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Volumn , Issue , 2007, Pages 59-76

The Ischemic Cascade: Events Within the Penumbra

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EID: 70349916932     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.3109/9781420047356-9     Document Type: Chapter
Times cited : (1)

References (193)
  • 1
    • 0037224703 scopus 로고    scopus 로고
    • Adventures in the pathophysiology of brain ischemia: Penumbra, gene expression, neuroprotection: The 2002 Thomas Willis lecture
    • Ginsberg MD. Adventures in the pathophysiology of brain ischemia: penumbra, gene expression, neuroprotection: the 2002 Thomas Willis lecture. Stroke 2003; 34(1):214-223.
    • (2003) Stroke , vol.34 , Issue.1 , pp. 214-223
    • Ginsberg, M.D.1
  • 2
    • 0033199996 scopus 로고    scopus 로고
    • Pathobiology of ischemic stroke: An integrated view
    • Dirnagl U, Iadecola C, Moskowitz MA. Pathobiology of ischemic stroke: an integrated view. Trends Neurosci 1999; 22(9):391-397.
    • (1999) Trends Neurosci , vol.22 , Issue.9 , pp. 391-397
    • Dirnagl, U.1    Iadecola, C.2    Moskowitz, M.A.3
  • 3
    • 0032520189 scopus 로고    scopus 로고
    • Changes in [Ca2+]i and membrane currents during impaired mitochondrial metabolism in dissociated rat hippocampal neurons
    • Nowicky AV, Duchen MR. Changes in [Ca2+]i and membrane currents during impaired mitochondrial metabolism in dissociated rat hippocampal neurons. J Physiol 1998; 507(1):131-145.
    • (1998) J Physiol , vol.507 , Issue.1 , pp. 131-145
    • Nowicky, A.V.1    Duchen, M.R.2
  • 4
    • 84984763363 scopus 로고    scopus 로고
    • Mechanisms, challenges and opportunities in stroke
    • Lo EH, Dalkara T, Moskowitz MA. Mechanisms, challenges and opportunities in stroke. Nat Rev Neurosci 2003; 4(5):399-415.
    • (2003) Nat Rev Neurosci , vol.4 , Issue.5 , pp. 399-415
    • Lo, E.H.1    Dalkara, T.2    Moskowitz, M.A.3
  • 5
    • 0026551820 scopus 로고
    • The effect of glutamate receptor blockade on anoxic depolarization and cortical spreading depression
    • Lauritzen M, Hansen AJ. The effect of glutamate receptor blockade on anoxic depolarization and cortical spreading depression. J Cereb Blood Flow Metab 1992; 12(2):223-229.
    • (1992) J Cereb Blood Flow Metab , vol.12 , Issue.2 , pp. 223-229
    • Lauritzen, M.1    Hansen, A.J.2
  • 6
    • 0033784006 scopus 로고    scopus 로고
    • Na(+) dependence and the role of glutamate receptors and Na(+) channels in ion fluxes during hypoxia of rat hippocampal slices
    • Muller M, Somjen GG. Na(+) dependence and the role of glutamate receptors and Na(+) channels in ion fluxes during hypoxia of rat hippocampal slices. J Neurophysiol 2000; 84(4):1869-1880.
    • (2000) J Neurophysiol , vol.84 , Issue.4 , pp. 1869-1880
    • Muller, M.1    Somjen, G.G.2
  • 7
    • 0035094866 scopus 로고    scopus 로고
    • Anoxic depolarization mediates acute damage independent of glutamate in neocortical brain slices
    • Jarvis CR, Anderson TR, Andrew RD. Anoxic depolarization mediates acute damage independent of glutamate in neocortical brain slices. Cereb Cortex 2001; 11(3):249-259.
    • (2001) Cereb Cortex , vol.11 , Issue.3 , pp. 249-259
    • Jarvis, C.R.1    Anderson, T.R.2    Andrew, R.D.3
  • 8
    • 0034688312 scopus 로고    scopus 로고
    • Glutamate release in severe brain ischemia is mainly by reversed uptake
    • Rossi DJ, Oshima T, Attwell D. Glutamate release in severe brain ischemia is mainly by reversed uptake. Nature 2000; 403(6767):316-321.
    • (2000) Nature , vol.403 , Issue.6767 , pp. 316-321
    • Rossi, D.J.1    Oshima, T.2    Attwell, D.3
  • 9
    • 0033581396 scopus 로고    scopus 로고
    • The nature of penumbral depolarizations following focal cerebral ischemia in the rat
    • Nallet H, MacKenzie ET, Roussel S. The nature of penumbral depolarizations following focal cerebral ischemia in the rat. Brain Res 1999; 842(1):148-158.
    • (1999) Brain Res , vol.842 , Issue.1 , pp. 148-158
    • Nallet, H.1    MacKenzie, E.T.2    Roussel, S.3
  • 10
    • 0842324698 scopus 로고    scopus 로고
    • Compromised metabolic recovery following spontaneous spreading depression in the penumbra
    • Selman WR, Lust WD, Pundik S, et al. Compromised metabolic recovery following spontaneous spreading depression in the penumbra. Brain Res 2004; 999(2):167-174.
    • (2004) Brain Res , vol.999 , Issue.2 , pp. 167-174
    • Selman, W.R.1    Lust, W.D.2    Pundik, S.3
  • 11
    • 0018419278 scopus 로고
    • Cerebral glucose utilization: Local changes during and after recovery from spreading cortical depression
    • Shinohara M, Dollinger B, Brown G, et al. Cerebral glucose utilization: local changes during and after recovery from spreading cortical depression. Science 1979; 203(4376):188-190.
    • (1979) Science , vol.203 , Issue.4376 , pp. 188-190
    • Shinohara, M.1    Dollinger, B.2    Brown, G.3
  • 12
    • 0028325495 scopus 로고
    • Pathophysiology of the migraine aura. The spreading depression theory [Review]
    • Lauritzen M. Pathophysiology of the migraine aura. The spreading depression theory [Review]. Brain 1994; 117(Pt 1):199-210.
    • (1994) Brain , vol.117 , pp. 199-210
    • Lauritzen, M.1
  • 13
    • 46749119380 scopus 로고
    • Further observations on the spreading depression of activity in the cerebral cortex
    • Leão AAP. Further observations on the spreading depression of activity in the cerebral cortex. J Neurophysiol 1947; 10:409-414.
    • (1947) J Neurophysiol , vol.10 , pp. 409-414
    • Leão, A.A.P.1
  • 14
    • 0017380161 scopus 로고
    • Extracellular potassium activity, evoked potential and tissue blood flow. Relationships during progressive ischemia in baboon cerebral cortex
    • Branston NM, Strong AJ, Symon L. Extracellular potassium activity, evoked potential and tissue blood flow. Relationships during progressive ischemia in baboon cerebral cortex. J Neurol Sci 1977; 32(3):305-321.
    • (1977) J Neurol Sci , vol.32 , Issue.3 , pp. 305-321
    • Branston, N.M.1    Strong, A.J.2    Symon, L.3
  • 15
    • 0031761035 scopus 로고    scopus 로고
    • Similar propagation of SD and hypoxic SD-like depolarization in rat hippocampus recorded optically and electrically
    • Aitken PG, Tombaugh GC, Turner DA, et al. Similar propagation of SD and hypoxic SD-like depolarization in rat hippocampus recorded optically and electrically. J Neurophysiol 1998; 80(3):1514-1521.
    • (1998) J Neurophysiol , vol.80 , Issue.3 , pp. 1514-1521
    • Aitken, P.G.1    Tombaugh, G.C.2    Turner, D.A.3
  • 16
    • 0033982951 scopus 로고    scopus 로고
    • Factors influencing the frequency of fluorescence transients as markers of peri-infarct depolarizations in focal cerebral ischemia
    • Strong AJ, Smith SE, Whittington DJ, et al. Factors influencing the frequency of fluorescence transients as markers of peri-infarct depolarizations in focal cerebral ischemia. Stroke 2000; 31(1):214-222.
    • (2000) Stroke , vol.31 , Issue.1 , pp. 214-222
    • Strong, A.J.1    Smith, S.E.2    Whittington, D.J.3
  • 17
    • 0028085047 scopus 로고
    • Cortical negative DC deflections following middle cerebral artery occlusion and KCl-induced spreading depression: Effect on blood flow, tissue oxygenation, and electroencephalogram
    • Back T, Kohno K, Hossmann KA. Cortical negative DC deflections following middle cerebral artery occlusion and KCl-induced spreading depression: effect on blood flow, tissue oxygenation, and electroencephalogram. J Cereb Blood Flow Metab 1994; 14(1):12-19.
    • (1994) J Cereb Blood Flow Metab , vol.14 , Issue.1 , pp. 12-19
    • Back, T.1    Kohno, K.2    Hossmann, K.A.3
  • 18
    • 33746580375 scopus 로고    scopus 로고
    • Vasoconstrictive neurovascular coupling during focal ischemic depolarizations
    • Shin HK, Dunn AK, Jones PB, et al. Vasoconstrictive neurovascular coupling during focal ischemic depolarizations. J Cereb Blood Flow Metab 2006; 26(8):1018-1030.
    • (2006) J Cereb Blood Flow Metab , vol.26 , Issue.8 , pp. 1018-1030
    • Shin, H.K.1    Dunn, A.K.2    Jones, P.B.3
  • 19
    • 0034433540 scopus 로고    scopus 로고
    • Products of hemolysis in the subarachnoid space inducing spreading ischemia in the cortex and focal necrosis in rats: A model for delayed ischemic neurological deficits after subarachnoid hemorrhage?
    • Dreier JP, Ebert N, Priller J, et al. Products of hemolysis in the subarachnoid space inducing spreading ischemia in the cortex and focal necrosis in rats: a model for delayed ischemic neurological deficits after subarachnoid hemorrhage? J Neurosurg 2000; 93(4):658-666.
    • (2000) J Neurosurg , vol.93 , Issue.4 , pp. 658-666
    • Dreier, J.P.1    Ebert, N.2    Priller, J.3
  • 20
    • 0031723199 scopus 로고    scopus 로고
    • Nitric oxide scavenging by hemoglobin or nitric oxide synthase inhibition by N-nitro-L-arginine induces cortical spreading ischemia when K+ is increased in the subarachnoid space
    • Dreier JP, Korner K, Ebert N, et al. Nitric oxide scavenging by hemoglobin or nitric oxide synthase inhibition by N-nitro-L-arginine induces cortical spreading ischemia when K+ is increased in the subarachnoid space. J Cereb Blood Flow Metab 1998; 18(9):978-990.
    • (1998) J Cereb Blood Flow Metab , vol.18 , Issue.9 , pp. 978-990
    • Dreier, J.P.1    Korner, K.2    Ebert, N.3
  • 21
    • 24344484333 scopus 로고    scopus 로고
    • Ion changes in spreading ischemia induce rat middle cerebral artery constriction in the absence of NO
    • Windmuller O, Lindauer U, Foddis M, et al. Ion changes in spreading ischemia induce rat middle cerebral artery constriction in the absence of NO. Brain 2005; 128(9):2042-2051.
    • (2005) Brain , vol.128 , Issue.9 , pp. 2042-2051
    • Windmuller, O.1    Lindauer, U.2    Foddis, M.3
  • 22
    • 0027158001 scopus 로고
    • Characterization of cortical depolarizations evoked in focal cerebral ischemia
    • Nedergaard M, Hansen AJ. Characterization of cortical depolarizations evoked in focal cerebral ischemia. J Cereb Blood Flow Metab 1993; 13(4):568-574.
    • (1993) J Cereb Blood Flow Metab , vol.13 , Issue.4 , pp. 568-574
    • Nedergaard, M.1    Hansen, A.J.2
  • 23
    • 0033523384 scopus 로고    scopus 로고
    • Correlation between tissue depolarizations and damage in focal ischemic rat brain
    • Dijkhuizen RM, Beekwilder JP, van der Worp HB, et al. Correlation between tissue depolarizations and damage in focal ischemic rat brain. Brain Res 1999; 840(1-2):194-205.
