Microglia and macrophages are the major source of tumor necrosis factor in permanent middle cerebral artery occlusion in mice

Journal of Cerebral Blood Flow and Metabolism

Volumn 20, Issue 1, 2000, Pages 53-65

  Gregersen, Rikke ^a   Lambertsen, Kate ^a   Finsen, Bente ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

Cerebral ischemia; Cytokines; Middle cerebral artery occlusion; Polymorphonuclear leukocytes; Tumor necrosis factor

Indexed keywords

CYTOKINE; GLIAL FIBRILLARY ACIDIC PROTEIN; TUMOR NECROSIS FACTOR;

ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MACROPHAGE; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEOCORTEX; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL;

EID: 0033976487     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-200001000-00009     Document Type: Article

References (61)

1. Adam D, Kassier U, Kronke M (1995) Cross-linking of the p55 tumor necrosis factor receptor cytoplasmic domain by a dimeric ligand induces nuclear factor-kappa B and mediates cell death. J Biol Chem 270:17482-17487
2. Akassoglou K, Probert L, Kontogeorgos G, Kollias G (1997) Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice. J Immiinol 158:438-445
3. Barone FC, Arvin B, White RF, Miller A, Webb CL, Willette RN, Lysko PG, Feurstein GZ (1997) Tumor necrosis factor-α: a mediator of focal ischemic brain injury. Stroke 28:1233-1244
4. Bignami A, Dahl D (1985) Glial filaments in brain differentiation and the transient expression of neurofilaments in Purkinje cell development. Ann NYAcad Sci 455:563-574
5. Borset M, Medvedev AE, Sundan A, Espevik T (1996) The role of the two TNF receptors in proliferation, NF-kappa B activation and discrimination between TNF and LT alpha signalling in the human myeloma cell line OH-2. Cytokine 8:430-438
6. Botchkina GI, Meistrell ME III, Botchkina IL, Tracey KJ (1997) Expression of TNF and TNF receptors (p55 and p75) in the rat brain after focal cerebral ischemia. Mol Med 3:765-781
7. Brodie C, Blumberg PM, Jacobson KA (1998) Activation of the A2A adenosine receptor inhibits nitric oxide production in glial cells. FEBS Lett 429:139-142
8. Bruce AJ, Boling W, Kindy MS, Peschon J, Kraemer PJ, Carpenter MK, Holtsberg FW, Mattson MP (1996) Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nat Med 2:788-794
9. Buttini M, Sauter A, Boddeke HW (1994) Induction of interleukin-1 beta mRNA after focal cerebral ischaemia in the rat. Brain Res Mol Brain Res 23:126-134
10. Buttini M, Appel K, Sauter A, Gebicke-Haerter PJ, Boddeke HW (1996) Expression of tumor necrosis factor alpha after focal cerebral ischaemia in the rat. Neuroscience 71:1-16
11. Cheng B, Chritakos S, Mattson MP (1994) Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis. Neuron 12:139-153
12. Colasanti M, Persichini T, Di Pucchio T, Gremo F, Lauro GM (1995) Human ramified microglial cells produce nitric oxide upon Escherichia coli lipopolysaccharide and tumor necrosis factor alpha stimulation. Neurosci Lett 200:144-146
13. Dawson DA, Martin D, Hallenbeck JM (1996) Inhibition of tumor necrosis factor-alpha reduces focal cerebral ischemic injury in the spontaneously hypertensive rat. Neurosd Lett 25:41-14
14. Dayer JM, Beutler B, Cerami A (1985) Cathectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts. J Exp Med 612:2163-2168
15. Dopp JM, Mackenzie-Graham A, Otero GC, Merrill JE (1997) Differential expression, cytokine modulation, and specific functions of type-1 and type-2 tumor necrosis factor receptors in rat glia. J Neuroimmunol 75:104-112
16. Finsen BR, Tonder N, Augood S, Zimmer J (1992) Somatostatin and neuropeptide Y in organotypic slice cultures of the rat hippocampus: an immunocytochemical and in situ hybridization study. Neuroscience 47:105-113
17. Finsen B, Lehrmann E, Castellano B, Kiefer R, Zimmer J (1996) The role of microglial cells and brain macrophages in transient global cerebral ischemia. In: Topical issues in microglial research (Ling E-A, Tan CK, eds), New York: Elsevier, pp 297-318
18. Fleming TJ, Fleming ML, Malek TR (1993) Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow: RB6-8C5 mAb to granulocyte differentiation antigen (Gr-1) detects members of the Ly-6 family. J Immunol 151:2399-2408
