The physiological estrogen metabolite 2-methoxyestradiol reduces tumor growth and induces apoptosis in human solid tumors

Journal of Cancer Research and Clinical Oncology

Volumn 127, Issue 7, 2001, Pages 405-410

  Schumacher, Guido ^a   Neuhaus, Peter ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

Author keywords

2 Methoxyestradiol; Angiogenesis; Apoptosis; Solid tumors; Therapy

Indexed keywords

2 METHOXYESTRADIOL; ESTROGEN; PROTEIN P53;

ANGIOGENESIS; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE; ENDOTHELIUM CELL; HUMAN; PRIORITY JOURNAL; SOLID TUMOR; TUMOR GROWTH;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL DIVISION; ESTRADIOL; HUMANS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC;

EID: 0034993154     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004320000233     Document Type: Article

References (51)

1. Is chemotherapy alone adequate for young women with oestrogen-receptor-positive breast cancer?
2. Immunohistochemical localization of catechol methyltransferase in normal and cancerous breast tissues of mice and rats
3. Enhancement of radiation effects in vitro by the estrogen metabolite 2-methoxyestradiol
4. The antiangiogenic agents TNP-470 and 2-methoxyestradiol inhibit the growth of angiosarcoma in mice
5. 2-Methoxyestradiol arrests cells in mitosis without depolymerizing tubulin
6. 2-Methoxyestradiol-induced phosphorylation of Bcl-2: Uncoupling from JNK/SAPK activation
7. 2-Methoxyestradiol blocks estrogen-induced rat pituitary tumor growth and tumor angiogenesis: Possible role of vascular endothelial growth factor
8. Concentrations of 2-methoxyoestrogens in human serum measured by a heterologous immunoassay with an 125I-labelled ligand
9. A new class of steroids inhibits angiogenesis in the presence of heparin or a heparin fragment
10. Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site
11. 2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site
12. Transport of estrogens in human plasma
13. Estrogens and breast cancer
14. The endogenous oestrogen metabolite 2-methoxyestradiol inhibits angiogenesis and suppresses tumor growth
15. The excretion of five different 2-hydroxyoestrogen monomethyl ethers in human pregnancy urine
16. Interactions of 2-methoxyestradiol, an endogeneous mammalian metabolite, with unpolymerized tubulin and with tabulin polymers
17. The effect of 2-methoxyestradiol on cell cycle distribution, caspase activation and DNA fragmentation in gastric cancer cells
18. Oral administration of an estrogen metabolite-induced potentiation of radiation antitumor effects in presence of wild-type p53 in non-small-cell lung cancer
19. An agent that increases tumor suppressor transgene product coupled with systemic transgene delivery inhibits growth of metastatic lung cancer in vivo
20. Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol
21. The role of apoptosis in hematologic malignancies and modulation of apoptosis as a new therapeutic approach
22. 2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors α and β
23. Comparison of 2-methoxyestradiol-induced, docetaxel-induced, and paclitaxel-induced apoptosis in hepatoma cells and its correlation with reactive oxygen species
24. Effects of 17 betaestradiol metabolites on cell cycle events in MCF-7 cells
25. Male predominance in hepatocellular carcinoma: New insight and a possible therapeutic alternative
26. Estrogens and endometrial cancer in a retirement community
27. P450 enzymes of estrogen metabolism
28. Preclinical development of 2-methoxyestradiol (2ME2, NSC-659853)
29. Exogenous estrogen and endometrial carcinoma: Case-control and incidence study
30. Comparative properties of the catechol estrogens, I: Methylation by catechol-O-methyltransferase and binding to cytosol estrogen receptors
31. Induction of apoptosis in human lung cancer cells after wild-type p53 activation by methoxyestradiol
32. Superinduction of wild-type p53 protein after 2-methoxyestradiol treatment of Ad5p53-transduced cells induces tumor cell apoptosis
33. The endogenous estrogen metabolite 2-methoxyestradiol induces apoptotic neuronal cell death in vitro
34. Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk
35. Regulation of oestrogen action: Role of 17 beta-hydroxysteroid dehydrogenases
36. A good estrogen
37. Current and future directions in medical therapy for breast carcinoma: Endocrine treatment
38. Inhibition of tumor necrosis factor alpha-stimulated aromatase activity by microtubule-stabilizing agents, paclitaxel and 2-methoxyestradiol
39. Inhibition of normal and experimental angiotumor endothelial cell proliferation and cell cycle progression by 2-methoxyestradiol
40. Potent antitumor activity of 2-methoxyestradiol in human pancreatic cancer cell lines
41. 2-Methoxyestradiol inhibits tumor growth and induces apoptosis in human hepatoma cells
42. The cytotoxic effects of estradiol-17 beta, catecholestradiols and methoxyestradiols on dividing MCF-7 and HeLa cells
43. The mammalian metabolite, 2-methoxyestradiol affects P53 levels and apoptosis induction in transformed cells but not in normal cells
44. 2-Methoxyestradiol, an endogenous metabolite of estrogen, enhances apoptosis and beta-galactosidase expression in vascular endothelial cells
45. Induction of mammalian cell transformation and genotoxicity by 2-methoxyestradiol, an endogenous metabolite of estrogen
46. A steroid derivative with paclitaxel-like effects on tubulin polymerization
47. Angiostatic treatment of neuroblastoma
48. 2-Methoxyestradiol, an endogenous estrogen metabolite, induces apoptosis in endothelial cells and inhibits angiogcnesis: Possible role for stress-activated protein kinase signaling pathway and Fas expression
49. Is 2-methoxyestradiol an endogenous estrogen metabolite that inhibits mammary carcinogenesis?
50. Increased risk of endometrial carcinoma among users of conjugated estrogens
51. 2-Methoxyestradiol-induced growth suppression and lethality in estrogen-responsive MCF-7 cells may be mediated by down regulation of p34cdc2 and cyclin B1 epression