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Volumn 83, Issue 6, 2002, Pages 1471-1480

Rat MYH, a glycosylase for repair of oxidatively damaged DNA, has brain-specific isoforms that localize to neuronal mitochondria

Author keywords

7,8 dihydro 8 oxoguanine; DNA repair; Hypoxia; Mitochondria; MYH; Rat brain

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; DNA GLYCOSYLTRANSFERASE; ISOENZYME; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE; SUPEROXIDE;

EID: 0036904660     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.01259.x     Document Type: Article
Times cited : (45)

References (46)
  • 1
    • 0027171266 scopus 로고
    • Oxidants, antioxidants, and the degenerative diseases of aging
    • Ames B. N., Shigenaga M. K. and Hagen T. M. (1993) Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl. Acad. Sci. USA 90, 7915-7922.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 7915-7922
    • Ames, B.N.1    Shigenaga, M.K.2    Hagen, T.M.3
  • 3
    • 0034057202 scopus 로고    scopus 로고
    • Improved recovery of highly enriched mitochondrial fractions from small brain tissue samples
    • Anderson M. F. and Sims N. R. (2000) Improved recovery of highly enriched mitochondrial fractions from small brain tissue samples. Brain Res. Brain Res. Protoc. 5, 95-101.
    • (2000) Brain Res. Brain Res. Protoc. , vol.5 , pp. 95-101
    • Anderson, M.F.1    Sims, N.R.2
  • 4
    • 0034237719 scopus 로고    scopus 로고
    • Energetics in the pathogenesis of neurodegenerative diseases
    • Beal M. F. (2000) Energetics in the pathogenesis of neurodegenerative diseases. Trends Neurosci. 23, 298-304.
    • (2000) Trends Neurosci. , vol.23 , pp. 298-304
    • Beal, M.F.1
  • 5
    • 0030008052 scopus 로고    scopus 로고
    • Superoxide production in rat hippocampal neurons: Selective imaging with hydroethidine
    • Bindokas V. P., Jordan J., Lee C. C. and Miller R. J. (1996) Superoxide production in rat hippocampal neurons: Selective imaging with hydroethidine. J. Neurosci. 16, 1324-1336.
    • (1996) J. Neurosci. , vol.16 , pp. 1324-1336
    • Bindokas, V.P.1    Jordan, J.2    Lee, C.C.3    Miller, R.J.4
  • 7
    • 0343517173 scopus 로고    scopus 로고
    • Detection of DNA baseexcision repair activity for oxidative lesions in adult rat brain mitochondria
    • Chen D., Lan J., Pei W. and Chen J. (2000) Detection of DNA baseexcision repair activity for oxidative lesions in adult rat brain mitochondria. J. Neurosci. Res. 61, 225-236.
    • (2000) J. Neurosci. Res. , vol.61 , pp. 225-236
    • Chen, D.1    Lan, J.2    Pei, W.3    Chen, J.4
  • 8
    • 0034798348 scopus 로고    scopus 로고
    • Reduction and restoration of mitochondrial DNA content after focal cerebral ischemia/reperfusion
    • Chen H., Hu C. J., He Y. Y., Yang D. I., Xu J. and Hsu C. Y. (2001) Reduction and restoration of mitochondrial DNA content after focal cerebral ischemia/reperfusion. Stroke 32, 2382-2387.
    • (2001) Stroke , vol.32 , pp. 2382-2387
    • Chen, H.1    Hu, C.J.2    He, Y.Y.3    Yang, D.I.4    Xu, J.5    Hsu, C.Y.6
  • 9
    • 0029915525 scopus 로고    scopus 로고
    • Computational method to predict mitochondrially imported proteins and their targeting sequences
    • Claros M. G. and Vincens P. (1996) Computational method to predict mitochondrially imported proteins and their targeting sequences. Eur. J. Biochem. 241, 779-786.
    • (1996) Eur. J. Biochem. , vol.241 , pp. 779-786
    • Claros, M.G.1    Vincens, P.2
  • 10
    • 0030881789 scopus 로고    scopus 로고
    • Repair of oxidative damage to nuclear and mitochondrial DNA in mammalian cells
    • Croteau D. L. and Bohr V. A. (1997) Repair of oxidative damage to nuclear and mitochondrial DNA in mammalian cells. J. Biol. Chem. 272, 25409-25412.
