 로고
    • Recommendations of the Advisory Committee on Immunization Practices (ACIP) Part 1: Immunization of infants, children, and adolescents. A comprehensive immunization strategy to eliminate transmission of hepatitis B virus infection in the United States
    • Mast EE, Margolis HS, Fiore AE, et al. Recommendations of the Advisory Committee on Immunization Practices (ACIP) Part 1: Immunization of infants, children, and adolescents. A comprehensive immunization strategy to eliminate transmission of hepatitis B virus infection in the United States. MMWR Morb Mortal Rep Wkly 2005; 54: 1-23.
    • (2005) MMWR Morb Mortal Rep Wkly , vol.54 , pp. 1-23
    • Mast, E.E.1    Margolis, H.S.2    Fiore, A.E.3
  • 22
    • 33646421976 scopus 로고    scopus 로고
    • Prophylactic human papillomavirus vaccines
    • Lowy DR, Schiller JT. Prophylactic human papillomavirus vaccines. J Clin Invest 2006; 116: 1167-1173.
    • (2006) J Clin Invest , vol.116 , pp. 1167-1173
    • Lowy, D.R.1    Schiller, J.T.2
  • 24
    • 0037452096 scopus 로고    scopus 로고
    • Dynamics and mechanics of the microtubule plus end
    • Howard J, Hyman AA. Dynamics and mechanics of the microtubule plus end. Nature 2003; 422: 753-758.
    • (2003) Nature , vol.422 , pp. 753-758
    • Howard, J.1    Hyman, A.A.2
  • 25
    • 1942438028 scopus 로고    scopus 로고
    • Microtubules as a target for anticancer drugs
    • Jordan MA, Wilson L. Microtubules as a target for anticancer drugs. Nat Rev Cancer 2004; 4: 253-265.
    • (2004) Nat Rev Cancer , vol.4 , pp. 253-265
    • Jordan, M.A.1    Wilson, L.2
  • 26
    • 44049097644 scopus 로고    scopus 로고
    • Microtubules: A dynamic target in cancer therapy
    • Pasquier E, Kavallaris M. Microtubules: A dynamic target in cancer therapy. IUBMB Life 2008; 60: 165-170.
    • (2008) IUBMB Life , vol.60 , pp. 165-170
    • Pasquier, E.1    Kavallaris, M.2
  • 27
    • 37249020371 scopus 로고    scopus 로고
    • Anti-mitotic activity of colchicine and the structural basis for its interaction with tubulin
    • Bhattacharyya B, Panda D, Gupta S, et al. Anti-mitotic activity of colchicine and the structural basis for its interaction with tubulin. Med Res Rev 2008; 28: 155-183.
    • (2008) Med Res Rev , vol.28 , pp. 155-183
    • Bhattacharyya, B.1    Panda, D.2    Gupta, S.3
  • 28
    • 0035146128 scopus 로고    scopus 로고
    • The spindle: A dynamic assembly of microtubules and motors
    • Wittmann T, Hyman A, Desai A. The spindle: A dynamic assembly of microtubules and motors. Nat Cell Biol 2001; 3: E28-34.
    • (2001) Nat Cell Biol , vol.3
    • Wittmann, T.1    Hyman, A.2    Desai, A.3
  • 29
    • 0025887459 scopus 로고
    • Microtubule dynamics: Mechanism, regulation, and function
    • Gelfand VI, Bershadsky AD. Microtubule dynamics: Mechanism, regulation, and function. Annu Rev Cell Biol 1991; 7: 93-116.
    • (1991) Annu Rev Cell Biol , vol.7 , pp. 93-116
    • Gelfand, V.I.1    Bershadsky, A.D.2
  • 31
    • 0021711717 scopus 로고
    • Microtubule assembly nucleated by isolated centrosomes
    • Mitchison T, Kirschner M. Microtubule assembly nucleated by isolated centrosomes. Nature 1984; 312: 232-237.
    • (1984) Nature , vol.312 , pp. 232-237
    • Mitchison, T.1    Kirschner, M.2
  • 32
    • 0021686169 scopus 로고
    • Dynamic instability of microtubule growth
    • Mitchison T, Kirschner M. Dynamic instability of microtubule growth. Nature 1984; 312: 237-242.
    • (1984) Nature , vol.312 , pp. 237-242
    • Mitchison, T.1    Kirschner, M.2
  • 33
    • 0032191054 scopus 로고    scopus 로고
    • Microtubule treadmilling: What goes around comes around
    • Margolis RL, Wilson L. Microtubule treadmilling: What goes around comes around. Bioessays 1998; 20: 830-836.
    • (1998) Bioessays , vol.20 , pp. 830-836
    • Margolis, R.L.1    Wilson, L.2
  • 34
    • 0029360519 scopus 로고
    • Microtubule dynamics: Taking aim at a moving target
    • Wilson L, Jordan MA. Microtubule dynamics: Taking aim at a moving target. Chem Biol 1995; 2: 569-673.
    • (1995) Chem Biol , vol.2 , pp. 569-673
    • Wilson, L.1    Jordan, M.A.2
  • 35
    • 0023199264 scopus 로고
    • Phase dynamics at microtubule ends: The coexistence of microtubule length changes and treadmilling
    • Farrell KW, Jordan MA, Miller HP, et al. Phase dynamics at microtubule ends: The coexistence of microtubule length changes and treadmilling. J Cell Biol 1987; 104: 1035-1046.
    • (1987) J Cell Biol , vol.104 , pp. 1035-1046
    • Farrell, K.W.1    Jordan, M.A.2    Miller, H.P.3
  • 36
    • 0019782697 scopus 로고
    • Microtubule treadmills - possible molecular machinery
    • Margolis RL, Wilson L. Microtubule treadmills - possible molecular machinery. Nature 1981; 293: 705-711.
    • (1981) Nature , vol.293 , pp. 705-711
    • Margolis, R.L.1    Wilson, L.2
  • 37
    • 0023788884 scopus 로고
    • New features of microtubule behaviour observed in vivo
    • Schulze E, Kirschner M. New features of microtubule behaviour observed in vivo. Nature 1988; 334: 356-359.
    • (1988) Nature , vol.334 , pp. 356-359
    • Schulze, E.1    Kirschner, M.2
  • 38
    • 0024109183 scopus 로고
    • Cytoskeletal dynamics and nerve growth
    • Mitchison T, Kirschner M. Cytoskeletal dynamics and nerve growth. Neuron 1988; 1: 761-72.
    • (1988) Neuron , vol.1 , pp. 761-772
    • Mitchison, T.1    Kirschner, M.2
  • 39
    • 0023837441 scopus 로고
    • Polewards chromosome movement driven by microtubule depolymerization in vitro
    • Koshland DE, Mitchison TJ, Kirschner MW. Polewards chromosome movement driven by microtubule depolymerization in vitro. Nature 1988; 331: 499-504.
    • (1988) Nature , vol.331 , pp. 499-504
    • Koshland, D.E.1    Mitchison, T.J.2    Kirschner, M.W.3
  • 41
    • 0022542941 scopus 로고
    • Sites of microtubule assembly and disassembly in the mitotic spindle
    • Mitchison T, Evans L, Schulze E, et al. Sites of microtubule assembly and disassembly in the mitotic spindle. Cell 1986; 45: 515-527.
    • (1986) Cell , vol.45 , pp. 515-527
    • Mitchison, T.1    Evans, L.2    Schulze, E.3
  • 42
    • 0032495513 scopus 로고    scopus 로고
    • Structure of the α β tubulin dimer by electron crystallography
    • Nogales E, Wolf SG, Downing KH. Structure of the α β tubulin dimer by electron crystallography. Nature 1998; 391: 199-203.
    • (1998) Nature , vol.391 , pp. 199-203
    • Nogales, E.1    Wolf, S.G.2    Downing, K.H.3
  • 43
    • 0022343283 scopus 로고
    • A photoaffinity derivative of colchicine: 6′-(4′-Azido-2′-nitrophenylamino) hexanoyldeacetylcolchicine. Photolabeling and location of the colchicine-binding site on the alpha-subunit of tubulin
    • Williams RF, Mumford CL, Williams GA, et al. A photoaffinity derivative of colchicine: 6′-(4′-Azido-2′-nitrophenylamino) hexanoyldeacetylcolchicine. Photolabeling and location of the colchicine-binding site on the alpha-subunit of tubulin. J Biol Chem 1985; 260: 13794-131802.