    • (1999) Brain Res , vol.840 , Issue.1-2 , pp. 194-205
    • Dijkhuizen, R.M.1    Beekwilder, J.P.2    van der Worp, H.B.3
  • 24
    • 0029858211 scopus 로고    scopus 로고
    • Potassium-induced cortical spreading depressions during focal cerebral ischemia in rats: Contribution to lesion growth assessed by diffusion-weighted NMR and biochemical imaging
    • Busch E, Gyngell ML, Eis M, et al. Potassium-induced cortical spreading depressions during focal cerebral ischemia in rats: contribution to lesion growth assessed by diffusion-weighted NMR and biochemical imaging. J Cereb Blood Flow Metab 1996; 16(6):1090-1099.
    • (1996) J Cereb Blood Flow Metab , vol.16 , Issue.6 , pp. 1090-1099
    • Busch, E.1    Gyngell, M.L.2    Eis, M.3
  • 25
    • 0029874934 scopus 로고    scopus 로고
    • The role of spreading depression in focal ischemia evaluated by diffusion mapping
    • Takano K, Latour LL, Formato JE, et al. The role of spreading depression in focal ischemia evaluated by diffusion mapping. Ann Neurol 1996; 39(3):308-318.
    • (1996) Ann Neurol , vol.39 , Issue.3 , pp. 308-318
    • Takano, K.1    Latour, L.L.2    Formato, J.E.3
  • 26
    • 0030039690 scopus 로고    scopus 로고
    • Induction of spreading depression in the ischemic hemisphere following experimental middle cerebral artery occlusion: Effect on infarct morphology
    • Back T, Ginsberg MD, Dietrich WD, et al. Induction of spreading depression in the ischemic hemisphere following experimental middle cerebral artery occlusion: effect on infarct morphology. J Cereb Blood Flow Metab 1996; 16(2):202-213.
    • (1996) J Cereb Blood Flow Metab , vol.16 , Issue.2 , pp. 202-213
    • Back, T.1    Ginsberg, M.D.2    Dietrich, W.D.3
  • 27
    • 0026554702 scopus 로고
    • The effect of MK-801 on cortical spreading depression in the penumbral zone following focal ischemia in the rat
    • Gill R, Andine P, Hillered L, et al. The effect of MK-801 on cortical spreading depression in the penumbral zone following focal ischemia in the rat. J Cereb Blood Flow Metab 1992; 12(3):371-379.
    • (1992) J Cereb Blood Flow Metab , vol.12 , Issue.3 , pp. 371-379
    • Gill, R.1    Andine, P.2    Hillered, L.3
  • 28
    • 0026658553 scopus 로고
    • Repeated negative DC deflections in rat cortex following middle cerebral artery occlusion are abolished by MK-801: Effect on volume of ischemic injury
    • Iijima T, Mies G, Hossmann KA. Repeated negative DC deflections in rat cortex following middle cerebral artery occlusion are abolished by MK-801: effect on volume of ischemic injury. J Cereb Blood Flow Metab 1992; 12(5):727-733.
    • (1992) J Cereb Blood Flow Metab , vol.12 , Issue.5 , pp. 727-733
    • Iijima, T.1    Mies, G.2    Hossmann, K.A.3
  • 29
    • 0030669472 scopus 로고    scopus 로고
    • Effective reduction of infarct volume by gap junction blockade in a rodent model of stroke
    • Rawanduzy A, Hansen A, Hansen TW, et al. Effective reduction of infarct volume by gap junction blockade in a rodent model of stroke. J Neurosurg 1997; 87(6):916-920.
    • (1997) J Neurosurg , vol.87 , Issue.6 , pp. 916-920
    • Rawanduzy, A.1    Hansen, A.2    Hansen, T.W.3
  • 30
    • 0345802826 scopus 로고    scopus 로고
    • Delayed secondary phase of peri-infarct depolarizations after focal cerebral ischemia: Relation to infarct growth and neuroprotection
    • Hartings JA, Rolli ML, Lu XC, et al. Delayed secondary phase of peri-infarct depolarizations after focal cerebral ischemia: relation to infarct growth and neuroprotection. J Neurosci 2003; 23(37):11602-11610.
    • (2003) J Neurosci , vol.23 , Issue.37 , pp. 11602-11610
    • Hartings, J.A.1    Rolli, M.L.2    Lu, X.C.3
  • 31
    • 0036901533 scopus 로고    scopus 로고
    • Spreading and synchronous depressions of cortical activity in acutely injured human brain
    • Strong AJ, Fabricius M, Boutelle MG, et al. Spreading and synchronous depressions of cortical activity in acutely injured human brain. Stroke 2002; 33(12):2738-2743.
    • (2002) Stroke , vol.33 , Issue.12 , pp. 2738-2743
    • Strong, A.J.1    Fabricius, M.2    Boutelle, M.G.3
  • 32
    • 0036175596 scopus 로고    scopus 로고
    • Mitochondrial contributions to tissue damage in stroke
    • Sims NR, Anderson MF. Mitochondrial contributions to tissue damage in stroke. Neurochem Int 2002; 40(6):511-526.
    • (2002) Neurochem Int , vol.40 , Issue.6 , pp. 511-526
    • Sims, N.R.1    Anderson, M.F.2
  • 33
    • 0035149749 scopus 로고    scopus 로고
    • Reactive oxygen radicals in signaling and damage in the ischemic brain
    • Chan PH. Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab 2001; 21(1):2-14.
    • (2001) J Cereb Blood Flow Metab , vol.21 , Issue.1 , pp. 2-14
    • Chan, P.H.1
  • 34
    • 0024153902 scopus 로고
    • Acidosis and ischemic brain damage
    • Siesjo BK. Acidosis and ischemic brain damage. Neurochem Pathol 1988; 9:31-88.
    • (1988) Neurochem Pathol , vol.9 , pp. 31-88
    • Siesjo, B.K.1
  • 35
    • 0017325852 scopus 로고
    • Nervous system effects of cardiac arrest in monkeys
    • Myers RE, Yamagutchi M. Nervous system effects of cardiac arrest in monkeys. Arch Neurol 1977; 34:65-74.
    • (1977) Arch Neurol , vol.34 , pp. 65-74
    • Myers, R.E.1    Yamagutchi, M.2
  • 36
    • 0020211722 scopus 로고
    • Moderate hyperglycemia augments ischemic brain damage: A neuropathologic study in the rat
    • Pulsinelli WA, Waldman S, Rawlinson D, et al. Moderate hyperglycemia augments ischemic brain damage: a neuropathologic study in the rat. Neurology 1982; 32(11):1239-1246.
    • (1982) Neurology , vol.32 , Issue.11 , pp. 1239-1246
    • Pulsinelli, W.A.1    Waldman, S.2    Rawlinson, D.3
  • 37
    • 0028290877 scopus 로고
    • Effect of blood pressure and diabetes on stroke in progression
    • Jorgensen HS, Nakayama H, Raaschou HO, et al. Effect of blood pressure and diabetes on stroke in progression. Lancet 1994; 344 (8916):156-159.
    • (1994) Lancet , vol.344 , Issue.8916 , pp. 156-159
    • Jorgensen, H.S.1    Nakayama, H.2    Raaschou, H.O.3
  • 38
    • 0030966075 scopus 로고    scopus 로고
    • Is hyperglycaemia an independent predictor of poor outcome after acute stroke? Results of a long-term follow up study
    • Weir CJ, Murray GD, Dyker AG, et al. Is hyperglycaemia an independent predictor of poor outcome after acute stroke? Results of a long-term follow up study. BMJ 1997; 314(7090):1303-1306.
    • (1997) BMJ , vol.314 , Issue.7090 , pp. 1303-1306
    • Weir, C.J.1    Murray, G.D.2    Dyker, A.G.3
  • 39
    • 0033556078 scopus 로고    scopus 로고
    • Acute blood glucose level and outcome from ischemic stroke. Trial of ORG 10172 in Acute Stroke Treatment (TOAST) Investigators
    • Bruno A, Biller J, Adams HP Jr. et al. Acute blood glucose level and outcome from ischemic stroke. Trial of ORG 10172 in Acute Stroke Treatment (TOAST) Investigators. Neurology 1999; 52(2):280-284.
    • (1999) Neurology , vol.52 , Issue.2 , pp. 280-284
    • Bruno, A.1    Biller, J.2    Adams, H.P.3
  • 40
    • 0037056360 scopus 로고    scopus 로고
    • NINDS rt-PA Stroke Study Group. Admission glucose level and clinical outcomes in the NINDS rt-PA Stroke Trial
    • Bruno A, Levine SR, Frankel MR, et al. NINDS rt-PA Stroke Study Group. Admission glucose level and clinical outcomes in the NINDS rt-PA Stroke Trial. Neurology 2002; 59(5):669-674.
    • (2002) Neurology , vol.59 , Issue.5 , pp. 669-674
    • Bruno, A.1    Levine, S.R.2    Frankel, M.R.3
  • 41
    • 0041917474 scopus 로고    scopus 로고
    • Persistent poststroke hyperglycemia is independently associated with infarct expansion and worse clinical outcome
    • Baird TA, Parsons MW, Phanh T, et al. Persistent poststroke hyperglycemia is independently associated with infarct expansion and worse clinical outcome. Stroke 2003; 34(9):2208-2214.
    • (2003) Stroke , vol.34 , Issue.9 , pp. 2208-2214
    • Baird, T.A.1    Parsons, M.W.2    Phanh, T.3
  • 42
    • 0027958061 scopus 로고
    • Hyperglycemia in the acute phase of stroke and stress response
    • Tracey F, Stout RW. Hyperglycemia in the acute phase of stroke and stress response. Stroke 1994; 25(2):524-525.
    • (1994) Stroke , vol.25 , Issue.2 , pp. 524-525
    • Tracey, F.1    Stout, R.W.2
  • 43
    • 85007690518 scopus 로고    scopus 로고
    • Hyperglycaemia after acute stroke. Other models find that hyperglycaemia is not independent predictor
    • Counsell C, McDowall M, Dennis M. Hyperglycaemia after acute stroke. Other models find that hyperglycaemia is not independent predictor. BMJ 1997; 315(7111):810.
    • (1997) BMJ , vol.315 , Issue.7111 , pp. 810
    • Counsell, C.1    McDowall, M.2    Dennis, M.3
  • 44
    • 0035744643 scopus 로고    scopus 로고
    • Glucose and the ischemic brain: A sour grape or a sweet treat?
    • Schurr A. Glucose and the ischemic brain: a sour grape or a sweet treat? Curr Opin Clin Nutr Metab Care 2001; 4(4):287-292.
    • (2001) Curr Opin Clin Nutr Metab Care , vol.4 , Issue.4 , pp. 287-292
    • Schurr, A.1
  • 45
    • 0029946863 scopus 로고    scopus 로고
    • Metyrapone, an inhibitor of glucocorticoid production, reduces brain injury induced by focal and global ischemia and seizures
    • Smith-Swintosky VL, Pettigrew LC, Sapolsky RM, et al. Metyrapone, an inhibitor of glucocorticoid production, reduces brain injury induced by focal and global ischemia and seizures. J Cereb Blood Flow Metab 1996; 16(4):585-598.
    • (1996) J Cereb Blood Flow Metab , vol.16 , Issue.4 , pp. 585-598
    • Smith-Swintosky, V.L.1    Pettigrew, L.C.2    Sapolsky, R.M.3
  • 46
    • 0036313995 scopus 로고    scopus 로고
    • Protective effect of high glucose against ischemia-induced synaptic transmission damage in rat hippocampal slices
    • Tian GF, Baker AJ. Protective effect of high glucose against ischemia-induced synaptic transmission damage in rat hippocampal slices. J Neurophysiol 2002; 88(1):236-248.
