메뉴 건너뛰기




Volumn 22, Issue 13, 2002, Pages 5423-5431

In vivo delivery of a Bcl-xL fusion protein containing the TAT protein transduction domain protects against ischemic brain injury and neuronal apoptosis

Author keywords

Bcl 2; Caspase 3, cytochrome c; Cerebral ischemia; Protein transduction; Stroke

Indexed keywords

CASPASE 3; CYTOCHROME C; HYBRID PROTEIN; PROTEIN BCL 2; PROTEIN BCL XL; TRANSACTIVATOR PROTEIN;

EID: 0036663014     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-13-05423.2002     Document Type: Article
Times cited : (412)

References (47)
  • 2
    • 0035045290 scopus 로고    scopus 로고
    • Intracellular Bax translocation after transient cerebral ischemia: Implications for a role of the mitochondrial apoptotic signaling pathway in ischemic neuronal death
    • Cao G, Minami M, Pei W, Yan C, Chen D, O'Horo C, Graham SH, Chen J (2001a) Intracellular Bax translocation after transient cerebral ischemia: Implications for a role of the mitochondrial apoptotic signaling pathway in ischemic neuronal death. J Cereb Blood Flow Metab 21:321-333.
    • (2001) J Cereb Blood Flow Metab , vol.21 , pp. 321-333
    • Cao, G.1    Minami, M.2    Pei, W.3    Yan, C.4    Chen, D.5    O'Horo, C.6    Graham, S.H.7    Chen, J.8
  • 3
    • 0035400124 scopus 로고    scopus 로고
    • Caspase-activated DNase/DNA fragmentation factor 40 mediates apoptotic DNA fragmentation in transient cerebral ischemia and in neuronal cultures
    • Cao G, Pei W, Lan J, Stetler RA, Luo Y, Nagayama T, Graham SH, Yin XM, Simon RP, Chen J (2001b) Caspase-activated DNase/DNA fragmentation factor 40 mediates apoptotic DNA fragmentation in transient cerebral ischemia and in neuronal cultures. J Neurosci 21:4678-4690.
    • (2001) J Neurosci , vol.21 , pp. 4678-4690
    • Cao, G.1    Pei, W.2    Lan, J.3    Stetler, R.A.4    Luo, Y.5    Nagayama, T.6    Graham, S.H.7    Yin, X.M.8    Simon, R.P.9    Chen, J.10
  • 4
    • 0036012750 scopus 로고    scopus 로고
    • Cloning and characterization of rat caspase-9: Implications for a role in mediating caspase-3 activation and hippocampal cell death after transient cerebral ischemia
    • Cao G, Luo Y, Nagayama T, Pei W, Stetler RA, Graham SH, Chen J (2002) Cloning and characterization of rat caspase-9: Implications for a role in mediating caspase-3 activation and hippocampal cell death after transient cerebral ischemia. J Cereb Blood Flow Metab 22:534-546.
    • (2002) J Cereb Blood Flow Metab , vol.22 , pp. 534-546
    • Cao, G.1    Luo, Y.2    Nagayama, T.3    Pei, W.4    Stetler, R.A.5    Graham, S.H.6    Chen, J.7
  • 5
    • 0034624061 scopus 로고    scopus 로고
    • Characterization of the rat DNA fragmentation factor 35/inhibitor of caspase-activated DNase (short form): The endogenous inhibitor of caspase-dependent DNA fragmentation in neuronal apoptosis
    • Chen D, Stetler RA, Cao G, Pei W, O'Horo C, Yin XM, Chen J (2000) Characterization of the rat DNA fragmentation factor 35/inhibitor of caspase-activated DNase (short form): The endogenous inhibitor of caspase-dependent DNA fragmentation in neuronal apoptosis. J Biol Chem 275:38508-38517.
    • (2000) J Biol Chem , vol.275 , pp. 38508-38517
    • Chen, D.1    Stetler, R.A.2    Cao, G.3    Pei, W.4    O'Horo, C.5    Yin, X.M.6    Chen, J.7
  • 6
    • 0011735219 scopus 로고    scopus 로고
    • Regulation of active cell death in ischemic brain injury: The role of Bax and the mitochondrial pathway
    • Krieglstein J, Klumpp S, eds, Stuttgart: Scientific Publishers
