Resistance to microtubule-stabilizing drugs involves two events: β-tubulin mutation in one allele followed by loss of the second allele

Cell Cycle

Volumn 4, Issue 12, 2005, Pages 1847-1853

  Wang, Yuefang ^a   O'Brate, Aurora ^a,b   Zhou, Wei ^a   Giannakakou, Paraskevi ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Department of Obstetrics Gynecology   (United States)

Author keywords

6p25; Drug resistance; Epothilones; FISH; LOH; Microtubules; SNP; Taxanes; tubulin

Indexed keywords

BETA TUBULIN; EPOTHILONE A; PACLITAXEL;

ALLELE; ARTICLE; CONTROLLED STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE MUTATION; GENE SEQUENCE; HETEROZYGOSITY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MICROTUBULE; MITOSIS INDEX; MOLECULAR CLONING; MUTANT; NUCLEOTIDE SEQUENCE; PHENOTYPE; SINGLE NUCLEOTIDE POLYMORPHISM; WILD TYPE;

EID: 29244460132     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.4.12.2264     Document Type: Article

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