    • (2002) J Neurophysiol , vol.88 , Issue.1 , pp. 236-248
    • Tian, G.F.1    Baker, A.J.2
  • 47
    • 0033570303 scopus 로고    scopus 로고
    • Neuroprotective effect of high glucose against NMDA, free radical, and oxygen-glucose deprivation through enhanced mitochondrial potentials
    • Seo SY, Kim EY, Kim H, et al. Neuroprotective effect of high glucose against NMDA, free radical, and oxygen-glucose deprivation through enhanced mitochondrial potentials. J Neurosci 1999; 19(20):8849-8855.
    • (1999) J Neurosci , vol.19 , Issue.20 , pp. 8849-8855
    • Seo, S.Y.1    Kim, E.Y.2    Kim, H.3
  • 48
    • 0023235238 scopus 로고
    • Hyperglycemia reduces the extent of cerebral infarction in rats
    • Ginsberg MD, Prado R, Dietrich WD, et al. Hyperglycemia reduces the extent of cerebral infarction in rats. Stroke 1987; 18(3):570-574.
    • (1987) Stroke , vol.18 , Issue.3 , pp. 570-574
    • Ginsberg, M.D.1    Prado, R.2    Dietrich, W.D.3
  • 49
    • 0024511626 scopus 로고
    • Hyperglycemia decreases acute neuronal ischemic changes after middle cerebral artery occlusion in cats
    • Zasslow MA, Pearl RG, Shuer LM, et al. Hyperglycemia decreases acute neuronal ischemic changes after middle cerebral artery occlusion in cats. Stroke 1989; 20(4):519-523.
    • (1989) Stroke , vol.20 , Issue.4 , pp. 519-523
    • Zasslow, M.A.1    Pearl, R.G.2    Shuer, L.M.3
  • 50
    • 0036288571 scopus 로고    scopus 로고
    • Acute hyperglycemia adversely affects stroke outcome:A magnetic resonance imaging and spectroscopy study
    • Parsons MW, Barber PA, Desmond PM, et al. Acute hyperglycemia adversely affects stroke outcome:a magnetic resonance imaging and spectroscopy study. Ann Neurol 2002; 52(1):20-28.
    • (2002) Ann Neurol , vol.52 , Issue.1 , pp. 20-28
    • Parsons, M.W.1    Barber, P.A.2    Desmond, P.M.3
  • 51
    • 0030692763 scopus 로고    scopus 로고
    • Cererbal ischemia-reperfusion injury and adhesion
    • Winquist RJ, Kerr S. Cererbal ischemia-reperfusion injury and adhesion. Neurology 1997; 49(S4):S23-S26.
    • (1997) Neurology , vol.49 , Issue.S4 , pp. S23-S26
    • Winquist, R.J.1    Kerr, S.2
  • 52
    • 0036897540 scopus 로고    scopus 로고
    • Inflammation and infection in clinical stroke
    • Emsley HC, Tyrrell PJ. Inflammation and infection in clinical stroke. J Cereb Blood Flow Metab 2002; 22(12):1399-1419.
    • (2002) J Cereb Blood Flow Metab , vol.22 , Issue.12 , pp. 1399-1419
    • Emsley, H.C.1    Tyrrell, P.J.2
  • 53
    • 0034989884 scopus 로고    scopus 로고
    • Targeting the central nervous system inflammatory response in ischemic stroke
    • Becker KJ. Targeting the central nervous system inflammatory response in ischemic stroke. Curr Opin Neurol 2001; 14(3):349-353.
    • (2001) Curr Opin Neurol , vol.14 , Issue.3 , pp. 349-353
    • Becker, K.J.1
  • 54
    • 0033979993 scopus 로고    scopus 로고
    • Inflammation and stroke: Putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia
    • del Zoppo G, Ginis I, Hallenbeck JM, et al. Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia. Brain Pathol 2000; 10(1):95-112.
    • (2000) Brain Pathol , vol.10 , Issue.1 , pp. 95-112
    • del Zoppo, G.1    Ginis, I.2    Hallenbeck, J.M.3
  • 55
    • 0029006577 scopus 로고
    • The temporal profiles of ICAM-1 protein and mRNA expression after transient MCA occlusion in the rat
    • Zhang RL, Chopp M, Zaloga C, et al. The temporal profiles of ICAM-1 protein and mRNA expression after transient MCA occlusion in the rat. Brain Res 1995; 682(1-2):182-188.
    • (1995) Brain Res , vol.682 , Issue.1-2 , pp. 182-188
    • Zhang, R.L.1    Chopp, M.2    Zaloga, C.3
  • 56
    • 0031942973 scopus 로고    scopus 로고
    • Increased expression of adhesion molecule CD1 (LFA-1beta) on the leukocytes of peripheral blood in patients with acute ischemic stroke
    • Fiszer U, Korczak-Kowalska G, Palasik W, et al. Increased expression of adhesion molecule CD1 (LFA-1beta) on the leukocytes of peripheral blood in patients with acute ischemic stroke. Acta Neurol Scand 1998; 97(4):221-224.
    • (1998) Acta Neurol Scand , vol.97 , Issue.4 , pp. 221-224
    • Fiszer, U.1    Korczak-Kowalska, G.2    Palasik, W.3
  • 57
    • 0038506990 scopus 로고    scopus 로고
    • Effects of a selective CD11b/CD18 antagonist and recombinant human tissue plasminogen activator treatment alone and in combination in a rat embolic model of stroke
    • Zhang L, Zhang ZG, Zhang RL, et al. Effects of a selective CD11b/CD18 antagonist and recombinant human tissue plasminogen activator treatment alone and in combination in a rat embolic model of stroke. Stroke 2003; 34(7):1790-1795.
    • (2003) Stroke , vol.34 , Issue.7 , pp. 1790-1795
    • Zhang, L.1    Zhang, Z.G.2    Zhang, R.L.3
  • 58
    • 0031681362 scopus 로고    scopus 로고
    • A longitudinal prospective study of soluble adhesion molecule in acute stroke
    • Bitsch A, Klene W, Murtada L, et al. A longitudinal prospective study of soluble adhesion molecule in acute stroke. Stroke 1998; 29(10):2129-2135.
    • (1998) Stroke , vol.29 , Issue.10 , pp. 2129-2135
    • Bitsch, A.1    Klene, W.2    Murtada, L.3
  • 59
    • 0029006577 scopus 로고
    • The temporal profiles of ICAM-1 protein and mRNA expression after transient MCA occlusion in the rat
    • Zhang RL, Chopp M, Zaloga C, et al. The temporal profiles of ICAM-1 protein and mRNA expression after transient MCA occlusion in the rat. Brain Res 1995; 682(1-2):182-188.
    • (1995) Brain Res , vol.682 , Issue.1-2 , pp. 182-188
    • Zhang, R.L.1    Chopp, M.2    Zaloga, C.3
  • 60
    • 0347356516 scopus 로고    scopus 로고
    • Decreased levels of plasma vitamin C and increased concentrations of inflammatory and oxidative stress markers after stroke
    • Sanchez-Moreno C, Dashe JF, Scott T, et al. Decreased levels of plasma vitamin C and increased concentrations of inflammatory and oxidative stress markers after stroke. Stroke 2004; 35(1):163-166.
    • (2004) Stroke , vol.35 , Issue.1 , pp. 163-166
    • Sanchez-Moreno, C.1    Dashe, J.F.2    Scott, T.3
  • 61
    • 0026667919 scopus 로고
    • Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke
    • Kochanek PM, Hallenbeck JM. Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke. Stroke 1992; 23:1367-1379.
    • (1992) Stroke , vol.23 , pp. 1367-1379
    • Kochanek, P.M.1    Hallenbeck, J.M.2
  • 62
    • 0027968777 scopus 로고
    • Role of cell adhesion molecules in brain injury after middle cerebral artery occlusion in the rat
    • Matsuo Y, Onodera H, Shiga Y, et al. Role of cell adhesion molecules in brain injury after middle cerebral artery occlusion in the rat. Brain Res 1994; 656(2):344-352.
    • (1994) Brain Res , vol.656 , Issue.2 , pp. 344-352
    • Matsuo, Y.1    Onodera, H.2    Shiga, Y.3
  • 63
    • 0029908393 scopus 로고    scopus 로고
    • Experimental antileukocyte interventions in cerebral ischemia
    • Hartl R, Schurer L, Schmid-Schonbein GW, et al. Experimental antileukocyte interventions in cerebral ischemia. J of Cereb Blood Flow Metab 1996; 16(6):1108-1119.
    • (1996) J of Cereb Blood Flow Metab , vol.16 , Issue.6 , pp. 1108-1119
    • Hartl, R.1    Schurer, L.2    Schmid-Schonbein, G.W.3
  • 64
    • 0025947863 scopus 로고
    • Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons
    • del Zoppo GJ, Schmid-Schonbein GW, Mori E, et al. Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons. Stroke 1991; 22(10):1276-1283.
    • (1991) Stroke , vol.22 , Issue.10 , pp. 1276-1283
    • del Zoppo, G.J.1    Schmid-Schonbein, G.W.2    Mori, E.3
  • 65
    • 0026729653 scopus 로고
    • Inhibition of polymorphonuclear leukocyte adherence suppresses no-reflow after focal cerebral ischemia in baboons
    • Mori E, del Zoppo GJ, Chambers JD. Inhibition of polymorphonuclear leukocyte adherence suppresses no-reflow after focal cerebral ischemia in baboons. Stroke 1992; 23(5):712-718.
    • (1992) Stroke , vol.23 , Issue.5 , pp. 712-718
    • Mori, E.1    del Zoppo, G.J.2    Chambers, J.D.3
  • 66
    • 0028351503 scopus 로고
    • Anti-CD11b monoclonal antibody reduces ischemic cell damage after transient focal cerebral ischemia in rat
    • Chen H, Chopp M, Zhang RL, et al. Anti-CD11b monoclonal antibody reduces ischemic cell damage after transient focal cerebral ischemia in rat. Ann Neurol 1994; 35:458-463.
    • (1994) Ann Neurol , vol.35 , pp. 458-463
    • Chen, H.1    Chopp, M.2    Zhang, R.L.3
  • 67
    • 0029096735 scopus 로고
    • Anti-intercellular adhesion molecule-1 antibody reduces ischemic cell damage after transient but not permanent middle cerebral artery occlusion in the Wistar rat
    • Zhang RL, Chopp M, Jiang N, et al. Anti-intercellular adhesion molecule-1 antibody reduces ischemic cell damage after transient but not permanent middle cerebral artery occlusion in the Wistar rat. Stroke 1995; 26(8):1438-1442.
    • (1995) Stroke , vol.26 , Issue.8 , pp. 1438-1442
    • Zhang, R.L.1    Chopp, M.2    Jiang, N.3
  • 68
    • 0032930869 scopus 로고    scopus 로고
    • Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury
    • Soriano SG, Coxon A, Wang YF, et al. Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury. Stroke 1999; 30(1):134-139.
    • (1999) Stroke , vol.30 , Issue.1 , pp. 134-139
    • Soriano, S.G.1    Coxon, A.2    Wang, Y.F.3
  • 69
    • 0032959532 scopus 로고    scopus 로고
    • Cd18-mediated neutrophil recruitment contributes to the pathogenesis of reperfused but not nonreperfused stroke
    • Prestigiacomo CJ, Kim SC, Connolly ES Jr. Cd18-mediated neutrophil recruitment contributes to the pathogenesis of reperfused but not nonreperfused stroke. Stroke 1999; 30(5):1110-1117.