    • Chen J, Yin XM (2000) Regulation of active cell death in ischemic brain injury: The role of Bax and the mitochondrial pathway. In: Pharmacology of Cerebral Ischemia (Krieglstein J, Klumpp S, eds), pp 189-198. Stuttgart: Scientific Publishers.
    • (2000) Pharmacology of Cerebral Ischemia , pp. 189-198
    • Chen, J.1    Yin, X.M.2
  • 8
    • 0032124903 scopus 로고    scopus 로고
    • Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia
    • Chen J, Nagayama T, Jin K, Stetler RA, Zhu RL, Graham SH, Simon RP (1998) Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia. J Neurosci 18:4914-4928.
    • (1998) J Neurosci , vol.18 , pp. 4914-4928
    • Chen, J.1    Nagayama, T.2    Jin, K.3    Stetler, R.A.4    Zhu, R.L.5    Graham, S.H.6    Simon, R.P.7
  • 10
    • 0022891493 scopus 로고
    • Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process
    • Friedlander AM (1986) Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process. J Biol Chem 261:7123-7126.
    • (1986) J Biol Chem , vol.261 , pp. 7123-7126
    • Friedlander, A.M.1
  • 11
    • 0033135367 scopus 로고    scopus 로고
    • Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome C and subsequent DNA fragmentation after permanent focal cerebral ischemia in mice
    • Fujimura M, Morita-Fujimura Y, Kawase M, Copin JC, Calagui B, Epstein CJ, Chan PH (1999) Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome C and subsequent DNA fragmentation after permanent focal cerebral ischemia in mice. J Neurosci 19:3414-3422.
    • (1999) J Neurosci , vol.19 , pp. 3414-3422
    • Fujimura, M.1    Morita-Fujimura, Y.2    Kawase, M.3    Copin, J.C.4    Calagui, B.5    Epstein, C.J.6    Chan, P.H.7
  • 12
    • 0000064578 scopus 로고    scopus 로고
    • Altered expression of Bcl-2, Bcl-X, Bax, and c-Fos colocalizes with DNA fragmentation and ischemic cell damage following middle cerebral artery occlusion in rats
    • Gillardon F, Lenz C, Waschke KF, Krajewski S, Reed JC, Zimmermann M, Kuschinsky W (1996) Altered expression of Bcl-2, Bcl-X, Bax, and c-Fos colocalizes with DNA fragmentation and ischemic cell damage following middle cerebral artery occlusion in rats Brain Res Mol Brain Res 40:254-260.
    • (1996) Brain Res Mol Brain Res , vol.40 , pp. 254-260
    • Gillardon, F.1    Lenz, C.2    Waschke, K.F.3    Krajewski, S.4    Reed, J.C.5    Zimmermann, M.6    Kuschinsky, W.7
  • 14
    • 0035122040 scopus 로고    scopus 로고
    • Programmed cell death in cerebral ischemia
    • Graham SH, Chen J (2001) Programmed cell death in cerebral ischemia. J Cereb Blood Flow Metab 21:99-109.
    • (2001) J Cereb Blood Flow Metab , vol.21 , pp. 99-109
    • Graham, S.H.1    Chen, J.2
  • 15
    • 0033782248 scopus 로고    scopus 로고
    • Bcl-2 family gene products in cerebral ischemia and traumatic brain injury
    • Graham SH, Chen J, Clark RS (2000) Bcl-2 family gene products in cerebral ischemia and traumatic brain injury. J Neurotrauma 17:831-841.
    • (2000) J Neurotrauma , vol.17 , pp. 831-841
    • Graham, S.H.1    Chen, J.2    Clark, R.S.3
  • 16
    • 0032515874 scopus 로고    scopus 로고
    • Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation
    • Hu Y, Benedict MA, Wu D, Inohara N, Nunez G (1998) Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation. Proc Natl Acad Sci USA 95:4386-4391.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 4386-4391
    • Hu, Y.1    Benedict, M.A.2    Wu, D.3    Inohara, N.4    Nunez, G.5
  • 17
    • 0031983648 scopus 로고    scopus 로고