    • (1997) J. Biol. Chem. , vol.272 , pp. 25409-25412
    • Croteau, D.L.1    Bohr, V.A.2
  • 11
  • 12
    • 0032509471 scopus 로고    scopus 로고
    • Repair pathways for processing of 8-oxoguanine in DNA by mammalian cell extracts
    • Dianov G., Bischoff C., Piotrowski J. and Bohr V. A. (1998) Repair pathways for processing of 8-oxoguanine in DNA by mammalian cell extracts. J. Biol. Chem. 273, 33811-33816.
    • (1998) J. Biol. Chem. , vol.273 , pp. 33811-33816
    • Dianov, G.1    Bischoff, C.2    Piotrowski, J.3    Bohr, V.A.4
  • 13
    • 0034535899 scopus 로고    scopus 로고
    • Enhanced mitochondrial DNA repair and cellular survival after oxidative stress by targeting the human 8-oxoguanine glycosylase repair enzyme to mitochondria
    • Dobson A. W., Xu Y., Kelley M. R., LeDoux S. P. and Wilson G. L. (2000) Enhanced mitochondrial DNA repair and cellular survival after oxidative stress by targeting the human 8-oxoguanine glycosylase repair enzyme to mitochondria. J. Biol. Chem. 275, 37518-37523.
    • (2000) J. Biol. Chem. , vol.275 , pp. 37518-37523
    • Dobson, A.W.1    Xu, Y.2    Kelley, M.R.3    LeDoux, S.P.4    Wilson, G.L.5
  • 14
    • 0027438888 scopus 로고
    • Repair of oxidative damage within the mitochondrial DNA of RINr 38 cells
    • Driggers W. J., LeDoux S. P. and Wilson G. L. (1993) Repair of oxidative damage within the mitochondrial DNA of RINr 38 cells. J. Biol. Chem. 268, 22042-22045.
    • (1993) J. Biol. Chem. , vol.268 , pp. 22042-22045
    • Driggers, W.J.1    LeDoux, S.P.2    Wilson, G.L.3
  • 15
    • 0031753652 scopus 로고    scopus 로고
    • Defective repair of oxidative damage in mitochondrial DNA in Down's syndrome
    • Druzhyna N., Nair R. G., LeDoux S. P. and Wilson G. L. (1998) Defective repair of oxidative damage in mitochondrial DNA in Down's syndrome. Mutat. Res. 409, 81-89.
    • (1998) Mutat. Res. , vol.409 , pp. 81-89
    • Druzhyna, N.1    Nair, R.G.2    LeDoux, S.P.3    Wilson, G.L.4
  • 17
    • 0014690248 scopus 로고
    • Apparent turnover of mitochondrial deoxyribonucleic acid and mitochondrial phospholipids in the tissues of the rat
    • Gross N. J., Getz G. S. and Rabinowitz M. (1969) Apparent turnover of mitochondrial deoxyribonucleic acid and mitochondrial phospholipids in the tissues of the rat. J. Biol. Chem. 244, 1552-1562.
    • (1969) J. Biol. Chem. , vol.244 , pp. 1552-1562
    • Gross, N.J.1    Getz, G.S.2    Rabinowitz, M.3
  • 19
    • 0032883894 scopus 로고    scopus 로고
    • Exacerbation of delayed cell injury after transient global ischemia in mutant mice with CuZn superoxide dismutase deficiency
    • Kawase M., Murakami K., Fujimura M., Morita-Fujimura Y., Gasche Y., Kondo T., Scott R. W. and Chan P. H. (1999) Exacerbation of delayed cell injury after transient global ischemia in mutant mice with CuZn superoxide dismutase deficiency. Stroke 30, 19621968.
    • (1999) Stroke , vol.30 , pp. 19621968
    • Kawase, M.1    Murakami, K.2    Fujimura, M.3    Morita-Fujimura, Y.4    Gasche, Y.5    Kondo, T.6    Scott, R.W.7    Chan, P.H.8
  • 20
    • 0031990207 scopus 로고    scopus 로고
    • Mitochondrial DNA synthesis studied autoradiographically in various cell types in vivo
    • Korr H., Kurz C., Seidler T. O., Sommer D. and Schmitz C. (1998) Mitochondrial DNA synthesis studied autoradiographically in various cell types in vivo. Braz. J.- Med. Biol. Res. 31, 289-298.