    • (1999) Stroke , vol.30 , Issue.5 , pp. 1110-1117
    • Prestigiacomo, C.J.1    Kim, S.C.2    Connolly, E.S.3
  • 70
    • 0029886071 scopus 로고    scopus 로고
    • Intercellular adhesion molecule-1-deficient mice are less susceptible to cerebral ischemia-reperfusion injury
    • Soriano SG, Lipton SA, Wang YF, et al. Intercellular adhesion molecule-1-deficient mice are less susceptible to cerebral ischemia-reperfusion injury. Ann Neurol 1996; 39(5):618-624.
    • (1996) Ann Neurol , vol.39 , Issue.5 , pp. 618-624
    • Soriano, S.G.1    Lipton, S.A.2    Wang, Y.F.3
  • 71
    • 0037112549 scopus 로고    scopus 로고
    • HuEP5C7 as a humanized monoclonal anti-E/P-selectin neurovascularprotective strategy in a blinded placebo-controlled trial of non-human primate stroke
    • Mocco J, Choudhri T, Huan J, et al. HuEP5C7 as a humanized monoclonal anti-E/P-selectin neurovascularprotective strategy in a blinded placebo-controlled trial of non-human primate stroke. Circ Res 2002; 91(10):907-914.
    • (2002) Circ Res , vol.91 , Issue.10 , pp. 907-914
    • Mocco, J.1    Choudhri, T.2    Huan, J.3
  • 72
    • 0034746690 scopus 로고    scopus 로고
    • Antibody to the alpha4 integrin decreases infarct size in transient focal cerebral ischemia in rats
    • Becker K, Kindrick D, Relton J, et al. Antibody to the alpha4 integrin decreases infarct size in transient focal cerebral ischemia in rats. Stroke 2001; 32(1):206-211.
    • (2001) Stroke , vol.32 , Issue.1 , pp. 206-211
    • Becker, K.1    Kindrick, D.2    Relton, J.3
  • 73
    • 0032579788 scopus 로고    scopus 로고
    • Neutrophil inhibitory factor treatment of focal cerebral ischemia in the rat
    • Jian N, Chopp M, Chahwala S. Neutrophil inhibitory factor treatment of focal cerebral ischemia in the rat. Brain Res 1998; 788(1-2):25-34.
    • (1998) Brain Res , vol.788 , Issue.1-2 , pp. 25-34
    • Jian, N.1    Chopp, M.2    Chahwala, S.3
  • 74
    • 0035164475 scopus 로고    scopus 로고
    • Examination of several potential mechanisms for the negative outcome in a clinical stroke trial of enlimomab, a murine anti-human intercellular adhesion molecule-1 antibody: A bedside-to-bench study
    • Furuya K, Takeda H, Azhar S, et al. Examination of several potential mechanisms for the negative outcome in a clinical stroke trial of enlimomab, a murine anti-human intercellular adhesion molecule-1 antibody: a bedside-to-bench study. Stroke 2001; 32(11):2665-2674.
    • (2001) Stroke , vol.32 , Issue.11 , pp. 2665-2674
    • Furuya, K.1    Takeda, H.2    Azhar, S.3
  • 75
    • 0036369590 scopus 로고    scopus 로고
    • Anti-Leukocyte antibodies: Leukarrest (Hu23F2G) and Enlimomab (R6.5) in acute stroke
    • Becker KJ. Anti-Leukocyte antibodies: Leukarrest (Hu23F2G) and Enlimomab (R6.5) in acute stroke. Curr Med Res Opin 2002; 18:S18-S22.
    • (2002) Curr Med Res Opin , vol.18 , pp. S18-S22
    • Becker, K.J.1
  • 76
    • 0028017705 scopus 로고
    • Microglial response to transient focal cerebral ischemia: An immunocytochemical study on the rat cerebral cortex using anti-phosphotyrosine antibody
    • Korematsu K, Goto S, Nagahiro S, et al. Microglial response to transient focal cerebral ischemia: an immunocytochemical study on the rat cerebral cortex using anti-phosphotyrosine antibody. J Cereb Blood Flow Metab 1994; 14(5):825-830.
    • (1994) J Cereb Blood Flow Metab , vol.14 , Issue.5 , pp. 825-830
    • Korematsu, K.1    Goto, S.2    Nagahiro, S.3
  • 77
    • 0035191983 scopus 로고    scopus 로고
    • Generation of a constitutively active fragment of PKN in microglia/macrophages after middle cerebral artery occlusion in rats
    • Ueyama T, Ren Y, Sakai N, et al. Generation of a constitutively active fragment of PKN in microglia/macrophages after middle cerebral artery occlusion in rats. J Neurochem 2001; 79(4):903-913.
    • (2001) J Neurochem , vol.79 , Issue.4 , pp. 903-913
    • Ueyama, T.1    Ren, Y.2    Sakai, N.3
  • 78
    • 0035571969 scopus 로고    scopus 로고
    • Characterization of the microglial response to cerebral ischemia in the stroke-prone spontaneously hypertensive rat
    • Marks L, Carswell HV, Peters EE, et al. Characterization of the microglial response to cerebral ischemia in the stroke-prone spontaneously hypertensive rat. Hypertension 2001; 38(1):116-122.
    • (2001) Hypertension , vol.38 , Issue.1 , pp. 116-122
    • Marks, L.1    Carswell, H.V.2    Peters, E.E.3
  • 79
    • 0036460691 scopus 로고    scopus 로고
    • Expression of fractalkine and its receptor, CX3CR1, in response to ischemia-reperfusion brain injury in the rat
    • Tarozzo G, Campanella M, Ghiani M, et al. Expression of fractalkine and its receptor, CX3CR1, in response to ischemia-reperfusion brain injury in the rat. Eur J Neurosci 2002; 15(10):1663-1668.
    • (2002) Eur J Neurosci , vol.15 , Issue.10 , pp. 1663-1668
    • Tarozzo, G.1    Campanella, M.2    Ghiani, M.3
  • 80
    • 0033539522 scopus 로고    scopus 로고
    • A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window
    • Yrjänheikki J, Tikka T, Keinanen R, et al. A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. Proc Natl Acad Sci U S A 1999; 96(23):13496-13500.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.23 , pp. 13496-13500
    • Yrjänheikki, J.1    Tikka, T.2    Keinanen, R.3
  • 81
    • 0029076362 scopus 로고
    • Microglia: Intrinsic immuneffector cell of the brain
    • Gehrmann J, Matsumoto Y, Kreutzberg GW. Microglia: intrinsic immuneffector cell of the brain. Brain Res Rev 1995; 20(3):269-287.
    • (1995) Brain Res Rev , vol.20 , Issue.3 , pp. 269-287
    • Gehrmann, J.1    Matsumoto, Y.2    Kreutzberg, G.W.3
  • 82
    • 0030892402 scopus 로고    scopus 로고
    • Differential and time-dependent expression of monocyte chemoattractant protein-1 mRNA by astrocytes and macrophages in rat brain: Effects of ischemia and peripheral lipopolysaccharide administration
    • Gourmala NG, Buttini M, Limonta S, et al. Differential and time-dependent expression of monocyte chemoattractant protein-1 mRNA by astrocytes and macrophages in rat brain: effects of ischemia and peripheral lipopolysaccharide administration. J Neuroimmunol 1997; 74(1-2):35-44.
    • (1997) J Neuroimmunol , vol.74 , Issue.1-2 , pp. 35-44
    • Gourmala, N.G.1    Buttini, M.2    Limonta, S.3
  • 83
    • 0035658031 scopus 로고    scopus 로고
    • Targeting gene-modified hematopoietic cells to the central nervous system: Use of green fluorescent protein uncovers microglial engraftment
    • Priller J, Flugel A, Wehner T. Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment. Nat Med 2001; 7(12):1356-1361.
    • (2001) Nat Med , vol.7 , Issue.12 , pp. 1356-1361
    • Priller, J.1    Flugel, A.2    Wehner, T.3
  • 84
    • 0030891163 scopus 로고    scopus 로고
    • Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice
    • Eglitis MA, Mezey E. Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice. Proc Natl Acad Sci U S A 1997; 94(8):4080-4085.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , Issue.8 , pp. 4080-4085
    • Eglitis, M.A.1    Mezey, E.2
  • 85
    • 0033606069 scopus 로고    scopus 로고
    • Targeting of marrow-derived astrocytes to the ischemic brain
    • Eglitis MA, Dawson D, Park KW, et al. Targeting of marrow-derived astrocytes to the ischemic brain. Neuroreport 1999; 10(6):1289-1292.
    • (1999) Neuroreport , vol.10 , Issue.6 , pp. 1289-1292
    • Eglitis, M.A.1    Dawson, D.2    Park, K.W.3
  • 86
    • 0038452714 scopus 로고    scopus 로고
    • Bone marrow-derived cells expressing green fluorescent protein under the control of the glial fibrillary acidic protein promoter do not differentiate into astrocytes in vitro and in vivo
    • Wehner T, Bontert M, Eyupoglu I. Bone marrow-derived cells expressing green fluorescent protein under the control of the glial fibrillary acidic protein promoter do not differentiate into astrocytes in vitro and in vivo. J Neurosci 2003; 23(12):5004-5011.
    • (2003) J Neurosci , vol.23 , Issue.12 , pp. 5004-5011
    • Wehner, T.1    Bontert, M.2    Eyupoglu, I.3
  • 87
    • 0034065392 scopus 로고    scopus 로고
    • Murine models define the role of TGF-beta as a master regulator of immune cell function
    • Letterio JJ. Murine models define the role of TGF-beta as a master regulator of immune cell function. Cytokine Growth Factor Rev 2000; 11(1-2):81-87.
    • (2000) Cytokine Growth Factor Rev , vol.11 , Issue.1-2 , pp. 81-87
    • Letterio, J.J.1
  • 88
    • 0036896201 scopus 로고    scopus 로고
    • Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: Evidence from an in vitro model
    • Ruscher K, Freyer D, Karsch M. Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: evidence from an in vitro model. J Neurosci 2002; 22(23):10291-10301.
    • (2002) J Neurosci , vol.22 , Issue.23 , pp. 10291-10301
    • Ruscher, K.1    Freyer, D.2    Karsch, M.3
  • 89
    • 0037101619 scopus 로고    scopus 로고
    • Serial analysis of gene expression identifies metallothionein-II as major neuroprotective gene in mouse focal cerebral ischemia
    • Trendelenburg G, Prass K, Priller J, et al. Serial analysis of gene expression identifies metallothionein-II as major neuroprotective gene in mouse focal cerebral ischemia. J Neurosci 2002; 22(14):5879-5888.
    • (2002) J Neurosci , vol.22 , Issue.14 , pp. 5879-5888
    • Trendelenburg, G.1    Prass, K.2    Priller, J.3
  • 90
    • 0032978333 scopus 로고    scopus 로고
    • The progression and topographic distribution of interleukin-1beta expression after permanent middle cerebral artery occlusion in the rat
    • Davies CA, Loddick SA, Toulmond S, et al. The progression and topographic distribution of interleukin-1beta expression after permanent middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 1999; 19(1):87-98.
    • (1999) J Cereb Blood Flow Metab , vol.19 , Issue.1 , pp. 87-98
    • Davies, C.A.1    Loddick, S.A.2    Toulmond, S.3
  • 91
    • 0033976487 scopus 로고    scopus 로고
    • Microglia and macrophages are the major source of tumor necrosis factor in permanent middle cerebral artery occlusion in mice
    • Gregersen R, Lambertsen K, Finsen B. Microglia and macrophages are the major source of tumor necrosis factor in permanent middle cerebral artery occlusion in mice. J Cereb Blood Flow Metab 2000; 20(1):53-65.
    • (2000) J Cereb Blood Flow Metab , vol.20 , Issue.1 , pp. 53-65
    • Gregersen, R.1    Lambertsen, K.2    Finsen, B.3
  • 92
    • 0036808244 scopus 로고    scopus 로고
    • Inflammatory cytokines in the nervous system: Multifunctional mediators in autoimmunity and cerebral ischemia
    • Stoll G. Inflammatory cytokines in the nervous system: multifunctional mediators in autoimmunity and cerebral ischemia. Rev Neurol (Paris) 2002; 158(10 Pt 1):887-891.