    • (1985) J Biol Chem , vol.260 , pp. 13794-131802
    • Williams, R.F.1    Mumford, C.L.2    Williams, G.A.3
  • 44
    • 0023112960 scopus 로고
    • Photoaffinity labeling of tubulin subunits with a photoactive analogue of vinblastine
    • Safa AR, Hamel E, Felsted RL. Photoaffinity labeling of tubulin subunits with a photoactive analogue of vinblastine. Biochem 1987; 26: 97-102.
    • (1987) Biochem , vol.26 , pp. 97-102
    • Safa, A.R.1    Hamel, E.2    Felsted, R.L.3
  • 45
    • 0028708677 scopus 로고
    • Taxol (paclitaxel): Mechanisms of action
    • Horwitz SB. Taxol (paclitaxel): Mechanisms of action. Ann Oncol 1994; 5: S3-S6.
    • (1994) Ann Oncol , vol.5
    • Horwitz, S.B.1
  • 46
    • 17544366715 scopus 로고    scopus 로고
    • Localization of the vinblastine-binding site on beta-tubulin
    • Rai SS, Wolff J. Localization of the vinblastine-binding site on beta-tubulin. J Biol Chem 1996; 271: 14707-4711.
    • (1996) J Biol Chem , vol.271 , pp. 14707-14711
    • Rai, S.S.1    Wolff, J.2
  • 47
    • 0031872051 scopus 로고    scopus 로고
    • Tubulin as a target for anticancer drugs: Agents which interact with the mitotic spindle
    • Jordan A, Hadfield JA, Lawrence NJ, et al. Tubulin as a target for anticancer drugs: Agents which interact with the mitotic spindle. Med Res Rev 1998; 18: 259-296.
    • (1998) Med Res Rev , vol.18 , pp. 259-296
    • Jordan, A.1    Hadfield, J.A.2    Lawrence, N.J.3
  • 48
    • 0034844674 scopus 로고    scopus 로고
    • Physiochemical aspects of tubulin-interacting antimitotic drugs
    • Correia JJ, Lobert S. Physiochemical aspects of tubulin-interacting antimitotic drugs. Curr Pharm Des 2001; 7: 1213-1228.
    • (2001) Curr Pharm Des , vol.7 , pp. 1213-1228
    • Correia, J.J.1    Lobert, S.2
  • 49
    • 0034665163 scopus 로고    scopus 로고
    • Novel actions of the antitumor drugs vinflunine and vinorelbine on microtubules
    • Ngan VK, Bellman K, Panda D, et al. Novel actions of the antitumor drugs vinflunine and vinorelbine on microtubules. Cancer Res 2000; 60: 5045-5051.
    • (2000) Cancer Res , vol.60 , pp. 5045-5051
    • Ngan, V.K.1    Bellman, K.2    Panda, D.3
  • 50
    • 0034856849 scopus 로고    scopus 로고
    • Cryptophycins: A novel class of potent antimitotic antitumor depsipeptides
    • Shih C, Teicher BA. Cryptophycins: A novel class of potent antimitotic antitumor depsipeptides. Curr Pharm Des 2001; 7: 1259-1276.
    • (2001) Curr Pharm Des , vol.7 , pp. 1259-1276
    • Shih, C.1    Teicher, B.A.2
  • 51
    • 0034594647 scopus 로고    scopus 로고
    • Indanocine, a microtubule-binding indanone and a selective inducer of apoptosis in multidrug-resistant cancer cells
    • Leoni LM, Hamel E, Genini D, et al. Indanocine, a microtubule-binding indanone and a selective inducer of apoptosis in multidrug-resistant cancer cells. J Natl Cancer Inst 2000; 92: 217-224.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 217-224
    • Leoni, L.M.1    Hamel, E.2    Genini, D.3
  • 52
    • 0034993154 scopus 로고    scopus 로고
    • The physiological estrogen metabolite 2-methoxyestradiol reduces tumor growth and induces apoptosis in human solid tumors
    • Schumacher G, Neuhaus P. The physiological estrogen metabolite 2-methoxyestradiol reduces tumor growth and induces apoptosis in human solid tumors. J Cancer Res Clin Oncol 2001; 127: 405-410.
    • (2001) J Cancer Res Clin Oncol , vol.127 , pp. 405-410
    • Schumacher, G.1    Neuhaus, P.2
  • 53
    • 0035879010 scopus 로고    scopus 로고
    • A-204197, a new tubulin-binding agent with antimitotic activity in tumor cell lines resistant to known microtubule inhibitors
    • Tahir SK, Han EK, Credo B, et al. A-204197, a new tubulin-binding agent with antimitotic activity in tumor cell lines resistant to known microtubule inhibitors. Cancer Res 2001; 61: 5480-5485.
    • (2001) Cancer Res , vol.61 , pp. 5480-5485
    • Tahir, S.K.1    Han, E.K.2    Credo, B.3
  • 54
    • 0018387446 scopus 로고
    • Promotion of microtubule assembly in vitro by taxol
    • Schiff PB, Fant J, Horwitz SB. Promotion of microtubule assembly in vitro by taxol. Nature 1979; 277: 665-667.
    • (1979) Nature , vol.277 , pp. 665-667
    • Schiff, P.B.1    Fant, J.2    Horwitz, S.B.3
  • 55
    • 0019889058 scopus 로고
    • Taxol assembles tubulin in the absence of exogenous guanosine 5′-triphosphate or microtubule-associated proteins
    • Schiff PB, Horwitz SB. Taxol assembles tubulin in the absence of exogenous guanosine 5′-triphosphate or microtubule-associated proteins. Biochem 1981; 20: 3247-3252.
    • (1981) Biochem , vol.20 , pp. 3247-3252
    • Schiff, P.B.1    Horwitz, S.B.2
  • 56
    • 0033214537 scopus 로고    scopus 로고
    • A structural view of microtubule dynamics
    • Nogales E. A structural view of microtubule dynamics. Cell Mol Life Sci 1999; 56: 133-142.
    • (1999) Cell Mol Life Sci , vol.56 , pp. 133-142
    • Nogales, E.1
  • 57
    • 0035942226 scopus 로고    scopus 로고
    • The binding conformation of Taxol in β-tubulin: A model based on electron crystallographic density
    • Snyder JP, Nettles JH, Cornett B, et al. The binding conformation of Taxol in β-tubulin: A model based on electron crystallographic density. Proc Natl Acad Sci USA 2001; 98: 5312-5316.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5312-5316
    • Snyder, J.P.1    Nettles, J.H.2    Cornett, B.3
  • 59
    • 0020371138 scopus 로고
    • Structure-activity study of cytotoxicity and microtubule assembly in vitro by taxol and related taxanes
    • Parness J, Kingston DG, Powell RG, et al. Structure-activity study of cytotoxicity and microtubule assembly in vitro by taxol and related taxanes. Biochem Biophys Res Commun 1982; 105: 1082-1089.
    • (1982) Biochem Biophys Res Commun , vol.105 , pp. 1082-1089
    • Parness, J.1    Kingston, D.G.2    Powell, R.G.3
  • 60
    • 0031040149 scopus 로고    scopus 로고
    • The development and clinical utility of the taxane class of antimicrotubule chemotherapy agents
    • Rowinsky EK. The development and clinical utility of the taxane class of antimicrotubule chemotherapy agents. Annu Rev Med 1997; 48: 353-374.
    • (1997) Annu Rev Med , vol.48 , pp. 353-374
    • Rowinsky, E.K.1
  • 61
    • 0036301285 scopus 로고    scopus 로고
    • Cyclooxygenase-2 induction by paclitaxel, docetaxel, and taxane analogues in human monocytes and murine macrophages: Structure-activity relationships and their implications
    • Cassidy PB, Moos PJ, Kelly RC, et al. Cyclooxygenase-2 induction by paclitaxel, docetaxel, and taxane analogues in human monocytes and murine macrophages: Structure-activity relationships and their implications. Clin Cancer Res 2002; 8: 846-855.
