D-24851, a novel synthetic microtubule inhibitor, exerts curative antitumoral activity in vivo, shows efficacy toward multidrug-resistant tumor cells, and lacks neurotoxicity

Cancer Research

Volumn 61, Issue 1, 2001, Pages 392-399

  Bacher, Gerald ^a   Nickel, Bernd ^a   Emig, Peter ^a   Vanhoefer, Udo ^b   Seeber, Siegfried ^b   Shandra, Alexei ^c   Klenner, Thomas ^a   Beckers, Thomas ^a  

^a ASTA MEDICA AG   (Germany)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

^c ODESSA NATIONAL MEDICAL UNIVERSITY   (Ukraine)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; D 24851; DOXORUBICIN; N (PYRIDIN 4 YL)[1 (4 CHLORBENZYL)INDOL 3 YL]GLYOXYLAMIDE; PACLITAXEL; PODOPHYLLOTOXIN; UNCLASSIFIED DRUG; VINBLASTINE; VINCRISTINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; GLIOBLASTOMA; HUMAN; HUMAN CELL; MOUSE; NEUROTOXICITY; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; SARCOMA; TUMOR REGRESSION;

ACETAMIDES; ANIMALS; ANTINEOPLASTIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; BINDING SITES; BINDING, COMPETITIVE; CELL CYCLE; CELL DIVISION; COLCHICINE; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; INDOLES; MICROTUBULES; MOTOR ACTIVITY; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NERVOUS SYSTEM DISEASES; NEURAL CONDUCTION; P-GLYCOPROTEIN; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; SARCOMA, YOSHIDA; TUBULIN; TUMOR CELLS, CULTURED; VINCRISTINE;

EID: 0035133804     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Microtubules and actin filaments: Dynamic targets for cancer chemotherapy
2. The development and clinical utility of the taxane class of antimicrotubule chemotherapy agents
3. Role of taxanes in lung-cancer chemotherapy
4. Update on the taxoids and other new agents in head and neck cancer therapy
5. Paclitaxel. An update of its use in the treatment of metastatic breast cancer and ovarian and other gynaecological cancers
6. Vinorelbine (Navelbine). A third-generation Vinca alkaloid
7. Tubulin as a target for anticancer drugs: Agents which interact with the mitotic spindle
8. Mechanisms of action of and resistance to antitubulin agents: Microtubule dynamics, drug transport, and cell death
9. Antimitotic agents
10. A CDK inhibitor-based cellular system for identifying novel cell cycle-specific antineoplastic compounds
11. The effect of antimicrotubule agents on signal transduction pathways of apoptosis: A review
12. The P-glycoprotein multidrug transporter
13. Multidrug resistance mediated by the ATP-binding cassette transporter protein MRP
14. Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization
15. Chemotherapeutic neuropathy
16. Vincristine treatment of advanced cancer: A cooperative study of 392 cases
17. Overview of paclitaxel (Taxol)
18. Neurotoxicity of antineoplastic agents
19. Effect on the peripheral nervous system of the short-term intravenous administration of paclitaxel in the rat
20. Localization of a novel multidrug resistance-associated gene in the HT1080/DR4 and H69AR human tumor cell lines
21. Comparison between short or long exposure to 5-fluorouracil in human gastric and colon cancer cell lines: Biochemical mechanism of resistance
22. PAK-104P, a pyridine analogue, reverses paclitaxel and doxorubicin resistance in cell lines and nude mice bearing xenografts that overexpress the multidrug resistance protein
23. Activity- and schedule-dependent interactions of paclitaxel, etoposide and hydroperoxy-ifosfamide in cisplatin-sensitive and -refractory human ovarian carcinoma cell lines
24. A unique human ovarian carcinoma cell line expressing CD34 in association with selection for multidrug resistance
25. Reversal of MDR1-associated resistance to topotecan by PAK-200S, a new dihydropyridine analogue, in human cancer cell lines
26. Interval between the synthesis and assembly of cytoskeletal proteins in cultured neurons
27. Epothilones, a new class of microtubulestabilizing agents with a Taxol-like mechanism of action
28. Evaluation of a soluble tetrazolium/ formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines
29. New colorimetric cytotoxicity assay for anticancer drug screening
30. Serial in vivo determinations of nerve conduction velocity in rat tails. Physiological and pathological changes
31. Mechanism of inhibition of cell proliferation by Vinca alkaloids
32. Effect of solution variables on the binding of vinblastine to tubulin
33. Adaptation of mouse leukemia cells L1210 to vincristine. Evidence for expression of P-glycoprotein
34. Vincristine neuropathy. Clinical and electrophysiological observations
35. Effects of vincristine, maytansine, and cis-platinum on behavioral and electrophysiological indices of neurotoxicity in the rat
36. Inhibition of tubulin-microtubule polymerization by drugs of the Vinca alkaloid class