    • (2002) Rev Neurol (Paris) , vol.158 , Issue.10 , pp. 887-891
    • Stoll, G.1
  • 93
    • 0031172065 scopus 로고    scopus 로고
    • NF-kappa B: A crucial transcription factor for glial and neuronal cell function
    • O’Neill LA, Kaltschmidt C. NF-kappa B: a crucial transcription factor for glial and neuronal cell function. Trends Neurosci 1997; 20(6):252-258.
    • (1997) Trends Neurosci , vol.20 , Issue.6 , pp. 252-258
    • O’Neill, L.A.1    Kaltschmidt, C.2
  • 94
    • 0035143182 scopus 로고    scopus 로고
    • Cerebral ischemia and inflammation
    • Iadecola C, Alexander M. Cerebral ischemia and inflammation. Curr Opin Neurol 2001; 14(1):89-94.
    • (2001) Curr Opin Neurol , vol.14 , Issue.1 , pp. 89-94
    • Iadecola, C.1    Alexander, M.2
  • 95
    • 0034616284 scopus 로고    scopus 로고
    • Expression of IL-6 in the ischemic penumbra
    • Block F, Peters M, Nolden-Koch M. Expression of IL-6 in the ischemic penumbra. Neuroreport 2000; 11(5):963-967.
    • (2000) Neuroreport , vol.11 , Issue.5 , pp. 963-967
    • Block, F.1    Peters, M.2    Nolden-Koch, M.3
  • 96
    • 0029132696 scopus 로고
    • Early intrathecal production of interleukin-6 predicts the size of brain lesion in stroke
    • Tarkowski E, Rosengren L, Blomstrand C, et al. Early intrathecal production of interleukin-6 predicts the size of brain lesion in stroke. Stroke 1995; 26(8):1393-1398.
    • (1995) Stroke , vol.26 , Issue.8 , pp. 1393-1398
    • Tarkowski, E.1    Rosengren, L.2    Blomstrand, C.3
  • 97
    • 0031005797 scopus 로고    scopus 로고
    • TNF-alpha pretreatment induces protective effects against focal cerebral ischemia in mice
    • Nawashiro H, Tasaki K, Ruetzler CA. TNF-alpha pretreatment induces protective effects against focal cerebral ischemia in mice. J Cereb Blood Flow Metab 1997; 17(5):483-490.
    • (1997) J Cereb Blood Flow Metab , vol.17 , Issue.5 , pp. 483-490
    • Nawashiro, H.1    Tasaki, K.2    Ruetzler, C.A.3
  • 98
    • 0029899586 scopus 로고    scopus 로고
    • Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors
    • Bruce AJ, Boling W, Kindy MS, et al. Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nat Med 1996; 2(7):788-794.
    • (1996) Nat Med , vol.2 , Issue.7 , pp. 788-794
    • Bruce, A.J.1    Boling, W.2    Kindy, M.S.3
  • 99
    • 0036548875 scopus 로고    scopus 로고
    • Neurodegenerative and neuroprotective effects of tumor necrosis factor (TNF) in retinal ischemia: Opposite roles of TNF receptor 1 and TNF receptor
    • Fontaine V, Mohand-Said S, Hanoteau N. Neurodegenerative and neuroprotective effects of tumor necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor J Neurosci 2002; 22(7):RC216.
    • (2002) J Neurosci , vol.22 , Issue.7
    • Fontaine, V.1    Mohand-Said, S.2    Hanoteau, N.3
  • 100
    • 0033933545 scopus 로고    scopus 로고
    • Lack of interleukin-6 expression is not protective against focal central nervous system ischemia
    • Clark WM, Rinker LG, Lessov NS, et al. Lack of interleukin-6 expression is not protective against focal central nervous system ischemia. Stroke 2000; 31(7):1715-1720.
    • (2000) Stroke , vol.31 , Issue.7 , pp. 1715-1720
    • Clark, W.M.1    Rinker, L.G.2    Lessov, N.S.3
  • 101
    • 0036361890 scopus 로고    scopus 로고
    • Inflammation in stroke--a potential target for neuroprotection?
    • Priller J, Dirnagl U. Inflammation in stroke--a potential target for neuroprotection? Ernst Schering Res Found Workshop 2002; 39:133-157.
    • (2002) Ernst Schering Res Found Workshop , vol.39 , pp. 133-157
    • Priller, J.1    Dirnagl, U.2
  • 102
    • 0026457998 scopus 로고
    • Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-beta and interleukin-
    • Bogdan C, Paik J, Vodovotz Y, et al. Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-beta and interleukin-J Biol Chem 1992; 267(32): 23301-23308
    • (1992) J Biol Chem , vol.267 , Issue.32 , pp. 23301-23308
    • Bogdan, C.1    Paik, J.2    Vodovotz, Y.3
  • 103
  • 104
    • 0027196619 scopus 로고
    • Transforming growth factor-beta 1 prevents glutamate neurotoxicity in rat neocortical cultures and protects mouse neocortex from ischemic injury in vivo
    • Prehn JH, Backhauss C, Krieglstein J. Transforming growth factor-beta 1 prevents glutamate neurotoxicity in rat neocortical cultures and protects mouse neocortex from ischemic injury in vivo. J Cereb Blood Flow Metab 1993; 13(3):521-525.
    • (1993) J Cereb Blood Flow Metab , vol.13 , Issue.3 , pp. 521-525
    • Prehn, J.H.1    Backhauss, C.2    Krieglstein, J.3
  • 105
    • 0032584685 scopus 로고    scopus 로고
    • IL-10 reduces rat brain injury following focal stroke
    • Spera PA, Ellison JA, Feuerstein GZ, et al. IL-10 reduces rat brain injury following focal stroke. Neurosci Lett 1998; 251(3):189-192.
    • (1998) Neurosci Lett , vol.251 , Issue.3 , pp. 189-192
    • Spera, P.A.1    Ellison, J.A.2    Feuerstein, G.Z.3
  • 106
    • 0030924054 scopus 로고    scopus 로고
    • Immunologic tolerance to myelin basic protein decreases stroke size after transient focal cerebral ischemia
    • Becker KJ, McCarron RM, Ruetzler C, et al. Immunologic tolerance to myelin basic protein decreases stroke size after transient focal cerebral ischemia. Proc Natl Acad Sci U. S. A. 1997; 94(20):10873-10878.
    • (1997) Proc Natl Acad Sci U. S. A. , vol.94 , Issue.20 , pp. 10873-10878
    • Becker, K.J.1    McCarron, R.M.2    Ruetzler, C.3
  • 107
    • 0037830589 scopus 로고    scopus 로고
    • Adoptive transfer of myelin basic protein-tolerized splenocytes to naive animals reduces infarct size: A role for lymphocytes in ischemic brain injury?
    • Becker K, Kindrick D, McCarron R, et al. Adoptive transfer of myelin basic protein-tolerized splenocytes to naive animals reduces infarct size: a role for lymphocytes in ischemic brain injury? Stroke 2003; 34(7):1809-1815.
    • (2003) Stroke , vol.34 , Issue.7 , pp. 1809-1815
    • Becker, K.1    Kindrick, D.2    McCarron, R.3
  • 108
    • 0036712364 scopus 로고    scopus 로고
    • Induction of mucosal tolerance to E-selectin prevents ischemic and hemorrhagic stroke in spontaneously hypertensive genetically stroke-prone rats
    • Takeda H, Spatz M, Ruetzler C, et al. Induction of mucosal tolerance to E-selectin prevents ischemic and hemorrhagic stroke in spontaneously hypertensive genetically stroke-prone rats. Stroke 2002; 33(9):2156.
    • (2002) Stroke , vol.33 , Issue.9 , pp. 2156
    • Takeda, H.1    Spatz, M.2    Ruetzler, C.3
  • 109
    • 0031020172 scopus 로고    scopus 로고
    • Bright and dark sides of nitric oxide in ischemic brain damage
    • Iadecola C. Bright and dark sides of nitric oxide in ischemic brain damage. Trends Neurosci 1997; 20(3):132-138.
    • (1997) Trends Neurosci , vol.20 , Issue.3 , pp. 132-138
    • Iadecola, C.1
  • 110
    • 0029073807 scopus 로고
    • The role of peroxynitrite in nitric oxide-mediated toxicity
    • Crow JP, Beckman JS. The role of peroxynitrite in nitric oxide-mediated toxicity. Curr Top Microbiol Immunol 1995; 196:57-73.
    • (1995) Curr Top Microbiol Immunol , vol.196 , pp. 57-73
    • Crow, J.P.1    Beckman, J.S.2
  • 111
    • 0033828545 scopus 로고    scopus 로고
    • Mechanisms involved in the pro-and anti-apoptotic role of NO in human leukemia
    • Kolb JP. Mechanisms involved in the pro-and anti-apoptotic role of NO in human leukemia. Leukemia 2000; 14(9):1685-1694.
    • (2000) Leukemia , vol.14 , Issue.9 , pp. 1685-1694
    • Kolb, J.P.1
  • 112
    • 0029794869 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase gene expression in vascular cells after transient focal cerebral ischemia
    • Iadecola C, Zhang F, Casey R, et al. Inducible nitric oxide synthase gene expression in vascular cells after transient focal cerebral ischemia. Stroke 1996; 27(8):1373-1380.
    • (1996) Stroke , vol.27 , Issue.8 , pp. 1373-1380
    • Iadecola, C.1    Zhang, F.2    Casey, R.3
  • 113
    • 0033014055 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase expression in human cerebral infarcts
    • Forster C, Clark HB, Ross ME. Inducible nitric oxide synthase expression in human cerebral infarcts. Acta Neurpathol 1999; 97(3):215-220.
    • (1999) Acta Neurpathol , vol.97 , Issue.3 , pp. 215-220
    • Forster, C.1    Clark, H.B.2    Ross, M.E.3
  • 114
    • 0030664096 scopus 로고    scopus 로고
    • Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene
    • Iadecola C, Zhang F, Casey R, et al. Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene. J Neurosci 1997; 17(23):9157-9164.
    • (1997) J Neurosci , vol.17 , Issue.23 , pp. 9157-9164
    • Iadecola, C.1    Zhang, F.2    Casey, R.3
  • 115
    • 0029670958 scopus 로고    scopus 로고
    • Aminoguanidine ameliorates and L-arginine worsens brain damage from intraluminal middle cerebral artery occlusion
    • Zhang F, Casey RM, Ross ME, et al. Aminoguanidine ameliorates and L-arginine worsens brain damage from intraluminal middle cerebral artery occlusion. Stroke 1996; 27(2):317-323.
    • (1996) Stroke , vol.27 , Issue.2 , pp. 317-323
    • Zhang, F.1    Casey, R.M.2    Ross, M.E.3
  • 116
    • 0028891572 scopus 로고
    • Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage
    • Iadecola C, Zhang, Xu X, et al. Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage. Am J Physiol 1995; 268(1 Pt 2):R286-R292.
    • (1995) Am J Physiol , vol.268 , Issue.1 , pp. R286-R292
    • Iadecola, C.1    Zhang Xu, X.2
  • 117
    • 0034725832 scopus 로고    scopus 로고
    • Gene-doing effect ad persistence of reduction in ischemic brian injury in mice lacking inducible nitric oxide snythase
    • Zhao X, Haensel C, Araki E. Gene-doing effect ad persistence of reduction in ischemic brian injury in mice lacking inducible nitric oxide snythase. Brain Res 2000; 872(1-2):215-218.