    • (2002) Clin Cancer Res , vol.8 , pp. 846-855
    • Cassidy, P.B.1    Moos, P.J.2    Kelly, R.C.3
  • 62
    • 0026686641 scopus 로고
    • Taxol, a microtubule-stabilizing antineoplastic agent, induces expression of tumor necrosis factor alpha and interleukin-1 in macrophages
    • Bogdan C, Ding A. Taxol, a microtubule-stabilizing antineoplastic agent, induces expression of tumor necrosis factor alpha and interleukin-1 in macrophages. J Leukoc Biol 1992; 52: 119-121.
    • (1992) J Leukoc Biol , vol.52 , pp. 119-121
    • Bogdan, C.1    Ding, A.2
  • 63
    • 0032584126 scopus 로고    scopus 로고
    • Taxane-mediated gene induction is independent of microtubule stabilization: Induction of transcription regulators and enzymes that modulate inflammation and apoptosis
    • Moos PJ, Fitzpatrick FA. Taxane-mediated gene induction is independent of microtubule stabilization: Induction of transcription regulators and enzymes that modulate inflammation and apoptosis. Proc Natl Acad Sci USA 1998; 95: 3896-3901.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 3896-3901
    • Moos, P.J.1    Fitzpatrick, F.A.2
  • 64
    • 0031955204 scopus 로고    scopus 로고
    • Effects of paclitaxel on cytokine synthesis by unprimed human monocytes, T lymphocytes, and breast cancer cells
    • White CM, Martin BK, Lee LF, et al. Effects of paclitaxel on cytokine synthesis by unprimed human monocytes, T lymphocytes, and breast cancer cells. Cancer Immunol Immunother. 1998; 46: 104-112.
    • (1998) Cancer Immunol Immunother , vol.46 , pp. 104-112
    • White, C.M.1    Martin, B.K.2    Lee, L.F.3
  • 65
    • 59349117682 scopus 로고    scopus 로고
    • Paclitaxel downregulates tissue factor in cancer and host tumour-associated cells
    • Napoleone E, Zurlo F, Latella MC, et al. Paclitaxel downregulates tissue factor in cancer and host tumour-associated cells. Eur J Cancer 2009; 45: 470-477.
    • (2009) Eur J Cancer , vol.45 , pp. 470-477
    • Napoleone, E.1    Zurlo, F.2    Latella, M.C.3
  • 66
    • 0035988631 scopus 로고    scopus 로고
    • Epothilones: A novel class of non-taxane microtubule-stabilizing agents
    • Altaha R, Fojo T, Reed E, et al. Epothilones: A novel class of non-taxane microtubule-stabilizing agents. Curr Pharm Des 2002; 8: 1707-1712.
    • (2002) Curr Pharm Des , vol.8 , pp. 1707-1712
    • Altaha, R.1    Fojo, T.2    Reed, E.3
  • 67
    • 0030761586 scopus 로고    scopus 로고
    • The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells
    • Kowalski RJ, Giannakakou P, Gunasekera SP, et al. The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells. Mol Pharmacol 1997; 52: 613-622.
    • (1997) Mol Pharmacol , vol.52 , pp. 613-622
    • Kowalski, R.J.1    Giannakakou, P.2    Gunasekera, S.P.3
  • 68
    • 33644977169 scopus 로고    scopus 로고
    • Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of beta-tubulin (Asp26Glu) and less stable microtubules
    • Hari M, Loganzo F, Annable T, et al. Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of beta-tubulin (Asp26Glu) and less stable microtubules. Mol Cancer Ther 2006; 5: 270-278.
    • (2006) Mol Cancer Ther , vol.5 , pp. 270-278
    • Hari, M.1    Loganzo, F.2    Annable, T.3
  • 69
    • 38449091336 scopus 로고    scopus 로고
    • Potential clinical applications of epothilones: A review of phase II studies
    • Suppl 5, v28-34
    • Larkin JM, Kaye SB. Potential clinical applications of epothilones: a review of phase II studies. Ann Oncol 2007; 18 (Suppl 5): v28-34.
    • (2007) Ann Oncol , pp. 18
    • Larkin, J.M.1    Kaye, S.B.2
  • 70
    • 0035416117 scopus 로고    scopus 로고
    • Microtubule-stabilizing agents: A growing class of important anticancer drugs
    • Altmann KH. Microtubule-stabilizing agents: A growing class of important anticancer drugs. Curr Opin Chem Biol 2001; 5: 424-431.
    • (2001) Curr Opin Chem Biol , vol.5 , pp. 424-431
    • Altmann, K.H.1
  • 71
    • 0035889710 scopus 로고    scopus 로고
    • Novel molecules that interact with microtubules and have functional activity similar to Taxol
    • He L, Orr GA, Horwitz SB. Novel molecules that interact with microtubules and have functional activity similar to Taxol. Drug Discov Today 2001; 6: 1153-1164.
    • (2001) Drug Discov Today , vol.6 , pp. 1153-1164
    • He, L.1    Orr, G.A.2    Horwitz, S.B.3
  • 72
    • 0037444278 scopus 로고    scopus 로고
    • Dicoumarol: A unique microtubule stabilizing natural product that is synergistic with Taxol
    • Madari H, Panda D, Wilson L, et al. Dicoumarol: A unique microtubule stabilizing natural product that is synergistic with Taxol. Cancer Res 2003; 63: 1214-1220.
    • (2003) Cancer Res , vol.63 , pp. 1214-1220
    • Madari, H.1    Panda, D.2    Wilson, L.3
  • 73
    • 18444400213 scopus 로고    scopus 로고
    • The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity
    • Pryor DE, O'Brate A, Bilcer G, et al. The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity. Biochem 2002; 41: 9109-9115.
    • (2002) Biochem , vol.41 , pp. 9109-9115
    • Pryor, D.E.1    O'Brate, A.2    Bilcer, G.3
  • 74
    • 0037096807 scopus 로고    scopus 로고
    • Peloruside A, a novel antimitotic agent with paclitaxel-like microtubule-stabilizing activity
    • Hood KA, West LM, Rouwé B, et al. Peloruside A, a novel antimitotic agent with paclitaxel-like microtubule-stabilizing activity. Cancer Res 2002; 62: 3356-3360.
    • (2002) Cancer Res , vol.62 , pp. 3356-3360
    • Hood, K.A.1    West, L.M.2    Rouwé, B.3
  • 75
    • 0028113390 scopus 로고
    • Microtubule dynamics in vitro are regulated by the tubulin isotype composition
    • Panda D, Miller HP, Banerjee A, et al. Microtubule dynamics in vitro are regulated by the tubulin isotype composition. Proc Natl Acad Sci USA 1994; 91: 11358-11362.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 11358-11362
    • Panda, D.1    Miller, H.P.2    Banerjee, A.3
  • 76
    • 0027228024 scopus 로고
    • Clinical toxicities encountered with paclitaxel (Taxol)
    • Rowinsky EK, Eisenhauer EA, Chaudhry V, et al. Clinical toxicities encountered with paclitaxel (Taxol). Semin Oncol 1993; 20: 1-15.
    • (1993) Semin Oncol , vol.20 , pp. 1-15
    • Rowinsky, E.K.1    Eisenhauer, E.A.2    Chaudhry, V.3
  • 78
    • 0031859489 scopus 로고    scopus 로고
    • Oral chemotherapy: Rationale and future directions
    • DeMario MD, Ratain MJ. Oral chemotherapy: Rationale and future directions. J Clin Oncol 1998; 16: 2557-2567.
    • (1998) J Clin Oncol , vol.16 , pp. 2557-2567
    • DeMario, M.D.1    Ratain, M.J.2
  • 79
    • 3543039989 scopus 로고    scopus 로고
    • Efficacy of novel P-glycoprotein inhibitors to increase the oral uptake of paclitaxel in mice
    • Bardelmeijer HA, Ouwehand M, Beijnen JH, et al. Efficacy of novel P-glycoprotein inhibitors to increase the oral uptake of paclitaxel in mice. Invest New Drugs 2004; 22: 219-229.