    • Differential regulation of Bax, Bcl-2, and Bcl-X proteins in focal cortical ischemia in the rat
    • Isenmann S, Stoll G, Schroeter M, Krajewski S, Reed JC, Bahr M (1998) Differential regulation of Bax, Bcl-2, and Bcl-X proteins in focal cortical ischemia in the rat. Brain Pathol 8:49-63.
    • (1998) Brain Pathol , vol.8 , pp. 49-63
    • Isenmann, S.1    Stoll, G.2    Schroeter, M.3    Krajewski, S.4    Reed, J.C.5    Bahr, M.6
  • 20
    • 0031037897 scopus 로고    scopus 로고
    • The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
    • Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD (1997) The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis. Science 275:1132-11136.
    • (1997) Science , vol.275 , pp. 1132-11136
    • Kluck, R.M.1    Bossy-Wetzel, E.2    Green, D.R.3    Newmeyer, D.D.4
  • 22
    • 0030025668 scopus 로고    scopus 로고
    • Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo
    • Lawrence MS, Ho DY, Sun GH, Steinberg GK, Sapolsky RM (1996) Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo. J Neurosci 16:486-496.
    • (1996) J Neurosci , vol.16 , pp. 486-496
    • Lawrence, M.S.1    Ho, D.Y.2    Sun, G.H.3    Steinberg, G.K.4    Sapolsky, R.M.5
  • 24
    • 0028981908 scopus 로고
    • Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia
    • Linnik MD, Zahos P, Geschwind MD, Federoff HJ (1995) Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia. Stroke 26:1670-1675.
    • (1995) Stroke , vol.26 , pp. 1670-1675
    • Linnik, M.D.1    Zahos, P.2    Geschwind, M.D.3    Federoff, H.J.4
  • 25
    • 0032845121 scopus 로고    scopus 로고
    • Ischemic cell death in brain neurons
    • Lipton P (1999) Ischemic cell death in brain neurons. Physiol Rev 79:1431-1568.
    • (1999) Physiol Rev , vol.79 , pp. 1431-1568
    • Lipton, P.1
  • 26
    • 0035824569 scopus 로고    scopus 로고
    • Inhibition of axotomy-induced neuronal apoptosis by extracellular delivery of a Bcl-XL fusion protein
    • Liu XH, Collier RJ, Youle RJ (2001) Inhibition of axotomy-induced neuronal apoptosis by extracellular delivery of a Bcl-XL fusion protein. J Biol Chem 276:46326-46332.
    • (2001) J Biol Chem , vol.276 , pp. 46326-46332
    • Liu, X.H.1    Collier, R.J.2    Youle, R.J.3
  • 29
    • 0031974368 scopus 로고    scopus 로고
    • Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency
    • Murakami K, Kondo T, Kawase M, Li Y, Sato S, Chen SF, Chan PH (1998) Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency. J Neurosci 18:205-213.
    • (1998) J Neurosci , vol.18 , pp. 205-213
    • Murakami, K.1    Kondo, T.2    Kawase, M.3    Li, Y.4    Sato, S.5    Chen, S.F.6    Chan, P.H.7
  • 32
    • 0035002886 scopus 로고    scopus 로고
    • Manganese superoxide dismutase affects cytochrome c release and caspase-9 activation after transient focal cerebral ischemia in mice
    • Noshita N, Sugawara T, Fujimura M, Morita-Fujimura Y, Chan PH (2001) Manganese superoxide dismutase affects cytochrome c release and caspase-9 activation after transient focal cerebral ischemia in mice. J Cereb Blood Flow Metab 21:557-567.
    • (2001) J Cereb Blood Flow Metab , vol.21 , pp. 557-567
    • Noshita, N.1    Sugawara, T.2    Fujimura, M.3    Morita-Fujimura, Y.4    Chan, P.H.5
  • 33
    • 0032489390 scopus 로고    scopus 로고
    • Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex
    • Pan G, O'Rourke K, Dixit VM (1998) Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex. J Biol Chem 273:5841-5845.
    • (1998) J Biol Chem , vol.273 , pp. 5841-5845