    • (2000) Brain Res , vol.872 , Issue.1-2 , pp. 215-218
    • Zhao, X.1    Haensel, C.2    Araki, E.3
  • 118
    • 0032896588 scopus 로고    scopus 로고
    • Cyclooxygenase-2: Molecular biology, pharmacology, and neurobiology
    • Ôbanion MK. Cyclooxygenase-2: molecular biology, pharmacology, and neurobiology. Crit Rev Neurobiol 1999; 13(1):45-82.
    • (1999) Crit Rev Neurobiol , vol.13 , Issue.1 , pp. 45-82
    • Ôbanion, M.K.1
  • 119
    • 0031841980 scopus 로고    scopus 로고
    • Cyclooxygenase-2 is induced globally in infarcted human brain
    • Sairanen T, Ristimaki A, Karjalainen-Lindsberg ML, et al. Cyclooxygenase-2 is induced globally in infarcted human brain. Ann Neurol 1998; 43(6):738-747.
    • (1998) Ann Neurol , vol.43 , Issue.6 , pp. 738-747
    • Sairanen, T.1    Ristimaki, A.2    Karjalainen-Lindsberg, M.L.3
  • 120
    • 0035970036 scopus 로고    scopus 로고
    • Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice
    • Iadecola C, Niwa K, Nogawa S, et al. Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice. Proc Natl Acad Sci U S A 2001; 98(3):1294-1249.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.3 , pp. 1249-1294
    • Iadecola, C.1    Niwa, K.2    Nogawa, S.3
  • 121
    • 0037449409 scopus 로고    scopus 로고
    • Delayed effect of administration of COX-2 inhibitor in mice with acute cerebral ischemia
    • Sugimoto K, Iadecola C. Delayed effect of administration of COX-2 inhibitor in mice with acute cerebral ischemia. Brain Res 2003; 960(1-2):273-276.
    • (2003) Brain Res , vol.960 , Issue.1-2 , pp. 273-276
    • Sugimoto, K.1    Iadecola, C.2
  • 122
    • 0033510313 scopus 로고    scopus 로고
    • The cyclooxygenase-2 inhibitor NS-398 ameliorates cerebral ischemic injury in wild-type mice but not in mice with deletion of the inducible nitric oxide synthase gene
    • Nagamaya M, Niwa K, Nagamaya T. The cyclooxygenase-2 inhibitor NS-398 ameliorates cerebral ischemic injury in wild-type mice but not in mice with deletion of the inducible nitric oxide synthase gene. J Cereb Blood Flow Metab 1999; 19(11):1213-1219.
    • (1999) J Cereb Blood Flow Metab , vol.19 , Issue.11 , pp. 1213-1219
    • Nagamaya, M.1    Niwa, K.2    Nagamaya, T.3
  • 123
    • 0005728038 scopus 로고    scopus 로고
    • Matrix metalloproteinases increase very early during experimental focal cerebral ischemia
    • Heo JH, Lucero J, Abuiya T. Matrix metalloproteinases increase very early during experimental focal cerebral ischemia. J Cereb Blood Flow Metab 1999; 19(6):624-633.
    • (1999) J Cereb Blood Flow Metab , vol.19 , Issue.6 , pp. 624-633
    • Heo, J.H.1    Lucero, J.2    Abuiya, T.3
  • 124
    • 0034121588 scopus 로고    scopus 로고
    • Dexamethasone regulation of matrix metalloptroteinase expression in CNS vascular endothelium
    • Harkness KA, Adamson P, Sussman JD. Dexamethasone regulation of matrix metalloptroteinase expression in CNS vascular endothelium. Brain 2000; 123(Pt 4):698-709.
    • (2000) Brain , vol.123 , pp. 698-709
    • Harkness, K.A.1    Adamson, P.2    Sussman, J.D.3
  • 125
    • 0033581392 scopus 로고    scopus 로고
    • Early appearance of activated matrix metalloproteinase-9 and blood-brain barrier disruption in mice after focal cerebral ischemia and reperfusion
    • Fujimara M, Gasche Y, Morita-Fujimara Y. Early appearance of activated matrix metalloproteinase-9 and blood-brain barrier disruption in mice after focal cerebral ischemia and reperfusion. Brain Res 1999; 842(1):92-100.
    • (1999) Brain Res , vol.842 , Issue.1 , pp. 92-100
    • Fujimara, M.1    Gasche, Y.2    Morita-Fujimara, Y.3
  • 126
    • 0033505281 scopus 로고    scopus 로고
    • Early appearance of activated matrix metalloproteinase-9 after focal cerebral ischemia in mice: A possible role in blood-brain barrier dysfunction
    • Gasche Y, Fujimura M, Morita-Fujimura Y. Early appearance of activated matrix metalloproteinase-9 after focal cerebral ischemia in mice: a possible role in blood-brain barrier dysfunction. J Cereb Blood Flow Metab 1999; 19(9):1020-1028.
    • (1999) J Cereb Blood Flow Metab , vol.19 , Issue.9 , pp. 1020-1028
    • Gasche, Y.1    Fujimura, M.2    Morita-Fujimura, Y.3
  • 127
    • 0033666754 scopus 로고    scopus 로고
    • Metalloproteinase inhibition reduces thrombolytic (tissue plasminogen activator)-induced hemorrhage after thromboembolic stroke
    • Lapchak PA, Chapman DF, Zivin JA. Metalloproteinase inhibition reduces thrombolytic (tissue plasminogen activator)-induced hemorrhage after thromboembolic stroke. Stroke 2000; 31(12):3034-3040.
    • (2000) Stroke , vol.31 , Issue.12 , pp. 3034-3040
    • Lapchak, P.A.1    Chapman, D.F.2    Zivin, J.A.3
  • 128
    • 0035478029 scopus 로고    scopus 로고
    • Effects of matrix metalloproteinase 9 gene knockout on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia
    • Asahi M, Wang X, Mori T, et al. Effects of matrix metalloproteinase 9 gene knockout on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia. J Neurosci 2001; 21(19):7724-7732.
    • (2001) J Neurosci , vol.21 , Issue.19 , pp. 7724-7732
    • Asahi, M.1    Wang, X.2    Mori, T.3
  • 129
    • 0031693557 scopus 로고    scopus 로고
    • Matrix metalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brain
    • Rosenberg GA, Estrada EY, Dencoff JE. Matrix metalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brain. Stroke 1998; 29(10):2189-2195.
    • (1998) Stroke , vol.29 , Issue.10 , pp. 2189-2195
    • Rosenberg, G.A.1    Estrada, E.Y.2    Dencoff, J.E.3
  • 130
    • 0034989619 scopus 로고    scopus 로고
    • Tissue type plasminogen activator is involved in the process of neuronal death by oxygen-glucose deprivation
    • Nagai N, Yamamoto S, Tsuboi T, et al. Tissue type plasminogen activator is involved in the process of neuronal death by oxygen-glucose deprivation. J Cereb Blood Flow Metab 2001; 21(6):631-634.
    • (2001) J Cereb Blood Flow Metab , vol.21 , Issue.6 , pp. 631-634
    • Nagai, N.1    Yamamoto, S.2    Tsuboi, T.3
  • 131
    • 0031951510 scopus 로고    scopus 로고
    • Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice
    • Wang YF, Tsirka SE, Strickland S, et al. Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice. Nat Med 1998; 4(2):228-231.
    • (1998) Nat Med , vol.4 , Issue.2 , pp. 228-231
    • Wang, Y.F.1    Tsirka, S.E.2    Strickland, S.3
  • 132
    • 0032741931 scopus 로고    scopus 로고
    • Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model: Studies in tPA-deficient mice and wild-type mice on a matched genetic background
    • Tabrizi P, Wang L, Seeds N, et al. Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model: studies in tPA-deficient mice and wild-type mice on a matched genetic background. Arterioscler Thromb Vasc Biol 1999; 19(11):2801-2806.
    • (1999) Arterioscler Thromb Vasc Biol , vol.19 , Issue.11 , pp. 2801-2806
    • Tabrizi, P.1    Wang, L.2    Seeds, N.3
  • 133
    • 0142137232 scopus 로고    scopus 로고
    • Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator
    • Wang X, Lee SR, Arai K, et al. Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator. Nat Med 2003; 9(10):1313-1317.
    • (2003) Nat Med , vol.9 , Issue.10 , pp. 1313-1317
    • Wang, X.1    Lee, S.R.2    Arai, K.3
  • 134
    • 0036850280 scopus 로고    scopus 로고
    • Development of thrombolytic therapy for stroke: A perspective
    • Lapchak PA. Development of thrombolytic therapy for stroke: a perspective. Expert Opin Investig Drugs 2002; 11:1623-1632.
    • (2002) Expert Opin Investig Drugs , vol.11 , pp. 1623-1632
    • Lapchak, P.A.1
  • 135
    • 0036330667 scopus 로고    scopus 로고
    • Rapid breakdown of microvascular barriers and subsequent hemorrhagic transformation after delayed recombinant tissue plasminogen activator treatment in a rat embolic stroke model
    • Dijkhuizen RM, Asahi M, Wu O, et al. Rapid breakdown of microvascular barriers and subsequent hemorrhagic transformation after delayed recombinant tissue plasminogen activator treatment in a rat embolic stroke model. Stroke 2002; 33(8):2100-2104.
    • (2002) Stroke , vol.33 , Issue.8 , pp. 2100-2104
    • Dijkhuizen, R.M.1    Asahi, M.2    Wu, O.3
  • 136
    • 0042623437 scopus 로고    scopus 로고
    • Closure of the blood-brain barrier by matrix metalloproteinase inhibition reduces rtPA-mediated mortality in cerebral ischemia with delayed reperfusion
    • Pfefferkorn T, Rosenberg GA. Closure of the blood-brain barrier by matrix metalloproteinase inhibition reduces rtPA-mediated mortality in cerebral ischemia with delayed reperfusion. Stroke 2003; 34(8):2025-2030.
    • (2003) Stroke , vol.34 , Issue.8 , pp. 2025-2030
    • Pfefferkorn, T.1    Rosenberg, G.A.2
  • 137
    • 0034746189 scopus 로고    scopus 로고
    • The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling
    • Nicole O, Docagne F, Ali C, et al. The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling. Nat Med 2001; 7(1):59-64.
    • (2001) Nat Med , vol.7 , Issue.1 , pp. 59-64
    • Nicole, O.1    Docagne, F.2    Ali, C.3
  • 138
    • 16844383081 scopus 로고    scopus 로고
    • Tissue plasminogen activator and NMDA receptor cleavage
    • Matys T, Strickland S. Tissue plasminogen activator and NMDA receptor cleavage. Nat Med 2003; 9(4):371-372.
    • (2003) Nat Med , vol.9 , Issue.4 , pp. 371-372
    • Matys, T.1    Strickland, S.2
  • 139
    • 0037321482 scopus 로고    scopus 로고
    • Vampire bat salivary plasminogen activator (desmoteplase):A unique fibrinolytic enzyme that does not promote neurodegeneration
    • Liberatore GT, Samson A, Bladin C, et al. Vampire bat salivary plasminogen activator (desmoteplase):a unique fibrinolytic enzyme that does not promote neurodegeneration. Stroke 2003; 34(2):537-543.
    • (2003) Stroke , vol.34 , Issue.2 , pp. 537-543
    • Liberatore, G.T.1    Samson, A.2    Bladin, C.3
  • 140
    • 20444372592 scopus 로고    scopus 로고
    • Vampire bat salivary plasminogen activator (desmoteplase) inhibits tissue-type plasminogen activator-induced potentiation of excitotoxic injury
    • Reddrop C, Moldrich RX, Beart PM. Vampire bat salivary plasminogen activator (desmoteplase) inhibits tissue-type plasminogen activator-induced potentiation of excitotoxic injury. Stroke 2005; 36(6):1241-1246.
