메뉴 건너뛰기




Volumn 13, Issue 9, 2003, Pages 1505-1508

Synthesis, in vitro, and in vivo evaluation of phosphate ester derivatives of combretastatin A-4

Author keywords

[No Author keywords available]

Indexed keywords

COMBRETASTATIN A4; ORGANOPHOSPHATE; PROTEIN INHIBITOR;

EID: 12444259666     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00206-3     Document Type: Article
Times cited : (32)

References (20)
  • 2
    • 0032729686 scopus 로고
    • Hori K., Saito S., Nihei Y., Suzuki M., Sato Y. Jpn. J. Cancer Res. 90:1990;1026 Blakey D.C., Ashton S.E., Westwood F.R., Walker M., Ryan A.J. Int. J. Rad. Onc., Bio., Phys. 54:2002;1497 Chaplin D.J., Hill S.A. Int. J. Rad. Onc., Bio., Phys. 54:2002;1491.
    • (1990) Jpn. J. Cancer Res. , vol.90 , pp. 1026
    • Hori, K.1    Saito, S.2    Nihei, Y.3    Suzuki, M.4    Sato, Y.5
  • 4
    • 0036891515 scopus 로고    scopus 로고
    • Hori K., Saito S., Nihei Y., Suzuki M., Sato Y. Jpn. J. Cancer Res. 90:1990;1026 Blakey D.C., Ashton S.E., Westwood F.R., Walker M., Ryan A.J. Int. J. Rad. Onc., Bio., Phys. 54:2002;1497 Chaplin D.J., Hill S.A. Int. J. Rad. Onc., Bio., Phys. 54:2002;1491.
    • (2002) Int. J. Rad. Onc., Bio., Phys. , vol.54 , pp. 1491
    • Chaplin, D.J.1    Hill, S.A.2
  • 7
    • 0037085753 scopus 로고    scopus 로고
    • Kanthou C., Tozer G.M. Blood. 99:2002;2060 Tozer G.M., Prise V.E., Wilson J., Cemazar M., Shan S., Dewhirst M.W., Barber R., Vojnovic B., Chaplin D.J. Cancer Res. 61:2001;6413 Galbraith S.M., Chaplin D.J., Lee F., Stratford M.R.L., Locke R.J., Vojnovic B., Tozer G.M. Anticancer Res. 21:2001;93.
    • (2002) Blood , vol.99 , pp. 2060
    • Kanthou, C.1    Tozer, G.M.2
  • 14
    • 85031194890 scopus 로고    scopus 로고
    • 31P NMR, HPLC, HRMS). Supplemental material containing a detailed experimental procedure and full characterization details for each compound is available from the authors upon request.
  • 17
    • 85031195152 scopus 로고    scopus 로고
    • 50 was defined as the drug concentration that reduced cell viability 50% in comparison with control.
  • 18
    • 85031208882 scopus 로고    scopus 로고
    • Relative cytoxicities were examined in several cell lines in addition to the MHEC5-T endotheliaoma model (data not shown).
  • 19
    • 85031196680 scopus 로고    scopus 로고
    • Unpublished data, M. L. Trawick, Baylor University.
  • 20
    • 85031199640 scopus 로고    scopus 로고
    • 3 (a size without development of necrosis), mice received ip doses of either 10 mg/kg or 100 mg/kg of the various compounds. Twenty-four h later 0.25 mL of diluted FluoSphere beads (1:6 in physiological saline) was injected in the tail vein. The animals were sacrificed after 3 min and the tumor was removed. Cryosections (8 μm thick) were directly examined under a fluorescent microscope. Blood vessels were indicated by blue fluorescence from injected microbeads. For quantification, three sections from three tumors treated in each group were examined and in each section, more than 70% of the area was automatically recorded with a microscopic digital camera at ×100 magnification. The computer program Stage Pro (Media Cybernetics, MD) was used to control the picture recording. Image analysis was performed with Image Plus software (Media Cybernetics, MD). The results were expressed as vessel density decrease in percent of the control.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.