Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model studies in tPA-deficient mice and wild-type mice on a matched genetic background

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 19, Issue 11, 1999, Pages 2801-2806

  Tabrizi, Peyman ^a   Wang, Liang ^a   Seeds, Nicholas ^b   McComb, J Gordon ^a   Yamada, Shinya ^a   Griffin, John H ^c   Carmeliet, Peter ^d   Weiss, Martin H ^a   Zlokovic, Berislav V ^a,e  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d Center for Transgcnc Technology and Gene Therapy   (Belgium)

^e RMR 506 ^*  (United States)

Author keywords

Cerebrovascular events; Fibrin; Ischemia; Neuroprotection; Tissue plasminogen activator

Indexed keywords

SERINE PROTEINASE; TISSUE PLASMINOGEN ACTIVATOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN INJURY; CONTROLLED STUDY; FIBRIN DEPOSITION; GENOTYPE; MOUSE; NEUROPROTECTION; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; PRIORITY JOURNAL; SCORING SYSTEM; STROKE; THROMBOGENESIS;

ANIMALS; BLOTTING, WESTERN; BRAIN EDEMA; BRAIN ISCHEMIA; CAPILLARIES; CEREBRAL INFARCTION; CEREBROVASCULAR ACCIDENT; CEREBROVASCULAR CIRCULATION; CIRCLE OF WILLIS; DISEASE MODELS, ANIMAL; FEMALE; FIBRIN; INTRACRANIAL THROMBOSIS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUROPROTECTIVE AGENTS; SUTURES; TISSUE PLASMINOGEN ACTIVATOR;

EID: 0032741931     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.19.11.2801     Document Type: Article

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