19. Furukawa K, Mattson MP (1998) The transcription factor NF-KB mediates increases in calcium currents and decreases in NMDA- and AMPA/kainate-induced currents induced by tumor necrosis factor-α in hippocampal neurons. J Neurochem 70:1876-1886
20. Hart PH, Hunt EK, Bonder CS, Watson CJ, Finlay-Jones JJ (1996) Regulation of surface and soluble TNF receptor expression on human monocytes and synovial fluid macrophages by IL-4 and IL-10. J Immunol 157:3672-3680
21. Henrich-Noack P, Prehn JH, Krieglstein J (1996) TGF-beta I protects hippocampal neurons against degeneration caused by transient global ischemia: dose-response relationship and potential neuroprotective mechanisms. Stroke 27:1609-1614
22. Hsu H, Xiong J, Goeddel DV (1995) The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. Cell 81:495-504
23. Lafortune L, Nalbantoglu J, Antel JP (1996) Expression of tumor necrosis factor alpha (TNF alpha) and interleukin 6 (IL-6) mRNA in adult human astrocytes: comparison with adult microglia and fetal astrocytes. J Neuropathol Exp Neural 55:515-521
24. Lavine SD, Hofman FM, Zlokovic BV (1998) Circulating antibody against tumor necrosis factor-α protects rat brain from reperfusion injury. J Cereb Blood Flow Metab 18:52-58
25. Lehrmann E, Christensen T, Zimmer J, Diemer NH, Finsen B (1997) Microglial and macrophage reactions mark progressive changes and define the penumbra in the rat neocortex and striatum after transient middle cerebral artery occlusion. J Comp Neural 386: 461-476
26. Liu T, Me Donnell PC, Young PR, White RF, Siren AL, Hallenbeck JM, Barone FC, Feuerstein GZ (1993) Interleukin-lβ mRNA expression in ischemic cortex. Stroke 24:1746-1751
27. Liu T, Clark RK, McDonnell PC, Young PR, White MS, Barone FC, Feuerstein GZ (1994) Tumor necrosis factor-α expression in ischemic neurons. Stroke 25:1481-1487
28. Loddick SA, Rothwell NJ (1996) Neuroprotective effects of human recombinant interleukin-1 receptor antagonist in focal cerebral ischaemia in the rat. J Cereb Blood Flow Metab 16:932-940
29. Mattson MP, Goodman Y, Luo H, Fu W, Furukawa K (1997) Activation of NF-kappaB protects hippocampal neuron's against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration. J Neurosci Res 49:681-697
30. McLeish KR, Knall C, Ward RA, Gerwins P, Coxon PY, Klein JB, Johnson GL (1998) Activation of mitogen-activated protein kinase cascades during priming of human neutrophils by TNF-alpha and GM-CSF. J Leukocyte Biol 64:537-545
31. Medana IM, Hunt NH, Chaudhri G (1997) Tumor necrosis factor-alpha expression in the brain during fatal murine cerebral malaria: evidence for production by microglia and astrocytes. Am J Pathol 150:1473-1486
32. 2+-channel blocker NS-638. Neural Res 17: 353-360
33. Morioka T, Kalehua AN, Streit WJ (1991) The microglial reaction in the rat dorsal hippocampus following transient forebrain ischemia. J Cereb Blood Flow Metab 11:966-973
34. Nawashiro H, Martin D, Hallenbeck JM (1997a) Neuroprotective effects of TNF binding protein in focal cerebral ischemia. Brain Res 778:265-271
35. Nawashiro H, Tasaki K, Ruetzler CA, Hallenbeck HM (1997b) TNF-α pretreatment induces protective effects against focal cerebral ischemia in mice. J Cereb Blood Flow Metab 17:483-490
36. Neumann H, Schmidt H, Cavalie A, Jenne D, Wekerle H (1997) Major histocompatibility complex (MHC) class I gene expression in single neurons of the central nervous system: differential regulation by interferon (IFN)-gamma and tumor necrosis factor (TNF)alpha. Exp Med 20:305-316
37. Ottonello L, Dapino P, Amelotti M, Barbera P, Arduino N, Bertolotto M, Dallegri F (1998) Activation of neutrophil respiratory burst by cytokines and chemoattractants: regulatory role of extracellular matrix glycoproteins. Inflamm Res 47:345-350
38. Pennica D, Hayflick JS, Bringman TS, Palladino MA, Goeddel DV (1985) Cloning and expression in Escherichia coli of the cDNA for murine tumor necrosis factor. Proc Natl Acad Sci USA 82:6060-6064
39. Perry VH, Hume DA, Gordon S (1985) Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain. Neuroscience 15:313-326
40. Prehn JH, Backhauss C, Krieglstein J (1993) Transforming growth factor-beta 1 prevents glutamate neurotoxicity in rat neocortical cultures and protects mouse neocortex from ischemic injury in vivo. J Cereb Blood Flow Metab 13:521-525