    • (2004) Invest New Drugs , vol.22 , pp. 219-229
    • Bardelmeijer, H.A.1    Ouwehand, M.2    Beijnen, J.H.3
  • 80
    • 8044220286 scopus 로고    scopus 로고
    • Pharmacokinetics of paclitaxel and carboplatin in a dose-escalating and dose-sequencing study in patients with non-small-cell lung cancer
    • Huizing MT, Giaccone G, van Warmerdam LJ, et al. Pharmacokinetics of paclitaxel and carboplatin in a dose-escalating and dose-sequencing study in patients with non-small-cell lung cancer. J Clin Oncol 1997; 15: 317-329.
    • (1997) J Clin Oncol , vol.15 , pp. 317-329
    • Huizing, M.T.1    Giaccone, G.2    van Warmerdam, L.J.3
  • 81
    • 0033708071 scopus 로고    scopus 로고
    • Modulation of oral bioavailability of anticancer drugs: From mouse to man
    • Schellens JH, Malingré MM, Kruijtzer CM, et al. Modulation of oral bioavailability of anticancer drugs: From mouse to man. Eur J Pharm Sci 2000; 12: 103-110.
    • (2000) Eur J Pharm Sci , vol.12 , pp. 103-110
    • Schellens, J.H.1    Malingré, M.M.2    Kruijtzer, C.M.3
  • 82
    • 9844250206 scopus 로고    scopus 로고
    • The bioavailability of oral GI147211 (GG211), a new topoisomerase I inhibitor
    • Gerrits CJ, Schellens JH, Creemers GJ, et al. The bioavailability of oral GI147211 (GG211), a new topoisomerase I inhibitor. Br J Cancer 1997; 76: 946-951.
    • (1997) Br J Cancer , vol.76 , pp. 946-951
    • Gerrits, C.J.1    Schellens, J.H.2    Creemers, G.J.3
  • 83
    • 12644278301 scopus 로고    scopus 로고
    • Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine
    • Sparreboom A, van Asperen J, Mayer U, et al. Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine. Proc Natl Acad Sci USA 1997; 94: 2031-2035.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2031-2035
    • Sparreboom, A.1    van Asperen, J.2    Mayer, U.3
  • 84
    • 0042233662 scopus 로고    scopus 로고
    • Microtubule-interacting drugs for cancer treatment
    • Checchi PM, Nettles JH, Zhou J, et al. Microtubule-interacting drugs for cancer treatment. Trends Pharmacol Sci 2003; 24: 361-365.
    • (2003) Trends Pharmacol Sci , vol.24 , pp. 361-365
    • Checchi, P.M.1    Nettles, J.H.2    Zhou, J.3
  • 85
    • 0027360552 scopus 로고
    • Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations
    • Jordan MA, Toso RJ, Thrower D, et al. Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations. Proc Natl Acad Sci USA 1993; 90: 9552-9556.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 9552-9556
    • Jordan, M.A.1    Toso, R.J.2    Thrower, D.3
  • 86
    • 29244460132 scopus 로고    scopus 로고
    • Resistance to microtubule-stabilizing drugs involves two events: β-tubulin mutation in one allele followed by loss of the second allele
    • Wang Y, O'Brate A, Zhou W, et al. Resistance to microtubule-stabilizing drugs involves two events: β-tubulin mutation in one allele followed by loss of the second allele. Cell Cycle 2005; 4: 1847-1853.
    • (2005) Cell Cycle , vol.4 , pp. 1847-1853
    • Wang, Y.1    O'Brate, A.2    Zhou, W.3
  • 87
    • 0036727801 scopus 로고    scopus 로고
    • Microtubule alterations and resistance to tubulin-binding agents (review)
    • Drukman S, Kavallaris M. Microtubule alterations and resistance to tubulin-binding agents (review). Int J Oncol 2002; 21: 621-628.
    • (2002) Int J Oncol , vol.21 , pp. 621-628
    • Drukman, S.1    Kavallaris, M.2
  • 88
    • 0033799839 scopus 로고    scopus 로고
    • Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs
    • Krishna R, Mayer LD. Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs. Eur J Pharm Sci 2000; 11: 265-283.
    • (2000) Eur J Pharm Sci , vol.11 , pp. 265-283
    • Krishna, R.1    Mayer, L.D.2
  • 89
    • 0037373889 scopus 로고    scopus 로고
    • Suppression of intestinal polyposis in Mdr1-deficient ApcMin/+ mice
    • Yamada T, Mori Y, Hayashi R, et al. Suppression of intestinal polyposis in Mdr1-deficient ApcMin/+ mice. Cancer Res 2003; 63: 895-901.
    • (2003) Cancer Res , vol.63 , pp. 895-901
    • Yamada, T.1    Mori, Y.2    Hayashi, R.3
  • 90
    • 0037380839 scopus 로고    scopus 로고
    • Small interfering RNA-induced suppression of MDR1 (P-glycoprotein) restores sensitivity to multidrug-resistant cancer cells
    • Wu H, Hait WN, Yang JM. Small interfering RNA-induced suppression of MDR1 (P-glycoprotein) restores sensitivity to multidrug-resistant cancer cells. Cancer Res 2003; 63: 1515-1519.
    • (2003) Cancer Res , vol.63 , pp. 1515-1519
    • Wu, H.1    Hait, W.N.2    Yang, J.M.3
  • 91
    • 12944277104 scopus 로고    scopus 로고
    • A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells
    • Giannakakou P, Gussio R, Nogales E, et al. A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells. Proc Natl Acad Sci USA 2000; 97: 2904-2409.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 2904-2409
    • Giannakakou, P.1    Gussio, R.2    Nogales, E.3
  • 92
    • 0020974109 scopus 로고
    • Tubulin isotypes and the multigene tubulin families
    • Cowan NJ, Dudley L. Tubulin isotypes and the multigene tubulin families. Int Rev Cytol 1983; 85: 147-173.
    • (1983) Int Rev Cytol , vol.85 , pp. 147-173
    • Cowan, N.J.1    Dudley, L.2
  • 93
    • 0025082006 scopus 로고
    • Diversity among tubulin subunits: Toward what functional end?
    • Joshi HC, Cleveland DW. Diversity among tubulin subunits: Toward what functional end? Cell Motil Cytoskeleton 1990; 16: 159-163.
    • (1990) Cell Motil Cytoskeleton , vol.16 , pp. 159-163
    • Joshi, H.C.1    Cleveland, D.W.2
  • 94
    • 0031978187 scopus 로고    scopus 로고
    • Preparation of a monoclonal antibody specific for the class I isotype of beta-tubulin: The beta isotypes of tubulin differ in their cellular distributions within human tissues
    • Roach MC, Boucher VL, Walss C, et al. Preparation of a monoclonal antibody specific for the class I isotype of beta-tubulin: The beta isotypes of tubulin differ in their cellular distributions within human tissues. Cell Motil Cytoskeleton 1998; 39: 273-285.
    • (1998) Cell Motil Cytoskeleton , vol.39 , pp. 273-285
    • Roach, M.C.1    Boucher, V.L.2    Walss, C.3
  • 95
    • 0035951505 scopus 로고    scopus 로고
    • The role of beta-tubulin isotypes in resistance to antimitotic drugs
    • Burkhart CA, Kavallaris M, Band Horwitz S. The role of beta-tubulin isotypes in resistance to antimitotic drugs. Biochim Biophys Acta 2001; 1471: 1-9.
    • (2001) Biochim Biophys Acta , vol.1471 , pp. 1-9
    • Burkhart, C.A.1    Kavallaris, M.2    Band Horwitz, S.3
  • 96
    • 0035422780 scopus 로고    scopus 로고
    • Multiple microtubule alterations are associated with Vinca alkaloid resistance in human leukemia cells
    • Kavallaris M, Tait AS, Walsh BJ, et al. Multiple microtubule alterations are associated with Vinca alkaloid resistance in human leukemia cells. Cancer Res 2001; 61: 5803-5809.
    • (2001) Cancer Res , vol.61 , pp. 5803-5809
    • Kavallaris, M.1    Tait, A.S.2    Walsh, B.J.3
  • 97
    • 0030012140 scopus 로고    scopus 로고
    • Severe vincristine neuropathy in Charcot-Marie-Tooth disease type 1A
    • Graf WD, Chance PF, Lensch MW, et al. Severe vincristine neuropathy in Charcot-Marie-Tooth disease type 1A. Cancer 1996; 77: 1356-1362.
