The cyclooxygenase-2 inhibitor NS-398 ameliorates ischemic brain injury in wild-type mice but not in mice with deletion of the inducible nitric oxide synthase gene

Journal of Cerebral Blood Flow and Metabolism

Volumn 19, Issue 11, 1999, Pages 1213-1219

  Nagayama, Masao ^a   Niwa, Kiyoshi ^a   Nagayama, Tomiko ^a   Ross, M Elizabeth ^a   Iadecola, Costantino ^a,b  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Cerebral ischemia; Inducible nitric oxide synthase null mice; Laser Doppler flowmetry; Middle cerebral artery occlusion; NS398

Indexed keywords

7 NITROINDAZOLE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PROSTAGLANDIN; THIONINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; CONTROLLED STUDY; GENE DELETION; HYPERCAPNIA; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL;

EID: 0033510313     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199911000-00005     Document Type: Article

References (17)

1. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA (1990) Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87:1620-1624
2. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H (1986) Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17: 472-476
3. Collaco-Moraes Y, Aspey B, Harrison M, de Belleroche J (1996) Cyclo-oxygenase-2 messenger RNA induction in focal cerebral ischemia. J Cereb Blood Flow Metab 16:1366-1372
4. Dawson VL, Brahmbhatt HP, Mong JA, Dawson TM (1994) Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures. Neuropharmacology 33:1425-1430
5. Eliasson MJ, Sampei K, Mandir AS, Hum PD, Traystman RJ, Bao J, Pieper A, Wang ZQ, Dawson TM, Snyder SH, Dawson VL (1997) Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nat Med 3:1089-1095
6. Forrester K, Ambs S, Lupold SE, Kapust RB, Spillare EA, Weinberg WC, E. F-B, Wang XW, Geller DA, Tzeng E, Billiar TR, Harris CC (1996) Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53. Proc Natl Acad Sci USA 93:2442-2447
7. Forster C, Clark HB, Ross ME, Iadecola C (1999) Inducible nitric oxide synthase expression in human cerebral infarcts. Acta Neuropathologica 97:215-220
8. Hewett SJ, Csernansky CA, Choi DW (1994) Selective potentiation of NMDA-induced neuronal injury following induction of astrocytic iNOS. Neuron 13:487-494
9. Hewett SJ, Muir JK, Lobner D, Symons A, Choi DW (1996) Potentiation of oxygen-glucose deprivation-induced neuronal death after induction of iNOS. Stroke 27:1586-1591
10. Iadecola C (1997) Bright and dark sides of nitric oxide in ischemic brain damage. Trends Neurosci 20:132-138
11. Iadecola C, Forster C, Shigeru N, Clark HB, Ross ME (1999) Cyclooxygenase-2 immunoreactivity in the human brain following cerebral ischemia. Acta Neuropathol 98:9-14
12. Iadecola C, Zhang F (1996) Permissive and obligatory roles of NO in cerebrovascular responses to hypercapnia and acetylcholine. Am J Physiol 271 (Regulatory Integrative Comp Physiol 40):R990-R1001
13. Iadecola C, Zhang F, Casey R, Clark HB, Ross ME (1996) Inducible nitric oxide synthase gene expression in vascular cells after transient focal cerebral ischemia. Stroke 27:1373-1380
14. Iadecola C, Zhang F, Casey R, Nagayama M, Ross ME (1997) Delayed reduction in ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene. J Neurosci 17: 9157-9164
15. Iadecola C, Zhang F, Xu X (1995a) Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage. Am J Physiol 268:R286-R292
16. Iadecola C, Zhang F, Xu X, Casey R, Ross ME (1995b) Inducible nitric oxide synthase gene expression in brain following cerebral ischemia. J Cereb Blood Flow Metab 15:378-384
17. Kamii H, Mikawa S, Murakami K, Kinouchi H, Yoshimoto T, Reola L, Carlson E, Epstein CJ, Chan PH (1996) Effects of nitric oxide synthase inhibition on brain infarction in SOD-1-transgenic mice following transient focal cerebral ischemia. J Cereb Blood Flow Metab 16:1153-1157