Efficacy of novel P-glycoprotein inhibitors to increase the oral uptake of paclitaxel in mice

Investigational New Drugs

Volumn 22, Issue 3, 2004, Pages 219-229

  Bardelmeijer, Heleen A ^a   Ouwehand, Mariët ^a   Beijnen, Jos H ^a   Schellens, Jan H M ^a   Van Tellingen, Olaf ^a,b  

^a ANTONI VAN LEEUWENHOEK HOSPITAL   (Netherlands)

^b Department of Clinical Chemistry ^*  (Netherlands)

Author keywords

Absorption; Drug transport; P glycoprotein; Paclitaxel; Pharmacokinetics

Indexed keywords

CREMOPHOR; CYCLOSPORIN A; ELACRIDAR; GLYCOPROTEIN P INHIBITOR; LANIQUIDAR; PACLITAXEL; UNCLASSIFIED DRUG; VALSPODAR; ZOSUQUIDAR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG ELIMINATION; DRUG RELEASE; DRUG TISSUE LEVEL; DRUG TRANSPORT; DRUG UPTAKE; FEMALE; INTESTINE; KINETICS; MASS; MOUSE; NONHUMAN; PRIORITY JOURNAL; STOMACH EMPTYING;

ACRIDINES; ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BENZAZEPINES; BIOLOGICAL AVAILABILITY; BIOLOGICAL TRANSPORT, ACTIVE; CYCLOSPORINE; CYCLOSPORINS; DIBENZOCYCLOHEPTENES; DRUG INTERACTIONS; FEMALE; INTESTINES; MICE; MODELS, BIOLOGICAL; P-GLYCOPROTEIN; PACLITAXEL; QUINOLINES; STOMACH; TETRAHYDROISOQUINOLINES; TIME FACTORS;

EID: 3543039989     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:DRUG.0000026248.45084.21     Document Type: Article

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