    • (1996) Cancer , vol.77 , pp. 1356-1362
    • Graf, W.D.1    Chance, P.F.2    Lensch, M.W.3
  • 99
    • 33947311186 scopus 로고    scopus 로고
    • The synergistic effect of dimethylamino benzoylphenylurea (NSC #639829) and X-irradiation on human lung carcinoma cell lines
    • Balcer-Kubiczek EK, Attarpour M, Edelman MJ. The synergistic effect of dimethylamino benzoylphenylurea (NSC #639829) and X-irradiation on human lung carcinoma cell lines. Cancer Chemother Pharmacol 2007; 59: 781-787.
    • (2007) Cancer Chemother Pharmacol , vol.59 , pp. 781-787
    • Balcer-Kubiczek, E.K.1    Attarpour, M.2    Edelman, M.J.3
  • 100
    • 33645693801 scopus 로고    scopus 로고
    • Benzoylphenylurea sulfur analogues with potent antitumor activity
    • Hallur G, Jimeno A, Dalrymple S, et al. Benzoylphenylurea sulfur analogues with potent antitumor activity. J Med Chem 2006; 49: 2357-2360.
    • (2006) J Med Chem , vol.49 , pp. 2357-2360
    • Hallur, G.1    Jimeno, A.2    Dalrymple, S.3
  • 101
    • 33645699183 scopus 로고    scopus 로고
    • Efficacy of novel BPU analogs in in vitro and in novel in vivo pancreas cancer models, and its relationship with microtubule associated protein tau (MAPT)
    • Philadelphia, USA, November
    • Jimeno A, Hallur G, Chan A, et al. Efficacy of novel BPU analogs in in vitro and in novel in vivo pancreas cancer models, and its relationship with microtubule associated protein tau (MAPT). AACR-NCI-EORTC International Conference. Philadelphia, USA, November 2005.
    • (2005) AACR-NCI-EORTC International Conference
    • Jimeno, A.1    Hallur, G.2    Chan, A.3
  • 102
    • 70350764474 scopus 로고    scopus 로고
    • Desai, N.P., Soon-Shiong, P.: WO2008150532A1 (2008).
    • Desai, N.P., Soon-Shiong, P.: WO2008150532A1 (2008).
  • 103
    • 42649132499 scopus 로고    scopus 로고
    • Protein nanoparticles as drug carriers in clinical medicine
    • Hawkins MJ, Soon-Shiong P, Desai N. Protein nanoparticles as drug carriers in clinical medicine. Adv Drug Deliv Rev 2008; 60: 876-885.
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 876-885
    • Hawkins, M.J.1    Soon-Shiong, P.2    Desai, N.3
  • 108
    • 70350757298 scopus 로고    scopus 로고
    • Desai, N.P., Tao, C., Yang, A., Louie, L., Zheng, T., Yao, Z., Soon-Shiong, P., Magdassi, S.: WO98014174A1 (1998).
    • Desai, N.P., Tao, C., Yang, A., Louie, L., Zheng, T., Yao, Z., Soon-Shiong, P., Magdassi, S.: WO98014174A1 (1998).
  • 109
    • 70350783508 scopus 로고    scopus 로고
    • Desai, N.P., Soon-Shiong, P., Magdassi, S., Sahadevan, D.C.: WO99000113A1 (1999).
    • Desai, N.P., Soon-Shiong, P., Magdassi, S., Sahadevan, D.C.: WO99000113A1 (1999).
  • 110
    • 70350773703 scopus 로고    scopus 로고
    • De, T., DesaiI, N.P., Yang, A., Yim, Z., Soon-Shiong, P.: WO2007027941A2 (2007).
    • De, T., DesaiI, N.P., Yang, A., Yim, Z., Soon-Shiong, P.: WO2007027941A2 (2007).
  • 111
    • 70350783604 scopus 로고    scopus 로고
    • DesaiI, N.P., Selvraj, R., Yang, A., Soon-Shiong, P.: WO2007027819A2 (2007).
    • DesaiI, N.P., Selvraj, R., Yang, A., Soon-Shiong, P.: WO2007027819A2 (2007).
  • 112
    • 30444457035 scopus 로고    scopus 로고
    • Abraxane in the treatment of ovarian cancer: The absence of hypersensitivity reactions
    • Micha JP, Goldstein BH, Birk CL, et al. Abraxane in the treatment of ovarian cancer: The absence of hypersensitivity reactions. Gynecol Oncol 2006; 100: 437-438.
    • (2006) Gynecol Oncol , vol.100 , pp. 437-438
    • Micha, J.P.1    Goldstein, B.H.2    Birk, C.L.3
  • 113
    • 0036096946 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of ABI-007, a Cremophor-free, protein-stabilized, nano-particle formulation of paclitaxel
    • Ibrahim NK, Desai N, Legha S, et al. Phase I and pharmacokinetic study of ABI-007, a Cremophor-free, protein-stabilized, nano-particle formulation of paclitaxel. Clin Cancer Res 2002; 8: 1038-1044.
    • (2002) Clin Cancer Res , vol.8 , pp. 1038-1044
    • Ibrahim, N.K.1    Desai, N.2    Legha, S.3
  • 114
    • 24944505659 scopus 로고    scopus 로고
    • Multicenter phase II trial of ABI-007, an albumin-bound paclitaxel, in women with metastatic breast cancer
    • Ibrahim NK, Samuels B, Page R, et al. Multicenter phase II trial of ABI-007, an albumin-bound paclitaxel, in women with metastatic breast cancer. J Clin Oncol 2005; 23: 6019-26.
    • (2005) J Clin Oncol , vol.23 , pp. 6019-6026
    • Ibrahim, N.K.1    Samuels, B.2    Page, R.3
  • 115
    • 32944482677 scopus 로고    scopus 로고
    • Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer
    • Gradishar WJ, Tjulandin S, Davidson N, et al. Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer. J Clin Oncol 2005; 23: 7794-7803.
    • (2005) J Clin Oncol , vol.23 , pp. 7794-7803
    • Gradishar, W.J.1    Tjulandin, S.2    Davidson, N.3
  • 116
    • 70350759399 scopus 로고    scopus 로고
    • Ishiguro, K., Gotoh, H., Andoh, T.: WO2008139952A1 (2008).
    • Ishiguro, K., Gotoh, H., Andoh, T.: WO2008139952A1 (2008).
  • 117
    • 53049095924 scopus 로고    scopus 로고
    • Specific reaction of alpha, beta-unsaturated carbonyl compounds such as 6-shogaol with sulfhydryl groups in tubulin leading to microtubule damage
    • Ishiguro K, Ando T, Watanabe O, et al. Specific reaction of alpha, beta-unsaturated carbonyl compounds such as 6-shogaol with sulfhydryl groups in tubulin leading to microtubule damage. FEBS Lett 2008; 582: 3531-3536.
    • (2008) FEBS Lett , vol.582 , pp. 3531-3536
    • Ishiguro, K.1    Ando, T.2    Watanabe, O.3
  • 118
    • 34548103599 scopus 로고    scopus 로고
    • Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms
    • Ishiguro K, Ando T, Maeda O, et al. Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms. Biochem Biophys Res Commun 2007; 362: 218-23.
    • (2007) Biochem Biophys Res Commun , vol.362 , pp. 218-223
    • Ishiguro, K.1    Ando, T.2    Maeda, O.3
  • 120
    • 0036083301 scopus 로고    scopus 로고
    • Mechanism of action of antitumor drugs that interact with microtubules and tubulin
    • Jordan MA. Mechanism of action of antitumor drugs that interact with microtubules and tubulin. Curr Med Chem Anticancer Agents 2002; 2: 1-17.
    • (2002) Curr Med Chem Anticancer Agents , vol.2 , pp. 1-17
    • Jordan, M.A.1
  • 121
    • 0037382060 scopus 로고    scopus 로고
    • Novel 2-methoxyestradiol analogues with antitumor activity
    • Tinley TL, Leal RM, Randall-Hlubek DA, et al. Novel 2-methoxyestradiol analogues with antitumor activity. Cancer Res 2003; 63: 1538-1549.