    • (2005) Stroke , vol.36 , Issue.6 , pp. 1241-1246
    • Reddrop, C.1    Moldrich, R.X.2    Beart, P.M.3
  • 141
    • 19944426190 scopus 로고    scopus 로고
    • The Desmoteplase in Acute Ischemic Stroke trial (DIAS): A phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase
    • Hacke W, Albers G, Al-Rawi Y, et al. DIAS Study Group. The Desmoteplase in Acute Ischemic Stroke trial (DIAS): a phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase. Stroke 2005; 36(1):66-73.
    • (2005) Stroke , vol.36 , Issue.1 , pp. 66-73
    • Hacke, W.1    Albers, G.2    Al-Rawi, Y.3
  • 142
    • 0037417220 scopus 로고    scopus 로고
    • Apoptosis and caspases in neurodegenerative diseases
    • Friedlander RM. Apoptosis and caspases in neurodegenerative diseases. N Engl J Med 2003; 348(14):1365-1375.
    • (2003) N Engl J Med , vol.348 , Issue.14 , pp. 1365-1375
    • Friedlander, R.M.1
  • 144
    • 0037384802 scopus 로고    scopus 로고
    • Signaling of cell death and cell survival following focal cerebral ischemia: Life and death struggle in the penumbra
    • Ferrer I, Planas AM. Signaling of cell death and cell survival following focal cerebral ischemia: life and death struggle in the penumbra. J Neuropathol Exp Neurol 2003; 62(4):329-339.
    • (2003) J Neuropathol Exp Neurol , vol.62 , Issue.4 , pp. 329-339
    • Ferrer, I.1    Planas, A.M.2
  • 145
    • 0035078659 scopus 로고    scopus 로고
    • Neurodegenerative disorders and ischemic brain diseases
    • Mattson MP, Duan W, Pedersen WA, et al. Neurodegenerative disorders and ischemic brain diseases. Apoptosis 2001; 6(1-2):69-81.
    • (2001) Apoptosis , vol.6 , Issue.1-2 , pp. 69-81
    • Mattson, M.P.1    Duan, W.2    Pedersen, W.A.3
  • 146
    • 0242499487 scopus 로고    scopus 로고
    • Selective neuronal vulnerability following mild focal brain ischemia in the mouse
    • Katchanov J, Waeber C, Gertz K, et al. Selective neuronal vulnerability following mild focal brain ischemia in the mouse. Brain Pathol 2003; 13(4):452-464.
    • (2003) Brain Pathol , vol.13 , Issue.4 , pp. 452-464
    • Katchanov, J.1    Waeber, C.2    Gertz, K.3
  • 147
    • 0029918952 scopus 로고    scopus 로고
    • Apoptosis and c-Jun in the thalamus of the rat following cortical infarction
    • Soriano MA, Ferrer I, Rodriguez-Farre E, et al. Apoptosis and c-Jun in the thalamus of the rat following cortical infarction. Neuroreport 1996; 7(2):425-428.
    • (1996) Neuroreport , vol.7 , Issue.2 , pp. 425-428
    • Soriano, M.A.1    Ferrer, I.2    Rodriguez-Farre, E.3
  • 148
    • 0037069451 scopus 로고    scopus 로고
    • Caspase activation and neuroprotection in caspase-3-deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation
    • Le DA, Wu Y, Huang Z, et al. Caspase activation and neuroprotection in caspase-3-deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation. Proc Natl Acad Sci USA 2002; 99(23):15188-15193.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.23 , pp. 15188-15193
    • Le, D.A.1    Wu, Y.2    Huang, Z.3
  • 149
    • 0030614952 scopus 로고    scopus 로고
    • Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage
    • Hara H, Friedlander RM, Gagliardini V, et al. Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage. Proc Natl Acad Sci USA 1997; 94(5):2007-2012.
    • (1997) Proc Natl Acad Sci USA , vol.94 , Issue.5 , pp. 2007-2012
    • Hara, H.1    Friedlander, R.M.2    Gagliardini, V.3
  • 150
    • 0037067317 scopus 로고    scopus 로고
    • Mediation of poly (ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor
    • Yu SW, Wang H, Poitras MF, et al. Mediation of poly (ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science 2002; 297(5579):259-263.
    • (2002) Science , vol.297 , Issue.5579 , pp. 259-263
    • Yu, S.W.1    Wang, H.2    Poitras, M.F.3
  • 151
    • 0141819063 scopus 로고    scopus 로고
    • Caspase-dependent and caspase-independent signaling of apoptosis in the penumbra following middle cerebral artery occlusion in the adult rat
    • Ferrer I, Friguls B, Dalfo E, et al. Caspase-dependent and caspase-independent signaling of apoptosis in the penumbra following middle cerebral artery occlusion in the adult rat. Neuropathol Appl Neurobiol 2003; 29(5):472-481.
    • (2003) Neuropathol Appl Neurobiol , vol.29 , Issue.5 , pp. 472-481
    • Ferrer, I.1    Friguls, B.2    Dalfo, E.3
  • 152
    • 0030832874 scopus 로고    scopus 로고
    • Ischemic brain injury is mediated by the activation of poly(ADP-ribose) polymerase
    • Endres M, Wang ZQ, Namura S, et al. Ischemic brain injury is mediated by the activation of poly(ADP-ribose) polymerase. J Cereb Blood Flow Metab 1997; 17(11):1143-1151.
    • (1997) J Cereb Blood Flow Metab , vol.17 , Issue.11 , pp. 1143-1151
    • Endres, M.1    Wang, Z.Q.2    Namura, S.3
  • 153
    • 0030842946 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia
    • Eliasson MJ, Sampei K, Mandir AS, et al. Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nat Med 1997; 3(10):1089-1095.
    • (1997) Nat Med , vol.3 , Issue.10 , pp. 1089-1095
    • Eliasson, M.J.1    Sampei, K.2    Mandir, A.S.3
  • 154
    • 0041573041 scopus 로고    scopus 로고
    • NAD+ repletion prevents PARP-1-induced glycolytic blockade and cell death in cultured mouse astrocytes
    • Ying W, Garnier P, Swanson RA. NAD+ repletion prevents PARP-1-induced glycolytic blockade and cell death in cultured mouse astrocytes. Biochem Biophys Res Commun 2003; 308(4):809-813.
    • (2003) Biochem Biophys Res Commun , vol.308 , Issue.4 , pp. 809-813
    • Ying, W.1    Garnier, P.2    Swanson, R.A.3
  • 156
    • 0037427415 scopus 로고    scopus 로고
    • Mitochondrial potassium channels and uncoupling proteins in synaptic plasticity and neuronal cell death
    • Mattson MP, Liu D. Mitochondrial potassium channels and uncoupling proteins in synaptic plasticity and neuronal cell death. Biochem Biophys Res Commun 2003; 304(3):539-549.
    • (2003) Biochem Biophys Res Commun , vol.304 , Issue.3 , pp. 539-549
    • Mattson, M.P.1    Liu, D.2
  • 157
    • 0037427444 scopus 로고    scopus 로고
    • Mitochondrial intermembrane proteins in cell death
    • van Gurp M, Festjens N, van Loo G, et al. Mitochondrial intermembrane proteins in cell death. Biochem Biophys Res Commun 2003; 304(3):487-497.
    • (2003) Biochem Biophys Res Commun , vol.304 , Issue.3 , pp. 487-497
    • van Gurp, M.1    Festjens, N.2    van Loo, G.3
  • 158
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome C and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    • Li P, Nijhawan D, Budihardjo I, et al. Cytochrome C and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 1997; 91(4):479-489.
    • (1997) Cell , vol.91 , Issue.4 , pp. 479-489
    • Li, P.1    Nijhawan, D.2    Budihardjo, I.3
  • 159
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner MO. The biochemistry of apoptosis. Nature 2000; 407(6805):770-776.
    • (2000) Nature , vol.407 , Issue.6805 , pp. 770-776
    • Hengartner, M.O.1
  • 160
    • 0028981908 scopus 로고
    • Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia
    • Linnik MD, Zahos P, Geschwind MD, et al. Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia. Stroke 1995; 26(9):1670-1674.
    • (1995) Stroke , vol.26 , Issue.9 , pp. 1670-1674
    • Linnik, M.D.1    Zahos, P.2    Geschwind, M.D.3
  • 161
    • 0027944004 scopus 로고
    • Overexpression of bcl-2 in transgenic mice protects neurons from naturally occuring cell death and experimental ischemia
    • Martinou JC, Dubois-Dauphin M, Staple JK, et al. Overexpression of bcl-2 in transgenic mice protects neurons from naturally occuring cell death and experimental ischemia. Neuron 1994;13:1017-1030.
    • (1994) Neuron , vol.13 , pp. 1017-1030
    • Martinou, J.C.1    Dubois-Dauphin, M.2    Staple, J.K.3
  • 162
    • 0033603335 scopus 로고    scopus 로고
    • Neuron-specific transgene expression of Bcl-XL but not Bcl-2 genes reduced lesion size after permanent middle cerebral artery occlusion in mice
    • Wiessner C, Allegrini PR, Rupalla K, et al. Neuron-specific transgene expression of Bcl-XL but not Bcl-2 genes reduced lesion size after permanent middle cerebral artery occlusion in mice. Neurosci Lett 1999; 268(3):119-222.
    • (1999) Neurosci Lett , vol.268 , Issue.3 , pp. 119-222
    • Wiessner, C.1    Allegrini, P.R.2    Rupalla, K.3
  • 163
    • 0036663014 scopus 로고    scopus 로고
    • Vivo delivery of a Bcl-xL fusion protein containing the TAT protein transduction domain protects against ischemic brain injury and neuronal apoptosis
    • Cao G, Pei W, Ge H, et al. Vivo delivery of a Bcl-xL fusion protein containing the TAT protein transduction domain protects against ischemic brain injury and neuronal apoptosis. J Neurosci 2002; 22(13):5423-5431.
    • (2002) J Neurosci , vol.22 , Issue.13 , pp. 5423-5431
    • Cao, G.1    Pei, W.2    Ge, H.3
  • 164
    • 0036829818 scopus 로고    scopus 로고
    • Intravenous TAT-Bcl-Xl is protective after middle cerebral artery occlusion in mice
    • Kilic E, Dietz GP, Hermann DM, et al. Intravenous TAT-Bcl-Xl is protective after middle cerebral artery occlusion in mice. Ann Neurol 2002; 52(5):617-622.
    • (2002) Ann Neurol , vol.52 , Issue.5 , pp. 617-622
    • Kilic, E.1    Dietz, G.P.2    Hermann, D.M.3
  • 165
    • 0038044666 scopus 로고    scopus 로고
    • Transgenic mice overexpressing XIAP in neurons show better outcome after transient cerebral ischemia
    • Trapp T, Korhonen L, Besselmann M, et al. Transgenic mice overexpressing XIAP in neurons show better outcome after transient cerebral ischemia. Mol Cell Neurosci 2003; 23(2):302-313.
    • (2003) Mol Cell Neurosci , vol.23 , Issue.2 , pp. 302-313
    • Trapp, T.1    Korhonen, L.2    Besselmann, M.3
  • 166
    • 0042838034 scopus 로고    scopus 로고
    • Interaction between XIAP and Smac/DIABLO in the mouse brain after transient focal cerebral ischemia
    • Saito A, Hayashi T, Okuno S, et al. Interaction between XIAP and Smac/DIABLO in the mouse brain after transient focal cerebral ischemia. J Cereb Blood Flow Metab 2003; 23(9):1010-1019.
    • (2003) J Cereb Blood Flow Metab , vol.23 , Issue.9 , pp. 1010-1019
    • Saito, A.1    Hayashi, T.2    Okuno, S.3
  • 167
    • 0027278557 scopus 로고
    • Instability and decay of the primary structure of DNA
    • Lindahl T. Instability and decay of the primary structure of DNA. Nature 1993; 362(6422):709-715.