41. Probert L, Akassoglou K, Kassiotis G, Pasparakis M, Alexopoulou L, Kollias G (1997) TNF-alpha transgenic and knockout models of CNS inflammation and degeneration. J Neuroimmunol 72:137-141
42. Rao P, Hsu KC, Chao MV (1995) Upregulation of NF-kappa B-dependent gene expression mediated by the p75 tumor necrosis factor receptor. J Interferon Cytokine Res 15:171-177
43. Renno T, Krakowski M, Piccirillo C, Lin JY, Owens T (1995) TNF-alpha expression by resident microglia and infiltrating leukocytes in the central nervous system of mice with experimental allergic encephalomyelitis: regulation by Thl cytokines. J Immunol 154: 944-953
44. Saito K, Suyama K, Nishida K, Sei Y, Basile AS (1996) Early increases in TNF-alpha, IL-6 and IL-1 beta levels following transient cerebral ischemia in gerbil brain. Neurosci Lett 206:149-152
45. Sawada M, Kondo N, Suzumura A, Marunouchi T (1989) Production of tumor necrosis factor-alpha by microglia and astrocytes in culture. Brain Res 491:394-397
46. Simmons RD, Willenborg (1990) Direct injection of cytokines into the spinal cord causes autoimmune encephalomyelitis-like inflammation. J Neural Sci 100:37-42
47. Stroemer RP, Rothwell NJ (1998) Exacerbation of ischemic brain damage by localized striatal injection of interleukin-lbeta in the rat. J Cereb Blood Flow Metab 18:833-839
48. Szaflarski J, Burtrum D, Silverstein FS (1995) Cerebral hypoxia-ischemia stimulates cytokine gene expression in perinatal rats. Stroke 26:1093-1100
49. Takahashi N, Roach A, Teplow DB, Prusiner SB, Hood L (1985) Cloning and characterization of the myelin basic protein gene from mouse: one gene can encode both 12 kd and 18.5 kd MBPs by alternate use of exons. Cell 42:139-148
50. Tchelingerian JL, Vignais L, Jacque C (1994) TNF alpha gene expression is induced in neurones after a hippocampal lesion. Neuroreport 5:585-588
51. Tchelingerian JL, Le Saux F, Jacque C (1996) Identification and topography of neuronal cell populations expressing TNF alpha and IL-1 alpha in response to hippocampal lesion. J Neurosci Res 43:99-106
52. Tokunaga K, Nakamura Y, Sakata K, Fujimori K, Ohkbo M, Sawada K, Sakiyama S (1987) Enhanced expression of a glyceraldehyde-3-phosphate dehydrogenase gene in human lung cancers. Cancer Res 47:5616-5619
53. Trembleau A, Roche D, Calas A (1993) Combination of nonradioactive and radioactive in situ hybridization with immunohistochemistry: a new method allowing the simultaneous detection of two mRNAs and one antigen in the same brain tissue section. J Histochem Cytochem 41:489-498
54. Uno H, Matsuyama T, Akita H, Nishimura H, Sugita M (1997) Induction of tumor necrosis factor-α in the mouse hippocampus following transient forebrain ischemia. J Cereb Blood Flow Metab 17: 491-499
55. Villarroya H, Violleau K, Ben Younes-Chennoufi A, Baumann N (1996) Myelin-induced experimental allergic encephalomyelitis in Lewis rats: tumor necrosis factor alpha levels in serum and cerebrospinal fluid immunohistochemical expression in glial cells and macrophages of optic nerve and spinal cord. J Neuroimmunol 64: 55-61
56. Wang X, Yue TL, Barone FC, White RF, Gagnon RC, Feuerstein GZ (1994) Concomitant cortical expression of TNF-alpha and IL-1 beta mRNAs follows early response gene expression in transient focal ischemia. Mol Cliem Neuropathol 23:103-114
57. Wang X, Yue TL, Young PR, Barone FC, Feuerstein GZ (1995) Expression of interleukin-6, c-fos, and zif268 mRNAs in rat ischemic cortex. J Cereb Blood Flow Metab 15:166-171
58. West JM, Ostergaard K, Andreasen OA, Finsen B (1996) Estimation of the number of somatostatin neurons in the striatum: an in situ hybridization study using the optical fractionator method. J Comp Neuro; 370:11-22
59. Winston BW, Lange-Carter CA. Gardner AM, Johnson GL, Riches DW (1995) Tumor necrosis factor alpha rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf-1-independent fashion in mouse macrophages. Proc Nail Acad Sci USA 92:1614-1618
60. Yang GY ( 1997) Overexpression of interleukin-1 receptor antagonist in the mouse brain reduces ischemic brain injury. Brain Res 751:181-187
61. Yang GY, Gong C, Qin Z, Ye W, Mao Y, Bertz AL (1998) Inhibition of TNFα attenuates infarct volume and ICAM-1 expression in ischemic mouse brain. Neurorcport 9:2131-2134