    • (2003) Cancer Res , vol.63 , pp. 1538-1549
    • Tinley, T.L.1    Leal, R.M.2    Randall-Hlubek, D.A.3
  • 122
    • 70350764473 scopus 로고    scopus 로고
    • The effect of a novel thalidomide analog, SC-2-71, on caspase activity in human bone endothelial cells
    • abstract 1349
    • Pruitt III FL, Evans A, Lynch JE, et al. The effect of a novel thalidomide analog, SC-2-71, on caspase activity in human bone endothelial cells. Proc Am Assoc Cancer Res 2006; 47: abstract 1349.
    • (2006) Proc Am Assoc Cancer Res , vol.47
    • Pruitt III, F.L.1    Evans, A.2    Lynch, J.E.3
  • 123
    • 70350745824 scopus 로고    scopus 로고
    • Martin, S., Whipple, R.: WO2007104011A2 (2007).
    • Martin, S., Whipple, R.: WO2007104011A2 (2007).
  • 124
    • 0028057613 scopus 로고
    • Disruption of epithelial cell-matrix interactions induces apoptosis
    • Frisch SM, Francis H. Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 1994; 124: 619-626.
    • (1994) J Cell Biol , vol.124 , pp. 619-626
    • Frisch, S.M.1    Francis, H.2
  • 125
    • 0029977947 scopus 로고    scopus 로고
    • Modulation of anchorage independent growth and experimental metastasis
    • Nikiforov MA, Hagen K, Ossovskaya VS, et al. Modulation of anchorage independent growth and experimental metastasis. Oncogene 1996; 13: 1709-1719.
    • (1996) Oncogene , vol.13 , pp. 1709-1719
    • Nikiforov, M.A.1    Hagen, K.2    Ossovskaya, V.S.3
  • 126
    • 0031577702 scopus 로고    scopus 로고
    • Suppression of apoptosis by bcl-2 does not prevent p53-mediated control of experimental metastasis and anchorage dependence
    • Nikiforov MA, Kwek SS, Mehta R, et al. Suppression of apoptosis by bcl-2 does not prevent p53-mediated control of experimental metastasis and anchorage dependence. Oncogene 1997; 15: 3007-3012.
    • (1997) Oncogene , vol.15 , pp. 3007-3012
    • Nikiforov, M.A.1    Kwek, S.S.2    Mehta, R.3
  • 127
    • 4043102579 scopus 로고    scopus 로고
    • Integrity of actin fibers and microtubules influences metastatic tumor cell adhesion
    • Korb T, Schlüter K, Enns A, et al. Integrity of actin fibers and microtubules influences metastatic tumor cell adhesion. Exp Cell Res 2004; 299: 236-247.
    • (2004) Exp Cell Res , vol.299 , pp. 236-247
    • Korb, T.1    Schlüter, K.2    Enns, A.3
  • 129
    • 0033287155 scopus 로고    scopus 로고
    • Novel suicide ligands of tubulin arrest cancer cells in S-phase
    • Davis A, Jiang JD, Middleton KM, et al. Novel suicide ligands of tubulin arrest cancer cells in S-phase. Neoplasia 1999; 1: 498-507.
    • (1999) Neoplasia , vol.1 , pp. 498-507
    • Davis, A.1    Jiang, J.D.2    Middleton, K.M.3
  • 130
    • 13044294012 scopus 로고    scopus 로고
    • Selective, covalent modification of beta-tubulin residue Cys-239 by T138067, an antitumor agent with in vivo efficacy against multidrug-resistant tumors
    • Shan B, Medina JC, Santha E, et al. Selective, covalent modification of beta-tubulin residue Cys-239 by T138067, an antitumor agent with in vivo efficacy against multidrug-resistant tumors. Proc Natl Acad Sci USA 1999; 96: 5686-5691.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 5686-5691
    • Shan, B.1    Medina, J.C.2    Santha, E.3
  • 131
    • 0036828201 scopus 로고    scopus 로고
    • Double blockade of cell cycle at G(1)-S transition and M phase by 3-iodoacetamido benzoyl ethyl ester, a new type of tubulin ligand
    • Jiang JD, Denner L, Ling YH, et al. Double blockade of cell cycle at G(1)-S transition and M phase by 3-iodoacetamido benzoyl ethyl ester, a new type of tubulin ligand. Cancer Res 2002; 62: 6080-6088.
    • (2002) Cancer Res , vol.62 , pp. 6080-6088
    • Jiang, J.D.1    Denner, L.2    Ling, Y.H.3
  • 132
    • 0030924052 scopus 로고    scopus 로고
    • Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein
    • Dey S, Ramachandra M, Pastan I, et al. Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein. Proc Natl Acad Sci USA 1997; 94: 10594-10599.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 10594-10599
    • Dey, S.1    Ramachandra, M.2    Pastan, I.3
  • 133
    • 0028086183 scopus 로고
    • Metastasis-associated mts1 gene expression correlates with increased p53 detection in the B16 murine melanoma
    • Parker C, Lakshmi MS, Piura B, et al. Metastasis-associated mts1 gene expression correlates with increased p53 detection in the B16 murine melanoma. DNA Cell Biol 1994; 13: 343-351.
    • (1994) DNA Cell Biol , vol.13 , pp. 343-351
    • Parker, C.1    Lakshmi, M.S.2    Piura, B.3
  • 134
    • 0037085753 scopus 로고    scopus 로고
    • The tumor vascular targeting agent combretastatin A-4-phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing in human endothelial cells
    • Kanthou C, Tozer GM. The tumor vascular targeting agent combretastatin A-4-phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing in human endothelial cells. Blood 2002; 99: 2060-2069.
    • (2002) Blood , vol.99 , pp. 2060-2069
    • Kanthou, C.1    Tozer, G.M.2
  • 136
    • 33845758418 scopus 로고    scopus 로고
    • Combretastatin CA-4 and combretastatin derivative induce mitotic catastrophe dependent on spindle checkpoint and caspase-3 activation in non-small cell lung cancer cells
    • Vitale I, Antoccia A, Cenciarelli C, et al. Combretastatin CA-4 and combretastatin derivative induce mitotic catastrophe dependent on spindle checkpoint and caspase-3 activation in non-small cell lung cancer cells. Apoptosis 2007; 12: 155-166.
    • (2007) Apoptosis , vol.12 , pp. 155-166
    • Vitale, I.1    Antoccia, A.2    Cenciarelli, C.3
  • 138
    • 0032950870 scopus 로고    scopus 로고
    • Anti-vascular approaches to solid tumour therapy: Evaluation of combretastatin A4 phosphate
    • Chaplin DJ, Pettit GR, Hill SA. Anti-vascular approaches to solid tumour therapy: Evaluation of combretastatin A4 phosphate. Anticancer Res 1999; 19: 189-195.
    • (1999) Anticancer Res , vol.19 , pp. 189-195
    • Chaplin, D.J.1    Pettit, G.R.2    Hill, S.A.3
  • 139
    • 0033119771 scopus 로고    scopus 로고
    • Combretastatin A-4 phosphate as a tumor vascular-targeting agent: Early effects in tumors and normal tissues
    • Tozer GM, Prise VE, Wilson J, et al. Combretastatin A-4 phosphate as a tumor vascular-targeting agent: Early effects in tumors and normal tissues. Cancer Res 1999; 59: 1626-1634.
    • (1999) Cancer Res , vol.59 , pp. 1626-1634
    • Tozer, G.M.1    Prise, V.E.2    Wilson, J.3
  • 140
    • 0031980124 scopus 로고    scopus 로고
    • Antineoplastic agents 389. New syntheses of the combretastatin A-4 prodrug
    • Pettit GR, Rhodes MR. Antineoplastic agents 389. New syntheses of the combretastatin A-4 prodrug. Anticancer Drug Des 1998; 13: 183-191.