    • (1993) Nature , vol.362 , Issue.6422 , pp. 709-715
    • Lindahl, T.1
  • 168
    • 0029875519 scopus 로고    scopus 로고
    • Repair of products of oxidative DNA base damage in human cells
    • Jaruga P, Dizdaroglu M. Repair of products of oxidative DNA base damage in human cells. Nucleic Acids Res 1996; 24(8):1389-1394.
    • (1996) Nucleic Acids Res , vol.24 , Issue.8 , pp. 1389-1394
    • Jaruga, P.1    Dizdaroglu, M.2
  • 169
    • 0035478431 scopus 로고    scopus 로고
    • Ischemic injury and faulty gene transcripts in the brain
    • Liu PK, Grossman RG, Hsu CY, Robertson CS. Ischemic injury and faulty gene transcripts in the brain. Trends Neurosci 2001; 24(10):581-588.
    • (2001) Trends Neurosci , vol.24 , Issue.10 , pp. 581-588
    • Liu, P.K.1    Grossman, R.G.2    Hsu, C.Y.3    Robertson, C.S.4
  • 170
    • 0029973192 scopus 로고    scopus 로고
    • Damage, repair, and mutagensis in nuclear genes after mouse forebrain ischemia-reperfusion
    • Liu PK, Hsu CY, Dizdaroglu M, et al. Damage, repair, and mutagensis in nuclear genes after mouse forebrain ischemia-reperfusion. J Neurosci 1996; 16(21):6795-6806.
    • (1996) J Neurosci , vol.16 , Issue.21 , pp. 6795-6806
    • Liu, P.K.1    Hsu, C.Y.2    Dizdaroglu, M.3
  • 171
    • 0036904660 scopus 로고    scopus 로고
    • Rat MYH, a glycosylase for repair of oxidatively damaged DNA, has brain-specific isoforms that localize to neuronal mitochondria
    • Englander EW, Hu Z, Sharma A. Rat MYH, a glycosylase for repair of oxidatively damaged DNA, has brain-specific isoforms that localize to neuronal mitochondria. J Neurochem 2002; 83(6):1471-1480.
    • (2002) J Neurochem , vol.83 , Issue.6 , pp. 1471-1480
    • Englander, E.W.1    Hu, Z.2    Sharma, A.3
  • 172
    • 0029972658 scopus 로고    scopus 로고
    • DNA damage and repair in central nervous system injury:National institute of neurological disorders and stroke workshop summary
    • Chopp M, Chan PH, Hsu CY, et al. DNA damage and repair in central nervous system injury:national institute of neurological disorders and stroke workshop summary. Stroke 1996; 27(3):363-369.
    • (1996) Stroke , vol.27 , Issue.3 , pp. 363-369
    • Chopp, M.1    Chan, P.H.2    Hsu, C.Y.3
  • 173
    • 0242490147 scopus 로고    scopus 로고
    • Inducible repair of oxidative DNA lesions in the rat brain after transient focal ischemia and reperfusion
    • Lan J, Li W, Zhang F, et al. Inducible repair of oxidative DNA lesions in the rat brain after transient focal ischemia and reperfusion. J Cereb Blood Flow Metab 2003; 23(11):1324-1339.
    • (2003) J Cereb Blood Flow Metab , vol.23 , Issue.11 , pp. 1324-1339
    • Lan, J.1    Li, W.2    Zhang, F.3
  • 174
    • 3042766227 scopus 로고    scopus 로고
    • Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase
    • Endres M, Biniszkiewicz D, Sobol RW, et al. Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase. J Clin Invest 2004; 113(12):1711-1721.
    • (2004) J Clin Invest , vol.113 , Issue.12 , pp. 1711-1721
    • Endres, M.1    Biniszkiewicz, D.2    Sobol, R.W.3
  • 175
    • 0038075338 scopus 로고    scopus 로고
    • Decision making by p53: Life, death and cancer
    • Oren M. Decision making by p53: life, death and cancer. Cell Death Differ 2003; 10(4):431-442.
    • (2003) Cell Death Differ , vol.10 , Issue.4 , pp. 431-442
    • Oren, M.1
  • 176
    • 0029973389 scopus 로고    scopus 로고
    • Cell-cycle control and its watchman
    • Jacks T, Weinberg RA. Cell-cycle control and its watchman. Nature 1996; 381(6584):643-644.
    • (1996) Nature , vol.381 , Issue.6584 , pp. 643-644
    • Jacks, T.1    Weinberg, R.A.2
  • 177
    • 0026607994 scopus 로고
    • p53 expression in brain after middle cerebral artery occlusion in the rat
    • Chopp M, Li Y, Zhang ZG, et al. p53 expression in brain after middle cerebral artery occlusion in the rat. Biochem Biophys Res Commun 1992; 182(3):1201-1207.
    • (1992) Biochem Biophys Res Commun , vol.182 , Issue.3 , pp. 1201-1207
    • Chopp, M.1    Li, Y.2    Zhang, Z.G.3
  • 178
    • 0028263192 scopus 로고
    • p53-immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats
    • Li Y, Chopp M, Zhang ZG, et al. p53-immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats. Stroke 1994; 25(4):849-855.
    • (1994) Stroke , vol.25 , Issue.4 , pp. 849-855
    • Li, Y.1    Chopp, M.2    Zhang, Z.G.3
  • 179
    • 0027985453 scopus 로고
    • Attenuation of p53 expression protects against focal ischemic damage in transgenic mice
    • Crumrine RC, Thomas AL, Morgan PF. Attenuation of p53 expression protects against focal ischemic damage in transgenic mice. J Cereb Blood Flow Metab 1994; 14(6):887-891.
    • (1994) J Cereb Blood Flow Metab , vol.14 , Issue.6 , pp. 887-891
    • Crumrine, R.C.1    Thomas, A.L.2    Morgan, P.F.3
  • 180
  • 181
    • 0035075845 scopus 로고    scopus 로고
    • Ischemia tolerance; model for research, hope for clinical practice?
    • Weih M, Prass K, Ruscher K, et al. Ischemia tolerance; model for research, hope for clinical practice? Nervenarzt 2001; 72:255-260.
    • (2001) Nervenarzt , vol.72 , pp. 255-260
    • Weih, M.1    Prass, K.2    Ruscher, K.3
  • 182
    • 0036843521 scopus 로고    scopus 로고
    • Ischemic tolerance
    • Kirino T. Ischemic tolerance. J Cereb Blood Flow Metab 2002; 22(11):1283-1296.
    • (2002) J Cereb Blood Flow Metab , vol.22 , Issue.11 , pp. 1283-1296
    • Kirino, T.1
  • 183
    • 0032881979 scopus 로고    scopus 로고
    • Attenuated stroke severity after prodromal TIA: A role for ischemic tolerance in the brain?
    • Weih M, Kallenberg K, Bergk A, et al. Attenuated stroke severity after prodromal TIA: a role for ischemic tolerance in the brain? Stroke 1999; 30(9):1851-1854.
    • (1999) Stroke , vol.30 , Issue.9 , pp. 1851-1854
    • Weih, M.1    Kallenberg, K.2    Bergk, A.3
  • 184
    • 10744222364 scopus 로고    scopus 로고
    • MRI in Acute Stroke Study Group of the German Competence Network Stroke. Transient ischemic attacks before ischemic stroke: Preconditioning the human brain? A multicenter magnetic resonance imaging study
    • Wegener S, Gottschalk B, Jovanovic V, et al. MRI in Acute Stroke Study Group of the German Competence Network Stroke. Transient ischemic attacks before ischemic stroke: preconditioning the human brain? A multicenter magnetic resonance imaging study. Stroke 2004; 35:616-621.
    • (2004) Stroke , vol.35 , pp. 616-621
    • Wegener, S.1    Gottschalk, B.2    Jovanovic, V.3
  • 185
    • 0032566706 scopus 로고    scopus 로고
    • Induction of hypoxia inducible factor 1 by oxygen glucose deprivation is attenuated by hypoxic preconditioning in rat cultured neurons
    • Ruscher K, Isaev N, Trendelenburg G, et al.. Induction of hypoxia inducible factor 1 by oxygen glucose deprivation is attenuated by hypoxic preconditioning in rat cultured neurons. Neurosci Lett 1998; 254(2):117-120.
    • (1998) Neurosci Lett , vol.254 , Issue.2 , pp. 117-120
    • Ruscher, K.1    Isaev, N.2    Trendelenburg, G.3
  • 186
    • 0036249884 scopus 로고    scopus 로고
    • Desferrioxamine induces delayed tolerance against cerebral ischemia in vivo and in vitro
    • Prass K, Ruscher K, Karsch M, et al. Desferrioxamine induces delayed tolerance against cerebral ischemia in vivo and in vitro. J Cereb Blood Flow Metab 2002; 22(5):520-525.
    • (2002) J Cereb Blood Flow Metab , vol.22 , Issue.5 , pp. 520-525
    • Prass, K.1    Ruscher, K.2    Karsch, M.3
  • 187
    • 20044373442 scopus 로고    scopus 로고
    • Emerging biological roles for erythropoietin in the nervous system
    • Brines M, Cerami A. Emerging biological roles for erythropoietin in the nervous system. Nat Rev Neurosci 2005; 6(6):484-494.
    • (2005) Nat Rev Neurosci , vol.6 , Issue.6 , pp. 484-494
    • Brines, M.1    Cerami, A.2
  • 188
    • 0042122371 scopus 로고    scopus 로고
    • Hypoxia-induced stroke tolerance in the mouse is mediated by erythropoietin
    • Prass K, Scharff A, Ruscher K, et al. Hypoxia-induced stroke tolerance in the mouse is mediated by erythropoietin. Stroke 2003; 34(8):1981-1986.
    • (2003) Stroke , vol.34 , Issue.8 , pp. 1981-1986
    • Prass, K.1    Scharff, A.2    Ruscher, K.3
  • 189
    • 2642555563 scopus 로고    scopus 로고
    • HIF1 and oxygen sensing in the brain
    • Sharp FR, Bernaudin M. HIF1 and oxygen sensing in the brain. Nat Rev Neurosci 2004; 5(6):437-448.
    • (2004) Nat Rev Neurosci , vol.5 , Issue.6 , pp. 437-448
    • Sharp, F.R.1    Bernaudin, M.2
  • 190
    • 0034641710 scopus 로고    scopus 로고
    • Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury
    • Brines ML, Ghezzi P, Keenan S, et al. Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Proc Natl Acad Sci USA 2000; 97(19):10526-10531.
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.19 , pp. 10526-10531
    • Brines, M.L.1    Ghezzi, P.2    Keenan, S.3
  • 191
    • 0032516086 scopus 로고    scopus 로고
    • In vivo evidence that erythropoietin protects neurons from ischemic damage
    • Sakanaka M, Wen TC, Matsuda S, et al. In vivo evidence that erythropoietin protects neurons from ischemic damage. Proc Natl Acad Sci USA 1998; 95(8):4635-4640.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.8 , pp. 4635-4640
    • Sakanaka, M.1    Wen, T.C.2    Matsuda, S.3
  • 192
    • 0036705708 scopus 로고    scopus 로고
    • Erythropoietin therapy for acute stroke is both safe and beneficial
    • Ehrenreich H, Hasselblatt M, Dembowski C, et al. Erythropoietin therapy for acute stroke is both safe and beneficial. Mol Med 2002; 8(8):495-505.
    • (2002) Mol Med , vol.8 , Issue.8 , pp. 495-505
    • Ehrenreich, H.1    Hasselblatt, M.2    Dembowski, C.3
  • 193
    • 3042725549 scopus 로고    scopus 로고
    • Derivatives of erythropoietin that are tissue protective but not erythropoietic
    • Leist M, Ghezzi P, Grasso G, et al. Derivatives of erythropoietin that are tissue protective but not erythropoietic. Scienc. 2004; 305(5681):239-242.
    • (2004) Scienc. , vol.305 , Issue.5681 , pp. 239-242
    • Leist, M.1    Ghezzi, P.2    Grasso, G.3


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