Selective, covalent modification of β-tubulin residue Cys-239 by T138067, an antitumor agent with in vivo efficacy against multidrug-resistant tumors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 10, 1999, Pages 5686-5691

  Shan, Bei ^a   Medina, Julio C ^a   Santha, Edit ^a   Frankmoelle, Walter P ^a   Chou, Ting C ^b   Learned, Robert M ^a   Narbut, Mathew R ^a   Stott, Dean ^a   Wu, Pengguang ^a   Jaen, Juan C ^a   Rosen, Terry ^a   Timmermans, Pieter B M W M ^a   Beckmann, Holger ^a  

^a AMGEN INC   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 FLUORO 1 METHOXY 4 PENTAFLUOROPHENYLSULFONAMIDOBENZENE; ANTINEOPLASTIC AGENT; BETA TUBULIN; COLCHICINE; DACTINOMYCIN; DOXORUBICIN; PACLITAXEL; T 138067; UNCLASSIFIED DRUG; VINBLASTINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER RESISTANCE; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG BINDING SITE; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MICROTUBULE; MICROTUBULE ASSEMBLY; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CYSTEINE; CYTOSKELETON; DRUG RESISTANCE, MULTIPLE; HUMANS; LEUKEMIA, LYMPHOCYTIC; MICE; MICE, NUDE; MICROTUBULES; MOLECULAR STRUCTURE; NEOPLASM TRANSPLANTATION; PACLITAXEL; PROTEIN BINDING; SULFONAMIDES; TUBULIN; TUMOR CELLS, CULTURED; VINBLASTINE;

ANIMALIA; MUS MUSCULUS;

EID: 13044294012     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.10.5686     Document Type: Article

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