Metyrapone, an inhibitor of glucocorticoid production, reduces brain injury induced by focal and global ischemia and seizures

Journal of Cerebral Blood Flow and Metabolism

Volumn 16, Issue 4, 1996, Pages 585-598

  Smith Swintosky, Virginia L ^a,b   Pettigrew, L Creed ^a,b   Sapolsky, Robert M ^c   Phares, Chris ^c   Craddock, Susan D ^b   Brooke, Sheila M ^c   Mattson, Mark P ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

Alzheimer's; Corticosterone; Excitotoxicity; Hippocampus; Kainic acid; Microtubule associated proteins; Middle cerebral artery occlusion; Transient global forebrain ischemia

Indexed keywords

KAINIC ACID; METYRAPONE; STEROID 11BETA MONOOXYGENASE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; EMOTIONAL STRESS; ENZYME INHIBITION; EPILEPSY; IMMUNOCHEMISTRY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; STROKE;

EID: 0029946863     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199607000-00008     Document Type: Article

References (15)

1. Ahima RS, Garcia MM, and Harlan RE (1992) Intracellular localization of corticosteroid receptors in brain: Potential interactions with signal transduction pathways. PSEBM 201:244-253
2. Avgerinos PC, Yanovski JA, Oldfield EH, Nieman LK, Cutler GB (1994) The metyrapone and dexamethasone suppression tests for the differential diagnosis of adrenocorticotropindependent Gushing syndrome: a comparison. Ann Intern Med 121:318-327
3. Beal MF (1992) Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? Ann Neurol 31:119-130
4. Bederson JB, Pitts LH, Germano SM, Nishimura MC, Davis RL, Bartkowski HM (1986) Evaluation of 2,3,5-triphenyl-tetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats. Stroke 17:1304-1308
5. Ben-Ari Y (1985) Limbic seizure and brain damage produced by kainic acid: Mechanisms and relevance of human temporal lobe epilepsy. Neuroscience 14:375-393
6. Brint S, Jacewicz M, Kiessling M, Tanabe J, Pulsinelli W (1988) Focal brain ischemia in the rat: methods for reproducible neocortical infarction using tandem occlusion of the distal middle cerebral and ipsilateral common carotid arteries. J Cereb Blood Flow Metab 8:474-485
7. Calabrese VP, Gruemer HD, Tripathi HL, Devvey W, Fortner CA, DeLorenzo RJ (1993) Serum cortisol and cerebrospinal fluid beta-endorphins in status epilepticus. Their possible relation to prognosis. Arch Neurol 50:689-693
8. Cheng B, Christakos S, Mattson MP (1994) Tumor necrosis fac-tors protect neurons against excitotoxic/metabolic insults and promote maintenance of calcium homeostatis. Neuron 12:139-153
9. Davalos A, Fernandez-Real JM, Ricart W, Soler S, Molins A, Planas E, Genis D (1994) Iron-related damage in acute ischemic stroke. Stroke 25:1543-1546
10. Stein-Behrens B, Mattson MP, Chang I, Yeh M, Sapolsky RM (1994) Stress exacerbates neuron loss and cytoskeletal pathology in the hippocampus. J Neurosci 14:5373-5380
11. Tombaugh G, Sapolsky R (1992) Corticosterone accelerates hypoxia-induced ATP loss in cultured hippocampal astrocytes. Brain Res 588;154-159
12. Tombaugh G, Yang S, Swanson R, Sapolsky R (1992) Glucocorticoids exacerbate hypoxic and hypoglycemic hippocampal injury in vitro: biochemical correlates and a role for astrocytes. J Neurochem 59:137-142
13. Van Eekelen JAM, Kiss JZ, Wesphal HM, de Kloet ER (1987) Immunocytochemical study on the intracellular localization of the type 2 glucocorticoid receptor in the rat brain. Brain Res 436:120-128
14. Verity MA (1993) Mechanisms of phospholipase A2 activation and neuronal injury. Ann NY Acad Sci 679:110-120
15. Watanabe Y, Gould E, McEwen BS (1992) Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons. Brain Res 588:341-345