    • (1998) Braz. J.- Med. Biol. Res. , vol.31 , pp. 289-298
    • Korr, H.1    Kurz, C.2    Seidler, T.O.3    Sommer, D.4    Schmitz, C.5
  • 21
    • 0036312376 scopus 로고    scopus 로고
    • Hypoxia induces mitochondrial DNA damage and stimulates expression of a DNA repair enzyme, the Escherichia coli MutY DNA glycosylase homolog (MYH), in vivo, in the rat brain
    • Lee H. M., Wang C., Hu Z., Greeley G. H., Makalowski W., Hellmich H. L. and Englander E. W. (2002) Hypoxia induces mitochondrial DNA damage and stimulates expression of a DNA repair enzyme, the Escherichia coli MutY DNA glycosylase homolog (MYH), in vivo, in the rat brain. J. Neurochem. 80, 928-937.
    • (2002) J. Neurochem. , vol.80 , pp. 928-937
    • Lee, H.M.1    Wang, C.2    Hu, Z.3    Greeley, G.H.4    Makalowski, W.5    Hellmich, H.L.6    Englander, E.W.7
  • 22
    • 0034548909 scopus 로고    scopus 로고
    • Intact MutY and its catalytic domain differentially contact with A/8-oxoG-containing DNA
    • Li X and Lu A. L. (2000) Intact MutY and its catalytic domain differentially contact with A/8-oxoG-containing DNA. Nucl. Acids Res. 28, 4593-4603.
    • (2000) Nucl. Acids Res. , vol.28 , pp. 4593-4603
    • Li, X.1    Lu, A.L.2
  • 23
    • 0037133283 scopus 로고    scopus 로고
    • Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl-L-camitine and/or R-alpha-lipoic acid
    • Liu J., Head E., Gharib A. M., Yuan W., Ingersoll R. T., Hagen T. M., Cotman C. W. and Ames B. N. (2002) Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl-L-camitine and/or R-alpha-lipoic acid. Proc. Natl. Acad. Sci. USA 99, 2356-2361.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 2356-2361
    • Liu, J.1    Head, E.2    Gharib, A.M.3    Yuan, W.4    Ingersoll, R.T.5    Hagen, T.M.6    Cotman, C.W.7    Ames, B.N.8
  • 24
    • 0033937733 scopus 로고    scopus 로고
    • The role of mitochondria in the pathogenesis of neurodegenerative diseases
    • Manfredi G. and Beal M. F. (2000) The role of mitochondria in the pathogenesis of neurodegenerative diseases. Brain Pathol. 10, 462-472.
    • (2000) Brain Pathol. , vol.10 , pp. 462-472
    • Manfredi, G.1    Beal, M.F.2
  • 25
    • 0032431037 scopus 로고    scopus 로고
    • Systemic hypoxia changes the organspecific distribution of vascular endothelial growth factor and its receptors
    • Marti H. H. and Risau W. (1998) Systemic hypoxia changes the organspecific distribution of vascular endothelial growth factor and its receptors. Proc. Natl. Acad. Sci. USA 95, 15809-15814.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 15809-15814
    • Marti, H.H.1    Risau, W.2
  • 27
    • 0028831129 scopus 로고
    • Characterization of a mammalian homolog of the Escherichia coli MutY mismatch repair protein
    • McGoldrick J. P., Yeh Y. C., Solomon M., Essigmann J. M. and Lu A. L. (1995) Characterization of a mammalian homolog of the Escherichia coli MutY mismatch repair protein. Mol. Cell. Biol. 15, 989-996.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 989-996
    • McGoldrick, J.P.1    Yeh, Y.C.2    Solomon, M.3    Essigmann, J.M.4    Lu, A.L.5
  • 29
    • 0031974368 scopus 로고    scopus 로고
    • Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency
    • Murakami K., Kondo T., Kawase M., Li Y., Sato S., Chen S. F. and Chan P. H. (1998) Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency. J. Neurosci. 18, 205-213.