    • (1998) Anticancer Drug Des , vol.13 , pp. 183-191
    • Pettit, G.R.1    Rhodes, M.R.2
  • 141
    • 0032532391 scopus 로고    scopus 로고
    • Induction of apoptosis in proliferating human endothelial cells by the tumor-specific antiangiogenesis agent combretastatin A-4
    • Iyer S, Chaplin DJ, Rosenthal DS, et al. Induction of apoptosis in proliferating human endothelial cells by the tumor-specific antiangiogenesis agent combretastatin A-4. Cancer Res 1998; 58: 4510-4514.
    • (1998) Cancer Res , vol.58 , pp. 4510-4514
    • Iyer, S.1    Chaplin, D.J.2    Rosenthal, D.S.3
  • 142
    • 0030951899 scopus 로고    scopus 로고
    • Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature
    • Dark GG, Hill SA, Prise VE, et al. Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature. Cancer Res 1997; 57: 1829-1834.
    • (1997) Cancer Res , vol.57 , pp. 1829-1834
    • Dark, G.G.1    Hill, S.A.2    Prise, V.E.3
  • 143
    • 70350768846 scopus 로고    scopus 로고
    • US5561122
    • George, R.P.: US5561122 (1996).
    • (1996)
    • George, R.P.1
  • 144
    • 1842607060 scopus 로고    scopus 로고
    • Combretastatin A4 phosphate
    • West CM, Price P. Combretastatin A4 phosphate. Anticancer Drugs 2004; 15: 179-187.
    • (2004) Anticancer Drugs , vol.15 , pp. 179-187
    • West, C.M.1    Price, P.2
  • 145
    • 41349118110 scopus 로고    scopus 로고
    • The microtubule-targeting agent CA4P regresses leukemic xenografts by disrupting interaction with vascular cells and mitochondrial-dependent cell death
    • Petit I, Karajannis MA, Vincent L, et al. The microtubule-targeting agent CA4P regresses leukemic xenografts by disrupting interaction with vascular cells and mitochondrial-dependent cell death. Blood 2008; 111: 1951-1961.
    • (2008) Blood , vol.111 , pp. 1951-1961
    • Petit, I.1    Karajannis, M.A.2    Vincent, L.3
  • 146
    • 12444259666 scopus 로고    scopus 로고
    • Synthesis, in vitro, and in vivo evaluation of phosphate ester derivatives of combretastatin A-4
    • Hadimani MB, Hua J, Jonklaas MD, et al. Synthesis, in vitro, and in vivo evaluation of phosphate ester derivatives of combretastatin A-4. Bioorg Med Chem Lett 2003; 13: 1505-1508.
    • (2003) Bioorg Med Chem Lett , vol.13 , pp. 1505-1508
    • Hadimani, M.B.1    Hua, J.2    Jonklaas, M.D.3
  • 147
    • 0037115398 scopus 로고    scopus 로고
    • ZD6126: A novel vascular-targeting agent that causes selective destruction of tumor vasculature
    • Davis PD, Dougherty GJ, Blakey DC, et al. ZD6126: A novel vascular-targeting agent that causes selective destruction of tumor vasculature. Cancer Res 2002; 62: 7247-7253.
    • (2002) Cancer Res , vol.62 , pp. 7247-7253
    • Davis, P.D.1    Dougherty, G.J.2    Blakey, D.C.3
  • 148
    • 38149029566 scopus 로고    scopus 로고
    • Early quantitative evaluation of a tumor vasculature disruptive agent AVE8062 using dynamic contrast-enhanced ultrasonography
    • Lavisse S, Lejeune P, Rouffiac V, et al. Early quantitative evaluation of a tumor vasculature disruptive agent AVE8062 using dynamic contrast-enhanced ultrasonography. Invest Radiol 2008; 43: 100-111.
    • (2008) Invest Radiol , vol.43 , pp. 100-111
    • Lavisse, S.1    Lejeune, P.2    Rouffiac, V.3
  • 154
    • 0030591653 scopus 로고    scopus 로고
    • Mutagenic damage to mammalian cells by therapeutic alkylating agents
    • Sanderson BJ, Shield AJ. Mutagenic damage to mammalian cells by therapeutic alkylating agents. Mutat Res 1996; 355: 41-57.
    • (1996) Mutat Res , vol.355 , pp. 41-57
    • Sanderson, B.J.1    Shield, A.J.2
  • 155
    • 70350779825 scopus 로고    scopus 로고
    • Papadopoulos, P., Doty, M., Kipp, J.E., Roessler, B.: WO2006052712A1 (2006).
    • Papadopoulos, P., Doty, M., Kipp, J.E., Roessler, B.: WO2006052712A1 (2006).
  • 156
    • 58249112739 scopus 로고    scopus 로고
    • Wienecke A, Bacher G. Indibulin, a novel microtubule inhibitor, discriminates between mature neuronal and nonneuronal tubulin. Cancer Res 2009; 69: 171-177.
    • Wienecke A, Bacher G. Indibulin, a novel microtubule inhibitor, discriminates between mature neuronal and nonneuronal tubulin. Cancer Res 2009; 69: 171-177.
  • 160
    • 0035133804 scopus 로고    scopus 로고
    • D-24851, a novel synthetic microtubule inhibitor, exerts curative antitumoral activity in vivo, shows efficacy toward multidrug-resistant tumor cells, and lacks neurotoxicity
    • Bacher G, Nickel B, Emig P, et al. D-24851, a novel synthetic microtubule inhibitor, exerts curative antitumoral activity in vivo, shows efficacy toward multidrug-resistant tumor cells, and lacks neurotoxicity. Cancer Res 2001; 61: 392-399.
    • (2001) Cancer Res , vol.61 , pp. 392-399
    • Bacher, G.1    Nickel, B.2    Emig, P.3
  • 161
    • 77952237860 scopus 로고    scopus 로고
    • Dose-finding and pharmacokinetic study of orally administered indibulin (D-24851) to patients with advanced solid tumors
    • Oostendorp RL, Witteveen PO, Schwartz B, et al. Dose-finding and pharmacokinetic study of orally administered indibulin (D-24851) to patients with advanced solid tumors. Invest New Drugs 2009.
    • (2009) Invest New Drugs
    • Oostendorp, R.L.1    Witteveen, P.O.2    Schwartz, B.3
  • 163
    • 70350776116 scopus 로고    scopus 로고
    • Haneda, T., Tsurukova, A., Kamata, J., Okabe, T., Takahashi, K., Nara, K., Hamoka, S., Ueda, N., Ohwa, T., Wakabayashi, T., Funahashi, Y., Semba, T., Hata, N., Yamamoto, Y., Ozawa, Y., Tsukahara, N.: WO0050395A1 (2000).
    • Haneda, T., Tsurukova, A., Kamata, J., Okabe, T., Takahashi, K., Nara, K., Hamoka, S., Ueda, N., Ohwa, T., Wakabayashi, T., Funahashi, Y., Semba, T., Hata, N., Yamamoto, Y., Ozawa, Y., Tsukahara, N.: WO0050395A1 (2000).
  • 164
    • 8444240000 scopus 로고    scopus 로고
    • Therapeutic synergy of oral taxane BMS-275183 and cetuximab versus human tumor xenografts
    • Rose WC, Wild R. Therapeutic synergy of oral taxane BMS-275183 and cetuximab versus human tumor xenografts. Clin Cancer Res 2004; 10: 7413-7417.
    • (2004) Clin Cancer Res , vol.10 , pp. 7413-7417
    • Rose, W.C.1    Wild, R.2
  • 165
    • 28944442712 scopus 로고    scopus 로고
    • Gemcitabine plus docetaxel: A new treatment option for anthracycline pretreated metastatic breast cancer patients?
    • Levy C, Fumoleau P. Gemcitabine plus docetaxel: A new treatment option for anthracycline pretreated metastatic breast cancer patients? Cancer Treat Rev 2005; 31: S17-22.
    • (2005) Cancer Treat Rev , vol.31
    • Levy, C.1    Fumoleau, P.2
  • 167
    • 0027954377 scopus 로고
    • Purification and characterization of platelet aggregation inhibitors from snake venoms
    • Trikha M, Rote WE, Manley PJ, et al. Purification and characterization of platelet aggregation inhibitors from snake venoms. Thromb Res 1994; 73: 39-52.
