Early appearance of activated matrix metalloproteinase-9 and blood-brain barrier disruption in mice after focal cerebral ischemia and reperfusion

Brain Research

Volumn 842, Issue 1, 1999, Pages 92-100

  Fujimura, Miki ^a   Gasche, Yvan ^a   Morita Fujimura, Yuiko ^a   Massengale, Justin ^a   Kawase, Makoto ^a   Chan, Pak H ^a  

^a Prog N   (United States)

Author keywords

Blood brain barrier; Brain edema; Cerebral ischemia; Matrix metalloproteinase; Reperfusion injury

Indexed keywords

GELATINASE B;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD FLOW; BRAIN EDEMA; BRAIN ISCHEMIA; ENZYME ACTIVATION; ENZYME ACTIVITY; IMMUNOBLOTTING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION; ZYMOGRAPHY;

ANIMALS; BLOOD-BRAIN BARRIER; BLOTTING, WESTERN; COLLAGEN; COLLAGENASES; COLORING AGENTS; DEXAMETHASONE; DRUG COMBINATIONS; ENZYME INHIBITORS; EVANS BLUE; GELATINASES; IMMUNOHISTOCHEMISTRY; INFARCTION, MIDDLE CEREBRAL ARTERY; ISCHEMIC ATTACK, TRANSIENT; MALE; MATRIX METALLOPROTEINASE 9; MICE; PENTOXIFYLLINE; REPERFUSION INJURY; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 0033581392     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)01843-0     Document Type: Article

References (36)

1. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group Tissue plasminogen activator for acute ischemic stroke. N. Engl. J. Med. 333:1995;1581-1587.
2. Aoki T., Suzuki Y., Nishio K., Suzuki K., Miyata A., Oyamada Y., Mori M., Fujita H., Yamaguchi K. Effect of antioxidants on hyperoxia-induced ICAM-1 expression in human endothelial cells. Adv. Exp. Med. Biol. 411:1997;503-511.
3. Backstrom J.R., Lim G.P., Cullen M.J., Tokes Z.A. Matrix metalloproteinase-9 (MMP-9) is synthesized in neurons of the human hippocampus and is capable of degrading the amyloid-beta peptide (1-40). J. Neurosci. 16:1996;7910-7919.
4. Belayev L., Busto R., Zhao W., Ginsberg M.D. Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats. Brain Res. 739:1996;88-96.
5. Bruno G., Todor R., Lewis I., Chyatte D. Vascular extracellular matrix remodeling in cerebral aneurysms. J. Neurosurg. 89:1998;431-440.
6. Chan P.H., Epstein C.J., Li Y., Huang T.T., Carlson E., Kinouchi H., Yang G., Kamii H., Mikawa S., Kondo T.et al. Transgenic mice and knockout mutants in the study of oxidative stress in brain injury. J. Neurotrauma. 12:1995;815-824.
7. Chan P.H. Role of oxidants in ischemic brain damage. Stroke. 27:1996;1124-1129.
8. Chopp M., Li Y., Jiang N., Zhang R.L., Prostak J. Antibodies against adhesion molecules reduce apoptosis after transient middle cerebral artery occlusion in rat brain. J. Cereb. Blood Flow Metab. 16:1996;578-584.
9. Clark A.W., Krekoski C.A., Bou S.S., Chapman K.R., Edwards D.R. Increased gelatinase A (MMP-2) and gelatinase B (MMP-9) activities in human brain after focal ischemia. Neurosci. Lett. 238:1997;53-56.
10. Connolly E.S. Jr., Winfree C.J., Springer T.A., Naka Y., Liao H., Yan S.D., Stern D.M., Solomon R.A., Gutierrez-Ramos J.C., Pinsky D.J. Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion. Role of neutrophil adhesion in the pathogenesis of stroke. J. Clin. Invest. 97:1996;209-216.
11. Fujimura M., Morita-Fujimura Y., Murakami K., Kawase M., Chan P.H. Cytosolic redistribution of cytochrome c after transient focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab. 18:1998;1239-1247.
12. Gottschall P.E., Yu X. Cytokines regulate gelatinase A and B (matrix metalloproteinase 2 and 9) activity in cultured rat astrocytes. J. Neurochem. 64:1995;1513-1520.
13. Gottschall P.E., Yu X., Bing B. Increased production of gelatinase B (matrix metalloproteinase-9) and interleukin-6 by activated rat microglia in culture. J. Neurosci. Res. 42:1995;335-342.
14. Hamann G.F., Okada Y., Fitridge R., del Zoppo G.J. Microvascular basal lamina antigens disappear during cerebral ischemia and reperfusion. Stroke. 26:1995;2120-2126.
15. Kim S.C., Singh M., Huang J., Prestigiacomo C.J., Winfree C.J., Solomon R.A., Connolly E.S. Jr. Matrix metalloproteinase-9 in cerebral aneurysms. Neurosurgery. 41:1997;642-666.
16. Kinouchi H., Epstein C.J., Mizui T., Carlson E., Chen S.F., Chan P.H. Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase. Proc. Natl. Acad. Sci. U.S.A. 88:1991;11158-11162.
17. Kleiner D.E., Stetler-Stevenson W.G. Quantitative zymography: detection of picogram quantities of gelatinases. Anal. Biochem. 218:1994;325-329.
18. Kondo T., Reaume A.G., Huang T.T., Carlson E., Murakami K., Chen S.F., Hoffman E.K., Scott R.W., Epstein C.J., Chan P.H. Reduction of CuZn-superoxide dismutase activity exacerbates neuronal cell injury and edema formation after transient focal cerebral ischemia. J. Neurosci. 17:1997;4180-4189.
19. Nguyen M., Arkell J., Jackson C.J. Active and tissue inhibitor of matrix metalloproteinase-free gelatinase B accumulates within human microvascular endothelial vesicles. J. Biol. Chem. 273:1998;5400-5404.
20. Oliver G.W., Leferson J.D., Stetler-Stevenson W.G., Kleiner D.E. Quantitative reverse zymography: analysis of picogram amounts of metalloproteinase inhibitors using gelatinase A and B reverse zymograms. Anal. Biochem. 244:1997;161-166.
21. Quesada A.R., Barbacid M.M., Mira E., Fernandez-Resa P., Marquez G., Aracil M. Evaluation of fluorometric and zymographic methods as activity assays for stromelysins and gelatinases. Clin. Exp. Metastasis. 15:1997;26-32.
22. Rajagopalan S., Meng X.P., Ramasamy S., Harrison D.G., Galis Z.S. Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability. J. Clin. Invest. 98:1996;2572-2579.
23. Romanic A.M., White R.F., Arleth A.J., Ohlstein E.H., Barone F.C. Matrix metalloproteinase expression increases after cerebral focal ischemia in rats: inhibition of matrix metalloproteinase-9 reduces infarct size. Stroke. 29:1998;1020-1030.
24. Rosenberg G.A., Navratil M., Barone F., Feuerstein G. Proteolytic cascade enzymes increase in focal cerebral ischemia in rat. J. Cereb. Blood Flow Metab. 16:1996;360-366.
25. Rosenberg G.A., Dencoff J.E., Correa N. Jr., Reiners M., Ford C.C. Effect of steroids on CSF matrix metalloproteinases in multiple sclerosis: relation to blood-brain barrier injury. Neurology. 46:1996;1626-1632.
26. Rosenberg G.A., Navratil M. Metalloproteinase inhibition blocks edema in intracerebral hemorrhage in the rat. Neurology. 48:1997;921-926.
27. Rosenberg G.A., Estrada E.Y., Dencoff J.E. Matrix metalloproteinases and TIMPs are associated with blood-brain-barrier opening after reperfusion in rat brain. Stroke. 29:1998;2189-2195.
28. Salminen A., Liu P.K., Hsu C.Y. Alteration of transcription factor binding activities in the ischemic rat brain. Biochem. Biophys. Res. Commun. 212:1995;939-944.
29. Shingu M., Isayama T., Yasutake C., Naono T., Nobunaga M., Tomari K., Horie K., Goto Y. Role of oxygen radicals and IL-6 in IL-1-dependent cartilage matrix degradation. Inflammation. 18:1994;613-623.
30. Soriano S.G., Lipton S.A., Wang Y.F., Xiao M., Springer T.A., Gutierrez-Ramos J.C., Hickey P.R. Intercellular adhesion molecule-1-deficient mice are less susceptible to cerebral ischemia-reperfusion injury. Ann. Neurol. 39:1996;618-624.
31. Uhm J.H., Dooley N.P., Oh L.Y., Yong V.W. Oligodendrocytes utilize a matrix metalloproteinase, MMP-9, to extend processes along an astrocyte extracellular matrix. Glia. 22:1998;53-63.
32. Van Wart H.E., Birkedal-Hansen H. The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family. Proc. Natl. Acad. Sci. U.S.A. 87:1990;5578-5582.
33. Yang G., Chan P.H., Chen J., Carlson E., Chen S.F., Weinstein P., Epstein C.J., Kamii H. Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia. Stroke. 25:1994;165-170.
34. Yang G.Y., Betz A.L. Reperfusion-induced injury to the blood-brain barrier after middle cerebral artery occlusion in rats. Stroke. 25:1994;1658-1664. Discussion 1664-1655.
35. Zhang R.L., Chopp M., Jiang N., Tang W.X., Prostak J., Manning A.M., Anderson D.C. Anti-intercellular adhesion molecule-1 antibody reduces ischemic cell damage after transient but not permanent middle cerebral artery occlusion in the Wistar rat. Stroke. 26:1995;1438-1442.
36. Zhang J.W., Gottschall P.E. Zymographic measurement of gelatinase activity in brain tissue after detergent extraction and affinity-support purification. J. Neurosci. Methods. 76:1997;15-20.