    • Pan, G.1    O'Rourke, K.2    Dixit, V.M.3
  • 36
    • 0033985183 scopus 로고    scopus 로고
    • Apoptosis and the nervous system
    • Sastry PS, Rao KS (2000) Apoptosis and the nervous system. J Neurochem 74:1-20.
    • (2000) J Neurochem , vol.74 , pp. 1-20
    • Sastry, P.S.1    Rao, K.S.2
  • 37
    • 0032918137 scopus 로고    scopus 로고
    • Caspases as treatment targets in stroke and neurodegenerative diseases
    • Schulz JB, Weller M, Moskowitz MA (1999) Caspases as treatment targets in stroke and neurodegenerative diseases. Ann Neurol 45:421-429.
    • (1999) Ann Neurol , vol.45 , pp. 421-429
    • Schulz, J.B.1    Weller, M.2    Moskowitz, M.A.3
  • 38
    • 0033520487 scopus 로고    scopus 로고
    • In vivo protein transduction: Delivery of a biologically active protein into the mouse
    • Schwarze SR, Ho A, Vocero-Akbani A, Dowdy SF (1999) In vivo protein transduction: Delivery of a biologically active protein into the mouse. Science 285:1569-1572.
    • (1999) Science , vol.285 , pp. 1569-1572
    • Schwarze, S.R.1    Ho, A.2    Vocero-Akbani, A.3    Dowdy, S.F.4
  • 40
    • 0034141623 scopus 로고    scopus 로고
    • Adenovirus-mediated transfer of Bcl-X(L) protects neuronal cells from Bax-induced apoptosis
    • Shinoura N, Satou R, Yoshida Y, Asai A, Kirino T, Hamada H (2000) Adenovirus-mediated transfer of Bcl-X(L) protects neuronal cells from Bax-induced apoptosis. Exp Cell Res 254:221-231.
    • (2000) Exp Cell Res , vol.254 , pp. 221-231
    • Shinoura, N.1    Satou, R.2    Yoshida, Y.3    Asai, A.4    Kirino, T.5    Hamada, H.6
  • 41
    • 34248642353 scopus 로고    scopus 로고
    • Mitochondrial release of cytochrome c corresponds to the selective vulnerability of hippocampal CA1 neurons in rats after transient global cerebral ischemia
    • Sugawara T, Fujimura M, Morita-Fujimura Y, Kawase M, Chan PH (1999) Mitochondrial release of cytochrome c corresponds to the selective vulnerability of hippocampal CA1 neurons in rats after transient global cerebral ischemia. J Neurosci 19:RC39:1-6.
    • (1999) J Neurosci , vol.19 RC39 , pp. 1-6
    • Sugawara, T.1    Fujimura, M.2    Morita-Fujimura, Y.3    Kawase, M.4    Chan, P.H.5
  • 43
    • 0033971901 scopus 로고    scopus 로고
    • Bcl-2 family: Life-or-death switch
    • Tsujimoto Y, Shimizu S (2000) Bcl-2 family: Life-or-death switch. FEBS Lett 466:6-10.
    • (2000) FEBS Lett , vol.466 , pp. 6-10
    • Tsujimoto, Y.1    Shimizu, S.2
  • 44
    • 0030796183 scopus 로고    scopus 로고
    • Bcl-2 and Bcl-xL block apoptosis as well as necrosis: Possible involvement of common mediators in apoptotic and necrotic signal transduction pathways
    • Tsujimoto Y, Shimizu S, Eguchi Y, Kamiike W, Matsuda H (1997) Bcl-2 and Bcl-xL block apoptosis as well as necrosis: Possible involvement of common mediators in apoptotic and necrotic signal transduction pathways. Leukemia 11 [Suppl 3]:380-382.
    • (1997) Leukemia , vol.11 , Issue.SUPPL. 3 , pp. 380-382
    • Tsujimoto, Y.1    Shimizu, S.2    Eguchi, Y.3    Kamiike, W.4    Matsuda, H.5
  • 46
    • 0028040278 scopus 로고
    • Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia
    • Yang G, Chan PH, Chen J, Carlson E, Chen SF, Weinstein P, Epstein CJ, Kamii H (1994) Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia. Stroke 25:165-170.
    • (1994) Stroke , vol.25 , pp. 165-170
    • Yang, G.1    Chan, P.H.2    Chen, J.3    Carlson, E.4    Chen, S.F.5    Weinstein, P.6    Epstein, C.J.7    Kamii, H.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.