    • (1994) Thromb Res , vol.73 , pp. 39-52
    • Trikha, M.1    Rote, W.E.2    Manley, P.J.3
  • 168
    • 38449122195 scopus 로고    scopus 로고
    • Anti-angiogenesis and RGD-containing snake venom disintegrins
    • Swenson S, Ramu S, Markland FS. Anti-angiogenesis and RGD-containing snake venom disintegrins. Curr Pharm Des 2007; 13: 2860-2871.
    • (2007) Curr Pharm Des , vol.13 , pp. 2860-2871
    • Swenson, S.1    Ramu, S.2    Markland, F.S.3
  • 169
    • 0032539565 scopus 로고    scopus 로고
    • Opium alkaloid noscapine is an antitumor agent that arrests metaphase and induces apoptosis in dividing cells
    • Ye K, Ke Y, Keshava N, et al. Opium alkaloid noscapine is an antitumor agent that arrests metaphase and induces apoptosis in dividing cells. Proc Natl Acad Sci USA. 1998; 95: 1601-1616.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 1601-1616
    • Ye, K.1    Ke, Y.2    Keshava, N.3
  • 170
    • 0037131307 scopus 로고    scopus 로고
    • 2-terminal kinase-mediated apoptosis in response to noscapine
    • 2-terminal kinase-mediated apoptosis in response to noscapine. J Biol Chem 2002; 277: 39777-39785.
    • (2002) J Biol Chem , vol.277 , pp. 39777-39785
    • Zhou, J.1    Gupta, K.2    Yao, J.3
  • 172
    • 0037099621 scopus 로고    scopus 로고
    • Noscapine alters microtubule dynamics in living cells and inhibits theprogression of melanoma
    • Landen JW, Lang R, McMahon SJ, et al. Noscapine alters microtubule dynamics in living cells and inhibits theprogression of melanoma. Cancer Res 2002; 62: 4109-4114.
    • (2002) Cancer Res , vol.62 , pp. 4109-4114
    • Landen, J.W.1    Lang, R.2    McMahon, S.J.3
  • 173
    • 0033928547 scopus 로고    scopus 로고
    • Noscapine inhibits tumor growth with little toxicity to normal tissues or inhibition of immune responses
    • Ke Y, Ye K, Grossniklaus HE, et al. Noscapine inhibits tumor growth with little toxicity to normal tissues or inhibition of immune responses. Cancer Immunol Immunother 2000; 49: 217-225.
    • (2000) Cancer Immunol Immunother , vol.49 , pp. 217-225
    • Ke, Y.1    Ye, K.2    Grossniklaus, H.E.3
  • 174
    • 33644780790 scopus 로고    scopus 로고
    • Drug-resistant T-lymphoid tumors undergo apoptosis selectively in response to an antimicrotubule agent, EM011
    • Aneja R, Zhou J, Vangapandu SN, et al. Drug-resistant T-lymphoid tumors undergo apoptosis selectively in response to an antimicrotubule agent, EM011. Blood 2006; 107: 2486-2492.
    • (2006) Blood , vol.107 , pp. 2486-2492
    • Aneja, R.1    Zhou, J.2    Vangapandu, S.N.3
  • 175
    • 4143090412 scopus 로고    scopus 로고
    • Noscapine crosses the blood-brain barrier and inhibits glioblastoma growth
    • Landen JW, Hau V, Wang M, et al. Noscapine crosses the blood-brain barrier and inhibits glioblastoma growth. Clin Cancer Res 2004; 10: 5187-5201.
    • (2004) Clin Cancer Res , vol.10 , pp. 5187-5201
    • Landen, J.W.1    Hau, V.2    Wang, M.3
  • 176
    • 34548574659 scopus 로고    scopus 로고
    • Preclinical pharmacokinetics and bioavailability of noscapine, a tubulin-binding anticancer agent
    • Aneja R, Dhiman N, Idnani J, et al. Preclinical pharmacokinetics and bioavailability of noscapine, a tubulin-binding anticancer agent. Cancer Chemother Pharmacol 2007; 60: 831-839.
    • (2007) Cancer Chemother Pharmacol , vol.60 , pp. 831-839
    • Aneja, R.1    Dhiman, N.2    Idnani, J.3
  • 177
    • 0037379660 scopus 로고    scopus 로고
    • Brominated derivatives of noscapine are potent microtubule-interfering agents that perturb mitosis and inhibit cell proliferation
    • Zhou J, Gupta K, Aggarwal S, et al. Brominated derivatives of noscapine are potent microtubule-interfering agents that perturb mitosis and inhibit cell proliferation. Mol Pharmacol 2003; 63: 799-807.
    • (2003) Mol Pharmacol , vol.63 , pp. 799-807
    • Zhou, J.1    Gupta, K.2    Aggarwal, S.3
  • 178
    • 33745933637 scopus 로고    scopus 로고
    • Synthesis of microtubule-interfering halogenated noscapine analogs that perturb mitosis in cancer cells followed by cell death
    • Aneja R, Vangapandu SN, Lopus M, et al. Synthesis of microtubule-interfering halogenated noscapine analogs that perturb mitosis in cancer cells followed by cell death. Biochem Pharmacol 2006; 72: 415-426.
    • (2006) Biochem Pharmacol , vol.72 , pp. 415-426
    • Aneja, R.1    Vangapandu, S.N.2    Lopus, M.3
  • 179
    • 40449135879 scopus 로고    scopus 로고
    • Multidrug resistance-associated protein-overexpressing teniposide-resistant human lymphomas undergo apoptosis by a tubulin-binding agent
    • Aneja R, Liu M, Yates C, et al. Multidrug resistance-associated protein-overexpressing teniposide-resistant human lymphomas undergo apoptosis by a tubulin-binding agent. Cancer Res 2008; 68: 1495-1503.
    • (2008) Cancer Res , vol.68 , pp. 1495-1503
    • Aneja, R.1    Liu, M.2    Yates, C.3
  • 180
    • 36749086504 scopus 로고    scopus 로고
    • Nonimmunosuppressive chemotherapy: EM011-treated mice mount normal T-cell responses to an acute lymphocytic choriomeningitis virus infection
    • Aneja R, Kalia V, Ahmed R, et al. Nonimmunosuppressive chemotherapy: EM011-treated mice mount normal T-cell responses to an acute lymphocytic choriomeningitis virus infection. Mol Cancer Ther 2007; 6: 2891-2899.
    • (2007) Mol Cancer Ther , vol.6 , pp. 2891-2899
    • Aneja, R.1    Kalia, V.2    Ahmed, R.3
  • 181
    • 33645740451 scopus 로고    scopus 로고
    • Rational design of the microtubule-targeting anti-breast cancer drug EM015
    • Aneja R, Lopus M, Zhou J, et al. Rational design of the microtubule-targeting anti-breast cancer drug EM015. Cancer Res 2006; 66: 3782-3791.
    • (2006) Cancer Res , vol.66 , pp. 3782-3791
    • Aneja, R.1    Lopus, M.2    Zhou, J.3
  • 184
    • 70350783509 scopus 로고    scopus 로고
    • US20067090853
    • Kapp, J., Ke, Y.: US20067090853 (2006).
    • (2006)
    • Kapp, J.1    Ke, Y.2
  • 185
    • 70350757300 scopus 로고    scopus 로고
    • Ivashchenko, A.V., Kysil, V.M., Khvat, A.V., Malyarchuk, S.V., Okun, I.M., Tkachenko, S. Y., Kyselev, A.S.: WO2007133112A1 (2007).
    • Ivashchenko, A.V., Kysil, V.M., Khvat, A.V., Malyarchuk, S.V., Okun, I.M., Tkachenko, S. Y., Kyselev, A.S.: WO2007133112A1 (2007).
  • 186
    • 70350768758 scopus 로고    scopus 로고
    • Aneja, R., Joshi, H.C., Vandapandu, S.N.: WO2008109609A1 (2008).
    • Aneja, R., Joshi, H.C., Vandapandu, S.N.: WO2008109609A1 (2008).
  • 187
    • 70350753960 scopus 로고    scopus 로고
    • Chandra, R.: WO2008109614A1 (2008).
    • Chandra, R.: WO2008109614A1 (2008).


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