    • (1998) J. Neurosci. , vol.18 , pp. 205-213
    • Murakami, K.1    Kondo, T.2    Kawase, M.3    Li, Y.4    Sato, S.5    Chen, S.F.6    Chan, P.H.7
  • 30
    • 0033961277 scopus 로고    scopus 로고
    • Terminally differentiated human neurons repair transcribed genes but display attenuated global DNA repair and modulation of repair gene expression
    • Nouspikel T. and Hanawalt P. C. (2000) Terminally differentiated human neurons repair transcribed genes but display attenuated global DNA repair and modulation of repair gene expression. Mol. Cell. Biol. 20, 1562-1570.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 1562-1570
    • Nouspikel, T.1    Hanawalt, P.C.2
  • 31
    • 0034654256 scopus 로고    scopus 로고
    • Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria
    • Ohtsubo T., Nishioka K., Imaiso Y., Iwai S., Shimokawa H., Oda H., Fujiwara T. and Nakabeppu Y. (2000) Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria. Nucl. Acids Res. 28, 1355-1364.
    • (2000) Nucl. Acids Res. , vol.28 , pp. 1355-1364
    • Ohtsubo, T.1    Nishioka, K.2    Imaiso, Y.3    Iwai, S.4    Shimokawa, H.5    Oda, H.6    Fujiwara, T.7    Nakabeppu, Y.8
  • 32
    • 0034284108 scopus 로고    scopus 로고
    • Purification and characterization of a mammalian homolog of Escherichia coli MutY mismatch repair protein from calf liver mitochondria
    • Parker A., Gu Y. and Lu A. L. (2000) Purification and characterization of a mammalian homolog of Escherichia coli MutY mismatch repair protein from calf liver mitochondria. Nucl. Acids Res. 28, 3206-3215.
    • (2000) Nucl. Acids Res. , vol.28 , pp. 3206-3215
    • Parker, A.1    Gu, Y.2    Lu, A.L.3
  • 33
    • 0031952184 scopus 로고    scopus 로고
    • Efficient repair of abasic sites in DNA by mitochondrial enzymes
    • Pinz K. G. and Bogenhagen D. F. (1998) Efficient repair of abasic sites in DNA by mitochondrial enzymes. Mol. Cell. Biol. 18, 1257-1265.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 1257-1265
    • Pinz, K.G.1    Bogenhagen, D.F.2
  • 34
    • 0028901020 scopus 로고
    • Action of mitochondrial DNA polymerase gamma at sites of base loss or oxidative damage
    • Pinz K. G., Shibutani S. and Bogenhagen D. F. (1995) Action of mitochondrial DNA polymerase gamma at sites of base loss or oxidative damage. J. Biol. Chem. 270, 9202-9206.
    • (1995) J. Biol. Chem. , vol.270 , pp. 9202-9206
    • Pinz, K.G.1    Shibutani, S.2    Bogenhagen, D.F.3
  • 35
    • 0026072341 scopus 로고
    • Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice
    • Semenza G. L., Koury S. T., Nejfelt M. K., Gearhart J. D. and Antonarakis S. E. (1991) Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice. Proc. Natl. Acad. Sci. USA 88, 8725-8729.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 8725-8729
    • Semenza, G.L.1    Koury, S.T.2    Nejfelt, M.K.3    Gearhart, J.D.4    Antonarakis, S.E.5
  • 36
    • 0030004207 scopus 로고    scopus 로고
    • Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage
    • Slupska M. M., Baikalov C., Luther W. M., Chiang J. H., Wei Y. F. and Miller J. H. (1996) Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage. J. Bacteriol. 178, 3885-3892.
    • (1996) J. Bacteriol. , vol.178 , pp. 3885-3892
    • Slupska, M.M.1    Baikalov, C.2    Luther, W.M.3    Chiang, J.H.4    Wei, Y.F.5    Miller, J.H.6
  • 37
    • 0033561246 scopus 로고    scopus 로고
    • Age-associated increase in 8-oxo-deoxyguanosine glycosylase/AP lyase activity in rat mitochondria
    • Souza-Pinto N. C., Croteau D. L., Hudson E. K., Hansford R. G. and Bohr V. A. (1999) Age-associated increase in 8-oxo-deoxyguanosine glycosylase/AP lyase activity in rat mitochondria. Nucl. Acids Res. 27, 1935-1942.
    • (1999) Nucl. Acids Res. , vol.27 , pp. 1935-1942
    • Souza-Pinto, N.C.1    Croteau, D.L.2    Hudson, E.K.3    Hansford, R.G.4    Bohr, V.A.5
  • 38
    • 0036138386 scopus 로고    scopus 로고
    • Overexpression of copper/zinc superoxide dismutase in transgenic rats protects vulnerable neurons against ischemic damage by blocking the mitochondrial pathway of caspase activation
    • Sugawara T., Noshita N., Lewen A., Gasche Y., Ferrand-Drake M., Fujimura M., Morita-Fujimura Y. and Chan P. H. (2002) Overexpression of copper/zinc superoxide dismutase in transgenic rats protects vulnerable neurons against ischemic damage by blocking the mitochondrial pathway of caspase activation. J. Neurosci. 22, 209-217.
    • (2002) J. Neurosci. , vol.22 , pp. 209-217
    • Sugawara, T.1    Noshita, N.2    Lewen, A.3    Gasche, Y.4    Ferrand-Drake, M.5    Fujimura, M.6    Morita-Fujimura, Y.7    Chan, P.H.8
  • 39
    • 0032526616 scopus 로고    scopus 로고
    • Mitochondrial targeting of human DNA glycosylases for repair of oxidative DNA damage
    • Takao M., Aburatani H., Kobayashi K. and Yasui A. (1998) Mitochondrial targeting of human DNA glycosylases for repair of oxidative DNA damage. Nucl. Acids Res. 26, 2917-2922.
    • (1998) Nucl. Acids Res. , vol.26 , pp. 2917-2922
    • Takao, M.1    Aburatani, H.2    Kobayashi, K.3    Yasui, A.4
  • 40
    • 0033568099 scopus 로고    scopus 로고
    • Differential subcellular localization of human MutY homolog (hMYH) and the functional activity of adenine: 8-Oxoguanine DNA glycosylase
    • Takao M., Zhang Q. M., Yonei S. and Yasui A. (1999) Differential subcellular localization of human MutY homolog (hMYH) and the functional activity of adenine: 8-Oxoguanine DNA glycosylase. Nucl. Acids Res. 27, 3638-3644.
    • (1999) Nucl. Acids Res. , vol.27 , pp. 3638-3644
    • Takao, M.1    Zhang, Q.M.2    Yonei, S.3    Yasui, A.4
  • 41
  • 42
    • 0345379628 scopus 로고    scopus 로고
    • Phenotypic change caused by transcriptional bypass of uracil in nondividing cells
    • Viswanathan A., You H. J. and Doetsch P. W. (1999) Phenotypic change caused by transcriptional bypass of uracil in nondividing cells. Science 284, 159-162.
    • (1999) Science , vol.284 , pp. 159-162
    • Viswanathan, A.1    You, H.J.2    Doetsch, P.W.3
  • 44
    • 0024561501 scopus 로고
    • Cytochrome oxidase: An endogenous metabolic marker for neuronal activity
    • Wong-Riley M. T. (1989) Cytochrome oxidase: An endogenous metabolic marker for neuronal activity. Trends Neurosci. 12, 94-101.
    • (1989) Trends Neurosci. , vol.12 , pp. 94-101
    • Wong-Riley, M.T.1
  • 45
    • 0031032817 scopus 로고    scopus 로고
    • Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress
    • Yakes F. M. and Van Houten B. (1997) Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc. Natl. Acad. Sci. USA 94, 514-519.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 514-519
    • Yakes, F.M.1    Van Houten, B.2
  • 46
    • 0035253515 scopus 로고    scopus 로고
    • Enhanced activity of adenine-DNA glycosylase (Myh) by apurinic/apyrimidinic endonuclease (Ape1) in mammalian base excision repair of an A/GO mismatch
    • Yang H., Clendenin W. M., Wong D., Demple B., Slupska M. M., Chiang J. H. and Miller J. H. (2001) Enhanced activity of adenine-DNA glycosylase (Myh) by apurinic/apyrimidinic endonuclease (Ape1) in mammalian base excision repair of an A/GO mismatch. Nucl. Acids Res. 29, 743-752.
    • (2001) Nucl. Acids Res. , vol.29 , pp. 743-752
    • Yang, H.1    Clendenin, W.M.2    Wong, D.3    Demple, B.4    Slupska, M.M.5    Chiang, J.H.6    Miller, J.H.7


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